Gene: EPAS1

2034
ECYT4|HIF2A|HLF|MOP2|PASD2|bHLHe73
endothelial PAS domain protein 1
protein-coding
2p21
Ensembl:ENSG00000116016 MIM:603349 Vega:OTTHUMG00000128818 UniprotKB:Q99814
NG_016000.1
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.781e-1 (AD)  1.908e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITGA60.836
HLA-E0.832
TLN10.824
CALD10.823
LAMB20.823
SLC2A10.818
EPS80.816
TIMP30.812
MSN0.812
STOM0.804

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.515
OR4F5-0.48
SMIM18-0.391
KCNB2-0.379
DRD5-0.371
HAS1-0.371
SLC7A4-0.368
ABCC12-0.367
DLK2-0.362
GALNT14-0.36

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5171131,1-bis(4-hydroxyphenyl)cyclohexane"1,1-bis(4-hydroxyphenyl)cyclohexane results in decreased expression of EPAS1 mRNA"28591870
C0685431,2-diethyl-3-hydroxypyridin-4-one"1,2-diethyl-3-hydroxypyridin-4-one results in increased expression of EPAS1 protein"21558026
C5598531-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid results in increased expression of EPAS1 protein26723917
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]"24403227
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]"21994956
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of EPAS1 mRNA19933214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23958427
C0467282,2'-azobis(2-amidinopropane)"2,2'-azobis(2-amidinopropane) results in decreased expression of EPAS1 mRNA"26177723
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23958427
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23958427
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of EPAS1 mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of EPAS1 mRNA"23196670
C5202903,4-dihydroxybenzoate"[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EPAS1 mRNA"19679656
C5202903,4-dihydroxybenzoate"3,4-dihydroxybenzoate results in increased expression of EPAS1 mRNA"19679656
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased expression of EPAS1 mRNA25716159
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of EPAS1 mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of EPAS1 mRNA"28591870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of EPAS1 mRNA"21346803
C5258724'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide results in decreased expression of EPAS1 mRNA23264615
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]"23958427
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]"23958427
C5015886-O-carboxypropyl-alpha-tocotrienol6-O-carboxypropyl-alpha-tocotrienol inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]24790010
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23958427
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23958427
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of EPAS1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EPAS1 mRNA16483693
D000968Antimycin AAntimycin A inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]18353899
C000228aristolochic acid Iaristolochic acid I results in increased expression of EPAS1 protein21554934
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of EPAS1 mRNA"18687144
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [nickel sulfate results in increased expression of EPAS1 protein]16288478
D001280AtrazineAtrazine results in decreased expression of EPAS1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of EPAS1 mRNA22323515
C416282BAY 11-7085BAY 11-7085 inhibits the reaction [T-2 Toxin results in increased expression of EPAS1 mRNA]22800716
C416282BAY 11-7085BAY 11-7085 inhibits the reaction [T-2 Toxin results in increased expression of EPAS1 protein]22800716
C031000benzimidazolebenzimidazole results in increased stability of EPAS1 protein23545307
D001564Benzo(a)pyreneEPAS1 protein affects the susceptibility to Benzo(a)pyrene23333640
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EPAS1 mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EPAS1 mRNA22228805|2373587
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EPAS1 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of EPAS1 mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP3 protein results in increased stability of EPAS1 protein]]23545307
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP5 protein results in increased stability of EPAS1 protein]]23545307
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased stability of EPAS1 protein23545307
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of EPAS1 mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of EPAS1 mRNA24758408|2859187
D004958Estradiol[letrozole results in decreased abundance of Estradiol] which results in decreased expression of EPAS1 mRNA19620711
C044887beta-methylcholinebeta-methylcholine affects the expression of EPAS1 mRNA21179406
