Gene: CTTN

2017
EMS1
cortactin
protein-coding
11q13.3
Ensembl:ENSG00000085733 MIM:164765 Vega:OTTHUMG00000134307 UniprotKB:Q14247
NG_029881.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.896e-1 (AD)  5.642e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11263997chr11:70257280CTTN4.300e-29Smoking27651444
cg23261640chr11:70280489CTTN2.600e-8Smoking27651444
cg10395806chr11:70280601CTTN3.000e-8Smoking27651444
cg16061668chr11:70257149CTTN9.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRSF50.949
EWSR10.934
UBE2G20.934
TRPC4AP0.93
SAFB0.929
RING10.927
CDC370.926
XPO60.926
SRSF40.922
SSRP10.922

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.765
OR4F29-0.757
MTRNR2L9-0.28
MTRNR2L6-0.267
MTRNR2L10-0.244
TRDN-0.198
OR4F16-0.194
TTLL10-0.192
TTLL10-AS1-0.183
C8orf74-0.168

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CTTN mRNA"19095052
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CTTN mRNA"19167446
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of CTTN mRNA19643169
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CTTN mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CTTN mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTTN mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CTTN mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTTN mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CTTN protein22230336
D000082AcetaminophenAcetaminophen results in increased expression of CTTN protein22230336
D020106AcrylamideAcrylamide affects the expression of CTTN mRNA28959563
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of CTTN mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CTTN mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CTTN mRNA24449571
D001151ArsenicArsenic affects the methylation of CTTN gene25304211
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of CTTN mRNA15894607
C015001arsenitearsenite results in increased expression of CTTN mRNA18191166
D001554BenzeneBenzene results in decreased expression of CTTN mRNA19162166
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CTTN mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of CTTN protein16819149
C006780bisphenol Abisphenol A affects the expression of CTTN mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CTTN protein16819149
C006780bisphenol Abisphenol A affects the expression of CTTN mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CTTN mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of CTTN protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CTTN mRNA12419474
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CTTN mRNA21297351
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of CTTN mRNA25596134
C059262cidofovircidofovir results in increased expression of CTTN mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of CTTN mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of CTTN mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of CTTN mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CTTN mRNA"19167446
C057862cyanoginosin LRcyanoginosin LR results in increased expression of CTTN mRNA17654400
D016572CyclosporineCyclosporine results in increased expression of CTTN mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased phosphorylation of and results in decreased expression of CTTN protein23038006
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of CTTN mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CTTN mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CTTN mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CTTN mRNA27392435
D002945CisplatinCisplatin results in increased expression of CTTN mRNA25596134
D002945CisplatinCisplatin results in increased expression of CTTN mRNA21151649
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CTTN protein16819149
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CTTN protein23301498
D005419FlavonoidsFlavonoids results in increased expression of CTTN mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of CTTN protein15585135|1680352
D005485FlutamideFlutamide results in increased expression of CTTN mRNA24136188
C013038hydroxyhydroquinonehydroxyhydroquinone results in increased expression of CTTN mRNA17572062
C492448ICG 001ICG 001 results in increased expression of CTTN mRNA26191083
D007069IfosfamideIfosfamide results in increased expression of CTTN mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CTTN mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CTTN mRNA27392435
C544151jinfukangjinfukang results in increased expression of CTTN mRNA27392435
C008261lead acetatelead acetate results in decreased expression of CTTN mRNA21829687
D008687MetforminMetformin results in increased expression of CTTN mRNA25596134
C005219methyl cellosolvemethyl cellosolve results in increased expression of CTTN mRNA19643169
C005219methyl cellosolvemethyl cellosolve results in increased expression of CTTN protein19643169
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CTTN mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of CTTN protein26558463
C030957methylmercury IImethylmercury II results in increased expression of CTTN mRNA27241350
C030957methylmercury IIProbucol inhibits the reaction [methylmercury II results in increased expression of CTTN mRNA]27241350
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CTTN mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CTTN mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CTTN protein26558463
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CTTN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CTTN mRNA"25554681
D009532NickelNickel results in increased expression of CTTN mRNA23195993
C017557nickel subsulfidenickel subsulfide results in decreased expression of CTTN mRNA12760830
D009543NifedipineNifedipine inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of CTTN protein]19556728
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of CTTN mRNA27148699
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of CTTN protein27148699
D010100OxygenOxygen deficiency results in decreased expression of CTTN mRNA25596134
D017239PaclitaxelPaclitaxel results in decreased expression of CTTN protein15907983
D052638Particulate MatterParticulate Matter results in decreased expression of CTTN protein17922515
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of CTTN mRNA19095052
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CTTN mRNA28126411
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CTTN mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CTTN mRNA26272509
D010705PhosgenePhosgene affects the expression of CTTN mRNA16300373
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CTTN mRNA23608068
D011341ProbucolProbucol inhibits the reaction [methylmercury II results in increased expression of CTTN mRNA]27241350
D011794QuercetinQuercetin results in increased expression of CTTN mRNA21632981
C059514resveratrolresveratrol results in decreased expression of CTTN protein25505154
D015474IsotretinoinIsotretinoin results in decreased expression of CTTN mRNA20436886
C089730rosiglitazonerosiglitazone results in decreased expression of CTTN mRNA25596134
D019821SimvastatinSimvastatin affects the localization of CTTN protein14630613
D019821SimvastatinSimvastatin affects the reaction [F2 affects the localization of CTTN protein]14630613
C017947sodium arsenitesodium arsenite results in decreased expression of CTTN mRNA12760830
C017947sodium arsenitesodium arsenite results in increased expression of CTTN protein19072884
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of CTTN mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CTTN mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CTTN mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of CTTN mRNA23411599
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of CTTN mRNA15894607
D014635Valproic AcidValproic Acid results in increased expression of CTTN mRNA23179753|2352703
D014635Valproic AcidValproic Acid results in increased methylation of CTTN gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CTTN protein17922515
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CTTN gene25560391
C025643vinclozolinvinclozolin affects the expression of CTTN mRNA19015723
D014810Vitamin EVitamin E results in decreased expression of CTTN mRNA19244175
D015032ZincZinc deficiency results in increased expression of CTTN mRNA19111725
C088658zoledronic acidzoledronic acid results in decreased expression of CTTN mRNA25596134

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15169891  15574754  16636290  17065230  17255943  17620599  
18387954  19146815  19419567  21847094  22252131  22282019  
24658140  25241761  
GO:0005522profilin binding-IPI24700464  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IMP17959782  
GO:0006898receptor-mediated endocytosis-ISS-  
GO:0006930substrate-dependent cell migration, cell extension-IEA-  
GO:0030041actin filament polymerization-IEA-  
GO:0030516regulation of axon extension-ISS-  
GO:0030838positive regulation of actin filament polymerization-IMP24700464  
GO:0030838positive regulation of actin filament polymerization-ISS-  
GO:0031532actin cytoskeleton reorganization-ISS-  
GO:0045987positive regulation of smooth muscle contraction-IMP24700464  
GO:0048041focal adhesion assembly-ISS-  
GO:0048812neuron projection morphogenesis-ISS-  
GO:0048870cell motility-ISS-  
GO:0061024membrane organization-TAS-  
GO:0097062dendritic spine maintenance-IEA-  
GO:0097581lamellipodium organization-ISS-  
GO:1903146regulation of autophagy of mitochondrion-IEA-  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-ISS-  
GO:0002102podosome-IEA-  
GO:0005737cytoplasm-IDA10760273  24700464  
GO:0005737cytoplasm-ISS-  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-TAS9054437  
GO:0005884actin filamentcolocalizes_withIDA12151401  
GO:0005886plasma membrane-IDA-  
GO:0005905clathrin-coated pit-ISS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005938cell cortex-IDA14742709  24700464  
GO:0005938cell cortex-ISS-  
GO:0008076voltage-gated potassium channel complexcolocalizes_withIDA12151401  
GO:0030027lamellipodium-IDA10760273  12151401  
GO:0030027lamellipodium-ISS-  
GO:0030426growth conecolocalizes_withISS-  
GO:0030863cortical cytoskeleton-IDA12151401  
GO:0043197dendritic spine-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:1990023mitotic spindle midzone-IEA-  
KEGG ID KEGG Term
hsa04530Tight junction
hsa05100Bacterial invasion of epithelial cells
hsa05130Pathogenic Escherichia coli infection
hsa05131Shigellosis
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-5627123RHO GTPases activate PAKsIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24278325Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma. (2013)Urashima MPLoS One