Gene: ENDOG

2021
-
endonuclease G
protein-coding
9q34.11
Ensembl:ENSG00000167136 MIM:600440 Vega:OTTHUMG00000020763 UniprotKB:Q14249
NG_046991.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.154e-1 (AD)  5.548e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TPGS10.896
MFSD30.888
TMEM1210.878
C1QTNF40.877
TGFBR3L0.871
ZNF7710.87
MESP10.869
FBXL150.862
NCBP2-AS20.86
SAC3D10.858

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EBF1-0.487
REST-0.462
FCGR3B-0.459
KCNJ15-0.452
IL18RAP-0.452
CXCR2-0.452
MTRNR2L9-0.449
VNN2-0.447
DISC1-0.446
OR4F5-0.446

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of ENDOG mRNA"20453058
C4408502,4,3',5'-tetramethoxystilbene"2,4,3',5'-tetramethoxystilbene results in increased localization of ENDOG protein"20490654
C0460622-thiomalic acid[Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG protein16407272
C0415253,3',4,5'-tetrahydroxystilbene"PD 150606 inhibits the reaction [3,3',4,5'-tetrahydroxystilbene affects the localization of ENDOG protein]"20484155
C5514663,3',5,5'-tetrahydroxystilbene"3,3',5,5'-tetrahydroxystilbene affects the localization of ENDOG protein"20484155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENDOG mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENDOG mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ENDOG mRNA25704631
D000082AcetaminophenAcetaminophen affects the localization of ENDOG protein20423716
D000082AcetaminophenAcetaminophen results in increased transport of ENDOG protein28123000
D000082AcetaminophenCanertinib inhibits the reaction [Acetaminophen results in increased transport of ENDOG protein]28123000
D000082Acetaminophen[NQO1 gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of ENDOG protein25224400
D000111AcetylcysteineAcetylcysteine inhibits the reaction [perfosfamide results in increased localization of ENDOG protein]18034189
D000111Acetylcysteine[Glucose deficiency co-treated with Acetylcysteine] affects the localization of ENDOG protein17309078
D000640AmitroleAmitrole results in decreased activity of ENDOG protein16407272
D001151ArsenicArsenic results in increased methylation of ENDOG promoter21291286
D001280AtrazineAtrazine results in decreased expression of ENDOG mRNA25929836
D001280AtrazineAtrazine results in decreased expression of ENDOG mRNA22378314
C044887beta-methylcholinebeta-methylcholine affects the expression of ENDOG mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of ENDOG protein21277958
C006780bisphenol Abisphenol A results in increased methylation of ENDOG gene28505145
C022777bufalinbufalin results in increased expression of ENDOG mRNA27444971
C022777bufalinbufalin results in increased expression of ENDOG protein27444971
D002104CadmiumCadmium results in increased expression of ENDOG mRNA23256528
D002104CadmiumCadmium affects the localization of ENDOG protein23315796
C028031cadmium acetatecadmium acetate affects the localization of ENDOG protein24577723
C028031cadmium acetatepyrazolanthrone inhibits the reaction [cadmium acetate affects the localization of ENDOG protein]24577723
C028031cadmium acetateU 0126 inhibits the reaction [cadmium acetate affects the localization of ENDOG protein]24577723
D019256Cadmium ChlorideCadmium Chloride affects the localization of ENDOG protein19887573
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ENDOG promoter22457795
C420268CanertinibCanertinib inhibits the reaction [Acetaminophen results in increased transport of ENDOG protein]28123000
D002193CantharidinCantharidin results in increased expression of ENDOG protein27113412
D002220CarbamazepineCarbamazepine affects the expression of ENDOG mRNA24752500
C074702chromium hexavalent ionchromium hexavalent ion affects the localization of ENDOG protein16166740
C074702chromium hexavalent ionchromium hexavalent ion affects the localization of ENDOG protein19459161
D002994ClofibrateClofibrate results in decreased expression of ENDOG mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of ENDOG mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ENDOG mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of ENDOG mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of ENDOG protein22239859
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENDOG mRNA]11007951
D016572CyclosporineCyclosporine results in decreased expression of ENDOG mRNA20106945|2556210
C004315danthrondanthron affects the localization of and results in increased expression of ENDOG protein21126053
C004315danthrondanthron results in increased expression of ENDOG mRNA21126053
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ENDOG mRNA]27941970
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ENDOG mRNA24848799
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ENDOG mRNA21266533
D002945CisplatinCisplatin results in decreased expression of ENDOG mRNA27392435
D002945Cisplatin[Quercetin co-treated with Cisplatin] results in increased expression of ENDOG mRNA24999622
D004008DiclofenacDiclofenac affects the expression of ENDOG mRNA24752500
C000944dicrotophosdicrotophos results in decreased expression of ENDOG mRNA28302478
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the localization of ENDOG protein22535522
D004178DiquatDiquat affects the expression of ENDOG mRNA22814884
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of ENDOG protein"23315830
D004610Ellagic AcidEllagic Acid results in increased expression of ENDOG protein23554011
D000431EthanolEthanol affects the localization of ENDOG protein22535522
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENDOG mRNA17942748
C017875fisetinfisetin results in increased localization of ENDOG protein28181380
D005947Glucose[Glucose deficiency co-treated with Acetylcysteine] affects the localization of ENDOG protein17309078
D005947Glucose[Glucose deficiency co-treated with CAT] affects the localization of ENDOG protein17309078
D005947Glucose[Glucose deficiency co-treated with Tetradecanoylphorbol Acetate] affects the localization of ENDOG protein17309078
D005947GlucoseGlucose affects the localization of ENDOG protein23192364
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ENDOG mRNA21179406
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG protein16407272
C492448ICG 001ICG 001 affects the expression of ENDOG mRNA26191083
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ENDOG mRNA24848799
D007529IsoflavonesIsoflavones results in decreased expression of ENDOG mRNA17374662
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ENDOG mRNA26011545
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ENDOG mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of ENDOG protein19562491
D009942Organometallic CompoundsOrganometallic Compounds results in increased expression of ENDOG protein21437708
D010100OxygenOxygen deficiency results in increased expression of ENDOG mRNA20880076
C100442PD 150606"PD 150606 inhibits the reaction [3,3',4,5'-tetrahydroxystilbene affects the localization of ENDOG protein]"20484155
C100442PD 150606PD 150606 inhibits the reaction [resveratrol affects the localization of ENDOG protein]20484155
C011272perfosfamideAcetylcysteine inhibits the reaction [perfosfamide results in increased localization of ENDOG protein]18034189
C011272perfosfamideENDOG results in increased susceptibility to perfosfamide18034189
C011272perfosfamideperfosfamide results in increased expression of and results in increased localization of ENDOG protein18034189
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ENDOG mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of and affects the localization of ENDOG protein26122529
D010936Plant ExtractsPlant Extracts results in increased expression of ENDOG mRNA26122529
D011192Potassium DichromatePotassium Dichromate results in increased expression of ENDOG protein23718831
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [cadmium acetate affects the localization of ENDOG protein]24577723
D011794Quercetin[Quercetin co-treated with Cisplatin] results in increased expression of ENDOG mRNA24999622
D011794QuercetinQuercetin results in increased expression of ENDOG mRNA23727915
C059514resveratrolPD 150606 inhibits the reaction [resveratrol affects the localization of ENDOG protein]20484155
C059514resveratrolresveratrol affects the localization of ENDOG protein16617056|2048415
C089730rosiglitazonerosiglitazone results in increased expression of ENDOG mRNA24848799
D017975Ruthenium CompoundsRuthenium Compounds results in increased expression of ENDOG protein21437708
D012643SeleniumSelenium results in increased expression of ENDOG mRNA19244175
D012834SilverSilver results in decreased expression of ENDOG mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of ENDOG mRNA12377979
C016766sulforafansulforafan results in increased expression of ENDOG protein26833863
D013467SulindacSulindac affects the localization of ENDOG protein15946692
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENDOG mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ENDOG mRNA11007951
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENDOG mRNA17942748
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ENDOG mRNA28973375
D013752TetracyclineTetracycline results in decreased expression of ENDOG mRNA24489787
D013755Tetradecanoylphorbol Acetate[Glucose deficiency co-treated with Tetradecanoylphorbol Acetate] affects the localization of ENDOG protein17309078
C009438tetrandrinetetrandrine results in decreased expression of ENDOG protein26822499
C042172thallium nitratethallium nitrate affects the localization of ENDOG protein19371624
C042172thallium nitratethallium nitrate analog results in increased localization of ENDOG protein19371624
D019284ThapsigarginThapsigargin results in decreased expression of ENDOG mRNA22378314
C009495titanium dioxidetitanium dioxide affects the expression of ENDOG mRNA23557971
C011559tributyltintributyltin results in increased expression of ENDOG mRNA24848799
C012589trichostatin Atrichostatin A results in increased expression of ENDOG mRNA24935251
C001899triptolidetriptolide results in increased expression of ENDOG protein26990902
D014415TunicamycinTunicamycin results in decreased expression of ENDOG mRNA22378314
C113580U 0126U 0126 inhibits the reaction [cadmium acetate affects the localization of ENDOG protein]24577723
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENDOG mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ENDOG mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of ENDOG mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of ENDOG gene29154799
C025643vinclozolinvinclozolin results in increased expression of ENDOG mRNA23034163
D014810Vitamin EVitamin E results in increased expression of ENDOG mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0004518nuclease activity-IBA21873635  
GO:0004519endonuclease activity-IEA-  
GO:0004536deoxyribonuclease activity-IEA-  
GO:0005515protein binding-IPI25036637  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000737DNA catabolic process, endonucleolytic-IBA21873635  
GO:0001701in utero embryonic development-IEA-  
GO:0006309apoptotic DNA fragmentation-IBA21873635  
GO:0006310DNA recombination-TAS18309324  
GO:0007568aging-IEA-  
GO:0009612response to mechanical stimulus-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0034612response to tumor necrosis factor-IEA-  
GO:0036475neuron death in response to oxidative stress-IEA-  
GO:0046677response to antibiotic-IEA-  
GO:0071277cellular response to calcium ion-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:1901300positive regulation of hydrogen peroxide-mediated programmed cell death-IEA-  
GO:1902512positive regulation of apoptotic DNA fragmentation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-IEA-  
GO:0043204perikaryon-IEA-  
KEGG ID KEGG Term
hsa04210Apoptosis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24120969Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells. (2013 Dec)Lloyd MMFree Radic Biol Med