Gene: EPHB4

2050
HFASD|HTK|MYK1|TYRO11
EPH receptor B4
protein-coding
7q22.1
Ensembl:ENSG00000196411 MIM:600011 Vega:OTTHUMG00000157040 UniprotKB:P54760
NG_052671.1
PubMed
CD|ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.146e-1 (AD)  1.614e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH50.853
MMRN20.848
ACVRL10.845
DOCK60.844
MYO1C0.842
FGR0.841
PXN0.834
STARD80.832
PKN30.832
ACSL50.828

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.498
CRH-0.464
MARCH4-0.443
SLC7A4-0.437
ABCC12-0.429
PPEF1-0.418
KCNB2-0.408
SLC1A6-0.405
AARD-0.403
FSTL5-0.403

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01254DasatinibSmall Molecule302962-49-8Approved|InvestigationalTarget
DB07249N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amineSmall MoleculeExperimentalTarget
DB07250N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINESmall MoleculeExperimentalTarget
DB07251N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINESmall MoleculeExperimentalTarget
DB072523-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamideSmall MoleculeExperimentalTarget
DB07253N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineSmall MoleculeExperimentalTarget
DB07254N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDESmall MoleculeExperimentalTarget
DB07255N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINESmall MoleculeExperimentalTarget
DB072563-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDESmall MoleculeExperimentalTarget
DB11973TesevatinibSmall Molecule781613-23-8InvestigationalTarget
ID Drug Name Action PubMed
C0455751,2,4-triazole"1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of EPHB4 protein]"28693887
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of EPHB4 protein"25670856
D000082AcetaminophenAcetaminophen results in increased expression of EPHB4 mRNA22230336
D000880AnthraquinonesAnthraquinones analog results in decreased activity of EPHB4 protein27473261
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EPHB4 mRNA24449571
D001151ArsenicArsenic affects the methylation of EPHB4 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EPHB4 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of EPHB4 mRNA16705744
C044887beta-methylcholinebeta-methylcholine affects the expression of EPHB4 mRNA21179406
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of EPHB4 mRNA15336504
C584509C646 compoundC646 compound results in decreased expression of EPHB4 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of EPHB4 mRNA26472689
D002251Carbon Tetrachloride"1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of EPHB4 protein]"28693887
D002251Carbon Tetrachloride[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of EPHB4 protein28693887
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of EPHB4 mRNA24763279
D002994ClofibrateClofibrate results in decreased expression of EPHB4 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of EPHB4 mRNA19320972
D003042CocaineCocaine results in decreased expression of EPHB4 mRNA18000554
D003042CocaineCocaine affects the expression of EPHB4 mRNA15691709
D019327Copper SulfateCopper Sulfate results in decreased expression of EPHB4 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of EPHB4 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of EPHB4 mRNA25562108
D000069439DasatinibDasatinib binds to EPHB4 protein18180381
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of EPHB4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of EPHB4 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of EPHB4 mRNA26924002
D004052Diethylnitrosamine"1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of EPHB4 protein]"28693887
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of EPHB4 protein28693887
D019833GenisteinGenistein results in decreased expression of EPHB4 mRNA16705744
D006072Gossypol[zoledronic acid co-treated with Gossypol] results in decreased expression of EPHB4 mRNA19825521
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of EPHB4 mRNA24763279
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of EPHB4 mRNA25270620
D017313FenretinideFenretinide results in increased expression of EPHB4 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of EPHB4 mRNA27392435
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [[EPHB4 protein binds to EFNB2 protein] which results in increased phosphorylation of EPHB4 protein]21479221
D008727MethotrexateMethotrexate affects the expression of EPHB4 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EPHB4 mRNA28001369
C517284monomethyl phthalatemonomethyl phthalate affects the expression of EPHB4 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of EPHB4 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EPHB4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EPHB4 mRNA"25554681
D009966OrphenadrineOrphenadrine affects the expression of EPHB4 mRNA23665939
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of EPHB4 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of EPHB4 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of EPHB4 mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of EPHB4 mRNA19710929
C545373ponatinibponatinib results in decreased activity of EPHB4 protein19878872
D011794QuercetinQuercetin results in decreased expression of EPHB4 mRNA20596804
C017947sodium arsenitesodium arsenite results in decreased expression of EPHB4 mRNA10910055
C017947sodium arsenitesodium arsenite results in decreased expression of EPHB4 mRNA16014739
C004648testosterone enanthatetestosterone enanthate affects the expression of EPHB4 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPHB4 mRNA21570461
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EPHB4 gene25560391
C088658zoledronic acid[zoledronic acid co-treated with Gossypol] results in decreased expression of EPHB4 mRNA19825521

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-EXP11580899  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IDA8188704  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005003ephrin receptor activity-IDA12734395  15930280  
GO:0005005transmembrane-ephrin receptor activity-IBA21873635  
GO:0005515protein binding-IPI16867992  26481148  
GO:0005524ATP binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-ISS-  
GO:0002042cell migration involved in sprouting angiogenesis-IDA12734395  
GO:0003007heart morphogenesis-ISS-  
GO:0007155cell adhesion-IDA12734395  
GO:0007275multicellular organism development-IBA21873635  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0046777protein autophosphorylation-IDA8188704  
GO:0048013ephrin receptor signaling pathway-IDA12734395  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA8188704  
GO:0043005neuron projection-IBA21873635  
GO:0043235receptor complex-IBA21873635  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-3928662EPHB-mediated forward signalingIEA
R-HSA-3928664Ephrin signalingIEA
R-HSA-3928664Ephrin signalingTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26676959Shear stress, arterial identity and atherosclerosis. (2016 Mar)Lehoux SThromb Haemost
22722787Phase II study of the multitargeted tyrosine kinase inhibitor XL647 in patients with non-small-cell lung cancer. (2012 May)Pietanza MCJ Thorac Oncol
17043250The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma. (2006 Oct)Sinha UKArch Otolaryngol Head Neck Surg
18000554Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. (2007 Nov 14)Mash DCPLoS One