Gene: EMX2

2018
-
empty spiracles homeobox 2
protein-coding
10q26.11
Ensembl:ENSG00000170370 MIM:600035 Vega:OTTHUMG00000019123 UniprotKB:Q04743
NG_013009.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.176e-2 (AD)  6.686e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EZR0.908
TP53BP20.904
CHDH0.891
METTL7A0.889
SELENBP10.887
PAX60.886
STOX10.884
NR2E10.883
PBXIP10.883
CDC42EP40.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TYRP1-0.504
SAMD5-0.499
LRRC55-0.492
GABRG3-0.483
NRG1-0.482
QRFPR-0.476
ZNF860-0.476
HTR7-0.473
OSBPL10-0.473
COL19A1-0.47

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of EMX2 mRNA23792671
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of EMX2 mRNA28329830
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EMX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EMX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EMX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EMX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EMX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EMX2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EMX2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of EMX2 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EMX2 mRNA24449571
D001104ArbutinArbutin results in decreased expression of EMX2 mRNA17103032
D004958EstradiolEstradiol affects the expression of EMX2 mRNA23557687
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EMX2 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of EMX2 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of EMX2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of EMX2 mRNA21285323
D003471CuprizoneCuprizone results in decreased expression of EMX2 mRNA26577399|2752363
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EMX2 mRNA28628672
D002945CisplatinEMX2 protein results in increased susceptibility to Cisplatin20697358
D004041Dietary FatsDietary Fats results in decreased expression of EMX2 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EMX2 mRNA21285323
D004147DioxinsDioxins affects the expression of EMX2 mRNA20463971
C118739entinostatentinostat results in decreased expression of EMX2 mRNA26272509
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of EMX2 gene16724327
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of EMX2 mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of EMX2 mRNA28329830
D005492Folic AcidFolic Acid inhibits the reaction [ochratoxin A results in decreased expression of EMX2 mRNA]17688467
C039281furanfuran results in increased expression of EMX2 mRNA27387713
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of EMX2 mRNA22634610
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EMX2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EMX2 mRNA28628672
D008558MelphalanMelphalan results in decreased expression of EMX2 mRNA22363485
D008628MercuryMercury results in increased expression of EMX2 mRNA16823088
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EMX2 mRNA22555245|2800136
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EMX2 mRNA22555245
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EMX2 mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in increased expression of EMX2 mRNA29191790
C523799MRK 003MRK 003 results in increased expression of EMX2 mRNA21169257
C568376MT19c compoundMT19c compound results in decreased expression of EMX2 mRNA21781307
D009532NickelNickel results in decreased expression of EMX2 mRNA25583101
C025589ochratoxin AFolic Acid inhibits the reaction [ochratoxin A results in decreased expression of EMX2 mRNA]17688467
C025589ochratoxin Aochratoxin A results in decreased expression of EMX2 mRNA17688467
D000073878Palm OilPalm Oil results in decreased expression of EMX2 mRNA18042831
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EMX2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of EMX2 mRNA26272509
D010672PhenytoinPhenytoin results in decreased expression of EMX2 mRNA9118846
D010936Plant ExtractsPlant Extracts results in decreased expression of EMX2 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of EMX2 mRNA19690047
D012715Sesame OilSesame Oil results in decreased expression of EMX2 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EMX2 mRNA23806026
D012834SilverSilver results in decreased expression of EMX2 mRNA26551752
D012999SomanSoman results in increased expression of EMX2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EMX2 mRNA24058054
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EMX2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of EMX2 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EMX2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EMX2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EMX2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of EMX2 mRNA24849673
D014635Valproic AcidValproic Acid results in increased expression of EMX2 mRNA9098922

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0005515protein binding-IPI15247416  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0021542dentate gyrus development-IEA-  
GO:0021796cerebral cortex regionalization-IEA-  
GO:0021846cell proliferation in forebrain-IEA-  
GO:0021885forebrain cell migration-IEA-  
GO:0030182neuron differentiation-IEA-  
GO:0042493response to drug-IEA-  
GO:0072001renal system development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25023662The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma. (2014 Sep)Giroux Leprieur ELung Cancer