Gene: AK4

205
AK 4|AK3|AK3L1|AK3L2
adenylate kinase 4
protein-coding
1p31.3
Ensembl:ENSG00000162433 MIM:103030 Vega:OTTHUMG00000009033 UniprotKB:P27144
NC_000001.11
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.948e-1 (AD)  7.546e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1889925chr1:65221873 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1109374chr1:65167814 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDAH10.87
SLC1A30.87
STOX10.866
NR2E10.865
NEBL0.863
TMEM470.863
AHCYL20.851
NADK20.85
PITPNC10.849
PGM10.842

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.568
OR4F29-0.519
OR6C74-0.296
CETP-0.277
PTPRH-0.267
KEL-0.249
GALNT6-0.247
DYNAP-0.246
TRPV5-0.242
MUSK-0.241

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of AK4 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of AK4 mRNA"21354444|2741311
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of AK4 mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AK4 mRNA"20056577
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AK4 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of AK4 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AK4 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of AK4 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK4 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of AK4 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK4 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of AK4 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of AK4 mRNA25704631|2669055
D000082AcetaminophenAcetaminophen affects the expression of AK4 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of AK4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AK4 mRNA]17585979
D000082AcetaminophenAcetaminophen results in increased expression of AK4 protein16538043
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of AK4 mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AK4 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AK4 gene27153756
D000638AmiodaroneAmiodarone affects the expression of AK4 mRNA25064622
D000638AmiodaroneAmiodarone results in increased expression of AK4 protein16538043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AK4 mRNA16483693
D001205Ascorbic AcidAscorbic Acid results in decreased expression of AK4 mRNA15305145
D001280AtrazineAtrazine results in decreased expression of AK4 mRNA27614199
D001554BenzeneBenzene affects the expression of AK4 mRNA15878777
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AK4 mRNA19770486|2719552
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of AK4 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of AK4 mRNA23019147
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of AK4 mRNA18192240
C006780bisphenol Abisphenol A affects the expression of AK4 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of AK4 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of AK4 mRNA12075121
C006780bisphenol Abisphenol A results in increased methylation of AK4 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AK4 mRNA28628672
D002065BuspironeBuspirone results in decreased expression of AK4 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of AK4 mRNA15003993
C018475butyraldehydebutyraldehyde results in decreased expression of AK4 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AK4 mRNA25596134
C459604candoxincandoxin results in decreased expression of AK4 mRNA16309724
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AK4 protein16538043
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of AK4 mRNA25596134
D002746ChlorpromazineChlorpromazine affects the expression of AK4 mRNA25064622
D004390ChlorpyrifosChlorpyrifos results in increased expression of AK4 mRNA21356183
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of AK4 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of AK4 mRNA20938992
C059262cidofovircidofovir results in increased expression of AK4 mRNA25596134
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of AK4 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of AK4 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AK4 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of AK4 mRNA22202117|2382409
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of AK4 mRNA]22202117
C018021cobaltous chloridecobaltous chloride results in increased expression of AK4 mRNA24386269
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of AK4 mRNA21356183
D003300CopperCopper results in decreased expression of AK4 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of AK4 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of AK4 mRNA26577399
D016572CyclosporineCyclosporine affects the expression of AK4 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of AK4 mRNA25562108
C014347decitabinedecitabine affects the expression of AK4 mRNA23300844
C014347decitabine[decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AK4 mRNA15251184
C014347decitabinedecitabine results in decreased expression of AK4 mRNA15251184
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AK4 mRNA28628672
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of AK4 mRNA26873546
D003976DiazinonDiazinon results in increased methylation of AK4 gene22964155
D002945CisplatinCisplatin affects the expression of AK4 mRNA23300844
D002945CisplatinCisplatin results in increased expression of AK4 mRNA25596134|2739243
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of AK4 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of AK4 mRNA19467301
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of AK4 mRNA19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AK4 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of AK4 mRNA19638242
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of AK4 mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of AK4 mRNA16243910|2687354
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of AK4 mRNA21040762
C118739entinostatentinostat results in increased expression of AK4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK4 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of AK4 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of AK4 mRNA15953391|1710823
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AK4 mRNA12075121
C024565ethylene dichlorideethylene dichloride results in decreased expression of AK4 mRNA28189721
D011345FenofibrateFenofibrate affects the expression of AK4 mRNA25596134
D005419FlavonoidsFlavonoids results in increased expression of AK4 mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of AK4 mRNA28329830
D005459FluoridesFluorides results in increased expression of AK4 protein19497429
D005485FlutamideFlutamide results in decreased expression of AK4 mRNA24793618
D005492Folic AcidFolic Acid affects the expression of AK4 mRNA17320366
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of AK4 mRNA20938992
D019833GenisteinGenistein results in increased expression of AK4 mRNA23019147
D019833GenisteinGenistein results in increased expression of AK4 mRNA12075121
D017313FenretinideFenretinide results in decreased expression of AK4 mRNA28973697
D017313FenretinideFenretinide results in increased expression of AK4 mRNA28973697
D007052IbuprofenIbuprofen results in decreased expression of AK4 mRNA25596134
D007069IfosfamideIfosfamide results in increased expression of AK4 mRNA25596134
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AK4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of AK4 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of AK4 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of AK4 mRNA]27292261
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AK4 mRNA26752646
C410337K 7174K 7174 results in decreased expression of AK4 mRNA24086573
C045463leflunomideleflunomide results in increased expression of AK4 mRNA24136188
D001556LindaneLindane results in decreased expression of AK4 mRNA24356939
D008687MetforminMetformin results in decreased expression of AK4 mRNA25596134
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of AK4 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AK4 mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AK4 mRNA23179753|2718838
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AK4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of AK4 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of AK4 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AK4 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of AK4 mRNA24136188
C022838nickel chlorideHIF1A affects the reaction [nickel chloride results in increased expression of AK4 mRNA]12729255
C022838nickel chloridenickel chloride results in increased expression of AK4 mRNA12729255
C022838nickel chloridenickel chloride affects the expression of AK4 mRNA22110744
C028007nickel monoxidenickel monoxide results in increased expression of AK4 mRNA19167457
C017557nickel subsulfidenickel subsulfide affects the expression of AK4 mRNA12729255
C012655nimesulidenimesulide results in decreased expression of AK4 mRNA24136188
D010100Oxygen(+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of AK4 mRNA]27292261
D010100OxygenOxygen deficiency results in increased expression of AK4 mRNA25596134|2651600
D010100OxygenOxygen deficiency results in increased expression of AK4 mRNA20880076
D010269ParaquatParaquat affects the expression of AK4 mRNA25064622
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of AK4 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AK4 mRNA27614199
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AK4 mRNA19162173
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of AK4 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of AK4 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of AK4 mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of AK4 mRNA19270015
D010634PhenobarbitalPhenobarbital results in decreased expression of AK4 mRNA19162173
D010656PhenylephrinePhenylephrine results in increased expression of AK4 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of AK4 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of AK4 mRNA18445702|2081375
D011374ProgesteroneProgesterone results in increased expression of AK4 mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of AK4 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of AK4 mRNA24780913
D011748PyrogallolPyrogallol results in increased expression of AK4 mRNA20362636
D011748PyrogallolSilymarin inhibits the reaction [Pyrogallol results in increased expression of AK4 mRNA]20362636
D011794QuercetinQuercetin results in increased expression of AK4 mRNA19729006
D011794QuercetinQuercetin affects the expression of AK4 mRNA18178720
C089730rosiglitazonerosiglitazone results in increased expression of AK4 mRNA25596134
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of AK4 mRNA25895662
D012834SilverSilver results in decreased expression of AK4 mRNA27131904
D012838SilymarinSilymarin inhibits the reaction [Pyrogallol results in increased expression of AK4 mRNA]20362636
C009277sodium arsenatesodium arsenate results in decreased expression of AK4 mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of AK4 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of AK4 mRNA27862939
D012999SomanSoman results in decreased expression of AK4 mRNA19281266
D013311StreptozocinStreptozocin results in decreased expression of AK4 protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in decreased expression of AK4 protein]19634143
C061133tamibarotenetamibarotene results in decreased expression of AK4 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AK4 mRNA16443690
D013749Tetrachlorodibenzodioxin[decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AK4 mRNA15251184
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AK4 mRNA21570461|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AK4 mRNA15251184|1977048
D013752TetracyclineTetracycline affects the expression of AK4 mRNA25064622
D013752TetracyclineTetracycline results in increased expression of AK4 protein16538043
D019284ThapsigarginThapsigargin results in decreased expression of AK4 mRNA22378314
D013849ThimerosalThimerosal results in decreased expression of AK4 mRNA27188386
D013853ThioacetamideThioacetamide affects the expression of AK4 mRNA25064622
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AK4 mRNA28943392
D014212TretinoinTretinoin affects the expression of AK4 mRNA15498508
D014212TretinoinTretinoin results in decreased expression of AK4 mRNA21934132
C011559tributyltintributyltin results in decreased expression of AK4 mRNA27614199
C012589trichostatin Atrichostatin A results in increased expression of AK4 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of AK4 mRNA24935251
D014266TrientineTrientine inhibits the reaction [Streptozocin results in decreased expression of AK4 protein]19634143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of AK4 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of AK4 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of AK4 mRNA22378314
D014520UrethaneUrethane results in decreased expression of AK4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of AK4 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of AK4 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AK4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of AK4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AK4 mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in increased expression of AK4 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of AK4 gene29154799
D014640VancomycinVancomycin results in increased expression of AK4 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of AK4 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of AK4 mRNA26682919
C111237vorinostatvorinostat results in decreased expression of AK4 mRNA27188386
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of AK4 mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004017adenylate kinase activity-IDA19766732  
GO:0004017adenylate kinase activityNOTIDA11485571  
GO:0004550nucleoside diphosphate kinase activity-IDA23416111  
GO:0005524ATP binding-IEA-  
GO:0005525GTP binding-IEA-  
GO:0046899nucleoside triphosphate adenylate kinase activity-IDA19766732  
GO:0046899nucleoside triphosphate adenylate kinase activityNOTIDA11485571  
GO:0050145nucleoside monophosphate kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001889liver development-IEA-  
GO:0006165nucleoside diphosphate phosphorylation-IDA23416111  
GO:0007420brain development-IEA-  
GO:0009142nucleoside triphosphate biosynthetic process-IDA23416111  
GO:0015949nucleobase-containing small molecule interconversion-TAS-  
GO:0042493response to drug-IEA-  
GO:0046033AMP metabolic process-IDA19766732  
GO:0046034ATP metabolic process-IDA19766732  
GO:0046039GTP metabolic process-IDA19766732  
GO:0046940nucleoside monophosphate phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA19766732  
GO:0005759mitochondrial matrix-ISS11485571  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-499943Interconversion of nucleotide di- and triphosphatesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal