Gene: TIGIT

201633
VSIG9|VSTM3|WUCAM
T cell immunoreceptor with Ig and ITIM domains
protein-coding
3q13.31
Ensembl:ENSG00000181847 MIM:612859 Vega:OTTHUMG00000159331 UniprotKB:Q495A1
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.286e-1 (AD)  8.704e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22870429chr3:114027859TIGIT5.000e-9Smoking27651444
cg20832020chr3:114012912TIGIT2.960e-9Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LCK0.722
KLRB10.711
TBX210.699
IL2RB0.674
CD3G0.669
SLAMF70.669
GZMK0.668
CD20.665
LY90.659
PYHIN10.639

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUM1L1-0.503
SIRT4-0.487
ADPRHL1-0.476
KCNS1-0.474
KCNJ6-0.47
EFNA5-0.466
NOS1AP-0.464
SSTR3-0.461
IPCEF1-0.461
CA7-0.459

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TIGIT gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TIGIT mRNA24449571
D001280AtrazineAtrazine results in increased expression of TIGIT mRNA22378314
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TIGIT mRNA25613284
C047806monomethylpropionmonomethylpropion results in increased expression of TIGIT mRNA22303338
D009532NickelNickel results in increased expression of TIGIT mRNA24768652|2558310
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TIGIT mRNA25613284

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI19011627  
GO:0005515protein binding-IPI19011627  21982860  25465800  27978489  28515320  
GO:0042802identical protein binding-IPI27978489  
GO ID GO Term Qualifier Evidence PubMed
GO:0032695negative regulation of interleukin-12 production-IMP19011627  
GO:0032733positive regulation of interleukin-10 production-IMP19011627  
GO:0050868negative regulation of T cell activation-IDA19011627  
GO:0050868negative regulation of T cell activation-IMP19011627  
GO ID GO Term Qualifier Evidence PubMed
GO:0009986cell surface-IDA19011627  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27777979The head and neck cancer immune landscape and its immunotherapeutic implications. (2016 Oct 20)Mandal RJCI Insight