Gene: EPHA1

2041
EPH|EPHT|EPHT1
EPH receptor A1
protein-coding
7q34-q35
Ensembl:ENSG00000146904 MIM:179610 Vega:OTTHUMG00000155894 UniprotKB:P21709
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.301e-1 (AD)  5.916e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZYX0.647
DOT1L0.642
ZC3H30.637
B4GALNT30.637
FBXL120.621
PCSK70.619
EME20.616
PRSS530.606
TSEN540.605
CDCA30.602

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIAPH3-0.29
RXRG-0.281
KLRC2-0.271
SLC40A1-0.271
NDNF-0.266
PTGFR-0.265
TSPAN12-0.256
KCNJ16-0.25
HMGN5-0.243
CARD17-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of EPHA1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of EPHA1 mRNA17562736
C016601afimoxifeneafimoxifene results in increased expression of EPHA1 mRNA12154049
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EPHA1 mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of and results in decreased activity of EPHA1 protein25154877
D016604Aflatoxin B1Benzopyrans inhibits the reaction [Aflatoxin B1 results in decreased expression of and results in decreased activity of EPHA1 protein]25154877
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of EPHA1 mRNA18585445
D001151ArsenicArsenic affects the methylation of EPHA1 gene25304211
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of EPHA1 mRNA18585445
C487081belinostatbelinostat results in increased expression of EPHA1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of EPHA1 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPHA1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPHA1 mRNA27858113
D001578BenzopyransBenzopyrans inhibits the reaction [Aflatoxin B1 results in decreased expression of and results in decreased activity of EPHA1 protein]25154877
D001578BenzopyransBenzopyrans results in increased expression of and results in increased activity of EPHA1 protein25154877
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPHA1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EPHA1 mRNA19770486|2222880
D004958EstradiolEstradiol results in increased expression of EPHA1 mRNA12154049
C006780bisphenol Abisphenol A results in decreased expression of EPHA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EPHA1 gene28505145
D000069286BortezomibBortezomib results in decreased expression of EPHA1 mRNA20977926
D002220CarbamazepineCarbamazepine affects the expression of EPHA1 mRNA25979313
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPHA1 mRNA27858113
D002922CiguatoxinsCiguatoxins affects the expression of EPHA1 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of EPHA1 mRNA23811191
D003042CocaineCocaine affects the expression of EPHA1 mRNA15691709
D019327Copper SulfateCopper Sulfate results in decreased expression of EPHA1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of EPHA1 mRNA25562108
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of EPHA1 mRNA16963248
C014347decitabinedecitabine results in decreased methylation of EPHA1 promoter19277044
C014347decitabinedecitabine results in increased expression of EPHA1 mRNA19277044
C014347decitabinedecitabine results in increased expression of EPHA1 protein19277044
D002117CalcitriolCalcitriol results in increased expression of EPHA1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of EPHA1 mRNA21592394
C118739entinostatentinostat results in increased expression of EPHA1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of EPHA1 mRNA17317680
C070081fulvestrantfulvestrant results in increased expression of EPHA1 mRNA12154049
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of EPHA1 mRNA16963248
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of EPHA1 mRNA16963248
D006046Gold[Gold co-treated with Polyethylene Glycols] results in increased expression of EPHA1 mRNA19695318
C401858GW 7604GW 7604 results in increased expression of EPHA1 mRNA12154049
D017313FenretinideFenretinide results in increased expression of EPHA1 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of EPHA1 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EPHA1 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of EPHA1 mRNA25613284
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of EPHA1 mRNA12634122
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of EPHA1 mRNA12710931
C028577monobutyl phthalatemonobutyl phthalate affects the expression of EPHA1 mRNA19162170
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EPHA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EPHA1 mRNA"25554681
C507134ON 01910ON 01910 results in increased phosphorylation of EPHA1 protein25472472
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of EPHA1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of EPHA1 mRNA18445702|2381119
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in increased expression of EPHA1 mRNA19695318
C545373ponatinibponatinib results in decreased activity of EPHA1 protein19878872
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of EPHA1 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of EPHA1 mRNA21278054
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of EPHA1 mRNA12154049
C059514resveratrolresveratrol results in increased expression of EPHA1 mRNA12154049
C017947sodium arsenitesodium arsenite results in increased expression of EPHA1 mRNA12760830
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of EPHA1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of EPHA1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of EPHA1 mRNA19693291
D013739TestosteroneTestosterone results in increased expression of EPHA1 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EPHA1 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EPHA1 mRNA25613284
C012589trichostatin Atrichostatin A results in increased expression of EPHA1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EPHA1 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of EPHA1 mRNA17127020
D014520UrethaneUrethane results in decreased expression of EPHA1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of EPHA1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EPHA1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of EPHA1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA12775584  
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005005transmembrane-ephrin receptor activity-IBA21873635  
GO:0005005transmembrane-ephrin receptor activity-IDA19118217  
GO:0005524ATP binding-IEA-  
GO:0019901protein kinase binding-IPI19118217  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001954positive regulation of cell-matrix adhesion-IDA19118217  
GO:0006469negative regulation of protein kinase activity-IDA19118217  
GO:0007166cell surface receptor signaling pathway-IDA19118217  
GO:0007275multicellular organism development-IBA21873635  
GO:0008284positive regulation of cell proliferation-IMP20043122  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0018108peptidyl-tyrosine phosphorylation-IDA12775584  
GO:0030154cell differentiation-IBA21873635  
GO:0030335positive regulation of cell migration-IMP20043122  
GO:0030336negative regulation of cell migration-IDA19118217  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0034446substrate adhesion-dependent cell spreading-IDA19118217  
GO:0035019somatic stem cell population maintenance-TAS-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043087regulation of GTPase activity-IDA19118217  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0045766positive regulation of angiogenesis-IMP20043122  
GO:0046777protein autophosphorylation-IDA19118217  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0051496positive regulation of stress fiber assembly-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0090630activation of GTPase activity-IDA19118217  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA19118217  
GO:0043005neuron projection-IBA21873635  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-2892247POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferationTAS
R-HSA-3928663EPHA-mediated growth cone collapseTAS
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-452723Transcriptional regulation of pluripotent stem cellsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget