Gene: EPHB2

2048
CAPB|DRT|EK5|EPHT3|ERK|Hek5|PCBC|Tyro5
EPH receptor B2
protein-coding
1p36.12
Ensembl:ENSG00000133216 MIM:600997 Vega:OTTHUMG00000002881 UniprotKB:P29323
NG_011804.2
PubMed|SNP Mapped
OD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.253e-1 (AD)  7.700e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6659914chr1:22819906 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAMTS80.87
TBC1D22B0.865
SMPD30.865
OSBP20.862
C2CD2L0.861
TBC1D250.86
ZNF3240.857
EXTL30.857
CX3CL10.855
SLC35C10.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.488
MYL3-0.481
GNG11-0.472
ADH1B-0.464
ASB4-0.461
HEY2-0.456
EBF1-0.454
PARD3B-0.454
CDA-0.451
IL18RAP-0.45

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of EPHB2 mRNA"25614096
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of EPHB2 mRNA29067470
D000393Air Pollutants[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of EPHB2 gene28843141
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of EPHB2 mRNA18585445
D001151ArsenicArsenic affects the methylation of EPHB2 gene25304211
C015001arsenitearsenite results in decreased methylation of EPHB2 promoter23974009
D001280AtrazineAtrazine results in increased expression of EPHB2 mRNA25929836
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of EPHB2 mRNA18585445
C487081belinostatbelinostat results in decreased expression of EPHB2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of EPHB2 gene25435355
C006780bisphenol Abisphenol A results in decreased methylation of EPHB2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of EPHB2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EPHB2 gene28505145
D000069286BortezomibBortezomib results in decreased expression of EPHB2 mRNA20977926
C013418bromfenacoumbromfenacoum results in increased expression of EPHB2 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of EPHB2 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of EPHB2 mRNA26079696
D002104CadmiumCadmium results in increased expression of EPHB2 mRNA24376830
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of EPHB2 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EPHB2 gene20938992
D060729Coal AshCoal Ash results in increased expression of EPHB2 mRNA19000753
C018021cobaltous chloridecobaltous chloride results in decreased expression of EPHB2 mRNA19320972|1937684
D003042CocaineCocaine results in increased expression of EPHB2 mRNA15691709
C055786columbaminecolumbamine results in decreased expression of EPHB2 mRNA23124089
C030973cupric oxidecupric oxide results in decreased expression of EPHB2 mRNA22077320
D003471CuprizoneCuprizone results in decreased expression of EPHB2 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of EPHB2 mRNA23640034
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of EPHB2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of EPHB2 mRNA19561079|2739243
D004041Dietary FatsDietary Fats results in increased expression of EPHB2 mRNA22609946
C058705diethyl malatediethyl malate affects the expression of EPHB2 mRNA24814887
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EPHB2 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of EPHB2 mRNA19167457
D017313FenretinideFenretinide results in decreased expression of EPHB2 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of EPHB2 mRNA27392435
D007854LeadLead affects the expression of EPHB2 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of EPHB2 mRNA12057914
C042720mercuric bromidemercuric bromide results in decreased expression of EPHB2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EPHB2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EPHB2 mRNA28001369
C523799MRK 003EPHB2 results in increased susceptibility to MRK 00319903844
C568507N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide"N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide results in decreased activity of EPHB2 protein"21888390
C028007nickel monoxidenickel monoxide results in decreased expression of EPHB2 mRNA19167457
D009585Nitrogen Dioxide[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of EPHB2 gene28843141
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of EPHB2 mRNA26272509
D010578PetroleumPetroleum results in increased expression of EPHB2 mRNA25208076
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of EPHB2 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of EPHB2 mRNA20813756
C545373ponatinibponatinib results in decreased activity of EPHB2 protein19878872
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EPHB2 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of EPHB2 mRNA23608068
C005556propionaldehydepropionaldehyde results in increased expression of EPHB2 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of EPHB2 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in decreased expression of EPHB2 mRNA24780913
C017947sodium arsenitesodium arsenite affects the methylation of EPHB2 gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of EPHB2 mRNA17685462
D012999SomanSoman results in decreased expression of EPHB2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPHB2 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPHB2 mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased phosphorylation of EPHB2 protein21439344
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EPHB2 mRNA16137721
D014212TretinoinTretinoin affects the expression of EPHB2 mRNA16251210
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of EPHB2 mRNA]27469509
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of EPHB2 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of EPHB2 mRNA24935251|2627250
D014415TunicamycinTunicamycin results in decreased expression of EPHB2 mRNA22378314
D014520UrethaneUrethane results in increased expression of EPHB2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EPHB2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EPHB2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of EPHB2 mRNA23179753
D014638VanadatesVanadates results in increased expression of EPHB2 mRNA22714537
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHB2 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of EPHB2 mRNA26272509|2718838
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of EPHB2 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-ISS-  
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-EXP11580899  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-ISS-  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005005transmembrane-ephrin receptor activity-IBA21873635  
GO:0005005transmembrane-ephrin receptor activity-ISS-  
GO:0005005transmembrane-ephrin receptor activity-TAS8589679  
GO:0005102signaling receptor binding-IEA-  
GO:0005515protein binding-IPI17255949  
GO:0005524ATP binding-IEA-  
GO:0008046axon guidance receptor activity-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0042802identical protein binding-IEA-  
GO:0044877protein-containing complex binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-ISS-  
GO:0001655urogenital system development-ISS-  
GO:0001933negative regulation of protein phosphorylation-ISS-  
GO:0007275multicellular organism development-IBA21873635  
GO:0007399nervous system development-TAS8589679  
GO:0007411axon guidance-ISS-  
GO:0007413axonal fasciculation-ISS-  
GO:0007611learning or memory-ISS-  
GO:0007612learning-ISS-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010628positive regulation of gene expression-ISS-  
GO:0016310phosphorylation-ISS-  
GO:0018108peptidyl-tyrosine phosphorylation-ISS-  
GO:0021631optic nerve morphogenesis-IEA-  
GO:0021952central nervous system projection neuron axonogenesis-IEA-  
GO:0022038corpus callosum development-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0031290retinal ganglion cell axon guidance-IEA-  
GO:0031915positive regulation of synaptic plasticity-ISS-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0042472inner ear morphogenesis-ISS-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0046580negative regulation of Ras protein signal transduction-ISS-  
GO:0048013ephrin receptor signaling pathway-ISS-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048168regulation of neuronal synaptic plasticity-ISS-  
GO:0048170positive regulation of long-term neuronal synaptic plasticity-IEA-  
GO:0048593camera-type eye morphogenesis-IEA-  
GO:0050771negative regulation of axonogenesis-IEA-  
GO:0050878regulation of body fluid levels-ISS-  
GO:0051389inactivation of MAPKK activity-ISS-  
GO:0051965positive regulation of synapse assembly-ISS-  
GO:0060021roof of mouth development-ISS-  
GO:0060996dendritic spine development-ISS-  
GO:0060997dendritic spine morphogenesis-ISS-  
GO:0070373negative regulation of ERK1 and ERK2 cascade-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071679commissural neuron axon guidance-ISS-  
GO:0099557trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission-IBA21873635  
GO:0099557trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission-IEA-  
GO:0106028neuron projection retraction-IEA-  
GO:1900273positive regulation of long-term synaptic potentiation-IBA21873635  
GO:1900273positive regulation of long-term synaptic potentiation-ISS-  
GO:1903078positive regulation of protein localization to plasma membrane-ISS-  
GO:1904782negative regulation of NMDA glutamate receptor activity-ISS-  
GO:1904783positive regulation of NMDA glutamate receptor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-ISS-  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-IEA-  
GO:0043235receptor complex-IBA21873635  
GO:0098794postsynapse-TAS26224839  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-373760L1CAM interactionsIEA
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-3928662EPHB-mediated forward signalingIEA
R-HSA-3928664Ephrin signalingIEA
R-HSA-3928664Ephrin signalingTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18772347EphB receptor signaling in mouse spinal cord contributes to physical dependence on morphine. (2009 Jan)Liu WTFASEB J
19025592Targeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in mice. (2008 Nov 21)Han YMol Pain