Gene info: ID 2047

Gene: EPHB1

GENE ID: 2047

Synonyms: ELK|EPHT2|Hek6|NET

Description: EPH receptor B1

Gene type: protein-coding

Location: 3q22.2

dbXrefs: Ensembl:ENSG00000154928 MIM:600600 Vega:OTTHUMG00000159804 UniprotKB:P54762

RefSeq: NC_000003.12

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.769e-2 (AD) 1.927e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs8179953	chr3:135235483 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)
rs11918092	chr3:134794514 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NCAN	0.863
PSD2	0.86
ACSS1	0.813
PYGM	0.808
SLC15A2	0.804
FGFR3	0.801
HHIPL1	0.8
SLC1A2	0.8
GPR37L1	0.797
SLC1A4	0.795

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
IGF2BP2	-0.423
SGMS2	-0.408
C19orf33	-0.407
GSDMA	-0.404
MBOAT1	-0.402
TNFAIP8	-0.398
PTGER4	-0.397
TFPI2	-0.393
OR4F5	-0.392
GADL1	-0.391

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of EPHB1 mRNA"	28973690
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane affects the expression of EPHB1 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHB1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHB1 mRNA"	27188386
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EPHB1 mRNA	22129741
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of EPHB1 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of EPHB1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of EPHB1 mRNA	24449571
C015001	arsenite	arsenite results in increased methylation of EPHB1 promoter	23974009
D001507	Beclomethasone	Beclomethasone results in decreased expression of EPHB1 mRNA	23656298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of EPHB1 mRNA	23735875
C006780	bisphenol A	bisphenol A results in increased methylation of EPHB1 promoter	27312807
C006780	bisphenol A	bisphenol A affects the expression of EPHB1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of EPHB1 gene	28505145
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB1 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of EPHB1 mRNA	26272509
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EPHB1 gene	20938992
D060729	Coal Ash	Coal Ash results in increased expression of EPHB1 mRNA	19000753
D003042	Cocaine	Cocaine results in increased expression of EPHB1 protein	11146119
D003042	Cocaine	Cocaine results in increased expression of EPHB1 mRNA	15691709
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of EPHB1 mRNA	24317228
C014347	decitabine	decitabine results in decreased expression of EPHB1 mRNA	27915011
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EPHB1 mRNA	22129741
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased activity of EPHB1 protein"	25856345
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of EPHB1 mRNA	23649840
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EPHB1 gene	20938992
D005557	Formaldehyde	Formaldehyde results in decreased expression of EPHB1 mRNA	23649840
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EPHB1 mRNA	22129741
C008261	lead acetate	lead acetate results in increased expression of EPHB1 mRNA	20542052
C042720	mercuric bromide	mercuric bromide results in decreased expression of EPHB1 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB1 mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EPHB1 gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of EPHB1 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of EPHB1 mRNA	23649840
D008777	Methyltestosterone	Methyltestosterone results in increased expression of EPHB1 mRNA	29191790
C568507	N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide	"N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide results in decreased activity of EPHB1 protein"	21888390
C025589	ochratoxin A	ochratoxin A results in increased acetylation of EPHB1 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of EPHB1 promoter] which results in increased expression of EPHB1 mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of EPHB1 mRNA	29098329
D016627	Oxidopamine	Oxidopamine results in decreased expression of EPHB1 protein	11146119
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of EPHB1 mRNA]"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of EPHB1 mRNA"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of EPHB1 mRNA]"	21673326
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of EPHB1 mRNA	26272509
C545373	ponatinib	ponatinib results in decreased activity of EPHB1 protein	19878872
D011441	Propylthiouracil	Propylthiouracil affects the expression of EPHB1 mRNA	24780913
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of EPHB1 mRNA	23806026
D053260	Soot	Soot results in decreased expression of EPHB1 mRNA	26551751
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of EPHB1 mRNA	19042947
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of EPHB1 mRNA	29024780
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHB1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of EPHB1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of EPHB1 mRNA	23179753\|2493525
D014635	Valproic Acid	Valproic Acid results in increased methylation of EPHB1 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of EPHB1 gene	25560391
D014750	Vincristine	Vincristine results in decreased expression of EPHB1 mRNA	23649840

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	EXP	11580899
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0005005	transmembrane-ephrin receptor activity	-	IBA	21873635
GO:0005005	transmembrane-ephrin receptor activity	-	IDA	18034775
GO:0005515	protein binding	-	IPI	8798570 9499402 12223469 12925710 18034775
GO:0005524	ATP binding	-	IEA	-
GO:0008046	axon guidance receptor activity	-	IEA	-
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0044877	protein-containing complex binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001525	angiogenesis	-	IDA	9499402
GO:0001771	immunological synapse formation	-	IEA	-
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0007411	axon guidance	-	ISS	-
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0014719	skeletal muscle satellite cell activation	-	ISS	-
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0021631	optic nerve morphogenesis	-	IEA	-
GO:0021952	central nervous system projection neuron axonogenesis	-	ISS	-
GO:0022008	neurogenesis	-	ISS	-
GO:0030010	establishment of cell polarity	-	ISS	-
GO:0030154	cell differentiation	-	IBA	21873635
GO:0031290	retinal ganglion cell axon guidance	-	ISS	-
GO:0031589	cell-substrate adhesion	-	IDA	9430661
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043410	positive regulation of MAPK cascade	-	IBA	21873635
GO:0046328	regulation of JNK cascade	-	IDA	9430661
GO:0046777	protein autophosphorylation	-	IDA	18034775
GO:0048013	ephrin receptor signaling pathway	-	IDA	12925710 18034775
GO:0048013	ephrin receptor signaling pathway	-	TAS	-
GO:0048593	camera-type eye morphogenesis	-	IEA	-
GO:0050965	detection of temperature stimulus involved in sensory perception of pain	-	ISS	-
GO:0051965	positive regulation of synapse assembly	-	ISS	-
GO:0060326	cell chemotaxis	-	IDA	12925710
GO:0060996	dendritic spine development	-	ISS	-
GO:0060997	dendritic spine morphogenesis	-	ISS	-
GO:0061351	neural precursor cell proliferation	-	ISS	-
GO:0070372	regulation of ERK1 and ERK2 cascade	-	IDA	12925710 18034775
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:1901214	regulation of neuron death	-	IMP	21085126
GO:1902723	negative regulation of skeletal muscle satellite cell proliferation	-	ISS	-
GO:1902725	negative regulation of satellite cell differentiation	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005783	endoplasmic reticulum	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IDA	18034775
GO:0030424	axon	-	IEA	-
GO:0030425	dendrite	-	IEA	-
GO:0031901	early endosome membrane	-	IDA	18034775
GO:0032433	filopodium tip	-	IEA	-
GO:0043005	neuron projection	-	IBA	21873635
GO:0043235	receptor complex	-	IBA	21873635
GO:0045121	membrane raft	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	20458337

KEGG ID	KEGG Term
hsa04360	Axon guidance

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-2682334	EPH-Ephrin signaling	TAS
R-HSA-2682334	EPH-Ephrin signaling	IEA
R-HSA-3928662	EPHB-mediated forward signaling	TAS
R-HSA-3928662	EPHB-mediated forward signaling	IEA
R-HSA-3928664	Ephrin signaling	IEA
R-HSA-3928664	Ephrin signaling	TAS
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18772347	EphB receptor signaling in mouse spinal cord contributes to physical dependence on morphine. (2009 Jan)	Liu WT	FASEB J
25129674	Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. (2014 Sep)	McClintick JN	Alcohol
19025592	Targeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in mice. (2008 Nov 21)	Han Y	Mol Pain