Gene: EPHA5

2044
CEK7|EHK-1|EHK1|EK7|HEK7|TYRO4
EPH receptor A5
protein-coding
4q13.1-q13.2
Ensembl:ENSG00000145242 MIM:600004 Vega:OTTHUMG00000129273 UniprotKB:P54756
NC_000004.12
PubMed|SNP Mapped
1   ANCO-SNPs
CD|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.011e-1 (AD)  7.252e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11131599chr4:65517712 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM102B0.947
FRMPD40.944
PGM2L10.941
PTPRR0.939
ROBO20.937
SLITRK10.936
RAB27B0.934
NBEA0.934
FAXC0.933
TRHDE0.933

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.636
RAB13-0.627
CHST14-0.611
CSAG1-0.609
STON2-0.599
HEY2-0.59
SYDE1-0.59
EMP3-0.588
RHOD-0.587
CMTM3-0.586

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01254DasatinibSmall Molecule302962-49-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of EPHA5 mRNA"25270620
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EPHA5 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of EPHA5 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EPHA5 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EPHA5 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EPHA5 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EPHA5 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of EPHA5 mRNA"20406850
D000082AcetaminophenAcetaminophen results in increased expression of EPHA5 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of EPHA5 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EPHA5 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EPHA5 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EPHA5 mRNA24449571
C015001arsenitearsenite results in increased methylation of EPHA5 promoter23974009
D001280AtrazineAtrazine results in decreased expression of EPHA5 mRNA25929836
D004958EstradiolEstradiol results in increased expression of EPHA5 mRNA25878060
C006780bisphenol Abisphenol A results in increased expression of EPHA5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EPHA5 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of EPHA5 mRNA26079696
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNA12634122
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of EPHA5 mRNA24763279
D004390ChlorpyrifosChlorpyrifos results in decreased expression of EPHA5 mRNA18668222
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNA12634122
D002994ClofibrateClofibrate results in increased expression of EPHA5 mRNA17585979
D003033Coal TarCoal Tar results in decreased expression of EPHA5 mRNA27858113
D003042CocaineCocaine affects the expression of EPHA5 mRNA15691709
D003471CuprizoneCuprizone results in decreased expression of EPHA5 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of EPHA5 mRNA20106945
D000069439DasatinibDasatinib binds to EPHA5 protein18180381
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of EPHA5 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of EPHA5 mRNA27392435
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of EPHA5 mRNA24763279
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of EPHA5 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of EPHA5 mRNA27392435
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNA12634122
D018021Lithium ChlorideLithium Chloride results in decreased expression of EPHA5 mRNA18772502
D018021Lithium ChlorideLithium Chloride results in decreased expression of EPHA5 protein18772502
D008558MelphalanMelphalan results in decreased expression of EPHA5 mRNA22363485
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of EPHA5 mRNA"20188158
C523799MRK 003EPHA5 results in decreased susceptibility to MRK 00319903844
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of EPHA5 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of EPHA5 mRNA27935865
D019319Okadaic AcidOkadaic Acid results in increased expression of EPHA5 mRNA25270620
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EPHA5 mRNA"25510870
D010862PilocarpinePilocarpine results in decreased expression of EPHA5 mRNA18772502
D010862PilocarpinePilocarpine results in decreased expression of EPHA5 protein18772502
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of EPHA5 mRNA27935865
D059808PolyphenolsPolyphenols results in decreased expression of EPHA5 mRNA16293270
C545373ponatinibponatinib results in decreased activity of EPHA5 protein19878872
C017947sodium arsenitesodium arsenite affects the methylation of EPHA5 gene28589171
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNA12634122
C017947sodium arsenitesodium arsenite results in increased expression of EPHA5 mRNA12634122
C017947sodium arsenitesodium arsenite results in increased expression of EPHA5 mRNA16014739
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPHA5 mRNA21570461
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of EPHA5 mRNA16010555
D014635Valproic AcidValproic Acid affects the expression of EPHA5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EPHA5 mRNA27188386
D014635Valproic AcidValproic Acid results in decreased methylation of EPHA5 gene29154799
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of EPHA5 mRNA25423262
C025643vinclozolinvinclozolin affects the expression of EPHA5 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of EPHA5 mRNA22615374
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of EPHA5 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005003ephrin receptor activity-ISS-  
GO:0005004GPI-linked ephrin receptor activity-ISS-  
GO:0005005transmembrane-ephrin receptor activity-IBA21873635  
GO:0005005transmembrane-ephrin receptor activity-NAS7898931  
GO:0005524ATP binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IBA21873635  
GO:0007411axon guidance-ISS-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0019933cAMP-mediated signaling-ISS-  
GO:0021766hippocampus development-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0032793positive regulation of CREB transcription factor activity-ISS-  
GO:0032956regulation of actin cytoskeleton organization-ISS-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043087regulation of GTPase activity-ISS-  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0048013ephrin receptor signaling pathway-ISS-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048666neuron development-IEP10375373  
GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005791rough endoplasmic reticulum-IDA10375373  
GO:0005886plasma membrane-IDA10375373  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0009897external side of plasma membrane-IDA10064801  
GO:0030424axon-IEA-  
GO:0030425dendrite-IDA10375373  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-IDA10375373  
GO:0043235receptor complex-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IDA10375373  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-3928663EPHA-mediated growth cone collapseTAS
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21628570Pathway-specific engagement of ephrinA5-EphA4/EphA5 system of the substantia nigra pars reticulata in cocaine-induced responses. (2011 Jun 14)Kimura KProc Natl Acad Sci U S A