D0150822,2'-Dipyridyl"2,2'-Dipyridyl inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]"12606543
D0150822,2'-Dipyridyl"[2,2'-Dipyridyl inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]"12606543
C006780bisphenol Abisphenol A results in decreased expression of EPAS1 mRNA28711546
C006780bisphenol Abisphenol A results in increased expression of EPAS1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of EPAS1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EPAS1 gene28505145
C492482bisphenol Bbisphenol B results in decreased expression of EPAS1 mRNA28591870
C000611646bisphenol Fbisphenol F results in decreased expression of EPAS1 mRNA28591870
C584509C646 compoundC646 compound results in decreased expression of EPAS1 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of EPAS1 promoter22457795
C100187chloropicrinchloropicrin affects the expression of EPAS1 mRNA26352163
D004390ChlorpyrifosChlorpyrifos results in decreased expression of EPAS1 mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of EPAS1 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EPAS1 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of EPAS1 mRNA28472532
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of EPAS1 mRNA16197558
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of EPAS1 mRNA19524605
D002994ClofibrateClofibrate results in decreased expression of EPAS1 mRNA23811191
D003035CobaltEPAS1 protein affects the reaction [Cobalt results in increased abundance of Nitric Oxide]23788631
D003035CobaltCobalt results in increased expression of EPAS1 protein17967803
D003035CobaltCobalt affects the degradation of EPAS1 protein12606543
D003035CobaltCobalt binds to EPAS1 protein12606543
D003035Cobalt[Cobalt binds to EPAS1 protein] inhibits the reaction [EPAS1 protein binds to VHL protein]12606543
D003035CobaltCobalt inhibits the reaction [EPAS1 protein modified form binds to VHL protein]12606543
D003035CobaltCobalt inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]12606543
D003035Cobalt[Cobalt inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]12606543
D003035CobaltCobalt results in increased expression of EPAS1 protein12606543
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]]23406266
C007095cobaltiprotoporphyrinHMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]]]23406266
C018021cobaltous chloride2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23958427
C018021cobaltous chloride2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23958427
C018021cobaltous chloride"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]"23958427
C018021cobaltous chloride6-O-carboxypropyl-alpha-tocotrienol inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]24790010
C018021cobaltous chlorideAcetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23958427
C018021cobaltous chloridecobaltous chloride affects the localization of EPAS1 protein21863063
C018021cobaltous chloridecobaltous chloride results in increased expression of and affects the localization of EPAS1 protein23958427
C018021cobaltous chloridecobaltous chloride results in increased expression of EPAS1 protein21036805|2450301
C018021cobaltous chloride[cobaltous chloride results in increased expression of EPAS1 protein] affects the reaction [EPAS1 protein binds to USF2 protein]23958427
C018021cobaltous chloride[cobaltous chloride results in increased expression of EPAS1 protein] which results in decreased expression of HIF1A protein25805230
C018021cobaltous chloride[cobaltous chloride results in increased expression of HIF1A protein] which results in decreased expression of EPAS1 protein25805230
C018021cobaltous chloridecobaltous chloride results in increased stability of EPAS1 protein18515279
C018021cobaltous chlorideCycloheximide inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23958427
C018021cobaltous chlorideEPAS1 protein results in increased susceptibility to cobaltous chloride25805230
C018021cobaltous chloride[EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of CD44 mRNA25805230
C018021cobaltous chloride[EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of NANOG mRNA25805230
C018021cobaltous chloride[EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of POU5F1 mRNA25805230
C018021cobaltous chloride[EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of PROM1 mRNA25805230
C018021cobaltous chloride[EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of SOX2 mRNA25805230
C018021cobaltous chlorideGlutathione inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23958427
C018021cobaltous chlorideIndican inhibits the reaction [cobaltous chloride affects the localization of EPAS1 protein]21863063
C018021cobaltous chlorideYES1 mutant form inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]24790010
C018021cobaltous chloridecobaltous chloride results in increased expression of EPAS1 protein24503013
C018021cobaltous chloride[AQP1 protein results in increased stability of EPAS1 protein] promotes the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23545307
C018021cobaltous chloride[AQP3 protein results in increased stability of EPAS1 protein] promotes the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23545307
C018021cobaltous chloride[AQP5 protein results in increased stability of EPAS1 protein] promotes the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23545307
C018021cobaltous chloridecobaltous chloride results in increased expression of EPAS1 protein21558026|2354530
D003300CopperCopper deficiency results in increased expression of EPAS1 protein23555700
D003300CopperEPAS1 gene mutant form inhibits the reaction [Copper deficiency results in increased expression of CYBRD1 mRNA]23555700
D003300CopperEPAS1 gene mutant form inhibits the reaction [Copper deficiency results in increased expression of SLC11A2 mRNA alternative form]23555700
D003300CopperEPAS1 gene mutant form inhibits the reaction [Copper deficiency results in increased expression of SLC40A1 mRNA]23555700
D019327Copper SulfateCopper Sulfate results in increased expression of EPAS1 mRNA19549813
D003474CurcuminCurcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]20554536
D003513CycloheximideCycloheximide inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23958427
D003513CycloheximideCycloheximide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23958427
D016572CyclosporineCyclosporine results in decreased expression of EPAS1 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased expression of EPAS1 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of EPAS1 mRNA19770486
D003609DactinomycinDactinomycin results in increased stability of EPAS1 protein23545307
D000069439DasatinibDasatinib results in increased expression of EPAS1 mRNA20579391
D003676DeferoxamineDeferoxamine inhibits the reaction [EPAS1 protein results in increased degradation of COX4I1 protein]18515279
D003676DeferoxamineDeferoxamine results in increased expression of EPAS1 protein27287256
D003676DeferoxamineDeferoxamine results in increased stability of EPAS1 protein18515279
D003676DeferoxamineDeferoxamine results in increased expression of EPAS1 protein18353899|2155802
D003676DeferoxamineDeferoxamine inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]12606543
D003676Deferoxamine[Deferoxamine inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]12606543
C107676deguelindeguelin results in decreased expression of EPAS1 protein19336726
C017185delphinidindelphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of EPAS1 protein]18603805
D003976DiazinonDiazinon results in increased methylation of EPAS1 gene22964155
D004008DiclofenacDiclofenac results in decreased expression of EPAS1 protein12912967
C000944dicrotophosdicrotophos results in increased expression of EPAS1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of EPAS1 mRNA18042831
C058705diethyl malatediethyl malate affects the expression of EPAS1 mRNA24814887
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of EPAS1 mRNA28939011
D0192972,4-Dinitrophenol"2,4-Dinitrophenol results in increased expression of EPAS1 mRNA"15740689
D0192972,4-Dinitrophenol"2,4-Dinitrophenol results in increased expression of EPAS1 protein"15740689
D004317DoxorubicinDoxorubicin results in decreased expression of EPAS1 mRNA26873546
D000431EthanolEthanol results in decreased expression of EPAS1 mRNA26177723
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EPAS1 mRNA17351261
C010953exochelinsexochelins results in increased expression of EPAS112460908
C540355fenamidonefenamidone results in increased expression of EPAS1 mRNA27029645
C029451ferrous chloride"2,2'-Dipyridyl inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]"12606543
C029451ferrous chloride"[2,2'-Dipyridyl inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]"12606543
C029451ferrous chlorideCobalt inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]12606543
C029451ferrous chloride[Cobalt inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]12606543
C029451ferrous chlorideDeferoxamine inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]12606543
C029451ferrous chloride[Deferoxamine inhibits the reaction [ferrous chloride results in increased hydroxylation of EPAS1 protein]] inhibits the reaction [EPAS1 protein binds to VHL protein]12606543
C029451ferrous chlorideferrous chloride results in increased hydroxylation of EPAS1 protein12606543
C029451ferrous chloride[ferrous chloride results in increased hydroxylation of EPAS1 protein] promotes the reaction [EPAS1 protein binds to VHL protein]12606543
C029451ferrous chloride[ferrous chloride results in increased hydroxylation of EPAS1 protein] promotes the reaction [HIF1A protein binds to VHL protein]12606543
C020748ferrous sulfateferrous sulfate inhibits the reaction [galangin results in increased expression of EPAS1 protein]17973296
C020748ferrous sulfateferrous sulfate inhibits the reaction [Quercetin results in increased expression of EPAS1 protein]17973296
D005472FluorouracilFluorouracil results in increased expression of EPAS1 mRNA16557594
D005485FlutamideFlutamide results in increased expression of EPAS1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of EPAS1 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EPAS1 gene20938992
C039281furanfuran results in increased expression of EPAS1 mRNA24183702
C037032galanginferrous sulfate inhibits the reaction [galangin results in increased expression of EPAS1 protein]17973296
C037032galangingalangin results in increased expression of EPAS1 protein17973296
C037032galanginIron inhibits the reaction [galangin results in increased expression of EPAS1 protein]17973296
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of EPAS1 mRNA]17109745
D005944GlucosamineGlucosamine results in decreased expression of EPAS1 mRNA17109745
D005944GlucosamineIL1B affects the reaction [Glucosamine results in decreased expression of EPAS1 mRNA]17109745
D005978GlutathioneGlutathione inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23958427
D005978GlutathioneGlutathione inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23958427
C568713GSK1210151AGSK1210151A results in increased expression of EPAS1 mRNA27292261
C554645GSK525762AGSK525762A results in increased expression of EPAS1 mRNA27292261
C554645GSK525762A[Oxygen deficiency co-treated with GSK525762A] results in increased expression of EPAS1 mRNA27292261
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of EPAS1 mRNA17183730
D006861Hydrogen Peroxidedelphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of EPAS1 protein]18603805
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EPAS1 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of EPAS1 protein18603805
D007052IbuprofenIbuprofen results in decreased expression of EPAS1 protein12912967
C492448ICG 001ICG 001 results in decreased expression of EPAS1 mRNA26191083
D007200IndicanIndican inhibits the reaction [cobaltous chloride affects the localization of EPAS1 protein]21863063
D007501IronIron inhibits the reaction [galangin results in increased expression of EPAS1 protein]17973296
D007501IronIron inhibits the reaction [Quercetin results in increased expression of EPAS1 protein]17973296
D007501IronIron deficiency results in increased expression of EPAS1 protein23814049
C410337K 7174K 7174 results in increased expression of EPAS1 mRNA24086573
D020910KetorolacKetorolac results in decreased expression of EPAS1 protein12912967
C045463leflunomideleflunomide results in increased expression of EPAS1 mRNA28988120
C067431letrozole[letrozole results in decreased abundance of Estradiol] which results in decreased expression of EPAS1 mRNA19620711
C025340manganese chloridemanganese chloride results in increased expression of EPAS1 mRNA17467022
C042720mercuric bromidemercuric bromide results in increased expression of EPAS1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of EPAS1 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of EPAS1 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EPAS1 gene20938992
D008727MethotrexateMethotrexate results in increased expression of EPAS1 mRNA17400583
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of EPAS1 mRNA23519560
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EPAS1 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of EPAS1 mRNA25234470
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of EPAS1 mRNA25234470
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EPAS1 mRNA"19679656
D009151Mustard GasMustard Gas results in increased expression of EPAS1 mRNA15674843
C030517myxothiazolmyxothiazol inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]18353899
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EPAS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EPAS1 mRNA"25554681
D009532NickelEPAS1 protein affects the reaction [Nickel results in increased abundance of Nitric Oxide]23788631
C029938nickel sulfateAscorbic Acid inhibits the reaction [nickel sulfate results in increased expression of EPAS1 protein]16288478
C029938nickel sulfate[HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in decreased expression of USP28 protein]20046830
C029938nickel sulfate[HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in increased degradation of MYC protein]20046830
C029938nickel sulfatenickel sulfate results in increased expression of EPAS1 mRNA22714537
C029938nickel sulfatenickel sulfate results in increased expression of EPAS1 protein16288478
C029938nickel sulfatenickel sulfate results in increased stability of EPAS1 protein20046830
D009569Nitric OxideEPAS1 protein affects the reaction [Cobalt results in increased abundance of Nitric Oxide]23788631
D009569Nitric OxideEPAS1 protein affects the reaction [Nickel results in increased abundance of Nitric Oxide]23788631
C007350nitrofennitrofen results in decreased expression of EPAS1 mRNA20638522
C558013NSC 689534NSC 689534 results in increased expression of EPAS1 mRNA20971185
C025589ochratoxin AEPAS1 protein inhibits the reaction [ochratoxin A results in decreased expression of VEGFA protein]21554934
C025589ochratoxin Aochratoxin A results in decreased expression of EPAS1 protein21554934
D019319Okadaic AcidOkadaic Acid results in increased expression of EPAS1 mRNA28939011
D010100Oxygen"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]"24403227
D010100Oxygen"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]"21994956
D010100Oxygen2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23958427
D010100Oxygen"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]"23958427
D010100OxygenAcetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23958427
D010100Oxygencobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]]23406266
D010100OxygenCurcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]20554536
D010100OxygenCycloheximide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23958427
D010100OxygenEPAS1 affects the reaction [Oxygen deficiency results in increased expression of MYC protein]24236059
D010100OxygenEPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of CPT1A mRNA]24503013
D010100OxygenEPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of FASN mRNA]24503013
D010100OxygenEPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of PPARGC1A protein]24503013
D010100OxygenEPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of SCD mRNA]24503013
D010100OxygenEPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of SREBF1 protein]24503013
D010100OxygenEPAS1 mutant form inhibits the reaction [Oxygen deficiency results in increased expression of NEK8 protein]25451921
D010100OxygenEPAS1 protein affects the reaction [Oxygen deficiency results in increased expression of EPO mRNA]23958427
D010100OxygenEPAS1 protein affects the reaction [Oxygen deficiency results in increased expression of SOD2 mRNA]23958427
D010100OxygenGlutathione inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23958427
D010100Oxygen[HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [Oxygen deficiency results in decreased expression of USP28 protein]20046830
D010100Oxygen[HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [Oxygen deficiency results in increased degradation of MYC protein]20046830
D010100OxygenHMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]]]23406266
D010100OxygenIL1B protein inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23406266
D010100OxygenOxygen deficiency affects the localization of EPAS1 protein24755467
D010100Oxygen[Oxygen deficiency co-treated with GSK525762A] results in increased expression of EPAS1 mRNA27292261
D010100OxygenOxygen deficiency results in increased expression of and affects the localization of EPAS1 protein23958427
D010100OxygenOxygen deficiency results in increased expression of EPAS1 mRNA20862257
D010100OxygenOxygen deficiency results in increased expression of EPAS1 protein20554536|2199495
D010100Oxygen[Oxygen deficiency results in increased expression of EPAS1 protein] promotes the reaction [EPAS1 protein binds to USF2 protein]23958427
D010100OxygenOxygen deficiency results in increased expression of EPAS1 mRNA22815834
D010100OxygenVitamin E inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 mRNA]22815834
D010100OxygenOxygen deficiency affects the localization of and results in increased activity of EPAS1 protein20880076
D010100OxygenOxygen deficiency results in increased expression of EPAS1 protein24503013|2672391
D010100OxygenAntimycin A inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]18353899
D010100Oxygen[AQP1 protein results in increased stability of EPAS1 protein] promotes the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23545307
D010100Oxygen[AQP3 protein results in increased stability of EPAS1 protein] promotes the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23545307
D010100Oxygen[AQP5 protein results in increased stability of EPAS1 protein] promotes the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23545307
D010100Oxygenbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP3 protein results in increased stability of EPAS1 protein]]23545307
D010100Oxygenbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP5 protein results in increased stability of EPAS1 protein]]23545307
D010100OxygenCOX10 protein affects the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]18353899
D010100OxygenEPAS1 mutant form inhibits the reaction [Oxygen deficiency results in increased expression of NTRK2 mRNA]26095976
D010100OxygenEPAS1 protein affects the reaction [Oxygen deficiency results in increased expression of CACNA1H mRNA]12679337
D010100OxygenEPAS1 protein affects the susceptibility to Oxygen deficiency12679337
D010100Oxygenmyxothiazol inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]18353899
D010100OxygenOxygen deficiency results in increased expression of EPAS1 protein18353899|2354530
D010100OxygenOxygen inhibits the reaction [AQP3 protein results in increased stability of EPAS1 protein]23545307
D010100OxygenOxygen inhibits the reaction [AQP5 protein results in increased stability of EPAS1 protein]23545307
D010100OxygenRotenone inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]18353899
D010100OxygenSodium Cyanide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]18353899
D010100OxygenUQCRFS1 protein affects the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]18353899
D010100OxygenOxygen deficiency results in increased expression of EPAS1 protein12606543
D000073878Palm OilPalm Oil results in decreased expression of EPAS1 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of EPAS1 mRNA26272509
D052638Particulate MatterParticulate Matter results in decreased expression of EPAS1 mRNA22178795
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of EPAS1 mRNA23602845
C011272perfosfamideperfosfamide results in increased expression of EPAS1 protein23251655
D010656PhenylephrinePhenylephrine results in decreased expression of EPAS1 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EPAS1 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of EPAS1 mRNA15728792
C006253pirinixic acidpirinixic acid results in increased expression of EPAS1 mRNA17426115|1830175
D010894PiroxicamPiroxicam results in decreased expression of EPAS1 mRNA21858171
D008926PlicamycinPlicamycin results in decreased expression of EPAS1 mRNA23814049
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of EPAS1 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of EPAS1 mRNA23012394|2301818
D011441PropylthiouracilPropylthiouracil results in decreased expression of EPAS1 mRNA24780913
C028025protoporphyrin IXprotoporphyrin IX affects the localization of EPAS1 protein23624237
C513428pyrachlostrobinpyrachlostrobin results in increased expression of EPAS1 mRNA27029645
D011794Quercetinferrous sulfate inhibits the reaction [Quercetin results in increased expression of EPAS1 protein]17973296
D011794QuercetinIron inhibits the reaction [Quercetin results in increased expression of EPAS1 protein]17973296
D011794QuercetinQuercetin results in increased expression of EPAS1 protein17973296
C012526quercitrinquercitrin results in increased expression of EPAS1 mRNA25193878
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of EPAS1 mRNA21127053
D012402RotenoneRotenone inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]18353899
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of EPAS1 mRNA25895662
D012834SilverSilver results in decreased expression of EPAS1 mRNA27131904
C017947sodium arsenitesodium arsenite affects the expression of EPAS1 mRNA19590694
C017947sodium arseniteEPAS1 mutant form inhibits the reaction [sodium arsenite results in increased expression of BMI1 protein]22662215
C017947sodium arseniteEPAS1 mutant form inhibits the reaction [sodium arsenite results in increased expression of TWIST1 protein]22662215
C017947sodium arseniteEPAS1 protein affects the susceptibility to sodium arsenite23333640
C017947sodium arseniteEPAS1 protein promotes the reaction [sodium arsenite results in increased expression of MIR191 mRNA]29277653
C017947sodium arsenitesodium arsenite promotes the reaction [EPAS1 protein binds to BMI1 promoter]22662215
C017947sodium arsenitesodium arsenite promotes the reaction [EPAS1 protein binds to TWIST1 promoter]22662215
C017947sodium arsenitesodium arsenite results in increased expression of and results in increased stability of EPAS1 protein22662215
C017947sodium arsenitesodium arsenite results in increased expression of EPAS1 mRNA22662215|2271453
C017947sodium arsenitesodium arsenite results in increased expression of EPAS1 protein27287256|2927765
D012966Sodium CyanideSodium Cyanide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]18353899
D018038Sodium SeleniteSodium Selenite results in increased expression of EPAS1 mRNA24383545
D014284TriiodothyronineTriiodothyronine results in increased expression of EPAS1 mRNA25172293
D013605T-2 ToxinBAY 11-7085 inhibits the reaction [T-2 Toxin results in increased expression of EPAS1 mRNA]22800716
D013605T-2 ToxinBAY 11-7085 inhibits the reaction [T-2 Toxin results in increased expression of EPAS1 protein]22800716
