Gene info: ID 2043

Gene: EPHA4

GENE ID: 2043

Synonyms: HEK8|SEK|TYRO1

Description: EPH receptor A4

Gene type: protein-coding

Location: 2q36.1

dbXrefs: Ensembl:ENSG00000116106 MIM:602188 Vega:OTTHUMG00000133142 UniprotKB:P54764

RefSeq: NC_000002.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.401e-2 (AD) 6.663e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
THRB	0.967
KIAA1549L	0.966
DLGAP1	0.964
ATRNL1	0.963
AAK1	0.96
KALRN	0.96
CHRM3	0.959
LMTK2	0.957
FRMPD4	0.957
PPM1L	0.956

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HEY2	-0.585
MYL3	-0.552
SNHG18	-0.55
RAI14	-0.546
RAB13	-0.538
ACAP1	-0.535
YES1	-0.531
SH2D1A	-0.523
CSAG1	-0.521
ROM1	-0.517

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of EPHA4 mRNA"	26377693
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of EPHA4 mRNA	19933214
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EPHA4 mRNA"	19167446
C017906	3-dinitrobenzene	3-dinitrobenzene results in decreased expression of EPHA4 mRNA	21983209
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of EPHA4 protein"	25670856
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
D000079	Acetaldehyde	Acetaldehyde affects the expression of EPHA4 mRNA	22634333
D000244	Adenosine Diphosphate	Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein	22273509
D000244	Adenosine Diphosphate	Benzoic Acid analog inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein]	22273509
C082481	arginyl-glycyl-aspartyl-tryptophan	arginyl-glycyl-aspartyl-tryptophan inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased phosphorylation of EPHA4 protein]	22273509
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of EPHA4 mRNA"	19446018
D001280	Atrazine	Atrazine results in decreased expression of EPHA4 mRNA	25929836
D019817	Benzoic Acid	Benzoic Acid analog inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein]	22273509
D019817	Benzoic Acid	Benzoic Acid analog inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased phosphorylation of EPHA4 protein]	22273509
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of EPHA4 mRNA	21569818
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of EPHA4 mRNA	22610609
D004958	Estradiol	EGF protein inhibits the reaction [Estradiol results in decreased expression of EPHA4 mRNA]	24758408
D004958	Estradiol	Estradiol affects the expression of EPHA4 mRNA	14699072
D004958	Estradiol	Estradiol results in decreased expression of EPHA4 mRNA	24758408\|2686566
D004958	Estradiol	Estradiol results in increased expression of EPHA4 mRNA	19698761
D004958	Estradiol	Estradiol results in increased expression of EPHA4 mRNA	22411564
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased expression of EPHA4 mRNA]	22411564
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EPHA4 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of EPHA4 mRNA	28711546
C006780	bisphenol A	bisphenol A results in decreased expression of EPHA4 mRNA	22687993
C006780	bisphenol A	bisphenol A results in decreased expression of EPHA4 mRNA	28196854
C006780	bisphenol A	bisphenol A affects the expression of EPHA4 mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in decreased expression of EPHA4 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased methylation of EPHA4 gene	28505145
D002220	Carbamazepine	Carbamazepine affects the expression of EPHA4 mRNA	22634333
D002737	Chloroprene	Chloroprene results in decreased expression of EPHA4 mRNA	23125180
D002857	Chromium	Chromium results in increased expression of EPHA4 mRNA	21437242
D003042	Cocaine	Cocaine affects the expression of EPHA4 mRNA	15691709
D003042	Cocaine	Cocaine results in increased expression of EPHA4 mRNA	17898221
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EPHA4 mRNA"	19167446
D003471	Cuprizone	Cuprizone results in decreased expression of EPHA4 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of EPHA4 mRNA	20106945
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EPHA4 mRNA	28628672
D002945	Cisplatin	Cisplatin results in decreased expression of EPHA4 mRNA	22023808
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of EPHA4 mRNA	26865669
C118739	entinostat	entinostat results in decreased expression of EPHA4 mRNA	26272509\|2718838
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EPHA4 mRNA	22079256
D004837	Epinephrine	Epinephrine results in increased phosphorylation of EPHA4 protein	22273509
D004970	Estrone	Estrone results in decreased expression of EPHA4 mRNA	26865669
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EPHA4 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of EPHA4 mRNA	17351261
D008656	Mestranol	Mestranol results in decreased expression of EPHA4 mRNA	26865669
C061365	flusilazole	flusilazole affects the expression of EPHA4 mRNA	22634333
D004397	Fonofos	Fonofos results in increased methylation of EPHA4 promoter	22847954
C069837	fullerene C60	fullerene C60 results in decreased expression of EPHA4 mRNA	19167457
C070081	fulvestrant	fulvestrant results in increased expression of EPHA4 mRNA	26865669
C039281	furan	furan results in decreased expression of EPHA4 mRNA	26194646
C546771	gardiquimod	gardiquimod results in decreased expression of EPHA4 mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of EPHA4 mRNA]	28003376
D019833	Genistein	Genistein results in decreased expression of EPHA4 mRNA	26865669
D006589	Hexestrol	Hexestrol results in decreased expression of EPHA4 mRNA	26865669
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EPHA4 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EPHA4 mRNA	28628672
C011890	kojic acid	kojic acid results in increased expression of EPHA4 mRNA	16595896
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of EPHA4 mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of EPHA4 mRNA"	26251327
D009151	Mustard Gas	Mustard Gas results in decreased expression of EPHA4 mRNA	18988085
C029938	nickel sulfate	nickel sulfate results in increased expression of EPHA4 mRNA	22714537
C558013	NSC 689534	NSC 689534 results in increased expression of EPHA4 mRNA	20971185
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C496932	panobinostat	panobinostat results in decreased expression of EPHA4 mRNA	26272509
D010278	Parathion	Parathion results in increased methylation of EPHA4 promoter	22847954
D052638	Particulate Matter	Particulate Matter results in decreased expression of EPHA4 mRNA	23085030
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of EPHA4 mRNA	26705709
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of EPHA4 mRNA	27153767
D010656	Phenylephrine	Phenylephrine results in decreased expression of EPHA4 mRNA	18158353
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of EPHA4 mRNA	26272509
C545373	ponatinib	ponatinib results in decreased activity of EPHA4 protein	19878872
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EPHA4 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of EPHA4 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of EPHA4 mRNA	22714537
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased expression of EPHA4 mRNA]	22411564
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of EPHA4 mRNA	24780913
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of EPHA4 mRNA]	28003376
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of EPHA4 mRNA	26865669
C059514	resveratrol	resveratrol results in increased expression of EPHA4 mRNA	12569576
D012822	Silicon Dioxide	Silicon Dioxide analog affects the expression of EPHA4 mRNA	25895662
D012834	Silver	Silver results in decreased expression of EPHA4 mRNA	26551752
C017947	sodium arsenite	sodium arsenite affects the methylation of EPHA4 gene	28589171
C012568	terbufos	terbufos results in increased methylation of EPHA4 promoter	22847954
D013739	Testosterone	Testosterone results in increased expression of EPHA4 mRNA	19693291
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in decreased expression of EPHA4 mRNA	26496021
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of EPHA4 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EPHA4 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of EPHA4 mRNA	19933214
C096900	thrombin receptor-activating peptide SFLLRNPNDKY	arginyl-glycyl-aspartyl-tryptophan inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased phosphorylation of EPHA4 protein]	22273509
C096900	thrombin receptor-activating peptide SFLLRNPNDKY	Benzoic Acid analog inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased phosphorylation of EPHA4 protein]	22273509
C096900	thrombin receptor-activating peptide SFLLRNPNDKY	thrombin receptor-activating peptide SFLLRNPNDKY results in increased phosphorylation of EPHA4 protein	22273509
C009495	titanium dioxide	titanium dioxide affects the expression of EPHA4 mRNA	23557971
D014212	Tretinoin	Tretinoin results in decreased expression of EPHA4 mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of EPHA4 mRNA	24935251\|2627250
C012589	trichostatin A	trichostatin A results in increased expression of EPHA4 mRNA	24935251
D017973	Tungsten Compounds	Tungsten Compounds results in decreased expression of EPHA4 mRNA	28666766
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of EPHA4 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of EPHA4 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in decreased methylation of EPHA4 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of EPHA4 mRNA	24935251
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of EPHA4 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of EPHA4 mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of EPHA4 mRNA	26682919
D002762	Cholecalciferol	Cholecalciferol results in increased expression of EPHA4 mRNA	17170073
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA4 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of EPHA4 mRNA	26272509
C088658	zoledronic acid	zoledronic acid results in increased expression of EPHA4 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004672	protein kinase activity	-	IDA	12775584
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0005004	GPI-linked ephrin receptor activity	-	ISS	-
GO:0005005	transmembrane-ephrin receptor activity	-	IBA	21873635
GO:0005005	transmembrane-ephrin receptor activity	-	ISS	-
GO:0005515	protein binding	-	IPI	12775584 19836338 23812375
GO:0005524	ATP binding	-	IEA	-
GO:0016301	kinase activity	-	IGI	24217950
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0042731	PH domain binding	-	IPI	12775584
GO:0042802	identical protein binding	-	IEA	-
GO:0046875	ephrin receptor binding	-	IEA	-
GO:0097161	DH domain binding	-	IDA	12775584
GO:1990782	protein tyrosine kinase binding	-	IPI	24217950

