Gene info: ID 2052

Gene: EPHX1

GENE ID: 2052

Synonyms: EPHX|EPOX|HYL1|MEH

Description: epoxide hydrolase 1

Gene type: protein-coding

Location: 1q42.12

dbXrefs: Ensembl:ENSG00000143819 MIM:132810 Vega:OTTHUMG00000037743 UniprotKB:P07099

RefSeq: NG_009776.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 71

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.817e-1 (AD) 3.665e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PBXIP1	0.911
METTL7A	0.89
UNG	0.885
TP53BP2	0.883
IL17RB	0.88
TBL1X	0.877
SOX9	0.877
SLC25A20	0.875
TPD52L1	0.865
PON2	0.86

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
COL19A1	-0.475
TYRP1	-0.472
GABRG3	-0.468
MCHR1	-0.467
OR4F5	-0.467
ZNF860	-0.464
OR4F29	-0.463
CDH7	-0.457
ARHGAP20	-0.456
IL12RB2	-0.452

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C004822	10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide	"[EPHX1 gene SNP affects the metabolism of carbamazepine epoxide] which affects the chemical synthesis of 10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide"	15692831
C004822	10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide	"[EPHX1 protein results in increased metabolism of carbamazepine epoxide] which results in increased chemical synthesis of 10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide"	15692831
C026486	1,2,5,6-dibenzanthracene	"EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of 1,2,5,6-dibenzanthracene]"	8961944
C026486	1,2,5,6-dibenzanthracene	"EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of 1,2,5,6-dibenzanthracene]"	8961944
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of EPHX1 mRNA"	26377693
C026486	1,2,5,6-dibenzanthracene	"EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of 1,2,5,6-dibenzanthracene]"	8961944
C026486	1,2,5,6-dibenzanthracene	"EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of 1,2,5,6-dibenzanthracene]"	8961944
C012277	1,2-diamino-4-nitrobenzene	"1,2-diamino-4-nitrobenzene results in increased expression of EPHX1 mRNA"	17070881
C042334	1,2-dihydroxy-1,2-dihydronaphthalene	"[EPHX1 protein results in increased metabolism of naphthalene] which results in increased chemical synthesis of 1,2-dihydroxy-1,2-dihydronaphthalene"	18363382\|2684074
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of EPHX1 mRNA"	19162173\|1969523
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of EPHX1 protein	22527513
C031763	1,3-butadiene	"EPHX1 5' UTR polymorphism results in increased susceptibility to 1,3-butadiene"	15716486
C031763	1,3-butadiene	"EPHX1 gene polymorphism results in increased susceptibility to 1,3-butadiene"	11238181\|1260538
C031763	1,3-butadiene	"GSTM1 gene polymorphism promotes the reaction [EPHX1 gene polymorphism results in increased susceptibility to 1,3-butadiene]"	11238181
C031763	1,3-butadiene	"GSTT1 gene polymorphism promotes the reaction [EPHX1 gene polymorphism results in increased susceptibility to 1,3-butadiene]"	11238181
C031763	1,3-butadiene	"EPHX1 gene mutant form results in increased susceptibility to 1,3-butadiene"	12929123\|1673068
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea results in increased expression of EPHX1 mRNA"	10190572
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea results in increased expression of EPHX1 protein"	10190572
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of EPHX1 mRNA"	19850644\|2269881
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of EPHX1 mRNA]"	19850644
C034086	1,5-naphthalenediamine	"1,5-naphthalenediamine affects the expression of EPHX1 mRNA"	17114358
C034086	1,5-naphthalenediamine	"1,5-naphthalenediamine results in increased expression of EPHX1 mRNA"	17311802
C035314	1-nitropropane	1-nitropropane results in decreased expression of EPHX1 mRNA	17070881
C060080	2,2-bis(bromomethyl)-1,3-propanediol	"2,2-bis(bromomethyl)-1,3-propanediol results in increased expression of EPHX1 mRNA"	17311802
C492600	(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate	"(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate affects the expression of EPHX1 mRNA"	19176366
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of EPHX1 mRNA"	20702594
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of EPHX1 mRNA"	17547211
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of EPHX1 mRNA"	28433925
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased activity of EPHX1 protein"	1372805
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of EPHX1 mRNA"	17070881
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene results in increased activity of EPHX1 protein"	3621371
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of EPHX1 mRNA"	21346803
C025235	2,6-diaminotoluene	"2,6-diaminotoluene results in decreased expression of EPHX1 mRNA"	17070881
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of EPHX1 mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of EPHX1 mRNA"	12376462
C014706	2-nitro-4-phenylenediamine	2-nitro-4-phenylenediamine results in increased expression of EPHX1 mRNA	17070881
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of EPHX1 mRNA	14600272\|1589037
C016617	2-nitropropane	2-nitropropane results in increased expression of EPHX1 mRNA	17070881
C488464	2-propenyl thiosulfate	2-propenyl thiosulfate results in increased expression of EPHX1 mRNA	20650352
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of EPHX1 exon	24704207
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of EPHX1 protein alternative form	24704207
C018855	2-tert-butylhydroquinone	NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of EPHX1 exon]	24704207
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of EPHX1 mRNA	20650352
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of EPHX1 mRNA"	23994337
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of EPHX1 mRNA"	20959002
C026308	3,4-dihydrocoumarin	"3,4-dihydrocoumarin results in decreased expression of EPHX1 mRNA"	22016648
C509288	3',4'-dimethoxyflavone	"3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of EPHX1 protein]"	16484233
C050224	3,5,5-trimethylhexanoylferrocene	"3,5,5-trimethylhexanoylferrocene results in increased expression of EPHX1 protein"	22649188
C473484	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of EPHX1 mRNA	14610520
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHX1 mRNA"	27188386
C028676	4-acetylaminofluorene	4-acetylaminofluorene results in increased expression of EPHX1 mRNA	17070881
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of EPHX1 mRNA"	21346803
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of EPHX1 mRNA	19191707
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of EPHX1 mRNA	14600272\|1589037
C029370	4-toluidine	4-toluidine results in increased expression of EPHX1 mRNA	27638505
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide results in increased expression of EPHX1 mRNA	22061827
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide results in increased expression of EPHX1 protein	22061827
C012606	4-vinyl-1-cyclohexene dioxide	EPHX1 protein results in increased metabolism of 4-vinyl-1-cyclohexene dioxide	22061827
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide results in decreased expression of EPHX1 mRNA	8806858
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide results in increased expression of EPHX1 mRNA	22061827\|8806858
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide results in increased expression of EPHX1 protein	22061827
C012606	4-vinyl-1-cyclohexene dioxide	[cyclohexene oxide results in decreased activity of EPHX1 protein] which results in increased susceptibility to 4-vinyl-1-cyclohexene dioxide	22061827
C012606	4-vinyl-1-cyclohexene dioxide	EPHX1 protein results in increased metabolism of 4-vinyl-1-cyclohexene dioxide	22061827
C522589	5,6-dihydrocyclopenta-1,2-dithiole-3-thione	"5,6-dihydrocyclopenta-1,2-dithiole-3-thione results in increased expression of EPHX1 mRNA"	19695238
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHX1 mRNA"	27188386
C024024	7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol	"EPHX1 results in increased chemical synthesis of 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol"	19027032
C050715	8,9-epoxyeicosatrienoic acid	"EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid"	28975360
C046665	9,10-epoxy-9,10-dihydrophenanthrene	"EPHX1 protein mutant form results in increased metabolism of 9,10-epoxy-9,10-dihydrophenanthrene"	26838043
D000082	Acetaminophen	Acetaminophen results in increased expression of EPHX1 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of EPHX1 mRNA	15606129\|1756273
D000082	Acetaminophen	[Acetaminophen results in increased activity of and results in increased localization of NFE2L2 protein] which results in increased expression of EPHX1 mRNA	15122755
D020106	Acrylamide	EPHX1 gene polymorphism affects the metabolism of Acrylamide	21402133
D020106	Acrylamide	[EPHX1 gene polymorphism affects the metabolism of Acrylamide] which affects the chemical synthesis of glycidamide analog	21402133
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of EPHX1 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of EPHX1 gene	27153756
D016604	Aflatoxin B1	EPHX1 gene mutant form results in increased susceptibility to Aflatoxin B1	7892276
D016604	Aflatoxin B1	EPHX1 gene SNP affects the susceptibility to Aflatoxin B1	12907637
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of EPHX1 mRNA	14600272\|1589037
C052669	aflatoxin B1-bovine serum albumin	EPHX1 gene mutant form results in increased abundance of aflatoxin B1-bovine serum albumin	7892276
D000348	Aflatoxins	EPHX1 gene polymorphism results in increased susceptibility to Aflatoxins	15734960
C038491	allyl sulfide	allyl sulfide results in increased activity of EPHX1 protein	1372805
C038491	allyl sulfide	allyl sulfide results in increased expression of EPHX1 mRNA	19695238
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of EPHX1 mRNA	28522335
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in increased activity of EPHX1 protein	1372805
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in increased expression of EPHX1 mRNA	16940010
D000638	Amiodarone	Amiodarone affects the expression of EPHX1 mRNA	18355885
D000639	Amitriptyline	Amitriptyline affects the expression of EPHX1 mRNA	18355885
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of EPHX1 mRNA	16483693
C023650	aniline	aniline results in increased expression of EPHX1 mRNA	22016648
C526219	apple polyphenol extract	apple polyphenol extract results in decreased expression of EPHX1 mRNA	16369997
C005752	araldite	araldite promotes the reaction [EPHX1 protein results in increased metabolism of stilbene oxide analog]	2043152
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of EPHX1 mRNA	23912714
C000228	aristolochic acid I	aristolochic acid I results in increased expression of EPHX1 mRNA	17483316
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of EPHX1 mRNA	23912714
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of EPHX1 mRNA	17547211
C015001	arsenite	arsenite results in increased expression of EPHX1 mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in increased expression of EPHX1 mRNA]	18929588
D001194	Asbestos	EPHX1 gene polymorphism affects the susceptibility to Asbestos	17159790
D001194	Asbestos	EPHX1 protein affects the susceptibility to Asbestos	15993904
D001205	Ascorbic Acid	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of EPHX1 mRNA	17639512
D001280	Atrazine	Atrazine results in increased expression of EPHX1 mRNA	25929836
D001280	Atrazine	Atrazine results in increased expression of EPHX1 mRNA	22378314
D001379	Azathioprine	Azathioprine results in increased expression of EPHX1 mRNA	22623647
D001463	Barbiturates	Barbiturates results in increased activity of EPHX1 protein	1372805
C030935	benz(a)anthracene	EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of benz(a)anthracene]	8961944
C030935	benz(a)anthracene	EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of benz(a)anthracene]	8961944
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of EPHX1 protein	2208584
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPHX1 mRNA	27858113
C030935	benz(a)anthracene	EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of benz(a)anthracene]	8961944
C030935	benz(a)anthracene	EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of benz(a)anthracene]	8961944
D001554	Benzene	EPHX1 polymorphism affects the susceptibility to Benzene	18784359\|1883692
D001554	Benzene	EPHX1 protein affects the metabolism of Benzene	10511268
D001554	Benzene	[EPHX1 protein affects the metabolism of Benzene] which affects the abundance of muconic acid	10511268
D001554	Benzene	EPHX1 protein results in increased metabolism of Benzene	17885617
D001554	Benzene	Benzene results in increased expression of EPHX1 mRNA	17311802
D001554	Benzene	EPHX1 protein affects the reaction [Benzene results in increased expression of CDKN1A mRNA]	12655032
D001554	Benzene	EPHX1 protein affects the susceptibility to Benzene	12655032
D001554	Benzene	Benzene affects the expression of EPHX1 mRNA	15878777
D001554	Benzene	EPHX1 protein promotes the reaction [CYP2E1 protein results in increased metabolism of Benzene]	8211999
D001554	Benzene	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of Benzene metabolite]	8211999
D001554	Benzene	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone]	8211999
D001554	Benzene	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of Phenol]	8211999
C015700	benzo-1,2,3-thiadiazole	"benzo-1,2,3-thiadiazole results in increased expression of EPHX1 mRNA"	8951341
C017228	benzo(a)pyrene 7,8-dihydrodiol	"[[CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol"	24530354
C043931	benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA	"EPHX1 gene SNP affects the reaction [Coal Tar results in increased abundance of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]"	27188524
C023393	benzo(a)pyrene 7,8-oxide	"CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of benzo(a)pyrene 7,8-oxide]"	12051674
C056612	benzo(a)pyrene-DNA adduct	EPHX1 protein affects the reaction [CYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]]	24530354
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPHX1 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of EPHX1 mRNA	26377693
C002615	benzo(c)phenanthrene	EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of benzo(c)phenanthrene]	8961944
C002615	benzo(c)phenanthrene	EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of benzo(c)phenanthrene]	8961944
C002615	benzo(c)phenanthrene	EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of benzo(c)phenanthrene]	8961944
C002615	benzo(c)phenanthrene	EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of benzo(c)phenanthrene]	8961944
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of EPHX1 mRNA	22258563
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased activity of EPHX1 protein	3621371
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of EPHX1 mRNA	23994337
C105430	benzofuran	benzofuran affects the expression of EPHX1 mRNA	17114358
C105430	benzofuran	benzofuran results in increased expression of EPHX1 mRNA	17311802
D001564	Benzo(a)pyrene	"3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of EPHX1 protein]"	16484233
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased activity of EPHX1 protein	16484233
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of EPHX1 mRNA	15735009\|1654541
D001564	Benzo(a)pyrene	EPHX1 protein polymorphism affects the metabolism of and results in increased activity of Benzo(a)pyrene	15298956
D001564	Benzo(a)pyrene	EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of Benzo(a)pyrene]	8961944
D001564	Benzo(a)pyrene	EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Benzo(a)pyrene]	8961944
D001564	Benzo(a)pyrene	resveratrol promotes the reaction [Benzo(a)pyrene results in increased activity of EPHX1 protein]	16484233
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPHX1 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of EPHX1 mRNA	19770486\|2156981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of EPHX1 protein	22759596
D001564	Benzo(a)pyrene	EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of Benzo(a)pyrene]	8961944
D001564	Benzo(a)pyrene	EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Benzo(a)pyrene]	8961944
D001564	Benzo(a)pyrene	POR protein affects the reaction [Benzo(a)pyrene results in increased expression of EPHX1 protein]	22759596
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with TNF protein] results in increased expression of EPHX1 mRNA	24025706
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of EPHX1 mRNA	24025706
D001564	Benzo(a)pyrene	[CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene	24530354
D001564	Benzo(a)pyrene	"[[CYP1A1 protein co-treated with POR protein co-treated with EPHX1 protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene 7,8-dihydrodiol"	24530354
D001564	Benzo(a)pyrene	EPHX1 protein affects the reaction [CYB5A protein promotes the reaction [[[CYP1A1 protein co-treated with POR protein] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-DNA adduct]]	24530354
C005465	benzothiazole	benzothiazole results in increased expression of EPHX1 mRNA	8951341
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EPHX1 mRNA	20061341
D004958	Estradiol	Estradiol affects the expression of EPHX1 mRNA	14699072
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of EPHX1 mRNA	26496021
C095105	bexarotene	bexarotene results in increased expression of EPHX1 mRNA	23292798
C099952	bifenthrin	bifenthrin results in increased expression of EPHX1 mRNA	26071804
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of EPHX1 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of EPHX1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of EPHX1 mRNA	29275510
C006780	bisphenol A	EPHX1 polymorphism affects the susceptibility to bisphenol A	26922413
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPHX1 mRNA	28628672
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of EPHX1 mRNA"	28433925
C006780	bisphenol A	bisphenol A affects the expression of EPHX1 mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of EPHX1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of EPHX1 protein	24752506
C006780	bisphenol A	bisphenol A results in increased expression of EPHX1 mRNA	27208089
C006780	bisphenol A	bisphenol A results in increased expression of EPHX1 protein	27208089
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EPHX1 mRNA	28628672
C584056	BMS-764459	BMS-764459 results in increased expression of EPHX1 mRNA	23831372
C032036	bromobenzene	bromobenzene results in increased expression of EPHX1 mRNA	12628495\|1753823
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of EPHX1 mRNA	22079614
D002065	Buspirone	Buspirone results in decreased expression of EPHX1 mRNA	24136188
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased activity of EPHX1 protein	3621371
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of EPHX1 mRNA	21382384
C018475	butyraldehyde	butyraldehyde results in decreased expression of EPHX1 mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of EPHX1 mRNA	17327699
C028031	cadmium acetate	cadmium acetate affects the expression of EPHX1 mRNA	16249259
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of EPHX1 mRNA	20061341
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of EPHX1 mRNA	24982889
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of EPHX1 mRNA	25993096
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of EPHX1 mRNA	17327699
D002220	Carbamazepine	Carbamazepine results in increased expression of EPHX1 mRNA	17112801
D002220	Carbamazepine	EPHX1 gene SNP affects the susceptibility to Carbamazepine	19620853
D002220	Carbamazepine	EPHX1 protein affects the susceptibility to Carbamazepine	26555147
D002220	Carbamazepine	Carbamazepine results in increased expression of EPHX1 mRNA	17381134
C012227	carbamazepine epoxide	"[EPHX1 gene SNP affects the metabolism of carbamazepine epoxide] which affects the chemical synthesis of 10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide"	15692831
C012227	carbamazepine epoxide	"[EPHX1 protein results in increased metabolism of carbamazepine epoxide] which results in increased chemical synthesis of 10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide"	15692831
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of EPHX1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of EPHX1 mRNA	21994235
D002251	Carbon Tetrachloride	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in decreased expression of EPHX1 mRNA]	21994235
D002251	Carbon Tetrachloride	thymoquinone inhibits the reaction [Carbon Tetrachloride results in decreased expression of EPHX1 mRNA]	21994235
D002330	Carmustine	Carmustine results in decreased expression of EPHX1 mRNA	15980968
C034221	catechol	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of catechol]	8211999
C028770	chalcone epoxide	chalcone epoxide results in increased activity of EPHX1 protein	3621371
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased expression of EPHX1 mRNA	27174168
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of EPHX1 mRNA	17851650
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of EPHX1 mRNA	18178546
D002737	Chloroprene	Chloroprene results in increased expression of EPHX1 mRNA	23125180
C002415	cholesterol alpha-oxide	disparlure promotes the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]	2043152
C002415	cholesterol alpha-oxide	EPHX1 protein results in increased metabolism of cholesterol alpha-oxide	2043152
C002415	cholesterol alpha-oxide	Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]	2043152
C031180	chrysene	EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of chrysene]	8961944
C031180	chrysene	EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of chrysene]	8961944
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPHX1 mRNA	27858113
C031180	chrysene	EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of chrysene]	8961944
C031180	chrysene	EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of chrysene]	8961944
C050403	chrysene-5,6-oxide	"EPHX1 protein results in increased metabolism of chrysene-5,6-oxide"	3037304
D002922	Ciguatoxins	Ciguatoxins affects the expression of EPHX1 mRNA	18353800
D002994	Clofibrate	Clofibrate results in increased activity of EPHX1 protein	3621371
D002994	Clofibrate	Clofibrate results in increased expression of EPHX1 protein	3318844\|4049385
D002994	Clofibrate	Clofibrate results in decreased activity of EPHX1 protein	10528994
D002997	Clomipramine	Clomipramine affects the expression of EPHX1 mRNA	18355885
D002998	Clonazepam	Clonazepam results in increased activity of EPHX1 protein	1372805
D003022	Clotrimazole	Clotrimazole results in increased activity of EPHX1 protein	1372805
D003033	Coal Tar	"EPHX1 gene SNP affects the reaction [Coal Tar results in increased abundance of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]"	27188524
D003033	Coal Tar	Coal Tar results in increased expression of EPHX1 mRNA	27858113
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of EPHX1 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in increased expression of EPHX1 mRNA	19320972
D005576	Colforsin	Colforsin affects the expression of EPHX1 mRNA	20726872
D005576	Colforsin	Valproic Acid affects the reaction [Colforsin affects the expression of EPHX1 mRNA]	20726872
D003300	Copper	[Thiosemicarbazones binds to Copper] which results in decreased expression of EPHX1 protein	20931265
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of EPHX1 mRNA	19549813
C030123	coumarin	coumarin results in increased expression of EPHX1 mRNA	17311802
D003471	Cuprizone	Cuprizone results in increased expression of EPHX1 mRNA	27523638
C007193	cyclohexene oxide	"[cyclohexene oxide results in decreased activity of EPHX1 protein] which results in decreased susceptibility to 9,10-Dimethyl-1,2-benzanthracene"	17204581
C007193	cyclohexene oxide	cyclohexene oxide results in decreased activity of EPHX1 protein	1500033\|22061827
C007193	cyclohexene oxide	[cyclohexene oxide results in decreased activity of EPHX1 protein] which results in increased susceptibility to 4-vinyl-1-cyclohexene dioxide	22061827
C007193	cyclohexene oxide	cyclohexene oxide results in decreased activity of EPHX1 protein	17204581
D003520	Cyclophosphamide	Cyclophosphamide affects the expression of EPHX1 mRNA	18246545
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of EPHX1 mRNA	18246545
D016572	Cyclosporine	Cyclosporine results in decreased expression of EPHX1 mRNA	20106945\|2798913
C017160	cypermethrin	cypermethrin results in increased expression of EPHX1 mRNA	22528246
C093628	cyproconazole	cyproconazole affects the expression of EPHX1 mRNA	21621602
C093628	cyproconazole	cyproconazole results in increased expression of EPHX1 mRNA	22334560
C093628	cyproconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of EPHX1 mRNA	29038839
C093628	cyproconazole	cyproconazole results in increased expression of EPHX1 mRNA	29038839
D015084	2,4-Dichlorophenoxyacetic Acid	"2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX1 protein"	3032197
D000069439	Dasatinib	Dasatinib results in increased expression of EPHX1 mRNA	20579391
D003634	DDT	DDT results in increased activity of EPHX1 protein	1372805
C014347	decitabine	decitabine results in increased expression of EPHX1 mRNA	19194470
D003671	DEET	DEET results in increased expression of EPHX1 mRNA	27091632
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of EPHX1 mRNA	15371230
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of EPHX1 mRNA]	27941970
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of EPHX1 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPHX1 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EPHX1 mRNA	28628672
C042577	diallyl trisulfide	diallyl trisulfide results in increased expression of EPHX1 mRNA	20650352
D003976	Diazinon	Diazinon results in decreased expression of EPHX1 mRNA	17311802
C061481	dibenzoylmethane	dibenzoylmethane results in increased activity of EPHX1 protein	3621371
C061481	dibenzoylmethane	dibenzoylmethane results in increased expression of EPHX1 mRNA	17942926
C061481	dibenzoylmethane	[sulforafan co-treated with dibenzoylmethane] results in increased expression of EPHX1 mRNA	17942926
D015946	Ethylene Dibromide	Ethylene Dibromide results in decreased expression of EPHX1 mRNA	17311802
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of EPHX1 mRNA	17361019
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of EPHX1 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of EPHX1 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of EPHX1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of EPHX1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of EPHX1 mRNA	21151649\|2138238
D002945	Cisplatin	Cisplatin affects the expression of EPHX1 mRNA	18246545
D002945	Cisplatin	Cisplatin results in increased expression of EPHX1 mRNA	18246545
D004008	Diclofenac	Diclofenac results in decreased expression of EPHX1 mRNA	17202759
C121718	dicyclanil	dicyclanil results in increased expression of EPHX1 mRNA	15664270
D004026	Dieldrin	Dieldrin promotes the reaction [EPHX1 protein results in increased metabolism of stilbene oxide]	2043152
D004041	Dietary Fats	Dietary Fats affects the expression of EPHX1 mRNA	19680557
D004042	Dietary Fats, Unsaturated	"Dietary Fats, Unsaturated results in increased expression of EPHX1 mRNA"	23626681
D004042	Dietary Fats, Unsaturated	"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of EPHX1 mRNA"	23626681
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased activity of EPHX1 protein	3621371
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of EPHX1 mRNA	19850644
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of EPHX1 protein	3318844
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of EPHX1 mRNA"	28433925
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased activity of EPHX1 protein	10528994
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of EPHX1 mRNA	17854601\|2160768
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of EPHX1 mRNA]	17854601
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of EPHX1 mRNA	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of EPHX1 mRNA	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of EPHX1 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of EPHX1 mRNA	17602206\|1963824
D004052	Diethylnitrosamine	[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of EPHX1 protein	20935162
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of EPHX1 mRNA	15890375
C035318	diethylthiourea	diethylthiourea results in increased expression of EPHX1 mRNA	10190572
C035318	diethylthiourea	diethylthiourea results in increased expression of EPHX1 protein	10190572
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of EPHX1 mRNA	27638505
D015127	9,10-Dimethyl-1,2-benzanthracene	"EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]"	8961944
D015127	9,10-Dimethyl-1,2-benzanthracene	"EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]"	8961944
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of EPHX1 mRNA"	17204581\|1902703
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of EPHX1 protein"	17204581
D015127	9,10-Dimethyl-1,2-benzanthracene	"[cyclohexene oxide results in decreased activity of EPHX1 protein] which results in decreased susceptibility to 9,10-Dimethyl-1,2-benzanthracene"	17204581
D015127	9,10-Dimethyl-1,2-benzanthracene	"EPHX1 protein affects the susceptibility to 9,10-Dimethyl-1,2-benzanthracene"	15331171\|1744266
D015127	9,10-Dimethyl-1,2-benzanthracene	"EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]"	8961944
D015127	9,10-Dimethyl-1,2-benzanthracene	"EPHX1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]"	8961944
D015127	9,10-Dimethyl-1,2-benzanthracene	"EPHX1 protein results in increased metabolism of and results in increased activity of 9,10-Dimethyl-1,2-benzanthracene"	17442664
D015127	9,10-Dimethyl-1,2-benzanthracene	"EPHX1 protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene"	11323178
D015127	9,10-Dimethyl-1,2-benzanthracene	"EPHX1 results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene"	19027032
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of EPHX1 mRNA"	12376462
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of EPHX1 mRNA"	19027032\|2457672
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of EPHX1 protein"	19027032
D015127	9,10-Dimethyl-1,2-benzanthracene	"EPHX1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene"	22061827\|2544868
D015127	9,10-Dimethyl-1,2-benzanthracene	"EPHX1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene metabolite"	17204581
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of EPHX1 mRNA	14600272\|1589037
C032788	diphenylthiourea	diphenylthiourea results in increased expression of EPHX1 mRNA	10190572
C032788	diphenylthiourea	diphenylthiourea results in increased expression of EPHX1 protein	10190572
C001150	disparlure	disparlure promotes the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]	2043152
D004237	Diuron	Diuron results in increased expression of EPHX1 mRNA	21551480
D004317	Doxorubicin	Doxorubicin results in increased expression of EPHX1 mRNA	15205334
D004317	Doxorubicin	Doxorubicin results in increased expression of EPHX1 mRNA	21382384\|2201664
D004317	Doxorubicin	Doxorubicin results in increased expression of EPHX1 mRNA	19915844
D004391	Dust	Dust results in decreased expression of EPHX1 mRNA	17805423
C109476	epoxiconazole	epoxiconazole results in increased expression of EPHX1 mRNA	22334560
C109476	epoxiconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of EPHX1 mRNA	29038839
C109476	epoxiconazole	epoxiconazole results in increased expression of EPHX1 mRNA	25182419
C073539	erucin	erucin results in increased expression of EPHX1 protein	21132492
C007366	erythritol anhydride	EPHX1 gene polymorphism affects the susceptibility to erythritol anhydride	15036125
C007366	erythritol anhydride	EPHX1 gene mutant form results in increased susceptibility to erythritol anhydride	12929123
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in decreased expression of EPHX1 protein	24752506
D000431	Ethanol	Ethanol results in increased expression of EPHX1 mRNA	23273579
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of EPHX1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of EPHX1 mRNA	16174780
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of EPHX1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EPHX1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of EPHX1 mRNA	16174780\|2909715
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of EPHX1 mRNA	16926038
C034096	ethoxyacetic acid	ethoxyacetic acid affects the expression of EPHX1 mRNA	21621602
D005015	Ethoxyquin	Ethoxyquin results in increased expression of EPHX1 mRNA	19695238
D005027	Ethylene Oxide	EPHX1 protein affects the metabolism of Ethylene Oxide	11437638
D005027	Ethylene Oxide	EPHX1 protein affects the metabolism of Ethylene Oxide	11437638
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased expression of EPHX1 mRNA	15954086
C100167	ethylphenylepoxygeranyl ether	ethylphenylepoxygeranyl ether promotes the reaction [EPHX1 protein results in increased metabolism of stilbene oxide]	2043152
C098546	ethyl tert-butyl ether	ethyl tert-butyl ether results in increased expression of EPHX1 protein	24090815
D005047	Etoposide	Etoposide results in increased expression of EPHX1 mRNA	21382384\|2527062
C047360	felbamate	felbamate results in increased expression of EPHX1 mRNA	17381134
C540355	fenamidone	fenamidone results in increased expression of EPHX1 mRNA	27029645
C017690	fenvalerate	fenvalerate metabolite results in increased activity of EPHX1 protein	10630566
D018120	Finasteride	Finasteride results in increased expression of EPHX1 mRNA	24136188
C082360	fipronil	fipronil results in increased expression of EPHX1 mRNA	23962444
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of EPHX1 mRNA	17317680\|2160768
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of EPHX1 mRNA	17070881
D005472	Fluorouracil	EPHX1 protein affects the susceptibility to Fluorouracil	16217747
D005472	Fluorouracil	Fluorouracil results in increased expression of EPHX1 mRNA	15205334
C061365	flusilazole	flusilazole affects the expression of EPHX1 mRNA	21621602
D005485	Flutamide	Flutamide results in increased expression of EPHX1 mRNA	24136188
C056933	fumonisin B1	fumonisin B1 results in increased expression of EPHX1 mRNA	16221962
C039281	furan	furan results in increased expression of EPHX1 mRNA	24183702
C039281	furan	furan results in increased expression of EPHX1 mRNA	25539665\|2619464
C039281	furan	furan results in increased methylation of EPHX1 gene	22079235
D019833	Genistein	Genistein results in increased expression of EPHX1 mRNA	18847459
D005897	Glafenine	Glafenine results in decreased expression of EPHX1 mRNA	24136188
C119493	glucoerucin	glucoerucin results in increased expression of EPHX1 protein	21132492
C119494	glucoraphanin	glucoraphanin results in increased expression of EPHX1 protein	21132492
D005978	Glutathione	Glutathione deficiency results in increased expression of EPHX1 mRNA	15345336
C071834	glycidamide	[CYP2E1 gene polymorphism co-treated with EPHX1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the abundance of glycidamide	19131562
C071834	glycidamide	[CYP2E1 gene polymorphism co-treated with EPHX1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of glycidamide	19131562
C071834	glycidamide	[EPHX1 gene polymorphism affects the metabolism of Acrylamide] which affects the chemical synthesis of glycidamide analog	21402133
C071834	glycidamide	glycidamide results in increased expression of EPHX1 mRNA	17822822
C071834	glycidamide	glycidamide results in increased expression of EPHX1 protein	17822822
C010176	halofuginone	halofuginone results in increased expression of EPHX1 mRNA	17180598
D006534	Heptachlor Epoxide	Heptachlor Epoxide promotes the reaction [EPHX1 protein results in increased metabolism of stilbene oxide]	2043152
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of EPHX1 mRNA	15159207
C001335	hexachlorobutadiene	hexachlorobutadiene results in increased expression of EPHX1 mRNA	21905055
D008742	Methyl n-Butyl Ketone	Methyl n-Butyl Ketone results in increased activity of EPHX1 protein	1372805
D017313	Fenretinide	Fenretinide results in increased expression of EPHX1 mRNA	28973697
C012351	HT-2 toxin	HT-2 toxin results in increased expression of EPHX1 mRNA	22982764
D006827	Hydantoins	Hydantoins results in increased activity of EPHX1 protein	1372805
D006841	Hydrocarbons, Aromatic	"EPHX1 protein affects the metabolism of Hydrocarbons, Aromatic"	12359356
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of EPHX1 mRNA	21382384
C031927	hydroquinone	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone]	8211999
C031927	hydroquinone	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of hydroquinone]	8211999
D007099	Imipramine	Imipramine affects the expression of EPHX1 mRNA	18355885
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of EPHX1 mRNA	21396975
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of EPHX1 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPHX1 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EPHX1 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EPHX1 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of EPHX1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EPHX1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EPHX1 mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of EPHX1 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of EPHX1 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of EPHX1 mRNA	22904298\|2479639
D007654	Ketoconazole	Ketoconazole affects the expression of EPHX1 mRNA	18355885
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of EPHX1 mRNA	18544905
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of EPHX1 mRNA	18544905
D007810	Lanosterol	Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]	2043152
D007854	Lead	Lead affects the expression of EPHX1 mRNA	28903495
C052901	lemongrass oil	lemongrass oil affects the expression of EPHX1 mRNA	25976427
D064704	Levofloxacin	Levofloxacin results in decreased expression of EPHX1 mRNA	24136188
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of EPHX1 protein"	25772430
D008095	Lithocholic Acid	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of EPHX1 mRNA	20359477
D008294	Malathion	Malathion results in decreased expression of EPHX1 mRNA	17311802
C037938	mandelic acid	EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]	25562543
D008345	Manganese	Manganese results in increased expression of EPHX1 mRNA	18284614
D017258	Medroxyprogesterone Acetate	ESR1 protein promotes the reaction [Medroxyprogesterone Acetate results in increased expression of EPHX1 protein]	20383792
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of EPHX1 mRNA	20383792
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of EPHX1 protein	20383792
D008694	Methamphetamine	Methamphetamine results in increased expression of EPHX1 mRNA	26307267
D008694	Methamphetamine	Methamphetamine results in increased methylation of EPHX1 promoter	26307267
D008701	Methapyrilene	Methapyrilene results in increased expression of EPHX1 mRNA	15890375
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of EPHX1 mRNA	21621602
D008748	Methylcholanthrene	Methylcholanthrene results in increased activity of EPHX1 protein	3621371
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of EPHX1 mRNA	23273579
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of EPHX1 mRNA	21382384
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of EPHX1 mRNA	21382384
C066851	mithramycin A	mithramycin A results in decreased expression of EPHX1 mRNA	24315822
D016685	Mitomycin	Mitomycin results in increased expression of EPHX1 mRNA	21382384
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of EPHX1 mRNA	12706301
C005939	muconic acid	[EPHX1 protein affects the metabolism of Benzene] which affects the abundance of muconic acid	10511268
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of EPHX1 mRNA"	29244179
C554954	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of EPHX1 mRNA	28174063
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of EPHX1 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of EPHX1 mRNA"	25554681\|2562005
C031721	naphthalene	naphthalene results in increased expression of EPHX1 mRNA	20500019
C031721	naphthalene	EPHX1 protein results in increased metabolism of naphthalene	18363382\|2684074
C031721	naphthalene	"[EPHX1 protein results in increased metabolism of naphthalene] which results in increased chemical synthesis of 1,2-dihydroxy-1,2-dihydronaphthalene"	18363382\|2684074
C031721	naphthalene	EPHX1 results in increased susceptibility to naphthalene	26840748
C031721	naphthalene	[propionamide analog results in decreased activity of EPHX1 protein] which results in increased glutathionylation of naphthalene	18363382
C051752	nefazodone	nefazodone results in increased expression of EPHX1 mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of EPHX1 mRNA	25583101
C012655	nimesulide	EPHX1 protein results in decreased glutathionylation of nimesulide	26524229
C012655	nimesulide	nimesulide results in increased expression of EPHX1 mRNA	24136188
C066443	N-methylolacrylamide	N-methylolacrylamide results in decreased expression of EPHX1 mRNA	17311802
C016340	o,p'-DDT	"o,p'-DDT affects the expression of EPHX1 mRNA"	17984292
D016566	Organoselenium Compounds	Organoselenium Compounds results in increased activity of EPHX1 protein	17163488
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of EPHX1 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of EPHX1 mRNA	25729387
D010126	Ozone	Ozone results in decreased expression of EPHX1 mRNA	12763052
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of EPHX1 mRNA	23892564
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of EPHX1 mRNA	27153767
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of EPHX1 mRNA	19429403
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of EPHX1 mRNA	20936131
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of EPHX1 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of EPHX1 mRNA	18281256\|1942940
C023036	perfluorooctanoic acid	"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of EPHX1 mRNA"	23626681
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of EPHX1 protein	28126411
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of EPHX1 mRNA	23626681
D010578	Petroleum	EPHX1 gene SNP affects the susceptibility to Petroleum	21716162
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of EPHX1 protein	21132492
D010634	Phenobarbital	Phenobarbital affects the expression of EPHX1 mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in increased expression of EPHX1 mRNA	22258563
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of EPHX1 mRNA]	19482888
D010634	Phenobarbital	NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of EPHX1 mRNA]	19850644
D010634	Phenobarbital	Phenobarbital affects the expression of EPHX1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased activity of EPHX1 protein	3621371
D010634	Phenobarbital	Phenobarbital results in increased expression of EPHX1 mRNA	19482888\|1985064
D010634	Phenobarbital	[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of EPHX1 protein	20935162
D010634	Phenobarbital	Phenobarbital results in increased expression of EPHX1 mRNA	11328961\|1694001
D010634	Phenobarbital	Phenobarbital results in increased expression of EPHX1 protein	24090815
D019800	Phenol	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of Phenol]	8211999
D019800	Phenol	EPHX1 protein promotes the reaction [CYP2E1 protein results in increased metabolism of Phenol]	8211999
D019800	Phenol	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of catechol]	8211999
D019800	Phenol	EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of hydroquinone]	8211999
D010636	Phenols	Phenols results in increased expression of EPHX1 mRNA	23561572
C415326	phenoxyacetic acid	phenoxyacetic acid affects the expression of EPHX1 mRNA	21621602
C012482	phenylglyoxylic acid	EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]	25562543
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHX1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of EPHX1 mRNA	26272509
D010672	Phenytoin	EPHX1 gene polymorphism affects the susceptibility to Phenytoin	19952982
D010672	Phenytoin	Phenytoin results in increased expression of EPHX1 mRNA	17381134
D010672	Phenytoin	EPHX1 protein results in increased metabolism of Phenytoin	19952982
D010695	Phlorhizin	Phlorhizin results in decreased expression of EPHX1 mRNA	22538082
C030090	phosphoramide mustard	phosphoramide mustard results in increased expression of EPHX1 mRNA	25070981
C030090	phosphoramide mustard	phosphoramide mustard results in increased expression of EPHX1 protein	25070981
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of EPHX1 mRNA	15728792
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of EPHX1 mRNA	15890375\|2248451
C006253	pirinixic acid	pirinixic acid results in increased expression of EPHX1 mRNA	15375163\|1622196
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of EPHX1 mRNA]	16221962
C006253	pirinixic acid	pirinixic acid results in decreased expression of EPHX1 mRNA	19162173
C006253	pirinixic acid	pirinixic acid results in increased expression of EPHX1 mRNA	15890375
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in decreased expression of EPHX1 mRNA]	21994235
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in increased activity of EPHX1 protein	3621371
D011084	Polycyclic Aromatic Hydrocarbons	EPHX1 gene polymorphism affects the susceptibility to Polycyclic Aromatic Hydrocarbons	15061915\|1546698
D011084	Polycyclic Aromatic Hydrocarbons	EPHX1 protein polymorphism affects the susceptibility to Polycyclic Aromatic Hydrocarbons	15355699
D011084	Polycyclic Aromatic Hydrocarbons	EPHX1 protein polymorphism results in decreased metabolism of Polycyclic Aromatic Hydrocarbons	15917149
D011084	Polycyclic Aromatic Hydrocarbons	EPHX1 protein polymorphism results in increased metabolism of Polycyclic Aromatic Hydrocarbons	15917149
D011285	Pregnenolone Carbonitrile	[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of EPHX1 mRNA	20359477
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of EPHX1 mRNA	20359477\|2741311
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of EPHX1 mRNA	19162173
D011374	Progesterone	Progesterone results in decreased expression of EPHX1 mRNA	23018184
C045950	propiconazole	propiconazole results in increased expression of EPHX1 mRNA	21278054\|2233456
C045950	propiconazole	propiconazole affects the expression of EPHX1 mRNA	17383973
C034666	propionamide	propionamide analog results in decreased activity of EPHX1 protein	18363382
C034666	propionamide	[propionamide analog results in decreased activity of EPHX1 protein] which results in increased glutathionylation of naphthalene	18363382
C034666	propionamide	propionamide analog results in decreased activity of EPHX1 protein	18363382
D054328	Proton Pump Inhibitors	Proton Pump Inhibitors results in increased expression of EPHX1 mRNA	25626140
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of EPHX1 mRNA	27029645
C031280	pyrazole	pyrazole results in increased expression of EPHX1 mRNA	17945193
D011791	Quartz	Quartz results in decreased expression of EPHX1 mRNA	27917503
D011794	Quercetin	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of EPHX1 mRNA	17639512
D011794	Quercetin	Quercetin results in increased expression of EPHX1 mRNA	18095365\|2156589
C005805	quintozene	quintozene results in increased expression of EPHX1 mRNA	17311802
C059514	resveratrol	resveratrol promotes the reaction [Benzo(a)pyrene results in increased activity of EPHX1 protein]	16484233
C059514	resveratrol	resveratrol results in increased expression of EPHX1 mRNA	11279601\|1808983
C059514	resveratrol	resveratrol results in increased expression of EPHX1 protein	18089832
C059514	resveratrol	resveratrol affects the expression of EPHX1 mRNA	23525482
D012293	Rifampin	Rifampin results in increased expression of EPHX1 mRNA	22258563\|2531320
C057006	Ro 21-5104	Ro 21-5104 results in increased expression of EPHX1 mRNA	25313206
C488333	Ro 65-7199	Ro 65-7199 results in increased expression of EPHX1 mRNA	14610520
C089730	rosiglitazone	rosiglitazone results in increased expression of EPHX1 mRNA	21172411
D012402	Rotenone	Rotenone results in increased expression of EPHX1 mRNA	22016648
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of EPHX1 mRNA	21427059
C009250	sevoflurane	sevoflurane affects the expression of EPHX1 mRNA	15967596
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of EPHX1 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of EPHX1 mRNA	27917503
D012834	Silver	NFE2L2 protein promotes the reaction [Silver results in increased expression of EPHX1 mRNA]	22036727
D012834	Silver	Silver results in increased expression of EPHX1 mRNA	22036727
D012834	Silver	Silver results in increased expression of EPHX1 mRNA	27131904
D012906	Smoke	Smoke affects the expression of EPHX1 mRNA	23693141
C009277	sodium arsenate	sodium arsenate results in decreased expression of EPHX1 mRNA	23922661
C017947	sodium arsenite	sodium arsenite results in increased expression of EPHX1 mRNA	25493608
C016104	sodium bichromate	sodium bichromate results in decreased expression of EPHX1 mRNA	22155349
D053260	Soot	Soot results in decreased expression of EPHX1 mRNA	22461453
C025906	stilbene oxide	araldite promotes the reaction [EPHX1 protein results in increased metabolism of stilbene oxide analog]	2043152
C025906	stilbene oxide	Dieldrin promotes the reaction [EPHX1 protein results in increased metabolism of stilbene oxide]	2043152
C025906	stilbene oxide	EPHX1 protein results in increased metabolism of stilbene oxide	2043152
C025906	stilbene oxide	EPHX1 protein results in increased metabolism of stilbene oxide analog	2043152
C025906	stilbene oxide	ethylphenylepoxygeranyl ether promotes the reaction [EPHX1 protein results in increased metabolism of stilbene oxide]	2043152
C025906	stilbene oxide	Heptachlor Epoxide promotes the reaction [EPHX1 protein results in increased metabolism of stilbene oxide]	2043152
C025906	stilbene oxide	tridiphane promotes the reaction [EPHX1 protein results in increased metabolism of stilbene oxide]	2043152
D013267	Stilbenes	Stilbenes results in increased activity of EPHX1 protein	3621371
D013311	Streptozocin	Streptozocin results in increased expression of EPHX1 protein	19634143
D013311	Streptozocin	Trientine inhibits the reaction [Streptozocin results in increased expression of EPHX1 protein]	19634143
D020058	Styrene	EPHX1 gene polymorphism affects the susceptibility to Styrene	14751678
D020058	Styrene	EPHX1 protein results in decreased susceptibility to Styrene	22386858
D020058	Styrene	Styrene results in increased expression of EPHX1 mRNA	16418063
D020058	Styrene	EPHX1 protein results in increased metabolism of Styrene	22386858
C031474	styrene glycol	EPHX1 protein results in increased chemical synthesis of styrene glycol	22386858
C013690	styrene oxide	CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]	12051674
C013690	styrene oxide	EPHX1 protein affects the hydrolysis of styrene oxide	11076696
C013690	styrene oxide	EPHX1 protein affects the metabolism of and results in decreased activity of styrene oxide	12694745
C013690	styrene oxide	EPHX1 protein results in increased hydrolysis of styrene oxide	17151961
C013690	styrene oxide	CYP1A1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]	12051674
C013690	styrene oxide	CYP2B1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]	12051674
C013690	styrene oxide	CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]	12051674
C013690	styrene oxide	CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]	12051674
D012460	Sulfasalazine	Sulfasalazine results in increased expression of EPHX1 mRNA	22016648
C016766	sulforafan	sulforafan promotes the reaction [NFE2L2 protein binds to EPHX1 enhancer]	24704207
C016766	sulforafan	sulforafan results in increased expression of EPHX1 exon	24704207
C016766	sulforafan	sulforafan results in increased expression of EPHX1 protein	24704207
C016766	sulforafan	sulforafan results in increased expression of EPHX1 protein alternative form	24704207
C016766	sulforafan	[sulforafan co-treated with dibenzoylmethane] results in increased expression of EPHX1 mRNA	17942926
C016766	sulforafan	sulforafan results in increased expression of EPHX1 mRNA	17942926
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in decreased expression of EPHX1 mRNA"	26680231
C446685	systhane	systhane affects the expression of EPHX1 mRNA	17383973
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in increased activity of EPHX1 protein"	3032197
C013698	tallow	tallow affects the expression of EPHX1 mRNA	19680557
D013629	Tamoxifen	Tamoxifen affects the expression of EPHX1 mRNA	14699072
D013629	Tamoxifen	Tamoxifen affects the expression of EPHX1 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of EPHX1 mRNA	20702594\|2157046
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of EPHX1 mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EPHX1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [NFE2L2 gene mutant form results in decreased expression of EPHX1 mRNA]	21846477
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of EPHX1 mRNA	15328365\|1580003
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of EPHX1 protein	2208584
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of EPHX1 mRNA	16960034
D013752	Tetracycline	Tetracycline results in decreased expression of EPHX1 mRNA	24489787
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of EPHX1 protein	24704207
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EPHX1 mRNA	25613284
C019107	tetramethylthiourea	tetramethylthiourea results in increased expression of EPHX1 mRNA	10190572
C019107	tetramethylthiourea	tetramethylthiourea results in increased expression of EPHX1 protein	10190572
D013844	Thiazoles	Thiazoles results in increased expression of EPHX1 mRNA	8951341
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of EPHX1 mRNA	28943392
D013882	Thiosemicarbazones	[Thiosemicarbazones binds to Copper] which results in decreased expression of EPHX1 protein	20931265
C003466	thymoquinone	thymoquinone inhibits the reaction [Carbon Tetrachloride results in decreased expression of EPHX1 mRNA]	21994235
C009495	titanium dioxide	titanium dioxide results in decreased expression of EPHX1 mRNA	23557971\|2776080
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of EPHX1 mRNA	25729387
D014239	Trichloroepoxypropane	Trichloroepoxypropane results in decreased activity of EPHX1 protein	1500033
C012589	trichostatin A	trichostatin A results in increased expression of EPHX1 mRNA	15901671
C051460	tridiphane	tridiphane promotes the reaction [EPHX1 protein results in increased metabolism of stilbene oxide]	2043152
D014266	Trientine	Trientine inhibits the reaction [Streptozocin results in increased expression of EPHX1 protein]	19634143
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of EPHX1 mRNA	21346803
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of EPHX1 protein	24685621
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of EPHX1 mRNA	29024780
D014315	Triterpenes	Triterpenes results in increased expression of EPHX1 mRNA	18544911
C080163	trovafloxacin	trovafloxacin results in decreased expression of EPHX1 mRNA	24136188
C406224	valdecoxib	valdecoxib results in increased expression of EPHX1 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in increased expression of EPHX1 mRNA	15901671
D014635	Valproic Acid	Valproic Acid affects the reaction [Colforsin affects the expression of EPHX1 mRNA]	20726872
D014635	Valproic Acid	Valproic Acid results in decreased methylation of EPHX1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of EPHX1 mRNA	21427059
D014635	Valproic Acid	Valproic Acid results in increased expression of EPHX1 mRNA	17381134
C025643	vinclozolin	vinclozolin affects the expression of EPHX1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of EPHX1 mRNA	23034163
D014750	Vincristine	Vincristine results in decreased expression of EPHX1 mRNA	21382384
C029297	vinylidene chloride	vinylidene chloride results in increased expression of EPHX1 mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of EPHX1 mRNA	21382384
D014859	Warfarin	EPHX1 gene polymorphism affects the susceptibility to Warfarin	17496169\|2084235
D014859	Warfarin	EPHX1 gene SNP affects the susceptibility to Warfarin	15900282\|2562904
D014859	Warfarin	EPHX1 intron SNP affects the susceptibility to Warfarin	21192345
D014859	Warfarin	EPHX1 polymorphism affects the susceptibility to Warfarin	24092646
D014859	Warfarin	EPHX1 protein results in increased susceptibility to Warfarin	17496169
D014859	Warfarin	EPHX1 SNP affects the susceptibility to Warfarin	28079798
D015032	Zinc	Zinc results in increased expression of EPHX1 mRNA	17074742
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of EPHX1 mRNA	17074742

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004301	epoxide hydrolase activity	-	IDA	22798687
GO:0033961	cis-stilbene-oxide hydrolase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006805	xenobiotic metabolic process	-	TAS	-
GO:0009636	response to toxic substance	-	IEA	-
GO:0014070	response to organic cyclic compound	-	IEA	-
GO:0019439	aromatic compound catabolic process	-	IEA	-
GO:0097176	epoxide metabolic process	-	IDA	22798687

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0031090	organelle membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa04976	Bile secretion

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23426996	Microsomal epoxide hydrolase gene polymorphisms and risk of chronic obstructive pulmonary disease: A comprehensive meta-analysis. (2013 Mar)	Li H	Oncol Lett
20886582	Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis. (2010 Nov)	Pande M	Mol Carcinog
16926176	Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps. (2007 Feb)	Goode EL	Carcinogenesis
20516053	EPHX1 polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis. (2011 Jan)	Lee J	Eur Respir J
22738861	Genetic association between obstructive bronchitis and enzymes of oxidative stress. (2012 Dec)	Bauer M	Metabolism
22214149	[Association analysis of polymorphisms of metabolizing enzyme genes with chronic benzene poisoning based on logistic regression and multifactor dimensionality reduction]. (2011 Jul)	Jin RF	Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
18394656	Chromosomal aberrations in tire plant workers and interaction with polymorphisms of biotransformation and DNA repair genes. (2008 May 10)	Musak L	Mutat Res
17885617	Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations. (2007 Oct)	Kim S	Pharmacogenet Genomics
15716486	Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1). (2005 May)	Abdel-Rahman SZ	Toxicol Sci
23159782	The effect of cigarette smoke and arsenic exposure on urothelial carcinoma risk is modified by glutathione S-transferase M1 gene null genotype. (2013 Jan 15)	Chung CJ	Toxicol Appl Pharmacol
22415791	Microsomal epoxide hydrolase polymorphisms, cigarette smoking, and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study. (2013 Aug)	Nisa H	Mol Carcinog
17082176	Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study. (2007 Apr)	Mitrou PN	Carcinogenesis
16125881	Influence of genetic polymorphisms of styrene-metabolizing enzymes and smoking habits on levels of urinary metabolites after occupational exposure to styrene. (2005 Dec 30)	Ma M	Toxicol Lett
18784359	Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population. (2008 Dec)	Sun P	Carcinogenesis
11480169	[Analysis of association between gene polymorphisms of microsomal epoxide hydrolase (EPHX1) and infant birthweight]. (2001)	Wu D	Yi Chuan Xue Bao
20847076	Genetic susceptibility to asbestos-related fibrotic pleuropulmonary changes. (2011 Sep)	Kukkonen MK	Eur Respir J
22200898	Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE). (2012 Feb)	Bonaventure A	Cancer Causes Control
18298806	Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years. (2008 Feb 25)	Rosenberger A	BMC Cancer
19287329	The role of epoxide hydrolase Y113H gene variant in pancreatic diseases. (2009 May)	Ockenga J	Pancreas
22301281	Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk. (2012 Apr)	Jang JH	Carcinogenesis
22027651	Genetic polymorphisms of xenobiotic-metabolizing enzymes influence the risk of pulmonary emphysema. (2011 Dec)	Kukkonen MK	Pharmacogenet Genomics
17412371	PAH-DNA adducts in environmentally exposed population in relation to metabolic and DNA repair gene polymorphisms. (2007 Jul 1)	Binkova B	Mutat Res
23797975	DNA adducts and combinations of multiple lung cancer at-risk alleles in environmentally exposed and smoking subjects. (2013 Jul)	Peluso ME	Environ Mol Mutagen
12491039	Association between head and neck cancer and microsomal epoxide hydrolase genotypes. (2003 Jan)	Wenghoefer M	Arch Toxicol
16284498	Childhood leukaemia, polymorphisms of metabolism enzyme genes, and interactions with maternal tobacco, coffee and alcohol consumption during pregnancy. (2005 Dec)	Clavel J	Eur J Cancer Prev
17418242	Chromosomal aberrations in environmentally exposed population in relation to metabolic and DNA repair genes polymorphisms. (2007 Jul 1)	Sram RJ	Mutat Res
15199549	Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer. (2004)	Harms C	Environ Mol Mutagen
20091863	Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer. (2010 Oct 1)	Timofeeva M	Int J Cancer
18571762	Functional polymorphisms of the microsomal epoxide hydrolase gene: a reappraisal on a early-onset lung cancer patients series. (2009 Feb)	Graziano C	Lung Cancer
21254355	Smoking, the xenobiotic pathway, and clubfoot. (2011 Jan)	Sommer A	Birth Defects Res A Clin Mol Teratol
17498780	The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. (2007 Aug 1)	Chen B	Sci Total Environ
15917149	Occupational exposure to polycyclic aromatic hydrocarbons in German industries: association between exogenous exposure and urinary metabolites and its modulation by enzyme polymorphisms. (2005 Jul 4)	Rihs HP	Toxicol Lett
19111454	Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. (2009 Apr)	Kim WJ	Respir Med
23061746	Impact of genetic factors (CYP2C9, VKORC1 and CYP4F2) on warfarin dose requirement in the Turkish population. (2013 Mar)	Ozer M	Basic Clin Pharmacol Toxicol
17564249	Microsomal epoxide hydrolase is not associated with COPD in a community-based sample. (2006 Dec)	Matheson MC	Hum Biol
15668489	Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma. (2005 Jan)	Huang WY	Cancer Epidemiol Biomarkers Prev
21715529	Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver. (2011 Sep)	O'Shaughnessy PJ	J Clin Endocrinol Metab
26653643	[Gene variance in microsomal epoxide hydrolase and the susceptibility of coal workers' pneumoconiosis]. (2015 Jul)	Chen C	Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
21778810	Genetics of COPD. (2011 Sep)	Nakamura H	Allergol Int
21734345	Combined analysis of EPHX1, GSTP1, GSTM1 and GSTT1 gene polymorphisms in relation to chronic obstructive pulmonary disease risk and lung function impairment. (2011)	Lakhdar R	Dis Markers
22976395	A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population. (2012)	Hua L	Genes Genet Syst
17526865	Passive smoking, metabolic gene polymorphisms, and infant birth weight in a prospective cohort study of Chinese women. (2007 Aug 1)	Wu T	Am J Epidemiol
20659238	Role of epoxide hydrolase 1 gene polymorphisms in esophageal cancer in a high-risk area in India. (2010 Aug)	Ihsan R	J Gastroenterol Hepatol
24845160	Gene-environment interaction among GSTT1, PON2 polymorphisms and organic solvents on gestational age in a Chinese women cohort. (2014 Jul)	Li S	J Assist Reprod Genet
21044285	Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study. (2010 Nov 2)	Penyige A	BMC Med Genet
17608547	Maternal smoking during early pregnancy, GSTP1 and EPHX1 variants, and risk of isolated orofacial clefts. (2007 Jul)	Ramirez D	Cleft Palate Craniofac J
10676631	High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers. (2000 Feb 1)	Jourenkova-Mironova N	Cancer Res
18258609	A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. (2008 Jun)	Zienolddiny S	Carcinogenesis
20932192	Microsomal epoxide hydrolase gene polymorphisms and susceptibility to chronic obstructive pulmonary disease in the Tunisian population. (2010 Dec)	Lakhdar R	Genet Test Mol Biomarkers
22257321	EPHX1 gene polymorphisms in alcohol dependence and their distribution among the Indian populations. (2013 Jan)	Bhaskar LV	Am J Drug Alcohol Abuse
19575027	Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility. (2009 Aug)	Polonikov AV	J Hum Genet
17590289	Impact of air pollution and genotype variability on DNA damage in Prague policemen. (2007 Jul 30)	Novotna B	Toxicol Lett
12928118	Genetic susceptibility and dietary patterns in lung cancer. (2003 Sep)	Tsai YY	Lung Cancer
22118311	Polymorphism of microsomal epoxide hydrolase is associated with chronic obstructive pulmonary disease and bronchodilator response. (2011 Nov)	Chen CZ	J Formos Med Assoc
15654505	Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (2005)	Liu Y	J Hum Genet
21110013	Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters. (2011 Apr)	Geisen C	Eur J Clin Pharmacol
18614560	Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD. (2008 Oct)	Chappell S	Eur Respir J
18461673	Glutathione S-transferase and microsomal epoxide hydrolase gene polymorphisms and risk of chronic obstructive pulmonary disease in Slovak population. (2008 Apr)	Zidzik J	Croat Med J
28049362	Warfarin Dose Model for the Prediction of Stable Maintenance Dose in Indian Patients. (2018 Mar)	Gaikwad T	Clin Appl Thromb Hemost
17996038	Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population. (2007 Nov 8)	Boccia S	BMC Cancer
22103900	Microsomal epoxide hydrolase polymorphisms, cigarette smoking and prostate cancer risk in the Slovak population. (2012)	Sivonova MK	Neoplasma
24260161	Parental smoking and risk of childhood brain tumors by functional polymorphisms in polycyclic aromatic hydrocarbon metabolism genes. (2013)	Barrington-Trimis JL	PLoS One
24084248	The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes. (2013 Dec 12)	Molina E	Mutat Res
12359356	Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk. (2002 Dec 10)	To-Figueras J	Cancer Lett
15746160	Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. (2005 Jul)	Broberg K	Carcinogenesis
24573875	Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene poisoning. (2007 Jul)	Sun P	Front Med China
28693112	Association of prenatal passive smoking and metabolic gene polymorphisms with child growth from birth to 3years of age in the Hokkaido Birth Cohort Study on Environment and Children's Health. (2017 Dec 15)	Braimoh TS	Sci Total Environ
11471167	Analysis of the EPHX1 113 polymorphism and GSTM1 homozygous null polymorphism and oral clefting associated with maternal smoking. (2001 Jul 22)	Hartsfield JK Jr	Am J Med Genet
21649467	Association of functionally important polymorphism of microsomal epoxide hydrolase gene (EPHX1) with lung cancer susceptibility. (2011 Jul)	Tilak AR	Cancer Invest
25524402	Association between plasma selenium level and NRF2 target genes expression in humans. (2015 Apr)	Reszka E	J Trace Elem Med Biol
21097530	Influence of GSTM1, GSTT1, GSTP1, NAT1, NAT2, EPHX1, MTR and MTHFR polymorphism on chromosomal aberration frequencies in human lymphocytes. (2011 Mar)	Skjelbred CF	Carcinogenesis