Gene: GAPT

202309
C5orf29
GRB2 binding adaptor protein, transmembrane
protein-coding
5q11.2
Ensembl:ENSG00000175857 Vega:OTTHUMG00000131219 UniprotKB:Q8N292
NC_000005.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.133e-1 (AD)  7.438e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6895889chr5:58490716 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAF3IP30.866
HLA-DOA0.852
TLR100.841
GAB30.838
C16orf540.835
LILRB20.833
LILRA10.83
RGS180.83
MS4A4E0.826
TNFAIP80.825

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.517
DBP-0.493
CYP46A1-0.492
CHRNA4-0.481
BDH1-0.467
HAGHL-0.46
C9orf24-0.456
KLHL26-0.453
C15orf59-0.446
RND1-0.444

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GAPT mRNA"23146750
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GAPT gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of GAPT mRNA"23195993
C006780bisphenol Abisphenol A results in decreased expression of GAPT mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of GAPT mRNA25979313
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of GAPT mRNA24763279
D003630DaunorubicinGAPT affects the susceptibility to Daunorubicin17545624
D002945CisplatinCisplatin results in decreased expression of GAPT mRNA27594783
C546771gardiquimodgardiquimod results in decreased expression of GAPT mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of GAPT mRNA]28003376
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of GAPT mRNA24763279
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GAPT mRNA25613284
D009532NickelNickel results in decreased expression of GAPT mRNA23195993
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of GAPT mRNA]28003376
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GAPT mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in increased methylation of GAPT gene27618143
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GAPT gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001782B cell homeostasis-IBA21873635  
GO:0002322B cell proliferation involved in immune response-IBA21873635  
GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal