Gene info: ID 2023

Gene: ENO1

GENE ID: 2023

Synonyms: ENO1L1|HEL-S-17|MPB1|NNE|PPH

Description: enolase 1

Gene type: protein-coding

Location: 1p36.23

dbXrefs: Ensembl:ENSG00000074800 MIM:172430 Vega:OTTHUMG00000001773 UniprotKB:P06733

RefSeq: NG_029470.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.751e-1 (AD) 2.620e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TXN2	0.944
TUFM	0.939
ECHS1	0.928
TSPAN3	0.925
RAB5C	0.924
GAPDH	0.923
TECR	0.922
YKT6	0.921
GNB2	0.917
LDHB	0.916

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.919
OR4F29	-0.889
OR6C74	-0.226
FCRL1	-0.193
CLEC6A	-0.187
GADL1	-0.174
IFNG	-0.169
LY9	-0.161
C2orf83	-0.158
CETP	-0.156

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target
DB11638	Artenimol	Small Molecule	71939-50-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C025205	1,10-phenanthroline	"1,10-phenanthroline results in increased expression of ENO1 mRNA"	19502547
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of ENO1 mRNA"	19162173
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in decreased expression of ENO1 mRNA"	22101062
C036423	1-aminomethylphosphonic acid	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of ENO1 mRNA	20566314
C016614	1-nitronaphthalene	1-nitronaphthalene metabolite binds to ENO1 protein	16453347
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of ENO1 protein"	21673325
C066841	2,3,7,8-tetrabromodibenzo-4-dioxin	"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ENO1 protein"	27604104
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ENO1 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ENO1 mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ENO1 mRNA"	12376462
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENO1 mRNA]	23152189
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of ENO1 mRNA	12958071
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENO1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENO1 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal binds to ENO1 protein	19374891
C544471	5-hydroxythalidomide	5-hydroxythalidomide binds to ENO1 protein	27464947
C544471	5-hydroxythalidomide	5-hydroxythalidomide binds to ENO1 protein	27464947
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENO1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENO1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of ENO1 mRNA	21420995
D000082	Acetaminophen	[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of ENO1 protein	25499718
D000082	Acetaminophen	Acetaminophen results in increased expression of ENO1 mRNA	15800402
D000082	Acetaminophen	Acetaminophen results in increased expression of ENO1 protein	15800402\|1653804
C016601	afimoxifene	ENO1 mRNA results in decreased susceptibility to afimoxifene	19655245
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of ENO1 gene	28458013
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ENO1 mRNA	19770486
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog affects the expression of ENO1 protein	26072098
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of ENO1 protein	26072098
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENO1 mRNA]	23152189
C061621	alpha-naphthyl isocyanate	alpha-naphthyl isocyanate affects the expression of ENO1 protein	16099942
D000638	Amiodarone	Amiodarone affects the expression of ENO1 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ENO1 mRNA	16483693
D000666	Amphotericin B	Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of ENO1 mRNA]	16189267
D000666	Amphotericin B	Amphotericin B results in increased expression of and results in increased secretion of ENO1 protein	26259607
C023650	aniline	aniline results in increased nitrosation of ENO1 protein	21708182
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of ENO1 mRNA	24449571
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of ENO1 mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of ENO1 mRNA	23912714
D001151	Arsenic	Arsenic results in decreased expression of ENO1 protein	19818359
D001151	Arsenic	Arsenic results in decreased expression of ENO1 mRNA	18315880
C015001	arsenite	arsenite results in increased oxidation of and results in decreased activity of ENO1 protein	20196163
C406592	azaspiracid	azaspiracid results in increased expression of ENO1 mRNA	28939011
C547126	AZM551248	AZM551248 results in increased expression of ENO1 mRNA	22323515
D001553	Benzbromarone	Benzbromarone affects the expression of ENO1 mRNA	19483382
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ENO1 protein	17292933\|1849531
D001564	Benzo(a)pyrene	[Soot co-treated with Benzo(a)pyrene] results in decreased expression of ENO1 protein	24464499
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of ENO1 protein]	16456883
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ENO1 protein	16456883
D001564	Benzo(a)pyrene	sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of ENO1 protein]	16456883
D004958	Estradiol	Estradiol affects the expression of ENO1 mRNA	18214933
D004958	Estradiol	Estradiol results in increased expression of ENO1 mRNA	15289156
C095105	bexarotene	bexarotene results in increased expression of ENO1 mRNA	16648578
C110172	BHTOH-QM	BHTOH-QM binds to ENO1 protein	16533022
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of ENO1 mRNA	15912405
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ENO1 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the methylation of ENO1 promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of ENO1 mRNA	12075121\|2518105
C423844	BL 11282	BL 11282 results in increased expression of ENO1 protein	17458497
C013418	bromfenacoum	bromfenacoum results in increased expression of ENO1 protein	28903499
C022777	bufalin	bufalin results in decreased expression of ENO1 protein	23091618
C026105	butylidenephthalide	butylidenephthalide results in decreased expression of ENO1 protein	23770345
D002104	Cadmium	Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of ENO1 mRNA]	10866824
D002104	Cadmium	Cadmium results in increased expression of and results in increased secretion of ENO1 protein	26259607
C028031	cadmium acetate	cadmium acetate results in decreased expression of ENO1 mRNA	18155341
C028031	cadmium acetate	cadmium acetate results in increased expression of ENO1 mRNA	12965115
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ENO1 mRNA	18560533
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of and results in increased secretion of ENO1 protein	26259607
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ENO1 mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ENO1 protein	24527689
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ENO1 mRNA	24982889
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA]"	20230807
D000074262	Canola Oil	Canola Oil affects the expression of ENO1 mRNA	16177195
C099555	CD 437	CD 437 results in decreased expression of ENO1 mRNA	12958071
D007631	Chlordecone	Chlordecone results in decreased expression of ENO1 protein	19666090
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of ENO1 mRNA	25596134
C007020	chlorophyllin	chlorophyllin analog results in decreased expression of ENO1 protein	22852132
C100187	chloropicrin	chloropicrin results in increased expression of ENO1 mRNA	26352163
D002922	Ciguatoxins	Ciguatoxins affects the expression of ENO1 mRNA	18353800
D002994	Clofibrate	Clofibrate affects the expression of ENO1 mRNA	19483382
D003024	Clozapine	Clozapine results in increased expression of ENO1 mRNA	15860345
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ENO1 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ENO1 mRNA	19502547
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ENO1 protein	22339908
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ENO1 mRNA	24386269
C026305	cobalt sulfate	cobalt sulfate results in increased expression of ENO1 mRNA	19502547
D003300	Copper	ENO1 protein binds to Copper	15359738
C015763	cumene	[cumene co-treated with KRAS gene mutant form] results in decreased expression of ENO1 mRNA	18648096
C029892	cupric chloride	cupric chloride results in decreased expression of ENO1 protein	21641295
D003474	Curcumin	Curcumin results in decreased expression of ENO1 mRNA	16880289
D016572	Cyclosporine	Cyclosporine results in decreased expression of ENO1 mRNA	21163907\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of and results in increased secretion of ENO1 protein	26259607
D003634	DDT	DDT results in decreased expression of ENO1 protein	26186133
C014347	decitabine	decitabine results in increased expression of ENO1 mRNA	17908484
D003676	Deferoxamine	Deferoxamine results in increased expression of ENO1 mRNA	16227210
D013759	Dronabinol	Dronabinol results in decreased expression of ENO1 mRNA	18454173
D013759	Dronabinol	Dronabinol results in increased expression of ENO1 protein	18163980
D013759	Dronabinol	Dronabinol results in increased expression of ENO1 mRNA	11015613
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ENO1 mRNA	28628672
C042577	diallyl trisulfide	diallyl trisulfide results in increased expression of ENO1 protein	16344271
D003976	Diazinon	Diazinon results in increased methylation of ENO1 gene	22964155
D003976	Diazinon	Diazinon results in increased expression of ENO1 protein	19647006
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in increased expression of ENO1 protein"	18495319
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of ENO1 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of ENO1 mRNA	17379624
D002945	Cisplatin	Cisplatin results in increased expression of and results in increased secretion of ENO1 protein	26259607
D004008	Diclofenac	Diclofenac results in increased expression of ENO1 mRNA	26934552
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of ENO1 mRNA	26924002
D004026	Dieldrin	Dieldrin results in decreased expression of ENO1 protein	20584760
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in decreased expression of ENO1 mRNA	17490981
D004041	Dietary Fats	Dietary Fats results in decreased expression of ENO1 mRNA	19030233
D004052	Diethylnitrosamine	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of ENO1 mRNA	16158176
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ENO1 mRNA	14656948
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of ENO1 mRNA	15289156
C039060	dihydroartemisinin	dihydroartemisinin analog binds to ENO1 protein	26340163
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of ENO1 protein"	22248470
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ENO1 protein"	22248470
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ENO1 mRNA"	12376462
D004237	Diuron	Diuron results in increased expression of ENO1 mRNA	21551480
D004317	Doxorubicin	Doxorubicin results in increased oxidation of ENO1 protein	28818578
D052244	Endocrine Disruptors	Endocrine Disruptors results in increased expression of ENO1 mRNA	25198161
C013525	ENNG	[ENNG co-treated with Isoflavones] results in increased expression of ENO1 protein	22248470
C013525	ENNG	ENNG results in increased expression of ENO1 protein	22248470
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ENO1 protein	23301498
D000431	Ethanol	Ethanol results in decreased expression of ENO1 protein	20621659
D000431	Ethanol	Ethanol results in increased expression of ENO1 protein	20621659
D000431	Ethanol	Ethanol affects the expression of ENO1 protein	22960358
D000431	Ethanol	Ethanol results in increased expression of ENO1 mRNA	15353170
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ENO1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ENO1 protein	20381887
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ENO1 mRNA	12075121\|1755790
D005001	Ethionine	Ethionine affects the expression of ENO1 mRNA	19483382
D011345	Fenofibrate	Fenofibrate results in increased expression of ENO1 mRNA	25596134
D005411	Flame Retardants	Flame Retardants results in increased expression of ENO1 protein	16451863\|1855017
D015073	2-Acetylaminofluorene	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of ENO1 mRNA	16158176
D015073	2-Acetylaminofluorene	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ENO1 mRNA	14656948
D005485	Flutamide	Flutamide results in increased expression of ENO1 mRNA	24136188
C039281	furan	furan affects the activity of ENO1 protein	27402187
C039281	furan	furan binds to ENO1 protein	22240984
C039281	furan	furan results in increased expression of ENO1 mRNA	15120968
D019833	Genistein	Genistein results in increased expression of ENO1 mRNA	15289156
D019833	Genistein	Genistein results in increased expression of ENO1 mRNA	12075121
D005839	Gentamicins	Gentamicins results in increased expression of ENO1 protein	22061828
D005947	Glucose	Glucose deficiency results in decreased secretion of ENO1 protein	24802182
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of ENO1 mRNA	22634610
C010974	glyphosate	[Surface-Active Agents co-treated with glyphosate] results in increased expression of ENO1 mRNA	22467014
D006046	Gold	Gold analog results in decreased expression of and results in increased phosphorylation of ENO1 protein	24780912
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins affects the expression of ENO1 protein	16414080
C412815	GW 4064	GW 4064 results in decreased expression of ENO1 protein	23178280
D006220	Haloperidol	Haloperidol results in increased expression of ENO1 mRNA	15860345
D006540	Herbicides	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of ENO1 mRNA	20566314
D006820	Hyaluronic Acid	Hyaluronic Acid analog results in decreased expression of ENO1 protein	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased activity of ENO1 protein	20196163
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of ENO1 protein	23178681
D007052	Ibuprofen	Ibuprofen affects the expression of ENO1 protein	18351690
D007052	Ibuprofen	Ibuprofen results in increased expression of ENO1 mRNA	25596134
C428264	indioside D	indioside D results in decreased expression of ENO1 protein	18376857
C020758	indium trichloride	indium trichloride results in increased expression of ENO1 protein	19539025
C503753	Indolinone A	Indolinone A results in increased phosphorylation of ENO1 protein	15838870
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ENO1 mRNA	28628672
C051890	irinotecan	irinotecan analog results in decreased expression of ENO1 mRNA	18927307
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ENO1 mRNA	28628672
D007529	Isoflavones	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of ENO1 protein"	22248470
D007529	Isoflavones	[ENNG co-treated with Isoflavones] results in increased expression of ENO1 protein	22248470
D007545	Isoproterenol	Isoproterenol results in decreased expression of ENO1 mRNA	20003209
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of ENO1 protein	10768784\|1733775
C410337	K 7174	K 7174 results in decreased expression of ENO1 mRNA	24086573
C008261	lead acetate	lead acetate results in increased expression of ENO1 protein	20797405
C029891	lead chloride	lead chloride results in increased expression of ENO1 protein	24419708
D008344	Maneb	[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein	23562983
D008344	Maneb	Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein]	23562983
D008344	Maneb	[Paraquat co-treated with Maneb] results in decreased expression of ENO1 mRNA	17532186\|1838618
D008344	Maneb	[Paraquat co-treated with Maneb] results in decreased expression of ENO1 protein	17532186
D008345	Manganese	Manganese results in decreased activity of ENO1 protein	22191580
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of and results in increased secretion of ENO1 protein	26259607
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of ENO1 protein	21458406
D008694	Methamphetamine	Methamphetamine results in decreased expression of ENO1 protein	19826936
D008727	Methotrexate	Methotrexate results in increased expression of ENO1 protein	24736981
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ENO1 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ENO1 mRNA"	20188158
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of ENO1 mRNA	17475336\|2277608
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ENO1 protein"	23562983
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ENO1 protein]"	23562983
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ENO1 protein]"	23562983
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of ENO1 mRNA	29191790
D008911	Minocycline	"Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ENO1 protein]"	23562983
D008911	Minocycline	Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein]	23562983
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of ENO1 mRNA	26924002
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of ENO1 mRNA	16357179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ENO1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ENO1 mRNA"	25620056
C031721	naphthalene	naphthalene metabolite binds to ENO1 protein	16453347
D009532	Nickel	Nickel results in increased expression of ENO1 mRNA	24768652\|2558310
C028007	nickel monoxide	nickel monoxide results in increased expression of ENO1 mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of ENO1 mRNA	16100012
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA]"	20230807
C007350	nitrofen	nitrofen results in decreased expression of ENO1 mRNA	20638522
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of ENO1 mRNA	17616710
C002741	N-nitrosomorpholine	N-nitrosomorpholine affects the expression of ENO1 protein	19716841
C025256	nonylphenol	nonylphenol results in decreased expression of ENO1 protein	19260726
C510003	nordy	nordy results in increased expression of ENO1 protein	18232056
C464660	obeticholic acid	obeticholic acid results in decreased expression of ENO1 mRNA	27939613
D009853	Omeprazole	Omeprazole affects the expression of ENO1 mRNA	19483382
D010100	Oxygen	Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of ENO1 mRNA]	16189267
D010100	Oxygen	Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of ENO1 mRNA]	10866824
D010100	Oxygen	Oxygen deficiency results in increased expression of ENO1 mRNA	10866824\|1950254
D010126	Ozone	Ozone results in increased expression of ENO1 mRNA	25838073
D010261	Paraoxon	Paraoxon results in decreased expression of ENO1 protein	20931991
D010269	Paraquat	[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein	23562983
D010269	Paraquat	Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein]	23562983
D010269	Paraquat	[Paraquat co-treated with Maneb] results in decreased expression of ENO1 mRNA	17532186\|1838618
D010269	Paraquat	[Paraquat co-treated with Maneb] results in decreased expression of ENO1 protein	17532186
D010269	Paraquat	Paraquat results in decreased expression of ENO1 mRNA	27111068
D010269	Paraquat	Paraquat results in decreased expression of ENO1 protein	27111068
D052638	Particulate Matter	Particulate Matter results in decreased expression of ENO1 mRNA	24769257
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of ENO1 protein	16451863\|1855017
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of ENO1 protein	19954255
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of ENO1 protein	19954255\|2561625
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of ENO1 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of ENO1 mRNA	19429403
C049032	pinosylvin	pinosylvin results in decreased expression of ENO1 mRNA	23333577
C006253	pirinixic acid	pirinixic acid affects the expression of ENO1 mRNA	19483382
D011374	Progesterone	Progesterone results in decreased expression of ENO1 mRNA	23018184
C045950	propiconazole	propiconazole results in increased metabolism of ENO1 protein	19714882
D011441	Propylthiouracil	Propylthiouracil affects the expression of ENO1 mRNA	19483382
C100573	prostaglandin A1	prostaglandin A1 analog results in increased metabolism of ENO1 protein	19800325
C009091	protocatechuic acid	protocatechuic acid results in increased expression of ENO1 mRNA	16227210
C010313	pseudocumene	pseudocumene results in decreased expression of ENO1 protein	17337753
D011748	Pyrogallol	Pyrogallol results in increased expression of ENO1 mRNA	20362636
D011794	Quercetin	Quercetin results in increased expression of ENO1 protein	17292933\|1920703
C059514	resveratrol	resveratrol results in decreased expression of ENO1 mRNA	15582268
D012176	Retinoids	Retinoids results in decreased expression of ENO1 protein	28886987
C089730	rosiglitazone	rosiglitazone affects the expression of ENO1 protein	19556978
D012524	Sarin	Sarin results in decreased expression of ENO1 protein	28973502
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased secretion of ENO1 protein	25895662
D019821	Simvastatin	Simvastatin results in decreased expression of ENO1 protein	20217863
C017947	sodium arsenite	HIF1A protein affects the reaction [sodium arsenite results in increased expression of ENO1 protein]	27287256
C017947	sodium arsenite	HIF1A protein inhibits the reaction [MALAT1 mRNA affects the reaction [sodium arsenite results in increased expression of ENO1 protein]]	27287256
C017947	sodium arsenite	MALAT1 mRNA affects the reaction [sodium arsenite results in increased expression of ENO1 protein]	27287256
C017947	sodium arsenite	sodium arsenite results in decreased expression of ENO1 protein	20050688
C017947	sodium arsenite	sodium arsenite results in increased expression of and results in increased secretion of ENO1 protein	26259607
C017947	sodium arsenite	sodium arsenite results in increased expression of ENO1 mRNA	23648393\|2728725
C017947	sodium arsenite	sodium arsenite results in increased expression of ENO1 protein	27287256
C017947	sodium arsenite	sodium arsenite results in decreased expression of ENO1 protein	24866292
C017947	sodium arsenite	sodium arsenite results in increased expression of ENO1 mRNA	17450228
C017947	sodium arsenite	Benzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of ENO1 protein]	16456883
C017947	sodium arsenite	sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of ENO1 protein]	16456883
C017947	sodium arsenite	sodium arsenite results in increased expression of ENO1 protein	16456883
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of ENO1 protein	27548804
D053260	Soot	[Soot co-treated with Benzo(a)pyrene] results in decreased expression of ENO1 protein	24464499
D053260	Soot	Soot results in increased expression of ENO1 protein	24464499
D013311	Streptozocin	Streptozocin results in increased expression of ENO1 protein	24924950
D013501	Surface-Active Agents	[Surface-Active Agents co-treated with glyphosate] results in increased expression of ENO1 mRNA	22467014
D014284	Triiodothyronine	Triiodothyronine results in increased expression of ENO1 mRNA	15507505
D013605	T-2 Toxin	T-2 Toxin affects the expression of ENO1 protein	26141394
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of ENO1 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENO1 mRNA]	23152189
D013749	Tetrachlorodibenzodioxin	alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENO1 mRNA]	23152189
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ENO1 mRNA	23152189
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ENO1 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ENO1 protein	16548065
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of ENO1 protein"	25852303
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of ENO1 protein"	25852303
C050950	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex	"tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ENO1 protein]"	23562983
D013849	Thimerosal	Thimerosal results in decreased expression of ENO1 mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of ENO1 mRNA	19483382
C009495	titanium dioxide	titanium dioxide results in decreased expression of ENO1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased metabolism of ENO1 protein	23396223
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of ENO1 protein	22595367
D014212	Tretinoin	Tretinoin affects the expression of ENO1 mRNA	16054129
D014212	Tretinoin	Tretinoin results in decreased expression of ENO1 mRNA	21934132
D014212	Tretinoin	Tretinoin results in decreased expression of ENO1 protein	17051635
D014241	Trichloroethylene	Trichloroethylene results in increased expression of ENO1 mRNA	19254012
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENO1 mRNA"	27188386
C012589	trichostatin A	trichostatin A affects the expression of ENO1 mRNA	28542535
C012589	trichostatin A	trichostatin A results in increased expression of ENO1 mRNA	24935251\|2627250
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of ENO1 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ENO1 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of ENO1 protein	21315101
D014520	Urethane	Urethane results in decreased expression of ENO1 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENO1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of ENO1 mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of ENO1 gene	25560391
D014810	Vitamin E	Vitamin E results in increased expression of ENO1 mRNA	19244175
C111237	vorinostat	vorinostat results in increased expression of ENO1 protein	20543569
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of ENO1 mRNA"	25198161
D019820	Xanthine	[Xanthine co-treated with XDH protein] results in decreased expression of ENO1 protein	19464573
D015032	Zinc	ENO1 protein binds to Zinc	14534351
D015032	Zinc	Zinc deficiency results in increased expression of ENO1 mRNA	16140947
D015032	Zinc	Zinc inhibits the reaction [Zinc deficiency results in increased expression of ENO1 mRNA]	16140947
D019345	Zinc Acetate	Zinc Acetate results in increased expression of ENO1 mRNA	16357179

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	IEA	-
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IDA	2005901
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	2005901
GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	-	IDA	2005901
GO:0003723	RNA binding	-	HDA	22658674
GO:0004634	phosphopyruvate hydratase activity	-	IMP	3529090
GO:0004634	phosphopyruvate hydratase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	11134351 12666133 15161933 15324660 18194455 19433310 20849852 21274509 23355646 23414517 23823123 28813417
GO:0042803	protein homodimerization activity	-	IDA	3529090
GO:0045296	cadherin binding	-	HDA	25468996
GO:0051020	GTPase binding	-	IPI	24337748

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	2005901
GO:0006094	gluconeogenesis	-	TAS	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0009615	response to virus	-	IEP	16548883
GO:0010756	positive regulation of plasminogen activation	-	IMP	12666133
GO:0030308	negative regulation of cell growth	-	IDA	10082554
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	10082554
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	10681589
GO:0045933	positive regulation of muscle contraction	-	IGI	15459207
GO:0061621	canonical glycolysis	-	IMP	3529090
GO:0061621	canonical glycolysis	-	TAS	-
GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	-	IDA	15459207
GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	-	IGI	15459207
GO:2001171	positive regulation of ATP biosynthetic process	-	IDA	15459207
GO:2001171	positive regulation of ATP biosynthetic process	-	IGI	15459207

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000015	phosphopyruvate hydratase complex	-	IDA	3529090
GO:0005615	extracellular space	-	HDA	16502470 22664934 23580065
GO:0005634	nucleus	-	HDA	21630459
GO:0005634	nucleus	-	IC	2005901 10082554
GO:0005737	cytoplasm	-	IDA	15459207 25468996
GO:0005829	cytosol	-	IDA	12666133 19433310
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	12666133
GO:0009986	cell surface	-	IDA	12666133 19433310
GO:0016020	membrane	-	HDA	19946888
GO:0016020	membrane	-	IDA	19433310
GO:0031430	M band	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	11487543 12519789 19199708 20458337 21362503 23533145
GO:0099738	cell cortex region	-	IDA	19433310

KEGG ID	KEGG Term
hsa00010	Glycolysis / Gluconeogenesis
hsa01100	Metabolic pathways
hsa03018	RNA degradation

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-70171	Glycolysis	TAS
R-HSA-70263	Gluconeogenesis	TAS
R-HSA-70326	Glucose metabolism	TAS
R-HSA-71387	Metabolism of carbohydrates	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18155341	Gene expression profiling in human lung fibroblast following cadmium exposure. (2008 Mar)	Li GY	Food Chem Toxicol
29538538	Diagnostic value of alpha-enolase expression and serum alpha-enolase autoantibody levels in lung cancer. (2018 Jan-Feb)	Zhang L	J Bras Pneumol
23287867	Circulating CD34(+) progenitor cell frequency is associated with clinical and genetic factors. (2013 Feb 21)	Cohen KS	Blood