Gene: SLC29A1

2030
ENT1
solute carrier family 29 member 1 (Augustine blood group)
protein-coding
6p21.1
Ensembl:ENSG00000112759 MIM:602193 Vega:OTTHUMG00000014759 UniprotKB:Q99808
NG_042893.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.939e-1 (AD)  5.395e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01993576chr6:44187674SLC29A11.100e-15Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ME30.924
GGT70.92
TECPR10.918
TRIM30.915
DEPDC50.915
RNF1230.912
GPRASP10.911
STRIP10.91
NICN10.91
DLG30.907

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.534
HEY2-0.505
REST-0.492
AKR1C3-0.489
STON2-0.479
ROM1-0.476
RAB13-0.475
RAI14-0.474
HVCN1-0.474
LRAT-0.473

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00441GemcitabineSmall Molecule95058-81-4ApprovedTransporter
DB00544FluorouracilSmall Molecule51-21-8ApprovedTransporter
DB00811RibavirinSmall Molecule36791-04-5ApprovedTransporter
DB00900DidanosineSmall Molecule69655-05-6ApprovedTransporter
DB00943ZalcitabineSmall Molecule7481-89-2Approved|InvestigationalTransporter
DB00987CytarabineSmall Molecule147-94-4Approved|InvestigationalTransporter
DB01033MercaptopurineSmall Molecule50-44-2ApprovedTransporter
DB01073FludarabineSmall Molecule21679-14-1ApprovedTransporter
DB02745UridineSmall Molecule58-96-8Experimental|InvestigationalTransporter
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTransporter
DB09327Tegafur-uracilSmall Molecule74578-38-4Approved|InvestigationalTransporter
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB00642PemetrexedSmall Molecule137281-23-3Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in increased expression of SLC29A1 mRNA"25270620
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC29A1 mRNA"25270620
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC29A1 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SLC29A1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC29A1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC29A1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC29A1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC29A1 mRNA"25510870
C0581182'-deoxyadenosine2'-deoxyadenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of SLC29A1 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of SLC29A1 mRNA]28655636
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC29A1 mRNA"16984957|2095900
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC29A1 mRNA"27188386
C0017894-nitrobenzylthioinosine4-nitrobenzylthioinosine binds to SLC29A1 protein28041785
C0017894-nitrobenzylthioinosine4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]10366666
C0017894-nitrobenzylthioinosine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in decreased susceptibility to Fluorouracil]17695509
C0017894-nitrobenzylthioinosine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of gemcitabine]17695509
C0017894-nitrobenzylthioinosine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301|9396714
C0017894-nitrobenzylthioinosinecilostazol inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]28041785
C0017894-nitrobenzylthioinosineDipyridamole inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]28041785
C0017894-nitrobenzylthioinosineDipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]10366666
C0017894-nitrobenzylthioinosinedraflazine inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]28041785
C0017894-nitrobenzylthioinosineTicagrelor inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]28041785
C0017894-nitrobenzylthioinosine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]11179696
C0017894-nitrobenzylthioinosine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]11179696
C0017894-nitrobenzylthioinosine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
C0017894-nitrobenzylthioinosine[4-nitrobenzylthioinosine results in decreased activity of SLC29A1 protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine]23437309
C0017894-nitrobenzylthioinosine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
C0017894-nitrobenzylthioinosine4-nitrobenzylthioinosine results in decreased activity of SLC29A1 protein10366666|1716706
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC29A1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SLC29A1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of SLC29A1 mRNA17562736
D000241Adenosinecilostazol inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]28041785
D000241AdenosineDipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]28041785
D000241Adenosinedraflazine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]28041785
D000241AdenosineEthanol promotes the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]21283641
D000241AdenosineEthanol promotes the reaction [SLC29A1 protein results in increased uptake of Adenosine]21283641
D000241AdenosineSLC29A1 protein alternative form results in increased uptake of Adenosine21283641
D000241AdenosineSLC29A1 protein results in increased uptake of Adenosine21283641|2804178
D000241AdenosineTicagrelor inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]28041785
D000241Adenosine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]11179696
D000241Adenosine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]11179696
D000241Adenosine[4-nitrobenzylthioinosine results in decreased activity of SLC29A1 protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine]23437309
D000241AdenosineDipyridamole inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]11179696
D000241AdenosineDipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]11179696
D000241AdenosineDipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine]21872611
D000241AdenosineSLC29A1 affects the abundance of Adenosine21872611
D000241Adenosine[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine21872611
D000241AdenosineSLC29A1 protein alternative form results in increased uptake of Adenosine11179696
D000241AdenosineSLC29A1 protein results in increased uptake of Adenosine11179696
D000241AdenosineAdenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC29A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC29A1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC29A1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC29A1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC29A1 mRNA16483693
D001151ArsenicArsenic affects the methylation of SLC29A1 gene25304211
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of SLC29A1 mRNA15894607
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of SLC29A1 mRNA25278499
D001280AtrazineAtrazine results in increased expression of SLC29A1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of SLC29A1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC29A1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC29A1 mRNA19770486
D004958EstradiolEstradiol results in increased expression of SLC29A1 mRNA19167446
D004958EstradiolEstradiol results in decreased expression of SLC29A1 mRNA15289156
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of SLC29A1 mRNA25270620
C006780bisphenol Abisphenol A results in increased expression of SLC29A1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC29A1 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of SLC29A1 mRNA25270620
C584509C646 compoundC646 compound results in decreased expression of SLC29A1 mRNA26191083
D002104CadmiumCadmium results in decreased expression of SLC29A1 mRNA23369406
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SLC29A1 mRNA27339419
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SLC29A1 mRNA28472532
C045645cilostazolcilostazol inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]28041785
C045645cilostazolcilostazol inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]28041785
D002994ClofibrateClofibrate results in decreased expression of SLC29A1 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC29A1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC29A1 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SLC29A1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC29A1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SLC29A1 mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of SLC29A1 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of SLC29A1 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of SLC29A1 mRNA21632981|2556210
D003561CytarabineSLC29A1 gene polymorphism results in decreased susceptibility to Cytarabine18381442
D003562CytidineCytidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D003562CytidineCytidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
D003703DemecolcineDemecolcine results in decreased expression of SLC29A1 mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SLC29A1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SLC29A1 mRNA27594783
D002945CisplatinCisplatin results in increased expression of SLC29A1 mRNA27392435
D002945CisplatinSLC29A1 protein affects the susceptibility to Cisplatin18728667
D004008DiclofenacDiclofenac results in decreased expression of SLC29A1 mRNA26934552
D004026DieldrinDieldrin results in decreased expression of SLC29A1 mRNA23153324
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of SLC29A1 mRNA15289156
D002117CalcitriolCalcitriol results in decreased expression of SLC29A1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of SLC29A1 mRNA21592394
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of SLC29A1 mRNA25270620
D004109DilazepDilazep inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301|9396714
D004109DilazepDilazep inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D004176DipyridamoleDipyridamole inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]28041785
D004176DipyridamoleDipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]28041785
D004176DipyridamoleDipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301|9396714
D004176DipyridamoleDipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]10366666
D004176DipyridamoleDipyridamole results in decreased activity of SLC29A1 protein21678404
D004176DipyridamoleDipyridamole inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]11179696
D004176DipyridamoleDipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]11179696
D004176DipyridamoleDipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D004176DipyridamoleDipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine]21872611
D004176DipyridamoleDipyridamole results in decreased activity of SLC29A1 protein10366666|1716706
D004317DoxorubicinSLC29A1 protein affects the susceptibility to Doxorubicin18452103
C072040draflazinedraflazine inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]28041785
C072040draflazinedraflazine inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]28041785
D000431EthanolEthanol promotes the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]21283641
D000431EthanolEthanol promotes the reaction [SLC29A1 protein results in increased uptake of Adenosine]21283641
D000431EthanolSLC29A1 protein affects the susceptibility to Ethanol21283641
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC29A1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC29A1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC29A1 mRNA17351261
D005472Fluorouracil4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in decreased susceptibility to Fluorouracil]17695509
D005472FluorouracilFluorouracil promotes the reaction [SLC29A1 protein results in increased uptake of gemcitabine]16868479
D005472FluorouracilFluorouracil results in increased expression of SLC29A118383843
D005472FluorouracilFluorouracil results in increased expression of SLC29A1 mRNA16868479
D005472FluorouracilSLC29A1 protein affects the susceptibility to Fluorouracil16217747
D005472FluorouracilSLC29A1 protein results in decreased susceptibility to Fluorouracil17695509
C056933fumonisin B1fumonisin B1 results in decreased expression of SLC29A1 mRNA16221962
C039281furanfuran results in decreased expression of SLC29A1 mRNA26194646
C056507gemcitabine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of gemcitabine]17695509
C056507gemcitabineFluorouracil promotes the reaction [SLC29A1 protein results in increased uptake of gemcitabine]16868479
C056507gemcitabine[S 1 (combination) results in increased expression of SLC29A1 mRNA] which results in increased uptake of gemcitabine18383843
C056507gemcitabineSLC29A1 mRNA results in increased susceptibility to gemcitabine18490900
C056507gemcitabineSLC29A1 protein affects the susceptibility to gemcitabine18452103|1872866
C056507gemcitabineSLC29A1 protein results in decreased susceptibility to gemcitabine17695509
C056507gemcitabineSLC29A1 protein results in increased susceptibility to gemcitabine15501974|1899224
C056507gemcitabineSLC29A1 protein results in increased uptake of gemcitabine16868479|1769550
D019833GenisteinGenistein results in decreased expression of SLC29A1 mRNA15289156
D006151GuanosineGuanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D006151GuanosineGuanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
D006533HeptachlorHeptachlor results in decreased expression of SLC29A1 mRNA23153324
C492448ICG 001ICG 001 results in decreased expression of SLC29A1 mRNA26191083
D007288InosineInosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D007288InosineInosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SLC29A1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of SLC29A1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC29A1 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC29A1 mRNA25982114
D008013LidoflazineLidoflazine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9396714
D008778MethylthioinosineSLC29A1 mRNA affects the transport of Methylthioinosine16859645
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC29A1 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SLC29A1 mRNA24810058
D008777MethyltestosteroneMethyltestosterone results in increased expression of SLC29A1 mRNA29191790
D009151Mustard GasMustard Gas results in decreased expression of SLC29A1 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC29A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC29A1 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of SLC29A1 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SLC29A1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SLC29A1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of SLC29A1 mRNA25729387
D010100Oxygen[4-nitrobenzylthioinosine results in decreased activity of SLC29A1 protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine]23437309
D010100OxygenDipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine]21872611
D010100OxygenOxygen deficiency results in increased expression of SLC29A1 mRNA23437309
D010100OxygenOxygen deficiency results in increased expression of SLC29A1 protein23437309
D010100Oxygen[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine21872611
C016030pantogabpantogab results in decreased expression of SLC29A1 mRNA17379144
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of SLC29A1 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of SLC29A1 mRNA28655636
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC29A1 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SLC29A1 mRNA19162173
D010656PhenylephrinePhenylephrine results in increased expression of SLC29A1 mRNA19966059
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC29A1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of SLC29A1 mRNA16221962|1844570
C006253pirinixic acidpirinixic acid results in decreased expression of SLC29A1 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC29A1 mRNA24677778
D011374ProgesteroneProgesterone results in increased expression of SLC29A1 mRNA23018184
C032114propentofyllinepropentofylline results in decreased activity of SLC29A1 protein23437309
D011794QuercetinQuercetin results in increased expression of SLC29A1 mRNA21632981
D012254RibavirinSLC29A1 protein results in increased uptake of Ribavirin20185188
D012293RifampinRifampin results in increased expression of SLC29A1 mRNA27199754
C079198S 1 (combination)S 1 (combination) results in increased expression of SLC29A1 mRNA18383843
C079198S 1 (combination)[S 1 (combination) results in increased expression of SLC29A1 mRNA] which results in increased uptake of gemcitabine18383843
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of SLC29A1 mRNA19244175
C078903seocalcitolseocalcitol results in decreased expression of SLC29A1 mRNA12040012
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SLC29A1 mRNA22431001
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of SLC29A1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of SLC29A1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC29A1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC29A1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC29A1 mRNA20959002|2121527
D013936ThymidineThymidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D013936ThymidineThymidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
C503700TicagrelorTicagrelor inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]28041785
C503700TicagrelorTicagrelor inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]28041785
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC29A1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SLC29A1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SLC29A1 mRNA25729387
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of SLC29A1 mRNA15894607
D014212TretinoinTretinoin results in decreased expression of SLC29A1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of SLC29A1 mRNA15894607
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SLC29A1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SLC29A1 mRNA28973697
C096910UFT(R) drugUFT(R) drug results in increased expression of SLC29A1 mRNA16868479
D014520UrethaneUrethane results in increased expression of SLC29A1 mRNA28818685
D014529Uridine4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]10366666
D014529Uridine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301|9396714
D014529UridineDilazep inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301|9396714
D014529UridineDipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301|9396714
D014529UridineDipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]10366666
D014529UridineLidoflazine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9396714
D014529Uridine[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine10366666
D014529UridineSLC29A1 protein results in increased uptake of Uridine10366666|1838144
D014529Uridine2'-deoxyadenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D014529Uridine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D014529UridineCytidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D014529UridineDilazep inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D014529UridineDipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D014529UridineGuanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D014529UridineInosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D014529UridineSLC29A1 protein results in increased uptake of Uridine11085929
D014529UridineThymidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]11085929
D014529Uridine4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
D014529UridineAdenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
D014529UridineCytidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
D014529UridineGuanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
D014529UridineInosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
D014529UridineSLC29A1 protein results in increased uptake of Uridine9353301
D014529UridineThymidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
D014529UridineUridine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]9353301
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC29A1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SLC29A1 mRNA26272509
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of SLC29A1 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of SLC29A1 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC29A1 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of SLC29A1 mRNA19165385
C025643vinclozolinvinclozolin affects the expression of SLC29A1 mRNA19015723
D014750VincristineVincristine results in decreased expression of SLC29A1 mRNA23649840
C030852vinorelbineSLC29A1 protein affects the susceptibility to vinorelbine18452103
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of SLC29A1 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of SLC29A1 mRNA19244175
D015215ZidovudineZidovudine results in increased expression of SLC29A1 mRNA24292225

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005337nucleoside transmembrane transporter activity-IBA21873635  
GO:0005337nucleoside transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-TAS8986748  
GO:0007595lactation-IEA-  
GO:0015858nucleoside transport-IDA12527552  
GO:0015862uridine transport-IBA21873635  
GO:0015862uridine transport-IEA-  
GO:0030431sleep-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:1901642nucleoside transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IBA21873635  
GO:0016323basolateral plasma membrane-IDA12527552  
GO:0016324apical plasma membrane-IDA12527552  
GO:0098794postsynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425397Transport of vitamins, nucleosides, and related moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-83936Transport of nucleosides and free purine and pyrimidine bases across the plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21283641Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. (2011 Jan 24)Kim JHPLoS One