Gene: EPHA3

2042
EK4|ETK|ETK1|HEK|HEK4|TYRO4
EPH receptor A3
protein-coding
3p11.1
Ensembl:ENSG00000044524 MIM:179611 Vega:OTTHUMG00000159040 UniprotKB:P29320
NG_023239.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.496e-1 (AD)  3.774e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGAP200.863
OSBPL100.842
MCHR20.838
ZNF8600.834
TMEM1690.833
TYRP10.831
EPHA50.831
XKR40.827
SLC16A140.823
FAM102B0.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STON2-0.561
ROM1-0.561
HIST1H1C-0.553
FXYD3-0.543
RAB13-0.543
HVCN1-0.538
TRIP6-0.536
SOD3-0.526
NUPR1-0.526
IMPA2-0.525

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of EPHA3 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of EPHA3 mRNA]"27071940
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of EPHA3 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA3 mRNA"27188386
D000452Aldrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA28263720
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of EPHA3 mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EPHA3 mRNA16483693
C547126AZM551248AZM551248 results in increased expression of EPHA3 mRNA22323515
C487081belinostatbelinostat results in increased expression of EPHA3 mRNA26272509
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EPHA3 mRNA18247414
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EPHA3 mRNA20823114
D004958EstradiolEstradiol results in decreased expression of EPHA3 mRNA21795739
C006780bisphenol Abisphenol A results in decreased expression of EPHA3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of EPHA3 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of EPHA3 mRNA17484886
D003042CocaineCocaine affects the expression of EPHA3 mRNA15691709
D003634DDT[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA28263720
D003703DemecolcineDemecolcine results in decreased expression of EPHA3 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of EPHA3 mRNA21266533
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EPHA3 mRNA20823114
D003632Dichlorodiphenyldichloroethane[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA28263720
D003633Dichlorodiphenyl Dichloroethylene[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA28263720
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of EPHA3 mRNA26924002
D004026Dieldrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA28263720
D004051Diethylhexyl Phthalate[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of EPHA3 mRNA25031359
D004732Endrin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA28263720
C118739entinostatentinostat results in decreased expression of EPHA3 mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of EPHA3 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of EPHA3 mRNA23649840
C039281furanfuran results in increased expression of EPHA3 mRNA26194646
D019833Genistein[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of EPHA3 mRNA25031359
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of EPHA3 mRNA21782745
D001556Lindane[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA28263720
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EPHA3 mRNA20823114
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of EPHA3 mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EPHA3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EPHA3 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EPHA3 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of EPHA3 mRNA24810058
C517284monomethyl phthalatemonomethyl phthalate affects the expression of EPHA3 mRNA26924002
D009538NicotineNicotine results in decreased expression of EPHA3 mRNA18247414
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of EPHA3 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of EPHA3 mRNA27935865
D010100OxygenOxygen deficiency results in increased expression of EPHA3 mRNA24236059
D010126OzoneOzone results in decreased expression of EPHA3 mRNA16330353
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA3 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of EPHA3 mRNA26272509
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of EPHA3 mRNA23602845
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EPHA3 mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of EPHA3 mRNA27935865
C545373ponatinibponatinib analog results in decreased activity of EPHA3 protein21561767
C545373ponatinibponatinib results in decreased activity of EPHA3 protein19878872
D011192Potassium DichromatePotassium Dichromate results in increased expression of EPHA3 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of EPHA3 mRNA21795739
C116926rofecoxibrofecoxib results in decreased expression of EPHA3 mRNA17070997
D012834SilverSilver results in decreased expression of EPHA3 mRNA27131904
D019821Simvastatin[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA28263720
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of EPHA3 mRNA28973375
D014212TretinoinTretinoin results in decreased expression of EPHA3 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of EPHA3 mRNA24935251|2627250
D014635Valproic AcidValproic Acid results in decreased expression of EPHA3 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of EPHA3 mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of EPHA3 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EPHA3 gene25560391
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of EPHA3 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005004GPI-linked ephrin receptor activity-IDA11870224  
GO:0005005transmembrane-ephrin receptor activity-IBA21873635  
GO:0005515protein binding-IPI11870224  11877430  21135139  
GO:0005524ATP binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010717regulation of epithelial to mesenchymal transition-ISS-  
GO:0010976positive regulation of neuron projection development-IMP17910947  
GO:0016477cell migration-ISS-  
GO:0018108peptidyl-tyrosine phosphorylation-IDA11877430  
GO:0030154cell differentiation-IBA21873635  
GO:0032956regulation of actin cytoskeleton organization-IDA11870224  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043087regulation of GTPase activity-IDA11870224  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0045806negative regulation of endocytosis-IDA11877430  
GO:0048013ephrin receptor signaling pathway-IDA11870224  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0051893regulation of focal adhesion assembly-IDA11870224  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070507regulation of microtubule cytoskeleton organization-IDA11870224  
GO:0071300cellular response to retinoic acid-IMP17910947  
GO:0097155fasciculation of sensory neuron axon-ISS-  
GO:0097156fasciculation of motor neuron axon-ISS-  
GO:1903078positive regulation of protein localization to plasma membrane-IDA11877430  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005769early endosome-IDA21135139  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA11870224  21135139  
GO:0043005neuron projection-IBA21873635  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-3928663EPHA-mediated growth cone collapseTAS
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18948947Somatic mutations affect key pathways in lung adenocarcinoma. (2008 Oct 23)Ding LNature