Gene: EN2

2020
-
engrailed homeobox 2
protein-coding
7q36.3
Ensembl:ENSG00000164778 MIM:131310 Vega:OTTHUMG00000151354 UniprotKB:P19622
NG_007124.1
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.859e-1 (AD)  7.861e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PKD1L20.647
RDH50.593
GTF2IRD2B0.583
UNC5CL0.581
SRMS0.562
CNPY10.551
CCDC150.542
DNHD10.54
USP30.538
USP400.535

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLS1-0.411
DPYS-0.404
KCNK3-0.388
HNF1A-0.378
KCNK12-0.373
KCNH5-0.368
NEK2-0.368
BEAN1-0.363
PHOSPHO1-0.361
FBLN7-0.359

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03309N-CyclohexyltaurineSmall Molecule-ExperimentalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EN2 mRNA22100608
C006780bisphenol Abisphenol A affects the methylation of EN2 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of EN2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of EN2 mRNA18974090
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of EN2 mRNA26924002
D004298Dopamine"[EN1 protein co-treated with EN2 protein] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]"21892157
D004298Dopamine[EN1 protein co-treated with EN2 protein] results in increased abundance of Dopamine21892157
D004298Dopamine"NDUFS1 mutant form inhibits the reaction [[EN1 protein co-treated with EN2 protein] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]]"21892157
D005047EtoposideEN2 protein affects the susceptibility to Etoposide16217747
D012701SerotoninEN2 protein affects the abundance of Serotonin16935268
D012701SerotoninEN2 protein affects the abundance of Serotonin metabolite16935268
D007608Kainic AcidEN2 protein affects the susceptibility to Kainic Acid19186208
D007608Kainic AcidKainic Acid results in decreased expression of EN2 mRNA19186208
D007854LeadLead affects the expression of EN2 mRNA28903495
D0156551-Methyl-4-phenylpyridiniumEN2 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium21892157
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[EN1 protein co-treated with EN2 protein] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]"21892157
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[EN1 protein co-treated with EN2 protein] results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"21892157
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"NDUFS1 mutant form inhibits the reaction [[EN1 protein co-treated with EN2 protein] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]]"21892157
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"NDUFS1 mutant form inhibits the reaction [[EN1 protein co-treated with EN2 protein] results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]"21892157
D008942MitoxantroneEN2 protein affects the susceptibility to Mitoxantrone16217747
C517284monomethyl phthalatemonomethyl phthalate affects the expression of EN2 mRNA26924002
D016627Oxidopamine[EN1 protein co-treated with EN2 protein] results in decreased susceptibility to Oxidopamine21892157
D010936Plant ExtractsPlant Extracts results in decreased expression of EN2 mRNA23557933
D012402RotenoneEN2 protein results in decreased susceptibility to Rotenone21892157
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EN2 mRNA25895662
C017947sodium arsenitesodium arsenite affects the expression of EN2 mRNA29319823
D018038Sodium SeleniteSodium Selenite results in increased expression of EN2 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EN2 mRNA24058054|2468072
D014212TretinoinTretinoin results in decreased expression of EN2 mRNA16604517
D014635Valproic AcidValproic Acid results in decreased expression of EN2 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions affects the methylation of EN2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-TAS1672471  
GO:0030901midbrain development-IEA-  
GO:0030902hindbrain development-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048666neuron development-IEA-  
GO:1990403embryonic brain development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16900666Alterations of biological features of the cerebellum in sudden perinatal and infant death. (2006 Jun)Lavezzi AMCurr Mol Med
17334803Ontogenesis of human cerebellar cortex and biopathological characterization in sudden unexplained fetal and infant death. (2007 Jan)Lavezzi AMVirchows Arch