Gene: ENO2

2026
HEL-S-279|NSE
enolase 2
protein-coding
12p13.31
Ensembl:ENSG00000111674 MIM:131360 Vega:OTTHUMG00000168967 UniprotKB:P09104
NC_000012.12
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.264e-1 (AD)  7.213e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDRG30.983
RTN10.983
PPME10.982
C16orf450.98
STXBP10.98
USP50.98
ATP6V1B20.979
GOT10.979
GOT20.979
ATP6AP10.979

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.614
OR4F29-0.581
REST-0.449
TFPI2-0.443
RAI14-0.44
YES1-0.432
CXCR2-0.428
KCNJ15-0.428
WWTR1-0.426
HEY2-0.426

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB027262-Phosphoglycolic AcidSmall Molecule13147-57-4ExperimentalTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in increased expression of ENO2 mRNA"19502547
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of ENO2 mRNA]"24403227
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENO2 mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of ENO2 protein"21673325
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ENO2 mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of ENO2 mRNA]"19414516
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENO2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENO2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENO2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENO2 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of ENO2 mRNA"20406850
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of ENO2 mRNA19643169
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of ENO2 mRNA"24172598
C0153923-nitropropionic acid3-nitropropionic acid results in decreased expression of ENO2 mRNA17672854
C0153923-nitropropionic acidCannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of ENO2 mRNA]17672854
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENO2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENO2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENO2 mRNA"27188386
D000117AcetylglucosamineAcetylglucosamine results in increased expression of ENO2 mRNA18047607
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ENO2 mRNA]"19414516
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ENO2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ENO2 gene27153756
D000535AluminumAluminum results in decreased activity of ENO2 protein11860913
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ENO2 mRNA16483693
D000661AmphetamineAmphetamine inhibits the reaction [MDK gene mutant form results in decreased expression of ENO2 protein]23459167
D000661AmphetamineAmphetamine inhibits the reaction [PTN gene mutant form results in decreased expression of ENO2 protein]23459167
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of ENO2 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ENO2 mRNA24449571
D034341Aristolochic AcidsAristolochic Acids results in increased expression of ENO2 mRNA19717638
C015001arsenitearsenite results in increased expression of ENO2 mRNA22613180
C015001arsenitearsenite results in increased expression of ENO2 protein22613180
D001374AzacitidineAzacitidine results in decreased expression of ENO2 protein20607034
C406592azaspiracidazaspiracid results in increased expression of ENO2 mRNA28939011
D001507BeclomethasoneBeclomethasone results in increased expression of ENO2 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ENO2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ENO2 protein19449198
D001564Benzo(a)pyreneCapsaicin inhibits the reaction [Benzo(a)pyrene results in increased expression of ENO2 protein]19449198
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ENO2 protein21467743
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ENO2 mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of ENO2 mRNA15159206
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of ENO2 mRNA27685785
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ENO2 mRNA28628672
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of ENO2 mRNA15912405
C006780bisphenol Abisphenol A affects the expression of ENO2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ENO2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of ENO2 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of ENO2 mRNA23798566
C006780bisphenol Abisphenol A results in increased expression of ENO2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ENO2 gene28505145
C025703bleomycetinbleomycetin results in increased expression of ENO2 mRNA21040473
D000069286BortezomibBortezomib results in increased expression of ENO2 mRNA20977926
C018475butyraldehydebutyraldehyde results in increased expression of ENO2 mRNA26079696
D002104CadmiumCadmium results in increased expression of ENO2 mRNA22613180
D002104CadmiumCadmium results in increased expression of ENO2 protein22613180
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ENO2 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ENO2 protein24527689
D002185CannabidiolCannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of ENO2 mRNA]17672854
D002211CapsaicinCapsaicin inhibits the reaction [Benzo(a)pyrene results in increased expression of ENO2 protein]19449198
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ENO2 mRNA17484886
D002509CephaloridineCephaloridine results in increased expression of ENO2 mRNA18500788
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of ENO2 mRNA25596134
D002746ChlorpromazineChlorpromazine results in increased expression of ENO2 mRNA25596134
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of ENO2 mRNA17382205
C059262cidofovircidofovir results in increased expression of ENO2 mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of ENO2 mRNA25596134
D003035Cobalt[tungsten carbide binds to Cobalt] which results in increased expression of ENO2 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in increased expression of ENO2 mRNA19376846|1950254
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ENO2 mRNA]22202117
C018021cobaltous chloridecobaltous chloride results in increased expression of ENO2 protein16772336
C026305cobalt sulfatecobalt sulfate results in increased expression of ENO2 mRNA19502547
D003042CocaineCocaine results in decreased expression of ENO2 mRNA12629581
D003042CocaineCocaine results in increased expression of ENO2 protein17075605
D016578Crack CocaineCrack Cocaine results in increased expression of ENO2 mRNA12629581
D016572CyclosporineCyclosporine results in decreased expression of ENO2 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of ENO2 mRNA25562108|2559613
C014347decitabinedecitabine affects the expression of ENO2 mRNA23300844
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of ENO2 mRNA17330099
C107676deguelindeguelin results in decreased secretion of ENO2 protein26884827
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ENO2 mRNA28628672
D002945CisplatinCisplatin affects the expression of ENO2 mRNA23300844
D002945CisplatinCisplatin results in increased expression of ENO2 mRNA25596134
D002945CisplatinCisplatin results in decreased expression of ENO2 mRNA22023808
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ENO2 mRNA]"23626681
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ENO2 mRNA15159206
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ENO2 mRNA17547211
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of ENO2 mRNA28939011
D004222DisulfotonDisulfoton results in increased expression of ENO2 mRNA12935443
D004237DiuronDiuron metabolite results in increased expression of ENO2 mRNA24172598
D004317DoxorubicinDoxorubicin affects the expression of ENO2 protein29385562
C118739entinostatentinostat results in increased expression of ENO2 mRNA22613180
D004964EstriolEstriol results in decreased expression of ENO2 mRNA15159206
D004970EstroneEstrone results in decreased expression of ENO2 mRNA15159206
D000431EthanolEthanol results in decreased expression of ENO2 mRNA28986285
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENO2 mRNA17942748
C000499ferric oxideferric oxide analog results in decreased expression of ENO2 mRNA24525745
C000499ferric oxideferric oxide analog results in increased expression of ENO2 mRNA25086211
D005411Flame RetardantsFlame Retardants results in increased expression of ENO2 protein16451863
C039281furanfuran results in increased expression of ENO2 mRNA27387713
D019833GenisteinGenistein results in decreased expression of ENO2 mRNA15159206
D005947GlucoseGlucose deficiency results in increased secretion of ENO2 protein24802182
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins affects the expression of ENO2 protein16414080
D006418HemeHeme metabolite results in increased expression of ENO2 mRNA19191707
C492448ICG 001ICG 001 results in increased expression of ENO2 mRNA26191083
D007069IfosfamideIfosfamide results in increased expression of ENO2 mRNA25596134
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ENO2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ENO2 mRNA28628672
C544151jinfukangjinfukang results in increased expression of ENO2 mRNA27392435
D007649KetamineKetamine results in decreased expression of ENO2 protein18504422
C045463leflunomideleflunomide results in increased expression of ENO2 mRNA28988120
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ENO2 mRNA26378955
D008344Maneb[Maneb co-treated with Paraquat] results in increased expression of ENO2 protein23562983
C025340manganese chloridemanganese chloride results in decreased expression of ENO2 protein24969583
C025340manganese chlorideMelatonin inhibits the reaction [manganese chloride results in decreased expression of ENO2 protein]24969583
C025340manganese chloridemanganese chloride results in increased expression of ENO2 mRNA22281203
D008550MelatoninMelatonin inhibits the reaction [manganese chloride results in decreased expression of ENO2 protein]24969583
D008687MetforminMetformin results in increased expression of ENO2 mRNA25596134
D008694MethamphetamineMethamphetamine results in increased expression of ENO2 protein19826936
D008727MethotrexateENO2 mRNA results in decreased susceptibility to Methotrexate18694510
C005219methyl cellosolvemethyl cellosolve results in increased expression of ENO2 mRNA19643169
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ENO2 mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ENO2 protein"23562983
C008493methylselenic acidmethylselenic acid results in increased expression of ENO2 mRNA18548127
D015741MetriboloneMetribolone results in decreased expression of ENO2 protein17152098
D015735MifepristoneMifepristone results in decreased expression of ENO2 mRNA25972201
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate results in increased expression of ENO2 mRNA"19615344
C091888monoisoamyl-2,3-dimercaptosuccinate"[sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of ENO2 mRNA"19615344
C452423N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amineN-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of ENO2 mRNA16052530
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ENO2 protein"22001959
C022838nickel chloridenickel chloride results in increased expression of ENO2 mRNA17312168|2145529
C028007nickel monoxidenickel monoxide results in increased expression of ENO2 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of ENO2 mRNA17382205
D009534NiclosamideNiclosamide results in increased expression of ENO2 mRNA22576131
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of ENO2 mRNA]"24929042
C025256nonylphenolnonylphenol results in decreased expression of ENO2 mRNA15159206
C558013NSC 689534NSC 689534 results in increased expression of ENO2 mRNA20971185
C025589ochratoxin Aochratoxin A results in increased expression of ENO2 mRNA19717638
D010100Oxygen"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of ENO2 mRNA]"24403227
D010100OxygenOxygen deficiency results in increased expression of ENO2 mRNA19502547|2004264
D010100OxygenOxygen deficiency affects the expression of ENO2 mRNA17193925
D010269Paraquat[Maneb co-treated with Paraquat] results in increased expression of ENO2 protein23562983
D010269ParaquatParaquat results in increased expression of ENO2 mRNA alternative form17064354
D010269ParaquatParaquat results in decreased expression of ENO2 protein24521700
D010269ParaquatParaquat results in increased expression of ENO2 mRNA18198484
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENO2 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ENO2 mRNA26705709
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ENO2 protein16451863
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ENO2 protein25616259
C076994perfluorooctane sulfonic acid[perfluorooctane sulfonic acid co-treated with Tretinoin] results in decreased expression of ENO2 mRNA23948355
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ENO2 mRNA23948355
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ENO2 mRNA]"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ENO2 mRNA23626681|2394835
D010656PhenylephrinePhenylephrine results in increased expression of ENO2 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENO2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ENO2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ENO2 mRNA19710929
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ENO2 mRNA17382205
C005556propionaldehydepropionaldehyde results in increased expression of ENO2 mRNA26079696
C502851quinocetonequinocetone results in decreased expression of ENO2 mRNA27046791
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of ENO2 mRNA14699072
C031389resorcinolresorcinol results in increased expression of ENO2 mRNA22623647
C059514resveratrolresveratrol results in decreased expression of ENO2 mRNA15582268
C059514resveratrolresveratrol results in increased expression of ENO2 protein24464877
C009172rhodioloside"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of ENO2 mRNA]"24929042
C009172rhodiolosideNOG protein inhibits the reaction [rhodioloside results in increased expression of ENO2 mRNA]24929042
C009172rhodiolosideNOG protein inhibits the reaction [rhodioloside results in increased expression of ENO2 protein]24929042
C009172rhodiolosiderhodioloside results in increased expression of ENO2 mRNA24929042
C009172rhodiolosiderhodioloside results in increased expression of ENO2 protein24929042
D012524SarinSarin results in decreased expression of ENO2 protein28973502
D012643SeleniumSelenium results in increased expression of ENO2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ENO2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of ENO2 mRNA25351596
C080703SK&F 83959SK&F 83959 results in increased expression of ENO2 protein25852303
C017947sodium arsenite"[sodium arsenite co-treated with monoisoamyl-2,3-dimercaptosuccinate] results in decreased expression of ENO2 mRNA"19615344
C017947sodium arsenitesodium arsenite results in decreased expression of ENO2 mRNA19615344
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ENO2 mRNA26378955
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of ENO2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ENO2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENO2 mRNA17942748
D013849ThimerosalThimerosal results in decreased expression of ENO2 mRNA27188386
D013853ThioacetamideThioacetamide results in increased methylation of ENO2 promoter27914986
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ENO2 mRNA28065790
D014212TretinoinTretinoin results in increased expression of ENO2 protein16473924
D014212Tretinoin[perfluorooctane sulfonic acid co-treated with Tretinoin] results in decreased expression of ENO2 mRNA23948355
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENO2 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of ENO2 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of ENO2 mRNA24935251|2627250
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in increased expression of ENO2 mRNA20105288
D014415TunicamycinTunicamycin results in decreased expression of ENO2 mRNA22378314
D014520UrethaneUrethane results in decreased expression of ENO2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ENO2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ENO2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ENO2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of ENO2 protein18599177
D014635Valproic AcidValproic Acid results in increased expression of ENO2 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of ENO2 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ENO2 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of ENO2 mRNA26682919
D014810Vitamin EVitamin E results in increased expression of ENO2 mRNA19244175
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of ENO2 mRNA17330099
C111237vorinostatvorinostat results in decreased expression of ENO2 mRNA18769122
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of ENO2 mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004634phosphopyruvate hydratase activity-ISS22087329  
GO:0004634phosphopyruvate hydratase activity-TAS-  
GO:0005515protein binding-IPI21044950  
GO ID GO Term Qualifier Evidence PubMed
GO:0006094gluconeogenesis-TAS-  
GO:0006096glycolytic process-ISS22087329  
GO:0061621canonical glycolysis-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000015phosphopyruvate hydratase complex-IEA-  
GO:0001917photoreceptor inner segment-IEA-  
GO:0005615extracellular space-HDA22664934  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016020membrane-IDA19433310  
GO:0043204perikaryon-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0070062extracellular exosome-HDA20458337  23533145  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa01100Metabolic pathways
hsa03018RNA degradation
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70171GlycolysisTAS
R-HSA-70263GluconeogenesisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
3963886Personal exposure and health effect relationship for NO2 with urinary hydroxyproline to creatinine ratio as indicator. (1986 Jan-Feb)Yanagisawa YArch Environ Health