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007155	cell adhesion	-	IEA	-
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0007628	adult walking behavior	-	IEA	-
GO:0008045	motor neuron axon guidance	-	ISS	-
GO:0008347	glial cell migration	-	IEA	-
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0010977	negative regulation of neuron projection development	-	ISS	-
GO:0018108	peptidyl-tyrosine phosphorylation	-	IDA	12775584
GO:0021957	corticospinal tract morphogenesis	-	ISS	-
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030517	negative regulation of axon extension	-	IBA	21873635
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043087	regulation of GTPase activity	-	ISS	-
GO:0043410	positive regulation of MAPK cascade	-	IBA	21873635
GO:0043507	positive regulation of JUN kinase activity	-	IEA	-
GO:0046777	protein autophosphorylation	-	IDA	12775584
GO:0048013	ephrin receptor signaling pathway	-	IGI	24217950
GO:0048013	ephrin receptor signaling pathway	-	TAS	-
GO:0048681	negative regulation of axon regeneration	-	ISS	-
GO:0048710	regulation of astrocyte differentiation	-	ISS	-
GO:0050770	regulation of axonogenesis	-	ISS	-
GO:0050775	positive regulation of dendrite morphogenesis	-	IEA	-
GO:0050821	protein stabilization	-	IGI	24217950
GO:0061001	regulation of dendritic spine morphogenesis	-	ISS	-
GO:0061098	positive regulation of protein tyrosine kinase activity	-	ISS	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0072178	nephric duct morphogenesis	-	IEA	-
GO:0097155	fasciculation of sensory neuron axon	-	ISS	-
GO:0097156	fasciculation of motor neuron axon	-	ISS	-
GO:0097485	neuron projection guidance	-	ISS	-
GO:0106030	neuron projection fasciculation	-	ISS	-
GO:1900272	negative regulation of long-term synaptic potentiation	-	ISS	-
GO:1902004	positive regulation of amyloid-beta formation	-	IGI	24217950
GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	-	IGI	24217950
GO:1903051	negative regulation of proteolysis involved in cellular protein catabolic process	-	IGI	24217950
GO:1904646	cellular response to amyloid-beta	-	ISS	-
GO:1905244	regulation of modification of synaptic structure	-	ISS	-
GO:2001108	positive regulation of Rho guanyl-nucleotide exchange factor activity	-	IDA	12775584

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	ISS	-
GO:0005741	mitochondrial outer membrane	-	IEA	-
GO:0005783	endoplasmic reticulum	-	IEA	-
GO:0005794	Golgi apparatus	-	IEA	-
GO:0005886	plasma membrane	-	NAS	24217950
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	ISS	-
GO:0009986	cell surface	-	IEA	-
GO:0014069	postsynaptic density	-	IEA	-
GO:0030054	cell junction	-	IEA	-
GO:0030175	filopodium	-	IEA	-
GO:0030424	axon	-	ISS	-
GO:0030425	dendrite	-	ISS	-
GO:0031594	neuromuscular junction	-	IEA	-
GO:0031901	early endosome membrane	-	ISS	-
GO:0043005	neuron projection	-	IBA	21873635
GO:0043197	dendritic spine	-	IBA	21873635
GO:0043197	dendritic spine	-	ISS	-
GO:0043198	dendritic shaft	-	ISS	-
GO:0043204	perikaryon	-	IEA	-
GO:0043235	receptor complex	-	IBA	21873635
GO:0043679	axon terminus	-	IEA	-
GO:0044295	axonal growth cone	-	IEA	-
GO:0045211	postsynaptic membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04360	Axon guidance

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-2682334	EPH-Ephrin signaling	TAS
R-HSA-2682334	EPH-Ephrin signaling	IEA
R-HSA-3928663	EPHA-mediated growth cone collapse	TAS
R-HSA-3928663	EPHA-mediated growth cone collapse	IEA
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	TAS
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26384852	Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry. (2015 Nov)	Levran O	CNS Neurosci Ther
28816646	Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis. (2017 Aug)	Solanki HS	OMICS
27994470	Identification of feature genes for smoking-related lung adenocarcinoma based on gene expression profile data. (2016)	Liu Y	Onco Targets Ther
21628570	Pathway-specific engagement of ephrinA5-EphA4/EphA5 system of the substantia nigra pars reticulata in cocaine-induced responses. (2011 Jun 14)	Kimura K	Proc Natl Acad Sci U S A