Gene: EPHA7

2045
EHK-3|EHK3|EK11|HEK11
EPH receptor A7
protein-coding
6q16.1
Ensembl:ENSG00000135333 MIM:602190 Vega:OTTHUMG00000015228 UniprotKB:Q15375
NG_033944.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.667e-1 (AD)  1.232e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs625822chr6:93403084 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MCTP10.904
SLC8A10.901
GPR120.901
LMO70.9
DGKI0.894
ANO30.89
CACNA1E0.883
TENM30.879
DRD10.879
NPY5R0.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.519
RAB13-0.497
CSAG1-0.493
MAPKAPK3-0.491
COPZ2-0.488
ASB4-0.485
S100A16-0.459
RNF135-0.459
FZD10-0.454
EMP3-0.447

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB079705-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamideSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of EPHA7 mRNA19933214
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of EPHA7 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA7 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EPHA7 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EPHA7 mRNA16483693
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of EPHA7 mRNA18585445
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of EPHA7 mRNA18585445
C487081belinostatbelinostat results in increased expression of EPHA7 mRNA26272509
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EPHA7 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EPHA7 mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EPHA7 mRNA21839799
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of EPHA7 mRNA20660070
C006780bisphenol Abisphenol A results in increased expression of EPHA7 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of EPHA7 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of EPHA7 promoter22457795
D003024ClozapineClozapine results in increased expression of EPHA7 mRNA17266109
D003042CocaineCocaine affects the expression of EPHA7 mRNA15691709
D003907DexamethasoneDexamethasone results in decreased expression of EPHA7 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of EPHA7 mRNA]20032058
D004041Dietary FatsDietary Fats results in increased expression of EPHA7 mRNA25016146
C058705diethyl malatediethyl malate affects the expression of EPHA7 mRNA24814887
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of EPHA7 mRNA"27840820
C118739entinostatentinostat results in increased expression of EPHA7 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA7 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of EPHA7 mRNA17108234
D004397FonofosFonofos results in increased methylation of EPHA7 promoter22847954
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of EPHA7 mRNA21782745
D019833GenisteinGenistein results in increased expression of EPHA7 mRNA21782745
C412815GW 4064GW 4064 results in increased expression of EPHA7 mRNA26655953
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of EPHA7 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of EPHA7 mRNA21782745
C005219methyl cellosolvemethyl cellosolve results in increased expression of EPHA7 mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EPHA7 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EPHA7 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of EPHA7 mRNA24810058
D009532NickelNickel affects the expression of EPHA7 mRNA14575637
D009532NickelNickel results in decreased expression of EPHA7 mRNA24768652|2558310
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of EPHA7 mRNA]14575637
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA7 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of EPHA7 mRNA26272509
D010278ParathionParathion results in increased methylation of EPHA7 promoter22847954
C046012pentanalpentanal results in decreased expression of EPHA7 mRNA26079696
D010795Phthalic AcidsPhthalic Acids results in increased expression of EPHA7 mRNA21061450
C545373ponatinibponatinib analog results in decreased activity of EPHA7 protein21561767
C545373ponatinibponatinib results in decreased activity of EPHA7 protein19878872
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of EPHA7 mRNA20660070
D011441PropylthiouracilPropylthiouracil affects the expression of EPHA7 mRNA24780913
D012834SilverSilver results in decreased expression of EPHA7 mRNA26551752
C012568terbufosterbufos results in increased methylation of EPHA7 promoter22847954
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of EPHA7 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPHA7 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EPHA7 mRNA19933214
D014212TretinoinTretinoin results in decreased expression of EPHA7 mRNA21934132
D014212TretinoinTretinoin results in increased expression of EPHA7 mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA7 mRNA"27188386
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of EPHA7 mRNA]14575637
C012589trichostatin Atrichostatin A results in decreased expression of EPHA7 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of EPHA7 mRNA24935251
D014415TunicamycinTunicamycin results in decreased expression of EPHA7 mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHA7 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EPHA7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EPHA7 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of EPHA7 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of EPHA7 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of EPHA7 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EPHA7 gene25560391
D019287Zinc SulfateZinc Sulfate results in increased expression of EPHA7 mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-ISS-  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005004GPI-linked ephrin receptor activity-ISS-  
GO:0005005transmembrane-ephrin receptor activity-IBA21873635  
GO:0005515protein binding-IPI22036564  
GO:0005524ATP binding-IEA-  
GO:0008046axon guidance receptor activity-ISS-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0045499chemorepellent activity-ISS-  
GO:0046875ephrin receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0007420brain development-ISS-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0016310phosphorylation-ISS-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0022407regulation of cell-cell adhesion-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0031290retinal ganglion cell axon guidance-IEA-  
GO:0031952regulation of protein autophosphorylation-ISS-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process-ISS-  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0043525positive regulation of neuron apoptotic process-ISS-  
GO:0048013ephrin receptor signaling pathway-IDA17726105  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048671negative regulation of collateral sprouting-IEA-  
GO:0048755branching morphogenesis of a nerve-ISS-  
GO:0050730regulation of peptidyl-tyrosine phosphorylation-IDA17726105  
GO:0050919negative chemotaxis-ISS-  
GO:0051964negative regulation of synapse assembly-IEA-  
GO:0070372regulation of ERK1 and ERK2 cascade-IDA17726105  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0072178nephric duct morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0030425dendrite-IEA-  
GO:0031594neuromuscular junction-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-IEA-  
GO:0043235receptor complex-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-3928663EPHA-mediated growth cone collapseTAS
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20126984Secreted form of EphA7 in lung cancer. (2010 Mar)Tsuboi MInt J Oncol