Gene: EP300

2033
KAT3B|RSTS2|p300
E1A binding protein p300
protein-coding
22q13.2
Ensembl:ENSG00000100393 MIM:602700 Vega:OTTHUMG00000150937 UniprotKB:Q09472
NG_009817.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.409e-1 (AD)  4.111e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRRAP0.924
NSD10.914
KMT2A0.911
MED13L0.906
CREBBP0.906
HELZ0.906
ANKFY10.903
ARID1A0.901
CNOT10.893
ZNF3840.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.593
OR4F29-0.56
NANOGNB-0.339
KLRC2-0.261
PAGE4-0.226
SPRR2D-0.222
ODAM-0.221
KLRC3-0.22
OR4F16-0.218
CD8B-0.215

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [EP300 protein binds to BIRC5 promoter]"20660371
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [EP300 protein binds to SP1 protein]"20660371
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 results in decreased localization of EP300 protein15641079
C4656642-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide results in decreased phosphorylation of EP300 protein26833564
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]]16928824
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA]11705990
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [EP300 protein binds to CYP1A1 promoter]"21703235
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran promotes the reaction [EP300 protein binds to CYP1B1 promoter]"21703235
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran promotes the reaction [EP300 protein binds to CYP1A1 promoter]"21703235
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran promotes the reaction [EP300 protein binds to CYP1B1 promoter]"21703235
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EP300 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRT6 protein affects the phosphorylation of EP300 protein]27094368
C5758943,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide"3,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide inhibits the reaction [[HIF1A protein binds to ARNT protein] binds to [EP300 protein binds to CREBBP protein]]"22032632
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]19281832
C0251603-aminobenzamide3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]22228707
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein]15767673
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in increased degradation of EP300 protein]15767673
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [MAP2K6 protein results in decreased expression of EP300 protein]15767673
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to EP300 protein modified form]"28751236
C5505476-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]]"25665036
C5505476-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased acetylation of EP300 protein"23297412
C0371129-deoxy-delta-9-prostaglandin D29-deoxy-delta-9-prostaglandin D2 results in decreased activity of EP300 protein22141352
C056165acetovanilloneacetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]19281832
D000111AcetylcysteineAcetylcysteine inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]19281832
D013196DihydrotestosteroneCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]22258452
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [AR protein binds to EP300 protein]18487222
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [EP300 protein binds to GAS6 promoter]20048160
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]22258452
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 promoter]18487222
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of EP300 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EP300 mRNA16483693
D000666Amphotericin BAmphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]16189267
C088115anacardic acidanacardic acid affects the activity of EP300 protein18349320
C088115anacardic acidanacardic acid results in decreased expression of EP300 protein23297412
C088115anacardic acidanacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]23297412
D047310ApigeninApigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D001152ArsenicalsArsenicals promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [NFE2L2 protein binds to EP300 protein]]24632381
C006632arsenic trioxidearsenic trioxide promotes the reaction [EP300 protein binds to and results in increased acetylation of TP73 protein]15031205
C006632arsenic trioxidearsenic trioxide results in increased activity of EP300 protein15031205
C006632arsenic trioxidearsenic trioxide results in increased expression of EP300 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of EP300 mRNA25929836
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]17927689
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]17927689
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]17927689
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of EP300 protein]15767673
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SIRT6 protein results in decreased expression of EP300 protein]27094368
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with SIRT1 protein] results in increased ubiquitination of and results in decreased acetylation of EP300 protein23297412
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol results in decreased expression of EP300 protein]23297412
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SIRT1 protein results in decreased expression of EP300 protein]23297412
D001599BerberineBerberine results in increased expression of EP300 mRNA27311644
D004958EstradiolEstradiol inhibits the reaction [TNF protein promotes the reaction [EP300 protein binds to IL6 promoter]]24771768
D004958EstradiolEstradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]16489025
D004958EstradiolEstradiol promotes the reaction [EP300 protein binds to EZH2 promoter]25088689
D004958EstradiolEstradiol promotes the reaction [EP300 protein binds to HOXB9 promoter]27182052
D004958EstradiolEstradiol promotes the reaction [EP300 protein binds to HOXC6 promoter]25725483
