Gene: EPHB6

2051
HEP
EPH receptor B6
protein-coding
7q34
Ensembl:ENSG00000106123 MIM:602757 Vega:OTTHUMG00000155707 UniprotKB:O15197
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.727e-1 (AD)  6.888e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNM10.97
STX1B0.967
KLC20.962
SCAMP50.96
SYT70.958
PHYHIP0.957
GRIN10.957
KCNJ40.956
GABRD0.953
CAMK2B0.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.581
OR4F29-0.539
TFPI2-0.507
WWTR1-0.495
ZNF114-0.49
C9orf135-0.488
REST-0.487
RAI14-0.482
AGTR1-0.476
DNAI2-0.475

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of EPHB6 mRNA"26377693
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EPHB6 mRNA"21346803
D020106AcrylamideAcrylamide results in increased expression of EPHB6 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EPHB6 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EPHB6 mRNA22100608
D006710HomocysteineHomocysteine results in decreased expression of EPHB6 mRNA17320366
D001622BetaineBetaine results in increased expression of EPHB6 mRNA26391144
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPHB6 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of EPHB6 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EPHB6 mRNA28628672
C018475butyraldehydebutyraldehyde results in increased expression of EPHB6 mRNA26079696
D003042CocaineCocaine affects the expression of EPHB6 mRNA15691709
D016572CyclosporineCyclosporine results in decreased expression of EPHB6 mRNA20106945|2798913
C014347decitabinedecitabine results in increased expression of EPHB6 mRNA27915011
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPHB6 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EPHB6 mRNA28628672
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene affects the expression of EPHB6 mRNA"26496743
D002945CisplatinCisplatin results in increased expression of EPHB6 mRNA27594783
D004041Dietary FatsDietary Fats results in increased expression of EPHB6 mRNA25016146
C058705diethyl malatediethyl malate affects the expression of EPHB6 mRNA24814887
D002117CalcitriolCalcitriol results in increased expression of EPHB6 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of EPHB6 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of EPHB6 mRNA"22485181
D005492Folic AcidFolic Acid affects the expression of EPHB6 mRNA17320366
C039281furanfuran results in decreased expression of EPHB6 mRNA25539665|2619464
D007052IbuprofenIbuprofen affects the expression of EPHB6 mRNA17070997
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of EPHB6 mRNA"26377693
C016517indole-3-carbinolindole-3-carbinol affects the expression of EPHB6 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPHB6 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EPHB6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPHB6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EPHB6 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EPHB6 mRNA23086925
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EPHB6 mRNA23519560
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of EPHB6 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EPHB6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EPHB6 mRNA"25554681
D009532NickelNickel results in decreased expression of EPHB6 mRNA24768652
C029938nickel sulfatenickel sulfate results in increased expression of EPHB6 mRNA18651567
C025589ochratoxin Aochratoxin A results in increased acetylation of EPHB6 promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of EPHB6 promoter] which results in increased expression of EPHB6 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of EPHB6 mRNA29098329
D011192Potassium DichromatePotassium Dichromate results in decreased expression of EPHB6 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of EPHB6 mRNA24780913
C116926rofecoxibrofecoxib results in decreased expression of EPHB6 mRNA17070997
D012643SeleniumSelenium results in increased expression of EPHB6 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EPHB6 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of EPHB6 mRNA23806026
D012834SilverSilver results in decreased expression of EPHB6 mRNA27131904
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of EPHB6 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of EPHB6 mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of EPHB6 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPHB6 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EPHB6 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EPHB6 mRNA23519560
D013853ThioacetamideThioacetamide results in decreased expression of EPHB6 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of EPHB6 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of EPHB6 mRNA23830798
C113580U 0126U 0126 results in increased expression of EPHB6 mRNA17320366
D014520UrethaneUrethane results in increased expression of EPHB6 mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EPHB6 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-EXP11580899  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005003ephrin receptor activity-IEA-  
GO:0005005transmembrane-ephrin receptor activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0038023signaling receptor activity-TAS9207182  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IBA21873635  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-3928662EPHB-mediated forward signalingIEA
R-HSA-3928664Ephrin signalingIEA
R-HSA-3928664Ephrin signalingTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24451080Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients. (2013)Szymanowska-Narloch AAdv Med Sci