Gene: ADAM32

203102
-
ADAM metallopeptidase domain 32
protein-coding
8p11.22
Ensembl:ENSG00000197140 Vega:OTTHUMG00000164071 UniprotKB:Q8TC27
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.807e-1 (AD)  3.948e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7830120chr8:39274171 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REPS10.772
EML60.752
NIPAL20.747
CBWD60.744
FAM153B0.737
ZBBX0.736
AGAP60.734
AHI10.732
NRG40.729
GOLGA8A0.727

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MDFI-0.409
SH2D1A-0.362
ACAP1-0.354
ANXA13-0.345
CCDC102A-0.33
DNAI2-0.329
TMSB15A-0.328
MYL3-0.325
TFPI2-0.322
KLRC2-0.321

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM32 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM32 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM32 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM32 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM32 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ADAM32 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ADAM32 gene28458013
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADAM32 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of ADAM32 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ADAM32 gene28505145
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ADAM32 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ADAM32 mRNA27392435
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM32 mRNA17942748
C039281furanfuran results in increased expression of ADAM32 mRNA24183702
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ADAM32 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ADAM32 mRNA27392435
C008261lead acetatelead acetate results in increased expression of ADAM32 mRNA22641619
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADAM32 mRNA"25620056
C029938nickel sulfatenickel sulfate results in decreased expression of ADAM32 mRNA22714537
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ADAM32 mRNA"25510870
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ADAM32 mRNA19710929
D059808PolyphenolsPolyphenols results in decreased expression of ADAM32 mRNA16293270
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ADAM32 mRNA22714537
D013629TamoxifenTamoxifen results in increased expression of ADAM32 mRNA25123088
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM32 mRNA17942748
D014241TrichloroethyleneTrichloroethylene results in increased expression of ADAM32 mRNA25549359
D014638VanadatesVanadates results in increased expression of ADAM32 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal