Gene info: ID 2050

Gene: EPHB4

GENE ID: 2050

Synonyms: HFASD|HTK|MYK1|TYRO11

Description: EPH receptor B4

Gene type: protein-coding

Location: 7q22.1

dbXrefs: Ensembl:ENSG00000196411 MIM:600011 Vega:OTTHUMG00000157040 UniprotKB:P54760

RefSeq: NG_052671.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.146e-1 (AD) 1.614e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CDH5	0.853
MMRN2	0.848
ACVRL1	0.845
DOCK6	0.844
MYO1C	0.842
FGR	0.841
PXN	0.834
STARD8	0.832
PKN3	0.832
ACSL5	0.828

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SMIM18	-0.498
CRH	-0.464
MARCH4	-0.443
SLC7A4	-0.437
ABCC12	-0.429
PPEF1	-0.418
KCNB2	-0.408
SLC1A6	-0.405
AARD	-0.403
FSTL5	-0.403

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01254	Dasatinib	Small Molecule	302962-49-8	Approved\|Investigational	Target
DB07249	N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine	Small Molecule		Experimental	Target
DB07250	N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE	Small Molecule		Experimental	Target
DB07251	N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE	Small Molecule		Experimental	Target
DB07252	3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide	Small Molecule		Experimental	Target
DB07253	N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine	Small Molecule		Experimental	Target
DB07254	N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE	Small Molecule		Experimental	Target
DB07255	N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE	Small Molecule		Experimental	Target
DB07256	3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE	Small Molecule		Experimental	Target
DB11973	Tesevatinib	Small Molecule	781613-23-8	Investigational	Target

ID	Drug Name	Action	PubMed
C045575	1,2,4-triazole	"1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of EPHB4 protein]"	28693887
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of EPHB4 protein"	25670856
D000082	Acetaminophen	Acetaminophen results in increased expression of EPHB4 mRNA	22230336
D000880	Anthraquinones	Anthraquinones analog results in decreased activity of EPHB4 protein	27473261
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of EPHB4 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of EPHB4 gene	25304211
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of EPHB4 mRNA	22228805
D004958	Estradiol	Estradiol results in decreased expression of EPHB4 mRNA	16705744
C044887	beta-methylcholine	beta-methylcholine affects the expression of EPHB4 mRNA	21179406
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of EPHB4 mRNA	15336504
C584509	C646 compound	C646 compound results in decreased expression of EPHB4 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of EPHB4 mRNA	26472689
D002251	Carbon Tetrachloride	"1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of EPHB4 protein]"	28693887
D002251	Carbon Tetrachloride	[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of EPHB4 protein	28693887
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of EPHB4 mRNA	24763279
D002994	Clofibrate	Clofibrate results in decreased expression of EPHB4 mRNA	17585979
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of EPHB4 mRNA	19320972
D003042	Cocaine	Cocaine results in decreased expression of EPHB4 mRNA	18000554
D003042	Cocaine	Cocaine affects the expression of EPHB4 mRNA	15691709
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of EPHB4 mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of EPHB4 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of EPHB4 mRNA	25562108
D000069439	Dasatinib	Dasatinib binds to EPHB4 protein	18180381
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of EPHB4 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of EPHB4 mRNA	27392435
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of EPHB4 mRNA	26924002
D004052	Diethylnitrosamine	"1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of EPHB4 protein]"	28693887
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of EPHB4 protein	28693887
D019833	Genistein	Genistein results in decreased expression of EPHB4 mRNA	16705744
D006072	Gossypol	[zoledronic acid co-treated with Gossypol] results in decreased expression of EPHB4 mRNA	19825521
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of EPHB4 mRNA	24763279
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in decreased expression of EPHB4 mRNA	25270620
D017313	Fenretinide	Fenretinide results in increased expression of EPHB4 mRNA	28973697
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of EPHB4 mRNA	27392435
D008095	Lithocholic Acid	Lithocholic Acid inhibits the reaction [[EPHB4 protein binds to EFNB2 protein] which results in increased phosphorylation of EPHB4 protein]	21479221
D008727	Methotrexate	Methotrexate affects the expression of EPHB4 mRNA	18502557
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of EPHB4 mRNA	28001369
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of EPHB4 mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in increased expression of EPHB4 mRNA	15674844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of EPHB4 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of EPHB4 mRNA"	25554681
D009966	Orphenadrine	Orphenadrine affects the expression of EPHB4 mRNA	23665939
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of EPHB4 protein	26879310
D010634	Phenobarbital	Phenobarbital affects the expression of EPHB4 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of EPHB4 mRNA	19270015
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of EPHB4 mRNA	19710929
C545373	ponatinib	ponatinib results in decreased activity of EPHB4 protein	19878872
D011794	Quercetin	Quercetin results in decreased expression of EPHB4 mRNA	20596804
C017947	sodium arsenite	sodium arsenite results in decreased expression of EPHB4 mRNA	10910055
C017947	sodium arsenite	sodium arsenite results in decreased expression of EPHB4 mRNA	16014739
C004648	testosterone enanthate	testosterone enanthate affects the expression of EPHB4 mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of EPHB4 mRNA	21570461
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of EPHB4 gene	25560391
C088658	zoledronic acid	[zoledronic acid co-treated with Gossypol] results in decreased expression of EPHB4 mRNA	19825521

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	EXP	11580899
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IDA	8188704
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0005003	ephrin receptor activity	-	IDA	12734395 15930280
GO:0005005	transmembrane-ephrin receptor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	16867992 26481148
GO:0005524	ATP binding	-	IEA	-
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001525	angiogenesis	-	ISS	-
GO:0002042	cell migration involved in sprouting angiogenesis	-	IDA	12734395
GO:0003007	heart morphogenesis	-	ISS	-
GO:0007155	cell adhesion	-	IDA	12734395
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0030154	cell differentiation	-	IBA	21873635
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043410	positive regulation of MAPK cascade	-	IBA	21873635
GO:0046777	protein autophosphorylation	-	IDA	8188704
GO:0048013	ephrin receptor signaling pathway	-	IDA	12734395
GO:0048013	ephrin receptor signaling pathway	-	TAS	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IDA	8188704
GO:0043005	neuron projection	-	IBA	21873635
GO:0043235	receptor complex	-	IBA	21873635
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa04360	Axon guidance

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-2682334	EPH-Ephrin signaling	TAS
R-HSA-2682334	EPH-Ephrin signaling	IEA
R-HSA-3928662	EPHB-mediated forward signaling	TAS
R-HSA-3928662	EPHB-mediated forward signaling	IEA
R-HSA-3928664	Ephrin signaling	IEA
R-HSA-3928664	Ephrin signaling	TAS
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26676959	Shear stress, arterial identity and atherosclerosis. (2016 Mar)	Lehoux S	Thromb Haemost
22722787	Phase II study of the multitargeted tyrosine kinase inhibitor XL647 in patients with non-small-cell lung cancer. (2012 May)	Pietanza MC	J Thorac Oncol
17043250	The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma. (2006 Oct)	Sinha UK	Arch Otolaryngol Head Neck Surg
18000554	Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. (2007 Nov 14)	Mash DC	PLoS One