Gene: AK1

203
HTL-S-58j
adenylate kinase 1
protein-coding
9q34.11
Ensembl:ENSG00000106992 MIM:103000 Vega:OTTHUMG00000020722 UniprotKB:P00568
NG_011792.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.006e-1 (AD)  3.898e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11714502chr9:130640212AK12.900e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPE0.947
TXN20.941
NDUFB70.938
ECHS10.935
LAMTOR40.934
FBXO20.93
GNPTG0.928
NDUFA130.928
COX5B0.927
PMVK0.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.833
OR4F29-0.803
FER1L6-0.314
PZP-0.305
SULT1E1-0.292
DNASE1L3-0.287
GSDMA-0.286
GADL1-0.286
HMCN1-0.282
COL14A1-0.278

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01717Bis(Adenosine)-5'-PentaphosphateSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in decreased expression of AK1 mRNA"19502547
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of AK1 mRNA"26377693
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of AK1 mRNA"22101062
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AK1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AK1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AK1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AK1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AK1 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AK1 mRNA"28973690
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of AK1 mRNA16788091
D000082AcetaminophenAcetaminophen results in increased expression of AK1 mRNA22230336
D000082AcetaminophenAcetaminophen results in increased expression of AK1 mRNA11752693
D020106AcrylamideAcrylamide results in decreased expression of AK1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AK1 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AK1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AK1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of AK1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of AK1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of AK1 mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of AK1 mRNA23656298
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of AK1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AK1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to AK1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AK1 mRNA21715664
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AK1 mRNA19770486|2222880
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of AK1 mRNA18192240
C044887beta-methylcholinebeta-methylcholine affects the expression of AK1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK1 mRNA28628672
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of AK1 mRNA15912405
C006780bisphenol Abisphenol A results in decreased expression of AK1 protein28279065
C006780bisphenol Abisphenol A affects the expression of AK1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of AK1 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of AK1 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AK1 protein24527689
D019256Cadmium ChlorideCadmium Chloride affects the expression of AK1 mRNA18974090
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AK1 protein21699967
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AK1 mRNA20938992
D007464ClioquinolClioquinol results in decreased expression of AK1 mRNA19502547
C018021cobaltous chloridecobaltous chloride results in decreased expression of AK1 mRNA19502547
C018021cobaltous chloridecobaltous chloride results in increased expression of AK1 protein24386269
C026305cobalt sulfatecobalt sulfate results in decreased expression of AK1 mRNA19502547
D003042CocaineCocaine results in decreased expression of AK1 mRNA15009677
D003078ColchicineColchicine results in decreased expression of AK1 mRNA20624997
D019327Copper SulfateCopper Sulfate results in decreased expression of AK1 mRNA19549813
D003474Curcumin[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein25866362
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of AK1 mRNA23914054
C017180decamethrindecamethrin results in increased activity of AK1 protein19326768
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK1 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of AK1 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of AK1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of AK1 mRNA19561079|2428008
D002945CisplatinCisplatin results in increased expression of AK1 mRNA24280081
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of AK1 mRNA"22485181
D004317DoxorubicinDoxorubicin results in decreased expression of AK1 mRNA19915844
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of AK1 mRNA17317680
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AK1 mRNA20938992
C039281furanfuran results in increased expression of AK1 mRNA22079235|2738771
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of AK1 mRNA21782745
D019833GenisteinGenistein results in increased expression of AK1 mRNA21782745
C492448ICG 001ICG 001 results in increased expression of AK1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AK1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of AK1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AK1 mRNA26644586
D008694MethamphetamineMethamphetamine results in decreased expression of AK1 protein19826936
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AK1 mRNA20938992
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of AK1 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of AK1 mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride affects the expression of AK1 protein27012723
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of AK1 mRNA24128854
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AK1 mRNA"25554681
C022838nickel chloridenickel chloride affects the expression of AK1 mRNA22546817
D009573Nitrites[Nitrites co-treated with Oxygen deficiency] results in increased activity of AK1 protein22892143
C025589ochratoxin Aochratoxin A results in increased expression of AK1 mRNA18417182
D010100Oxygen[Nitrites co-treated with Oxygen deficiency] results in increased activity of AK1 protein22892143
D010269ParaquatParaquat results in increased expression of AK1 mRNA21371552
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AK1 mRNA"25510870
D026023PermethrinPermethrin results in increased activity of AK1 protein19326768
D010578PetroleumPetroleum affects the expression of AK1 mRNA25208076
C045362prochlorazprochloraz results in decreased expression of AK1 mRNA21470553
D011374ProgesteroneProgesterone results in increased expression of AK1 mRNA20726854
D012524SarinSarin results in increased expression of AK1 protein25842371
D012524SarinSarin results in decreased expression of AK1 protein28973502
D012643SeleniumSelenium results in increased expression of AK1 mRNA19244175
D012834SilverSilver results in increased expression of AK1 mRNA27131904
D012969Sodium FluorideSodium Fluoride results in increased expression of AK1 protein28918527
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of AK1 mRNA16214533
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AK1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AK1 mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of AK1 mRNA23557971
C011559tributyltintributyltin results in decreased expression of AK1 mRNA29191790
D014241TrichloroethyleneTrichloroethylene results in increased methylation of AK1 gene27618143
D014635Valproic AcidValproic Acid affects the expression of AK1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of AK1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of AK1 mRNA19136453
D014747VinblastineVinblastine results in decreased expression of AK1 mRNA20624997
C025643vinclozolinvinclozolin affects the expression of AK1 mRNA19015723
D014750VincristineVincristine results in decreased expression of AK1 mRNA20624997
C029297vinylidene chloridevinylidene chloride results in decreased expression of AK1 mRNA26682919
D014810Vitamin EVitamin E results in increased expression of AK1 mRNA19244175
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of AK1 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004017adenylate kinase activity-EXP211388  2542324  
GO:0004550nucleoside diphosphate kinase activity-IDA23416111  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006165nucleoside diphosphate phosphorylation-IDA23416111  
GO:0009142nucleoside triphosphate biosynthetic process-IDA23416111  
GO:0015949nucleobase-containing small molecule interconversion-TAS-  
GO:0046034ATP metabolic process-IEA-  
GO:0046940nucleoside monophosphate phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-499943Interconversion of nucleotide di- and triphosphatesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18850517Smoking and human reproduction: the effect of adenylate kinase genetic polymorphism. (2009 Feb)Gloria-Bottini FAm J Perinatol