Gene: ENG

2022
END|HHT1|ORW1
endoglin
protein-coding
9q34.11
Ensembl:ENSG00000106991 MIM:131195 Vega:OTTHUMG00000020723 UniprotKB:P17813
NG_009551.1
PubMed
0   ANCO-SNPs
ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.745e-1 (AD)  7.417e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACVRL10.856
ESAM0.834
MYO1C0.832
CDH50.82
ROBO40.812
SMAD60.796
ADCY40.793
FOXC10.789
MMRN20.783
VWF0.776

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DRD5-0.35
SMIM18-0.329
SLC7A4-0.327
KCNB2-0.322
PPEF1-0.315
ST6GAL2-0.304
ABCC12-0.304
LYPD8-0.303
OR4F29-0.303
NEUROD6-0.302

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased expression of ENG protein]15539634
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ENG mRNA16788091
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ENG mRNA"21346803
C0343434-aminobenzhydrazide4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of ENG mRNA]24530881
D000082AcetaminophenAcetaminophen affects the expression of ENG mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ENG mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of ENG mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ENG mRNA22610609
D004958EstradiolEstradiol affects the expression of ENG mRNA15598610
C006780bisphenol Abisphenol A results in increased expression of ENG mRNA26546977
C006780bisphenol Abisphenol A results in decreased expression of ENG mRNA25181051|2757113
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ENG mRNA15336504
C081643candesartancandesartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]15539634
C081643candesartancandesartan inhibits the reaction [AGT protein results in increased expression of ENG protein]15539634
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ENG mRNA17484886
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ENG mRNA24763279
C022990chromic chloridechromic chloride results in increased expression of ENG mRNA12128095
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ENG mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of ENG mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of ENG mRNA19549813
D003630DaunorubicinDaunorubicin results in decreased expression of ENG mRNA27090888
C014347decitabinedecitabine inhibits the reaction [tobacco tar results in decreased expression of ENG mRNA]19559774
D003907DexamethasoneDexamethasone results in decreased expression of ENG mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ENG mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ENG mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ENG mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of ENG mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ENG mRNA17602206
D004298DopamineDopamine results in decreased expression of ENG mRNA21983523
D004317DoxorubicinDoxorubicin results in increased expression of ENG mRNA15033991
D004656Enalapril[Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA25037058
D018818FenoldopamFenoldopam results in increased expression of ENG mRNA21983523
C069837fullerene C60fullerene C60 results in increased expression of ENG mRNA19167457
D005897GlafenineGlafenine results in increased expression of ENG mRNA24136188
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ENG mRNA24763279
D017313FenretinideFenretinide results in increased expression of ENG mRNA28973697
C013038hydroxyhydroquinone4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of ENG mRNA]24530881
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of ENG mRNA24530881
C544151jinfukangjinfukang results in increased expression of ENG mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ENG protein26830473
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]15539634
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of ENG protein]15539634
C025340manganese chloridemanganese chloride results in increased expression of ENG mRNA17467022
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in increased expression of ENG mRNA]20431248
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ENG mRNA"25554681|2562005
C000621033napabucasinnapabucasin results in decreased expression of ENG mRNA25605917
C028007nickel monoxidenickel monoxide results in increased expression of ENG mRNA19167457
D009538NicotineNicotine results in decreased expression of ENG mRNA17456735
C007350nitrofennitrofen results in decreased expression of ENG mRNA27822781
C007350nitrofennitrofen results in decreased expression of ENG protein27822781
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ENG mRNA25729387
C084656paricalcitol[Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA25037058
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ENG protein26879310
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ENG mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ENG mRNA19482888
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in increased expression of ENG mRNA]20431248
D011374ProgesteroneProgesterone results in increased expression of ENG mRNA20431248
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of ENG mRNA20135064
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of ENG protein20135064
C009166retinol acetateretinol acetate results in increased expression of ENG mRNA16772331
C089730rosiglitazonerosiglitazone results in increased expression of ENG mRNA21515302
D012643SeleniumSelenium results in increased expression of ENG mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of ENG mRNA"16251409
C016104sodium bichromatesodium bichromate results in decreased expression of ENG mRNA17685462
C501413tesaglitazartesaglitazar results in increased expression of ENG mRNA21515302
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of ENG mRNA20189893
C004648testosterone enanthatetestosterone enanthate affects the expression of ENG mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ENG mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ENG mRNA26290441
C009495titanium dioxidetitanium dioxide results in decreased expression of ENG mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ENG mRNA28065790
C024746tobacco tardecitabine inhibits the reaction [tobacco tar results in decreased expression of ENG mRNA]19559774
C024746tobacco tartobacco tar results in decreased expression of ENG mRNA19559774
D014050TolueneToluene results in increased expression of ENG mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ENG mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of ENG mRNA"19682533
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ENG mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ENG mRNA29024780
C057693troglitazonetroglitazone results in increased expression of ENG mRNA21515302
D014520UrethaneUrethane results in decreased expression of ENG mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of ENG gene29154799
D014635Valproic AcidValproic Acid affects the expression of ENG mRNA17292431
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]15539634
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in increased expression of ENG protein]15539634
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ENG gene25560391
C025643vinclozolinvinclozolin affects the expression of ENG mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of ENG mRNA26682919
D014800VitalliumVitallium analog results in decreased expression of ENG mRNA23825117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-NAS18974388  
GO:0005072transforming growth factor beta receptor, cytoplasmic mediator activity-IDA12015308  
GO:0005114type II transforming growth factor beta receptor binding-IPI12015308  
GO:0005114type II transforming growth factor beta receptor binding-ISS8294451  
GO:0005515protein binding-IPI9872992  15702480  20856203  22940691  28564608  
GO:0005534galactose binding-IDA3262645  
GO:0005539glycosaminoglycan binding-IDA3262645  
GO:0005539glycosaminoglycan binding-ISS8294451  
GO:0034713type I transforming growth factor beta receptor binding-IPI12015308  
GO:0034713type I transforming growth factor beta receptor binding-ISS8294451  
GO:0036122BMP bindingcontributes_toIPI9872992  
GO:0042802identical protein binding-IPI28564608  
GO:0042803protein homodimerization activity-IEA-  
GO:0048185activin binding-TAS11382917  
GO:0050431transforming growth factor beta binding-IPI1326540  
GO:0050431transforming growth factor beta bindingcontributes_toIPI9872992  
GO ID GO Term Qualifier Evidence PubMed
GO:0001300chronological cell aging-IEA-  
GO:0001569branching involved in blood vessel morphogenesis-ISS8194490  
GO:0001570vasculogenesis-IMP7894484  
GO:0001934positive regulation of protein phosphorylation-IDA12015308  
GO:0001947heart looping-ISS8194490  
GO:0002040sprouting angiogenesisNOTISS-  
GO:0003148outflow tract septum morphogenesis-ISS-  
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formation-ISS-  
GO:0003203endocardial cushion morphogenesis-ISS-  
GO:0003208cardiac ventricle morphogenesis-ISS-  
GO:0003209cardiac atrium morphogenesis-ISS-  
GO:0003222ventricular trabecula myocardium morphogenesis-ISS-  
GO:0003273cell migration involved in endocardial cushion formation-IEA-  
GO:0006355regulation of transcription, DNA-templated-IMP15702480  
GO:0007155cell adhesion-IEA-  
GO:0010629negative regulation of gene expression-ISS-  
GO:0010665regulation of cardiac muscle cell apoptotic processNOTISS-  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IDA12015308  
GO:0017015regulation of transforming growth factor beta receptor signaling pathway-IDA15702480  
GO:0022009central nervous system vasculogenesis-IMP7894484  
GO:0030336negative regulation of cell migration-IDA19736306  
GO:0030509BMP signaling pathway-TAS11382917  
GO:0030513positive regulation of BMP signaling pathway-IDA17068149  
GO:0031953negative regulation of protein autophosphorylation-IDA12015308  
GO:0031960response to corticosteroid-IEA-  
GO:0032967positive regulation of collagen biosynthetic process-IEA-  
GO:0035912dorsal aorta morphogenesis-ISS-  
GO:0042493response to drug-IEA-  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048745smooth muscle tissue development-ISS8194490  
GO:0048844artery morphogenesis-ISS8194490  
GO:0048845venous blood vessel morphogenesis-ISS8194490  
GO:0051897positive regulation of protein kinase B signaling-IGI26857067  
GO:0055009atrial cardiac muscle tissue morphogenesis-ISS-  
GO:0060348bone development-IEA-  
GO:0070278extracellular matrix constituent secretion-IEA-  
GO:0071260cellular response to mechanical stimulus-IEA-  
GO:0071559response to transforming growth factor beta-IEA-  
GO:0090500endocardial cushion to mesenchymal transitionNOTISS-  
GO:0097084vascular smooth muscle cell development-ISS-  
GO:1905007positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation-ISS-  
GO:1905065positive regulation of vascular smooth muscle cell differentiation-ISS-  
GO:1905222atrioventricular canal morphogenesis-ISS-  
GO:1905310regulation of cardiac neural crest cell migration involved in outflow tract morphogenesisNOTISS-  
GO:2000136regulation of cell proliferation involved in heart morphogenesisNOTISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA19004009  
GO:0005925focal adhesion-HDA21423176  
GO:0009897external side of plasma membrane-IDA1537377  
GO:0043235receptor complex-IPI9872992  
GO:0070022transforming growth factor beta receptor complex-IC1326540  
GO:0072563endothelial microparticle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20346360Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (2010 Jul)Roberts KEGastroenterology
29580923Endoglin pathway genetic variation in preeclampsia: A validation study in Norwegian and Latina cohorts. (2018 Apr)Schmella MJPregnancy Hypertens
12265275[Lung cancer mortality and cigarette smoking in Europe, North America, Japan, and Australia: regional differences and chronological development]. (1980)Junge BBundesgesundheitsblatt
7332162[Relations between coronary risk factors and mortality for cancer in the Italian areas of Seven Countries Study (author's transl)]. (1981)Menotti AAnn Ist Super Sanita
21605946Development of a multicomponent prediction model for acute esophagitis in lung cancer patients receiving chemoradiotherapy. (2011 Oct 1)De Ruyck KInt J Radiat Oncol Biol Phys
23424094Lifestyle risk factors for ulnar neuropathy and ulnar neuropathy-like symptoms. (2013 Oct)Frost PMuscle Nerve
29289383Immunogenicity of a two-dose investigational hepatitis B vaccine, HBsAg-1018, using a toll-like receptor 9 agonist adjuvant compared with a licensed hepatitis B vaccine in adults. (2018 Jan 29)Jackson SVaccine
12264935[Introduction of a process of deterioration in the study of adult mortality: application of a simulation model to Norwegian generations, 1866-1916]. (1981 Jul-Dec)Bourbeau RGenus