D013605T-2 ToxinT-2 Toxin results in increased expression of EPAS1 mRNA22800716
D013605T-2 ToxinT-2 Toxin results in increased expression of EPAS1 protein22800716
C001803tempoltempol affects the localization of EPAS1 protein24755467
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPAS1 mRNA16962184|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to EPAS1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EPAS1 mRNA19933214|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPAS1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of EPAS1 mRNA23519560
D019284ThapsigarginThapsigargin results in decreased expression of EPAS1 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EPAS1 mRNA18087596
D014118Toxins, Biological"Toxins, Biological affects the expression of EPAS1 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of EPAS1 mRNA15894607|1713896
D014241TrichloroethyleneTrichloroethylene results in decreased expression of EPAS1 mRNA19448997
D014241TrichloroethyleneTrichloroethylene results in increased expression of EPAS1 mRNA15363585
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of EPAS1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of EPAS1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of EPAS1 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of EPAS1 mRNA22378314
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of EPAS1 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPAS1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of EPAS1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of EPAS1 mRNA17292431
D014638VanadatesVanadates results in increased expression of EPAS1 mRNA22714537
C025643vinclozolinvinclozolin affects the expression of EPAS1 mRNA19015723
D014810Vitamin EVitamin E inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 mRNA]22815834
D024483Vitamin K 3Vitamin K 3 affects the expression of EPAS1 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of EPAS1 mRNA18769122

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-IGI9000051  
GO:0005515protein binding-IPI11018023  15231748  16181639  17024177  17324924  17353276  
17418410  18000879  19129502  19208626  22678294  23434853  
24378640  25043030  25241761  
GO:0008134transcription factor binding-IPI9079689  
GO:0035035histone acetyltransferase binding-IPI15261140  
GO:0043565sequence-specific DNA bindingcontributes_toIDA9079689  
GO:0046982protein heterodimerization activity-IDA16181639  
GO:0046982protein heterodimerization activity-IPI9079689  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001666response to hypoxia-IDA11782478  
GO:0001892embryonic placenta development-IEA-  
GO:0001974blood vessel remodeling-IEA-  
GO:0002027regulation of heart rate-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-TAS9079689  
GO:0007005mitochondrion organization-IEA-  
GO:0007165signal transduction-TAS9079689  
GO:0007601visual perception-IEA-  
GO:0030218erythrocyte differentiation-IEA-  
GO:0030324lung development-IEA-  
GO:0042415norepinephrine metabolic process-IEA-  
GO:0043129surfactant homeostasis-IEA-  
GO:0043619regulation of transcription from RNA polymerase II promoter in response to oxidative stress-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA11573933  
GO:0045944positive regulation of transcription by RNA polymerase II-IGI9000051  9576906  
GO:0048469cell maturation-IEA-  
GO:0048625myoblast fate commitment-ISS-  
GO:0055072iron ion homeostasis-IEA-  
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia-TAS-  
GO:0071456cellular response to hypoxia-IDA11573933  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IDA9000051  
GO:0005667transcription factor complex-IPI9576906  
GO:0005829cytosol-TAS-  
GO:0016607nuclear speck-IEA-  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-1234158Regulation of gene expression by Hypoxia-inducible FactorTAS
R-HSA-1234162Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenIEA
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaIEA
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-2262749Cellular response to hypoxiaIEA
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262752Cellular responses to stressIEA
R-HSA-2262752Cellular responses to stressTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-452723Transcriptional regulation of pluripotent stem cellsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849473PTK6 ExpressionTAS
R-HSA-8951664NeddylationTAS
R-HSA-8953897Cellular responses to external stimuliIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24482100Hereditary gene mutations in Korean patients with isolated erythrocytosis. (2014 Jun)Jang JHAnn Hematol
23911636Germline genetic variations at 11q13 and 12p11 locus modulate age at onset for renal cell carcinoma. (2014 Feb)Audenet FJ Urol