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to EP300 protein]23665804
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to EZH2 promoter]]25088689
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]]16489025
D004958EstradiolEstradiol promotes the reaction [[EP300 protein binds to VEGFA promoter] which results in increased expression of VEGFA mRNA]15774498
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to EP300 protein modified form]28751236
C006780bisphenol Abisphenol A promotes the reaction [EP300 protein binds to EZH2 promoter]25088689
C006780bisphenol Abisphenol A promotes the reaction [EP300 protein binds to HOTAIR promoter]24533973
C006780bisphenol Abisphenol A promotes the reaction [EP300 protein binds to HOXB9 promoter]27182052
C006780bisphenol Abisphenol A promotes the reaction [EP300 protein binds to HOXC6 promoter]25725483
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A promotes the reaction [EP300 protein binds to EZH2 promoter]]25088689
C006780bisphenol Abisphenol A affects the methylation of EP300 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of EP300 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of EP300 mRNA22079614
C018475butyraldehydebutyraldehyde results in decreased expression of EP300 mRNA26079696
D020148Butyric AcidButyric Acid results in increased expression of EP300 mRNA23524101
C584509C646 compoundC646 compound results in decreased activity of EP300 protein26718586
C584509C646 compoundC646 compound inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]26612707
C584509C646 compoundC646 compound binds to EP300 protein25325435
C584509C646 compoundC646 compound results in decreased activity of EP300 protein20534345
D002104CadmiumCadmium promotes the reaction [MTF1 protein binds to EP300 protein]18458062
D002166CamptothecinCamptothecin results in decreased expression of EP300 mRNA10344722
D002166CamptothecinCamptothecin results in decreased expression of EP300 protein10344722
C054133casticincasticin results in decreased expression of EP300 mRNA27862857
D002719ChlormethiazoleChlormethiazole inhibits the reaction [Ethanol results in decreased expression of EP300 protein]24892905
D002857ChromiumChromium results in increased activity of EP300 protein21467744
C074702chromium hexavalent ionchromium hexavalent ion inhibits the reaction [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]]18605988
C074702chromium hexavalent ionEP300 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]]21467744
C074702chromium hexavalent ionchromium hexavalent ion inhibits the reaction [MTF1 protein binds to EP300 protein]21467744
C045645cilostazolcilostazol affects the expression of EP300 protein24254769
C045645cilostazol"(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol affects the expression of EP300 protein]"24254769
C045645cilostazolKT 5720 inhibits the reaction [cilostazol affects the expression of EP300 protein]24254769
C045645cilostazolSIRT1 protein affects the reaction [cilostazol affects the expression of EP300 protein]24254769
C045645cilostazolsirtinol inhibits the reaction [cilostazol affects the expression of EP300 protein]24254769
C018021cobaltous chloride[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]25192544
C018021cobaltous chloridescutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]25192544
D003300Copper[Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]22276220
D003300Copper[Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein22276220
D019327Copper SulfateCopper Sulfate results in increased expression of EP300 mRNA19549813
D003474Curcuminbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]17927689
D003474Curcuminbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]17927689
D003474Curcuminbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]17927689
D003474CurcuminCurcumin affects the localization of EP300 protein17927689
D003474CurcuminCurcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]22258452
D003474CurcuminCurcumin results in decreased expression of EP300 mRNA17927689
D003474CurcuminCurcumin results in decreased expression of EP300 protein17927689
D003474CurcuminCurcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]26612707
D003474CurcuminCurcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]22228707
D003474CurcuminCurcumin inhibits the reaction [TP53 protein binds to EP300 protein]26612707
D003474CurcuminCurcumin results in decreased activity of EP300 protein26612707
C093628cyproconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EP300 mRNA29038839
D017373Cyproterone Acetate[Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to EP300 protein modified form]28751236
C014347decitabinedecitabine affects the methylation of EP300 promoter17965222
C014347decitabinedecitabine promotes the reaction [EP300 protein binds to TP53 protein]17977830
C014347decitabinedecitabine results in decreased expression of EP300 mRNA27915011
C499810delta(12)-prostaglandin J(2)delta(12)-prostaglandin J(2) analog binds to EP300 protein22141352
C499810delta(12)-prostaglandin J(2)delta(12)-prostaglandin J(2) results in decreased activity of EP300 protein22141352
D003907DexamethasoneDexamethasone promotes the reaction [EP300 protein binds to SLC4A2 promoter]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter alternative form]18188457
D003907Dexamethasone[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]18188457
D003907DexamethasoneDexamethasone promotes the reaction [EP300 protein binds to FOXO3 gene]26758684
D003907DexamethasoneDexamethasone promotes the reaction [EP300 protein binds to SULT1A1 promoter]22465009
D003907DexamethasoneEP300 protein promotes the reaction [Dexamethasone results in increased expression of UCP3 mRNA]17884810
D003907DexamethasoneSIRT1 protein inhibits the reaction [EP300 protein promotes the reaction [Dexamethasone results in increased expression of UCP3 mRNA]]17884810
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of EP300 mRNA27392435
D002945CisplatinCisplatin promotes the reaction [APEX1 protein modified form binds to [YBX1 protein binds to EP300 protein]]20856196
D002945CisplatinCisplatin promotes the reaction [[APEX1 protein modified form promotes the reaction [YBX1 protein binds to EP300 protein]] which binds to ABCB1 promoter]20856196
D002945CisplatinCisplatin results in decreased expression of EP300 protein17498666
D002945CisplatinEP300 protein promotes the reaction [Cisplatin results in increased acetylation of APEX1 protein]20856196
D002945CisplatinCisplatin results in increased expression of EP300 protein21310163
D002945Cisplatin[PIWIL2 protein co-treated with Cisplatin] results in decreased expression of EP300 protein21310163
C000944dicrotophosdicrotophos results in increased expression of EP300 mRNA28302478
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [EP300 protein binds to EZH2 promoter]25088689
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [EP300 protein binds to HOTAIR promoter]24533973
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol promotes the reaction [EP300 protein binds to EZH2 promoter]]25088689
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of EP300 protein15019724
D002117CalcitriolCalcitriol affects the localization of EP300 protein15647825
D002117CalcitriolCalcitriol promotes the reaction [EP300 protein binds to CYP24A1 promoter]15647825
D002117CalcitriolCalcitriol promotes the reaction [EP300 protein binds to SPP1 promoter]15647825
C051904dinophysistoxin 1dinophysistoxin 1 affects the expression of EP300 mRNA28939011
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]19281832
D004317DoxorubicinDoxorubicin results in decreased expression of EP300 mRNA10344722
D004317DoxorubicinDoxorubicin results in decreased expression of EP300 protein10344722|1749866
D004317Doxorubicin[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin19047049
D004317Doxorubicin[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]19047049
D004317Doxorubicin[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]19047049
D004317Doxorubicin[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin19047049
D004317Doxorubicin[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]19047049
D004317Doxorubicin[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]19047049
D004317Doxorubicinresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin]19047049
D004317Doxorubicinresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin]19047049
D004317Doxorubicin"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]]"25665036
D004317DoxorubicinDoxorubicin results in decreased expression of EP300 protein14975762
D004317DoxorubicinDoxorubicin results in increased expression of EP300 protein25665036
D004317DoxorubicinEP300 protein results in decreased susceptibility to Doxorubicin14975762
D004317Doxorubicinresveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]25665036
D004317Doxorubicinsirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]]25665036
D004317Doxorubicin[1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 protein15767673
D004317Doxorubicin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein]15767673
D004317Doxorubicin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in increased degradation of EP300 protein]15767673
D004317Doxorubicinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of EP300 protein]15767673
D004317DoxorubicinDoxorubicin results in decreased expression of EP300 mRNA28865727
D004317DoxorubicinDoxorubicin results in decreased expression of EP300 protein11073966|1576767
D004317DoxorubicinDoxorubicin results in increased degradation of EP300 protein11073966
D004317DoxorubicinDoxorubicin results in increased phosphorylation of and results in increased degradation of EP300 protein15767673
D004317DoxorubicinEP300 inhibits the reaction [Doxorubicin results in decreased expression of MEF2C mRNA]11073966
D004317DoxorubicinSB 203580 inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein]15767673
C000590659(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid"(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol affects the expression of EP300 protein]"24254769
D004610Ellagic AcidEllagic Acid results in increased expression of EP300 mRNA12002526
C118739entinostatentinostat promotes the reaction [EP300 protein binds to RELA protein]20421217
D020536Enzyme Activators[Enzyme Activators results in increased activity of SIRT1 protein] inhibits the reaction [TGFB2 protein results in increased expression of EP300 protein]25707573
D020536Enzyme Activators[Enzyme Activators results in increased activity of SIRT1 protein] which results in decreased expression of EP300 protein25707573
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EP300 mRNA29038839
D000431EthanolChlormethiazole inhibits the reaction [Ethanol results in decreased expression of EP300 protein]24892905
D000431EthanolEthanol results in decreased expression of EP300 protein24892905
D005047Etoposide[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide19047049
D005047Etoposide[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]19047049
D005047Etoposide[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]19047049
D005047Etoposide[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide19047049
D005047Etoposide[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]19047049
D005047Etoposide[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]19047049
D005047Etoposideresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]19047049
D005047Etoposideresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide]19047049
C017875fisetinfisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
C043562flavoneflavone inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D005472FluorouracilFluorouracil promotes the reaction [EP300 protein binds to UBE2C promoter]27129209
C039281furanfuran results in decreased expression of EP300 mRNA24614236
C037032galangingalangin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D005707Gallic AcidEP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]27634460
D005707Gallic Acid[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]27634460
D005707Gallic AcidGallic Acid inhibits the reaction [EGF protein results in increased acetylation of and results in increased expression of EP300 protein]27634460
C054597garcinolgarcinol inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]19281832
D019833GenisteinEP300 promotes the reaction [Genistein promotes the reaction [trichostatin A results in increased expression of TP53 mRNA]]26768552
D019833GenisteinEP300 promotes the reaction [Genistein promotes the reaction [trichostatin A results in increased expression of TP53 protein]]26768552
D019833GenisteinGenistein results in increased expression of EP300 protein26768552
D019833Genisteintrichostatin A promotes the reaction [Genistein results in increased expression of EP300 protein]26768552
D005839GentamicinsGentamicins results in increased expression of EP300 mRNA22061828
D005947Glucose[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]25192544
D005947GlucoseERCC1 protein affects the reaction [Glucose results in increased expression of EP300 mRNA]22228707
D005947GlucoseERCC4 protein affects the reaction [Glucose results in increased expression of EP300 mRNA]22228707
D005947GlucoseGlucose results in increased expression of EP300 mRNA22228707|2604578
D005947Glucosescutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]25192544
D006046GoldEP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]27634460
D006046Gold[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]27634460
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of EP300 mRNA28433809
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine[1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 protein15767673
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in increased expression of EP300 protein15767673
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring inhibits the reaction [EP300 protein binds to CTNNB1 protein]"26833564
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring inhibits the reaction [EP300 protein binds to CTNNB1 protein]"26833564
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring inhibits the reaction [EP300 protein results in increased expression of AQP5 mRNA]"26833564
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in decreased phosphorylation of EP300 protein"26833564
D006820Hyaluronic Acid[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein19047049
D006820Hyaluronic Acid[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein19047049
D006820Hyaluronic Acid[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]19047049
D006820Hyaluronic Acid[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein19047049
D006820Hyaluronic Acid[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]19047049
D006820Hyaluronic Acid[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]19047049
D006820Hyaluronic Acid[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein19047049
D006820Hyaluronic Acid[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]19047049
D006820Hyaluronic Acid[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA19047049
D006820Hyaluronic Acid[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein19047049
D006820Hyaluronic Acid[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]19047049
D006820Hyaluronic Acid[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA]19047049
D006820Hyaluronic Acidresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein]19047049
D003900DesoxycorticosteroneDesoxycorticosterone promotes the reaction [EP300 protein binds to SULT1A1 promoter]22465009
D003900DesoxycorticosteroneDesoxycorticosterone promotes the reaction [EP300 protein binds to TAT promoter]22465009
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EP300 mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of EP300 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of EP300 mRNA15956246
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of EP300 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of EP300 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [EP300 protein promotes the reaction [RELA protein modified form binds to BRD4 protein]]23686307
C006552kaempferolkaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
C011890kojic acidkojic acid results in increased expression of EP300 mRNA16595896
C057416KT 5720KT 5720 inhibits the reaction [cilostazol affects the expression of EP300 protein]24254769
D007854LeadLead results in increased expression of EP300 mRNA24291742
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of EP300 mRNA"24972896
C530478LYR 71LYR 71 inhibits the reaction [CCL5 protein promotes the reaction [EP300 protein binds to MMP9 promoter]]18985009
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EP300 mRNA23103053
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to EP300 protein modified form]28751236
D008825MiconazoleMiconazole results in decreased expression of EP300 mRNA22262564
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate promotes the reaction [PPARA protein binds to EP300 protein]20123618
D009151Mustard GasMustard Gas results in decreased expression of EP300 mRNA18955075
C040015myricetinmyricetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EP300 mRNA"25554681
D009534NiclosamideNiclosamide results in increased expression of EP300 mRNA22576131
C007350nitrofennitrofen results in decreased expression of EP300 mRNA24488106
C007350nitrofennitrofen results in decreased expression of EP300 protein24488106
D019319Okadaic AcidOkadaic Acid results in decreased expression of EP300 mRNA28939011
D009853OmeprazoleOmeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]21703235
D009853OmeprazoleOmeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]21703235
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of EP300 mRNA25729387
D010100OxygenAmphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]16189267
D010100OxygenApigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D010100Oxygenfisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D010100Oxygenflavone inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D010100Oxygengalangin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D010100Oxygenkaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D010100Oxygenmyricetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D010100OxygenOxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]16189267|2015329
D010100OxygenQuercetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D052638Particulate MatterParticulate Matter promotes the reaction [EP300 protein binds to PTGS2 promoter]17395887
C410127PCB 180PCB 180 affects the expression of EP300 mRNA21703328
D010656PhenylephrineEP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]12724418
D010656Phenylephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA]11705990
D010656Phenylephrineanacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]23297412
D010656PhenylephrineEP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]27094368
D010656PhenylephrineEP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]11705990|2709436
D010656PhenylephrineEP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]27094368
D010656PhenylephrineEP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]15593114
D010656PhenylephrineEP300 protein results in increased susceptibility to Phenylephrine12477714
D010656PhenylephrineMAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]11705990
D010656PhenylephrinePhenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]23297412
D010656PhenylephrinePhenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]15220332
D010656Phenylephrine[Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein12477714
D010656PhenylephrinePhenylephrine results in increased expression of EP300 mRNA11705990
D010656PhenylephrinePhenylephrine results in increased expression of EP300 protein23297412|2709436
D010656PhenylephrinePhenylephrine results in increased phosphorylation of and results in increased activity of EP300 protein15006641
D010656Phenylephrineresveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]23297412
D010656Phenylephrineresveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]23297412
D010656Phenylephrine[SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]27094368
D010656Phenylephrine[SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]27094368
D010656PhenylephrineSIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]27094368
D010656PhenylephrineZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]15220332
D010695PhlorhizinPhlorhizin results in decreased expression of EP300 mRNA22538082
C006253pirinixic acidpirinixic acid promotes the reaction [PPARA protein binds to EP300 protein]20123618
C006253pirinixic acidpirinixic acid promotes the reaction [PPARA protein binds to EP300 protein]20123618
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of EP300 mRNA21334430
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of EP300 mRNA28433809
C045362prochloraz[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EP300 mRNA29038839
D011794QuercetinQuercetin inhibits the reaction [EP300 protein binds to PTGS2 promoter]21857970
D011794QuercetinQuercetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]20153296
D011794QuercetinQuercetin results in decreased expression of EP300 protein15580028
D011794QuercetinQuercetin results in decreased activity of EP300 protein21857970
C059514resveratrolresveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]21239502
C059514resveratrol[resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein]21239502
C059514resveratrolresveratrol promotes the reaction [[SIRT1 protein binds to EP300 protein] which binds to RUNX2 protein]21239502
C059514resveratrol[resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein21239502
C059514resveratrol[[resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein] which results in decreased acetylation of RELA protein21239502
C059514resveratrol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]]16928824
C059514resveratrolEP300 protein inhibits the reaction [resveratrol results in decreased expression of ZBTB7A mRNA]25875864
C059514resveratrolresveratrol inhibits the reaction [EP300 protein binds to ZBTB7A promoter]25875864
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Doxorubicin]19047049
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]19047049
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 mRNA]19047049
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein]19047049
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 mRNA]19047049
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein]19047049
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Doxorubicin]19047049
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide]19047049
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 mRNA]19047049
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein]19047049
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 mRNA]19047049
C059514resveratrolresveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein]19047049
C059514resveratrolresveratrol inhibits the reaction [TGFB2 protein promotes the reaction [EP300 protein binds to COL1A2 promoter]]25707573
C059514resveratrolresveratrol inhibits the reaction [TGFB2 protein results in increased expression of EP300 protein]25707573
C059514resveratrolresveratrol inhibits the reaction [TNF protein promotes the reaction [EP300 protein binds to IL6 promoter]]24771768
C059514resveratrolresveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]16928824
C059514resveratrolresveratrol promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]19047049
C059514resveratrolresveratrol results in decreased expression of EP300 mRNA25707573
C059514resveratrolresveratrol results in decreased expression of EP300 protein25707573
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]19047049
C059514resveratrol[[resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]] which results in decreased acetylation of and results in decreased activity of CTNNB1 protein19047049
C059514resveratrol[[resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]] which results in decreased acetylation of and results in decreased activity of RELA protein19047049
C059514resveratrolresveratrol results in increased expression of EP300 mRNA12002526|1256957
C059514resveratrol"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]]"25665036
C059514resveratrolresveratrol affects the expression of EP300 protein24254769
C059514resveratrolresveratrol inhibits the reaction [DMD gene mutant form results in increased expression of EP300 protein]23297412
C059514resveratrolresveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]25665036
C059514resveratrolresveratrol results in decreased expression of EP300 protein23297412
C059514resveratrolSIRT1 mutant form inhibits the reaction [resveratrol results in decreased expression of EP300 protein]23297412
C059514resveratrolsirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]]25665036
C059514resveratrolresveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]23297412
C059514resveratrolresveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]23297412
C059514resveratrolresveratrol results in decreased expression of EP300 mRNA25905778
C059514resveratrolresveratrol results in decreased expression of EP300 protein23297412
C059514resveratrolbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [resveratrol results in decreased expression of EP300 protein]23297412
C014794retinol palmitateretinol palmitate promotes the reaction [EP300 protein binds to MMP9 protein]17164434
C104586roscovitineroscovitine results in decreased activity of EP300 protein21857970
C089730rosiglitazone[rosiglitazone binds to PPARG protein] which affects the localization of EP300 protein10871190
C093642SB 203580SB 203580 inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein]15767673
C093642SB 203580SB 203580 inhibits the reaction [MAP2K6 protein results in decreased expression of EP300 protein]15767673
C484876scutellarinscutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]25192544
C002979selenomethylselenocysteineselenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]25321483
D012822Silicon DioxideSilicon Dioxide results in decreased expression of EP300 mRNA23623845
C439060sirtinolsirtinol inhibits the reaction [cilostazol affects the expression of EP300 protein]24254769
C439060sirtinolsirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]]25665036
C017947sodium arsenitesodium arsenite inhibits the reaction [EP300 protein binds to IVL promoter]20006635
D012969Sodium FluorideSodium Fluoride results in decreased expression of EP300 mRNA27862939
D018038Sodium SeleniteSodium Selenite results in decreased expression of EP300 mRNA10344722
D018038Sodium SeleniteSodium Selenite results in decreased expression of EP300 protein10344722
D013311Streptozocin3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]22228707
D013311StreptozocinCurcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]22228707
D013311StreptozocinStreptozocin results in increased expression of EP300 mRNA22228707
D013481SuperoxidesEP300 protein results in decreased abundance of Superoxides25440059
D013629TamoxifenTamoxifen inhibits the reaction [ESR1 protein binds to EP300 protein]23665804
D013749TetrachlorodibenzodioxinEP300 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]18842620
D013749TetrachlorodibenzodioxinEP300 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]18842620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to BRCA1 promoter]]16489025
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to CYP1A1 enhancer]18842620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to CYP1A1 promoter]18842620|2170323
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to CYP1B1 enhancer]18842620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to CYP1B1 promoter]18842620|2170323
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [EP300 protein binds to PTGS2 promoter]19056653
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EP300 mRNA21570461|2405805
D013755Tetradecanoylphorbol AcetateArsenicals promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [NFE2L2 protein binds to EP300 protein]]24632381
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate promotes the reaction [NFE2L2 protein binds to EP300 protein]24632381
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EP300 mRNA25613284
C020809tetrathiomolybdate[Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]22276220
C020809tetrathiomolybdate[Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein22276220
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EP300 mRNA27404394|2786577
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of EP300 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of EP300 mRNA25729387
D014212TretinoinEP300 protein promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA]16581781
D014212Tretinoin[GABPA protein binds to EP300 protein] promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA]16581781
D014212TretinoinTretinoin results in increased expression of EP300 mRNA28053092
D014212TretinoinTretinoin inhibits the reaction [EP300 protein binds to RETN promoter]15047602
C012589trichostatin AEP300 promotes the reaction [Genistein promotes the reaction [trichostatin A results in increased expression of TP53 mRNA]]26768552
C012589trichostatin AEP300 promotes the reaction [Genistein promotes the reaction [trichostatin A results in increased expression of TP53 protein]]26768552
C012589trichostatin AEP300 promotes the reaction [trichostatin A results in increased expression of TP53 protein]26768552
C012589trichostatin Atrichostatin A affects the expression of EP300 mRNA28542535
C012589trichostatin Atrichostatin A affects the localization of EP300 protein15647279
C012589trichostatin Atrichostatin A promotes the reaction [EP300 protein binds to APEX1 protein]20856196
C012589trichostatin Atrichostatin A promotes the reaction [EP300 protein binds to TGFBR2 promoter]15647279
C012589trichostatin Atrichostatin A promotes the reaction [[EP300 protein co-treated with EGR1 protein] results in increased expression of PTEN mRNA]17330857
C012589trichostatin Atrichostatin A promotes the reaction [Genistein results in increased expression of EP300 protein]26768552
C012589trichostatin AEP300 protein results in increased susceptibility to trichostatin A12477714
C012589trichostatin Atrichostatin A results in increased acetylation of EP300 protein23297412
C057693troglitazone[troglitazone binds to PPARG protein] which affects the localization of EP300 protein10871190
D014520UrethaneUrethane results in increased expression of EP300 mRNA28818685
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter alternative form]18188457
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]18188457
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid promotes the reaction [EP300 protein binds to SLC4A2 promoter]18188457
D014635Valproic AcidValproic Acid affects the expression of EP300 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of EP300 gene28853863
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [EP300 protein binds to PTGS2 promoter]17395887
D009536NiacinamideNiacinamide results in increased expression of and results in increased acetylation of EP300 protein23297412
C111237vorinostatvorinostat promotes the reaction [EP300 protein binds to RELA protein]20421217
D015032ZincZinc affects the expression of EP300 protein16636310
D015032Zincchromium hexavalent ion inhibits the reaction [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]]18605988
D015032ZincEP300 protein affects the reaction [Zinc results in increased expression of MT1 mRNA]18458062
D015032ZincEP300 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]]21467744
D015032ZincZinc promotes the reaction [MTF1 protein binds to EP300 protein]18458062|1860598
D015032ZincZinc promotes the reaction [MTF1 protein binds to EP300 protein binds to CREBBP protein]18458062
D015032Zinc[Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] which results in increased expression of MT1 mRNA21035574
D015032ZincZinc promotes the reaction [MTF1 protein promotes the reaction [EP300 protein binds to SP1 protein]]18458062

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA17641689  
GO:0001102RNA polymerase II activating transcription factor binding-IPI20018936  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0002039p53 binding-IEA-  
GO:0003677DNA binding-IDA9194565  
GO:0003682chromatin binding-IDA24939902  25818647  
GO:0003682chromatin binding-IMP17641689  
GO:0003684damaged DNA binding-IDA24939902  
GO:0003713transcription coactivator activity-IDA12435739  12586840  12929931  16687403  18487222  
GO:0003713transcription coactivator activity-TAS10362258  
GO:0004402histone acetyltransferase activity-IDA12040021  14645221  23415232  25818647  
GO:0004402histone acetyltransferase activity-TAS10362258  
GO:0004468lysine N-acetyltransferase activity, acting on acetyl phosphate as donor-IDA20019387  
GO:0005515protein binding-IPI1331501  8684459  9018065  9194564  9194565  9811832  
9881977  9887100  10049825  10330164  10487758  10518217  
10702269  10722728  10866661  11029584  11073990  11430825  
11438528  11481322  11533489  11581164  11804596  11907332  
11909954  11940655  12368347  12435739  12527917  12586840  
12743606  12750254  12929931  12970734  14645221  14716005  
14752053  15075319  15261140  15380363  15509808  15542844  
15588252  15632193  15674325  15843474  15890677  16291753  
16611888  16652169  16760386  16864582  16917507  17075044  
17382325  17403783  17438265  17476304  17525731  17872950  
17906639  18160048  18268343  18391200  18485870  18509338  
18722353  19047049  19064921  19071119  19217391  19218448  
19234109  19339993  19680224  20019387  20089040  20228809  
20603618  20609350  20808282  20856196  21108945  21471221  
21513714  21988832  22770219  23010591  23065768  23145062  
23441852  23455922  23461825  23746844  23870121  23999430  
24229708  24413532  24421387  24939902  25219498  25245946  
25314079  25519132  25651062  26302407  26751287  27018634  
GO:0008013beta-catenin binding-IPI12408825  
GO:0008022protein C-terminus binding-IDA17150957  
GO:0008134transcription factor binding-IPI8684459  11349124  15261140  26504087  
GO:0008270zinc ion binding-IEA-  
GO:0016407acetyltransferase activity-EXP12456660  16135789  20228809  
GO:0016407acetyltransferase activity-IDA18722353  24939902  
GO:0016407acetyltransferase activity-IMP12435739  
GO:0016746transferase activity, transferring acyl groups-IDA17403783  
GO:0031490chromatin DNA binding-IEA-  
GO:0033613activating transcription factor binding-IPI20590529  
GO:0034212peptide N-acetyltransferase activity-TAS-  
GO:0035257nuclear hormone receptor binding-IPI9862959  
GO:0050681androgen receptor binding-IPI18487222  
GO:0061733peptide-lysine-N-acetyltransferase activity-TAS-  
GO:0061920protein propionyltransferase activity-IDA17267393  
GO:0097157pre-mRNA intronic binding-IEA-  
GO:0097677STAT family protein binding-IPI26479788  
GO:0140065peptide butyryltransferase activity-IDA17267393  
GO:0140068histone crotonyltransferase activity-IDA25818647  
GO:0140069histone butyryltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA10733570  
GO:0001666response to hypoxia-IDA9887100  15261140  
GO:0001756somitogenesis-IEA-  
GO:0002223stimulatory C-type lectin receptor signaling pathway-TAS-  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006355regulation of transcription, DNA-templated-IDA15261140  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006473protein acetylation-IDA21030595  24939902  
GO:0006473protein acetylation-TAS22013210  
GO:0006475internal protein amino acid acetylation-IDA18722353  
GO:0006915apoptotic process-IMP9194565  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0006990positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response-ISS-  
GO:0007219Notch signaling pathway-TAS-  
GO:0007221positive regulation of transcription of Notch receptor target-TAS-  
GO:0007399nervous system development-TAS27256286  
GO:0007507heart development-IEA-  
GO:0007519skeletal muscle tissue development-IEA-  
GO:0007623circadian rhythm-ISS-  
GO:0009887animal organ morphogenesis-IEA-  
GO:0010506regulation of autophagy-TAS24852146  
GO:0010742macrophage derived foam cell differentiation-IDA26504087  
GO:0016032viral process-IEA-  
GO:0016573histone acetylation-IDA25818647  
GO:0018076N-terminal peptidyl-lysine acetylation-IDA12435739  
GO:0018393internal peptidyl-lysine acetylation-IDA17403783  
GO:0018394peptidyl-lysine acetylation-IDA23962722  
GO:0030183B cell differentiation-IEA-  
GO:0030220platelet formation-IEA-  
GO:0030324lung development-IEA-  
GO:0031648protein destabilization-IMP24939902  
GO:0032092positive regulation of protein binding-IEA-  
GO:0032460negative regulation of protein oligomerization-IDA23962722  
GO:0032481positive regulation of type I interferon production-TAS-  
GO:0034644cellular response to UV-IDA24939902  
GO:0035855megakaryocyte development-IEA-  
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-IDA17403783  
GO:0043627response to estrogen-IDA11581164  
GO:0043923positive regulation by host of viral transcription-IDA16687403  
GO:0043967histone H4 acetylation-IMP16325578  
GO:0043969histone H2B acetylation-IDA23415232  
GO:0045444fat cell differentiation-ISS-  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0045747positive regulation of Notch signaling pathway-TAS-  
GO:0045815positive regulation of gene expression, epigenetic-IDA25818647  
GO:0045815positive regulation of gene expression, epigenetic-TAS-  
GO:0045893positive regulation of transcription, DNA-templated-TAS27256286  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12586840  18722353  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP16325578  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO:0050821protein stabilization-ISS-  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA10518217  25818647  
GO:0051726regulation of cell cycle-TAS-  
GO:0060765regulation of androgen receptor signaling pathway-IDA18487222  
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia-TAS-  
GO:0061921peptidyl-lysine propionylation-IDA17267393  
GO:0090043regulation of tubulin deacetylation-IDA18722353  
GO:0140066peptidyl-lysine crotonylation-IDA25818647  
GO:0140067peptidyl-lysine butyrylation-IDA17267393  
GO:1900034regulation of cellular response to heat-TAS-  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000123histone acetyltransferase complex-IEA-  
GO:0005634nucleus-IDA9194565  12929931  14645221  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IEA-  
GO:0005694chromosome-IEA-  
GO:0005829cytosol-IDA-  
GO:0032993protein-DNA complex-ISS10362258  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04310Wnt signaling pathway
hsa04330Notch signaling pathway
hsa04350TGF-beta signaling pathway
hsa04520Adherens junction
hsa04630Jak-STAT signaling pathway
hsa04720Long-term potentiation
hsa04916Melanogenesis
hsa05016Huntington's disease
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05215Prostate cancer
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1234158Regulation of gene expression by Hypoxia-inducible FactorTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1368082RORA activates gene expressionTAS
R-HSA-1368082RORA activates gene expressionIEA
R-HSA-1430728MetabolismTAS
R-HSA-156711Polo-like kinase mediated eventsTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-1912408Pre-NOTCH Transcription and TranslationIEA
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingIEA
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980143Signaling by NOTCH1TAS
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-2197563NOTCH2 intracellular domain regulates transcriptionIEA
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-3134973LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN productionTAS
R-HSA-3214847HATs acetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-3371568Attenuation phaseTAS
R-HSA-3371571HSF1-dependent transactivationTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400253Circadian ClockIEA
R-HSA-400253Circadian ClockTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-5250913Positive epigenetic regulation of rRNA expressionTAS
R-HSA-5250924B-WICH complex positively regulates rRNA expressionTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5621575CD209 (DC-SIGN) signalingTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689901Metalloprotease DUBsTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestTAS
R-HSA-6804758Regulation of TP53 Activity through AcetylationTAS
R-HSA-6804760Regulation of TP53 Activity through MethylationTAS
R-HSA-6811555PI5P Regulates TP53 AcetylationTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8866907Activation of the TFAP2 (AP-2) family of transcription factorsTAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8878159Transcriptional regulation by RUNX3IEA
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS
R-HSA-8941856RUNX3 regulates NOTCH signalingIEA
R-HSA-8941856RUNX3 regulates NOTCH signalingTAS
R-HSA-8941858Regulation of RUNX3 expression and activityTAS
R-HSA-8951936RUNX3 regulates p14-ARFTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionTAS
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA
R-HSA-9018519Estrogen-dependent gene expressionTAS
R-HSA-918233TRAF3-dependent IRF activation pathwayTAS
R-HSA-933541TRAF6 mediated IRF7 activationTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics
28794006Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth. (2017 Oct)Kim BRMol Cell Proteomics
26873401Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016 May)Sawada GGastroenterology