Gene: EPHX2

2053
CEH|SEH
epoxide hydrolase 2
protein-coding
8p21.2-p21.1
Ensembl:ENSG00000120915 MIM:132811 Vega:OTTHUMG00000102115 UniprotKB:P34913
NG_012064.1
PubMed|SNP Mapped
ND
5   
4.658e-1 (AD)  3.578e-1 (ND)   (Frontal_Cortex)
8.541e-2 (AD)  5.672e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SELENBP10.865
MMP280.864
ADHFE10.859
C16orf890.841
PRODH0.84
ACY10.838
HOGA10.83
ALDH7A10.83
TTYH10.829
ACSS10.828

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.412
MUM1L1-0.381
OR4F29-0.38
MIP-0.362
FGF5-0.361
FAM160A1-0.359
HS3ST2-0.356
OSBPL10-0.347
KLHL38-0.338
IL12RB2-0.334

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02029N-Cyclohexyl-N'-(4-Iodophenyl)UreaSmall MoleculeExperimentalTarget
DB03677N-Cyclohexyl-N'-DecylureaSmall MoleculeExperimentalTarget
DB04213N-Cyclohexyl-N'-(Propyl)Phenyl UreaSmall MoleculeExperimentalTarget
DB08256N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINESmall MoleculeExperimentalTarget
DB082574-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACIDSmall MoleculeExperimentalTarget
DB082586-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACIDSmall MoleculeExperimentalTarget
DB082597-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACIDSmall MoleculeExperimentalTarget
DB12610EbselenSmall Molecule60940-34-3InvestigationalTarget
ID Drug Name Action PubMed
C41012811,12-dihydroxyeicosatrienoic acid"[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in increased abundance of 11,12-dihydroxyeicosatrienoic acid"22680237
C41012811,12-dihydroxyeicosatrienoic acid"EPHX2 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased abundance of 11,12-dihydroxyeicosatrienoic acid]"19896470
C41012811,12-dihydroxyeicosatrienoic acid"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]"19896470
C41012811,12-dihydroxyeicosatrienoic acid"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]"19896470
C41012811,12-dihydroxyeicosatrienoic acid"EPHX2 protein results in increased chemical synthesis of 11,12-dihydroxyeicosatrienoic acid"25377915
C04678311,12-epoxy-5,8,14-eicosatrienoic acid"[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 11,12-epoxy-5,8,14-eicosatrienoic acid"22680237
C04678311,12-epoxy-5,8,14-eicosatrienoic acid"EPHX2 gene mutant form results in increased abundance of 11,12-epoxy-5,8,14-eicosatrienoic acid"19896470
C04678311,12-epoxy-5,8,14-eicosatrienoic acid"EPHX2 protein results in increased hydrolysis of 11,12-epoxy-5,8,14-eicosatrienoic acid"25377915
C04678311,12-epoxy-5,8,14-eicosatrienoic acid"[Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 11,12-epoxy-5,8,14-eicosatrienoic acid"24472606
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea results in decreased activity of EPHX2 protein23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats inhibits the reaction [EPHX2 gene mutant form results in decreased phosphorylation of EIF2AK3 protein]]23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea results in decreased activity of EPHX2 protein23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Benzo(a)pyrene results in increased activity of EPHX2 protein]21383588
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea results in decreased activity of EPHX2 protein21383588
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in increased expression of EPHX2 protein]28694203
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [EPHX2 gene results in decreased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]23152114
C50489712-(3-adamantan-1-ylureido)dodecanoic acidEPHX2 gene mutant form results in decreased susceptibility to 12-(3-adamantan-1-ylureido)dodecanoic acid23152114
C10701614,15-dihydroxyeicosatrienoic acid"[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in increased abundance of 14,15-dihydroxyeicosatrienoic acid"22680237
C10701614,15-dihydroxyeicosatrienoic acid"EPHX2 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased abundance of 14,15-dihydroxyeicosatrienoic acid]"19896470
C10701614,15-dihydroxyeicosatrienoic acid"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]"19896470
C10701614,15-dihydroxyeicosatrienoic acid"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]"19896470
C49402214,15-eicosa-5-enoic acid"14,15-eicosa-5-enoic acid inhibits the reaction [EPHX2 gene mutant form results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]"23152114
C04678214,15-epoxy-5,8,11-eicosatrienoic acid"[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid"22680237
C04678214,15-epoxy-5,8,11-eicosatrienoic acid"EPHX2 gene mutant form results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid"19896470
C04678214,15-epoxy-5,8,11-eicosatrienoic acid"[Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid"24472606
C02598415-hydroxy-5,8,11,13-eicosatetraenoic acid"15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased activity of EPHX2 protein"25600587
C02810816 alpha,17-epoxyprogesterone"16 alpha,17-epoxyprogesterone inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]"2043152
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of EPHX2 protein"27604104
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [EPHX2 gene results in decreased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]23152114
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine"14,15-eicosa-5-enoic acid inhibits the reaction [EPHX2 gene mutant form results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]"23152114
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [EPHX2 gene results in decreased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]23152114
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineEPHX2 gene mutant form results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine23152114
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineEPHX2 gene results in decreased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine23152114
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineT 0070907 inhibits the reaction [EPHX2 gene mutant form results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]23152114
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of EPHX2 mRNA"28433925
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazole2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in decreased expression of EPHX2 mRNA25781201
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of EPHX2 protein26194647
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of EPHX2 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of EPHX2 mRNA"23196670
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of EPHX2 mRNA14610520
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of EPHX2 mRNA"21218783
C5729614-(4-(3-(4-trifluoromethoxy-phenyl)ureido)cyclohexyloxy)benzoic acid4-(4-(3-(4-trifluoromethoxy-phenyl)ureido)cyclohexyloxy)benzoic acid results in decreased activity of EPHX2 protein25377915
C5241064-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [EPHX2 gene results in decreased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]23152114
C5241064-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid results in increased expression of EPHX2 protein25724490
C5241064-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acidEPHX2 gene mutant form results in decreased susceptibility to 4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid23152114
C5241064-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid results in decreased activity of EPHX2 protein21398593|2361154
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of EPHX2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHX2 mRNA"27188386
C0718634-fluorochalcone oxide4-fluorochalcone oxide results in decreased activity of EPHX2 protein1500033
C0407765,6-epoxy-8,11,14-eicosatrienoic acid"EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid"19896470
C0220225-hydroxy-6,8,11,14-eicosatetraenoic acid"5-hydroxy-6,8,11,14-eicosatetraenoic acid results in increased activity of EPHX2 protein"25600587
C0220225-hydroxy-6,8,11,14-eicosatetraenoic acid"EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased abundance of 5-hydroxy-6,8,11,14-eicosatetraenoic acid]]"19896470
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHX2 mRNA"27188386
C0507158,9-epoxyeicosatrienoic acid"EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid"19896470
D000082AcetaminophenAcetaminophen results in decreased expression of EPHX2 mRNA29067470
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of EPHX2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EPHX2 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of EPHX2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EPHX2 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EPHX2 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of EPHX2 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EPHX2 mRNA16483693
D016718Arachidonic AcidEPHX2 protein results in increased metabolism of Arachidonic Acid26165641
C006632arsenic trioxidearsenic trioxide results in increased expression of EPHX2 mRNA17530438
C015001arsenitearsenite results in increased expression of EPHX2 mRNA18929588
D018053ArsenitesArsenites results in increased expression of and results in increased activity of EPHX2 protein22680237
D018053Arsenites"[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 11,12-epoxy-5,8,14-eicosatrienoic acid"22680237
D018053Arsenites"[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid"22680237
D018053Arsenites"[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in increased abundance of 11,12-dihydroxyeicosatrienoic acid"22680237
D018053Arsenites"[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in increased abundance of 14,15-dihydroxyeicosatrienoic acid"22680237
D018053Arsenites"[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in increased abundance of eicosa-5,11,14-trienoic acid analog"22680237
D018053ArsenitesArsenites results in increased expression of EPHX2 mRNA22680237
D017636Asbestos, Amphibole"Asbestos, Amphibole affects the expression of EPHX2 protein"20855422
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in decreased expression of EPHX2 mRNA17639512
D001241AspirinAspirin promotes the reaction [EPHX2 gene mutant form results in decreased susceptibility to Lipopolysaccharides]19896470
D001241AspirinEPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]19896470
D001241AspirinEPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Prostaglandin D2]]19896470
D001241Aspirin"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]"19896470
D001241Aspirin"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]"19896470
C547126AZM551248AZM551248 results in decreased expression of EPHX2 mRNA22323515
C006697benzilbenzil results in decreased activity of EPHX2 protein3621371
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EPHX2 mRNA20106945|2231617
D001564Benzo(a)pyrene1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Benzo(a)pyrene results in increased activity of EPHX2 protein]21383588
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased activity of EPHX2 protein22051199
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased activity of EPHX2 protein19889059|2138358
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EPHX2 mRNA19889059|2138358
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EPHX2 protein19889059
D001564Benzo(a)pyreneGlycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in decreased activity of EPHX2 protein]22051199
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EPHX2 mRNA20061341
C095105bexarotenebexarotene results in increased expression of EPHX2 mRNA23292798
C006780bisphenol Abisphenol A affects the expression of EPHX2 mRNA21786754
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of EPHX2 mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of EPHX2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EPHX2 gene28505145
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in decreased expression of EPHX2 protein3621371
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased activity of EPHX2 protein3621371
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of EPHX2 mRNA14729362
C028031cadmium acetatecadmium acetate affects the expression of EPHX2 mRNA16249259
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of EPHX2 mRNA20061341
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of EPHX2 mRNA25993096
D002118CalciumCalcium affects the expression of EPHX2 mRNA15913539
D002220CarbamazepineCarbamazepine results in decreased expression of EPHX2 mRNA17381134
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of EPHX2 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EPHX2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of EPHX2 mRNA12734012
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of EPHX2 mRNA16039398
C026690cerous chloridecerous chloride affects the expression of EPHX2 mRNA28954213
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of EPHX2 mRNA28954213
C031294chlorobenzenechlorobenzene results in decreased expression of EPHX2 mRNA19800902
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHX2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of EPHX2 mRNA26272509
C002415cholesterol alpha-oxidecholesterol alpha-oxide inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
D002922CiguatoxinsCiguatoxins affects the expression of EPHX2 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of EPHX2 mRNA17585979
D002994ClofibrateClofibrate results in increased activity of EPHX2 protein3621371
D002994ClofibrateClofibrate results in increased expression of EPHX2 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of EPHX2 protein3318844|3621371|
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EPHX2 mRNA]17585979
D002994ClofibrateClofibrate results in increased expression of EPHX2 mRNA11328961|1503359
D002994ClofibrateClofibrate results in increased expression of EPHX2 protein16470657|3768023
D003300CopperCopper results in decreased expression of EPHX2 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of EPHX2 mRNA19549813
D003314Corn OilCorn Oil affects the expression of EPHX2 mRNA16360708
D016572CyclosporineCyclosporine results in decreased expression of EPHX2 mRNA20106945|2383089
D016572CyclosporineCyclosporine affects the expression of EPHX2 mRNA19770486
D016572CyclosporineCyclosporine results in decreased expression of EPHX2 mRNA23830897
C093628cyproconazolecyproconazole results in decreased expression of EPHX2 mRNA22334560
D0150842,4-Dichlorophenoxyacetic Acid"2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX2 protein"1755024|3032197
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of EPHX2 mRNA23640034
D015230Prostaglandin D2EPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Prostaglandin D2]]19896470
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of EPHX2 mRNA]27941970
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EPHX2 mRNA16054899
D003907Dexamethasone[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EPHX2 mRNA]16054899
D003907DexamethasoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EPHX2 mRNA]16054899
D003907DexamethasoneDexamethasone results in increased expression of EPHX2 mRNA14618091
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of EPHX2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of EPHX2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of EPHX2 mRNA26165641
D002945CisplatinCisplatin results in decreased expression of EPHX2 protein26165641
D002945Cisplatinphenylmethylpyrazolone inhibits the reaction [Cisplatin results in decreased expression of EPHX2 protein]26165641
C121718dicyclanildicyclanil results in increased expression of EPHX2 mRNA15664270
D004026DieldrinDieldrin promotes the reaction [EPHX2 protein results in increased metabolism of stilbene oxide]2043152
D004041Dietary Fats1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats inhibits the reaction [EPHX2 gene mutant form results in decreased phosphorylation of EIF2AK3 protein]]23576437
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of EPHX2 mRNA]"19467301
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of EPHX2 mRNA28433925
D004041Dietary FatsDietary Fats inhibits the reaction [EPHX2 gene mutant form results in decreased phosphorylation of ATF6 protein]23576437
D004041Dietary FatsDietary Fats inhibits the reaction [EPHX2 gene mutant form results in decreased phosphorylation of EIF2AK3 protein]23576437
D004041Dietary FatsDietary Fats inhibits the reaction [EPHX2 gene mutant form results in decreased phosphorylation of EIF2S1 protein]23576437
D004041Dietary FatsDietary Fats results in increased expression of EPHX2 mRNA19467301
D004041Dietary FatsDietary Fats results in increased expression of EPHX2 protein23576437
D004041Dietary FatsEPHX2 gene mutant form inhibits the reaction [Dietary Fats results in decreased expression of PPP1R15A protein]23576437
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of EPHX2 mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of EPHX2 mRNA19850644
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of EPHX2 protein3318844|3621371
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of EPHX2 mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of EPHX2 mRNA"28433925
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of EPHX2 mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of EPHX2 mRNA18544905
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of EPHX2 mRNA"22485181
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of EPHX2 mRNA28939011
D004221DisulfiramDisulfiram results in decreased expression of EPHX2 mRNA20530235
D004237DiuronDiuron results in increased expression of EPHX2 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of EPHX2 mRNA19796650
C042986ebselenebselen binds to and results in decreased activity of EPHX2 protein23219563
C045533eicosa-5,11,14-trienoic acid"[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in increased abundance of eicosa-5,11,14-trienoic acid analog"22680237
D015777EicosanoidsEPHX2 gene mutant form results in decreased metabolism of Eicosanoids21832210
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of EPHX2 mRNA25198161
C109476epoxiconazoleepoxiconazole results in decreased expression of EPHX2 mRNA22334560
D004852Epoxy CompoundsEPHX2 gene mutant form results in decreased metabolism of Epoxy Compounds21832210
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of EPHX2 mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EPHX2 protein20227414
D005001EthionineEthionine results in decreased expression of EPHX2 protein3621371
D019830Adenosine-5'-(N-ethylcarboxamide)EPHX2 gene mutant form results in increased susceptibility to Adenosine-5'-(N-ethylcarboxamide)23152114
C100167ethylphenylepoxygeranyl etherethylphenylepoxygeranyl ether promotes the reaction [EPHX2 protein results in increased metabolism of stilbene oxide]2043152
C047360felbamatefelbamate results in decreased expression of EPHX2 mRNA17381134
D011345FenofibrateFenofibrate affects the expression of EPHX2 mRNA20801182
C017690fenvaleratefenvalerate metabolite results in increased activity of EPHX2 protein10630566
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of EPHX2 mRNA17347304
D005419FlavonoidsFlavonoids results in decreased expression of EPHX2 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of EPHX2 mRNA24136188
C039281furanfuran results in decreased expression of EPHX2 mRNA20194422
D019833GenisteinESR2 promotes the reaction [Genistein results in increased expression of EPHX2 protein]20884965
D019833GenisteinGenistein results in increased expression of EPHX2 protein20884965
D005839GentamicinsGentamicins results in decreased expression of EPHX2 protein22061828
D019695Glycyrrhizic AcidGlycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in decreased activity of EPHX2 protein]22051199
C453899GW 7647GW 7647 results in decreased activity of EPHX2 protein15798002
C010178heliotrineheliotrine results in decreased expression of EPHX2 mRNA26100227
D006534Heptachlor EpoxideHeptachlor Epoxide inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
D006534Heptachlor EpoxideHeptachlor Epoxide promotes the reaction [EPHX2 protein results in increased metabolism of stilbene oxide]2043152
D01937712-Hydroxy-5,8,10,14-eicosatetraenoic Acid"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid results in increased activity of EPHX2 protein"25600587
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of EPHX2 mRNA15159207
D017313FenretinideFenretinide results in increased expression of EPHX2 mRNA28973697
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in increased activity of EPHX2 protein"3621371
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in increased expression of EPHX2 protein"3621371
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EPHX2 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of EPHX2 mRNA14729362
C474021indirubin-3'-monoximeindirubin-3'-monoxime results in decreased expression of EPHX2 mRNA18958680
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EPHX2 mRNA16054899
D0150561-Methyl-3-isobutylxanthine[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EPHX2 mRNA]16054899
D0150561-Methyl-3-isobutylxanthineTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EPHX2 mRNA]16054899
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of EPHX2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of EPHX2 mRNA27392435
C410337K 7174K 7174 results in decreased expression of EPHX2 mRNA24086573
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of EPHX2 mRNA18544905
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of EPHX2 mRNA18544905
D007810LanosterolLanosterol analog inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of EPHX2 mRNA28954213
C008261lead acetatelead acetate affects the expression of EPHX2 mRNA21864555|2264161
C045463leflunomideleflunomide results in decreased expression of EPHX2 mRNA28988120
C001546limoninlimonin inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
C002385linsidominelinsidomine results in increased oxidation of EPHX2 protein28086193
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of EPHX2 mRNA"23939143
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in increased expression of EPHX2 mRNA26667767
D008070LipopolysaccharidesAspirin promotes the reaction [EPHX2 gene mutant form results in decreased susceptibility to Lipopolysaccharides]19896470
D008070LipopolysaccharidesEPHX2 gene mutant form affects the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]19896470
D008070Lipopolysaccharides"EPHX2 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased abundance of 11,12-dihydroxyeicosatrienoic acid]"19896470
D008070Lipopolysaccharides"EPHX2 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased abundance of 14,15-dihydroxyeicosatrienoic acid]"19896470
D008070LipopolysaccharidesEPHX2 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]19896470
D008070LipopolysaccharidesEPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]19896470
D008070LipopolysaccharidesEPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Prostaglandin D2]]19896470
D008070Lipopolysaccharides"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]"19896470
D008070Lipopolysaccharides"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]"19896470
D008070Lipopolysaccharides"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]"19896470
D008070Lipopolysaccharides"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]"19896470
D008070Lipopolysaccharides"EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased abundance of 5-hydroxy-6,8,11,14-eicosatetraenoic acid]]"19896470
D008070LipopolysaccharidesEPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]]19896470
D008070LipopolysaccharidesEPHX2 gene mutant form results in decreased susceptibility to Lipopolysaccharides19896470
D008070LipopolysaccharidesMK-886 promotes the reaction [EPHX2 gene mutant form results in decreased susceptibility to Lipopolysaccharides]19896470
C008340mecopropmecoprop results in increased activity of EPHX2 protein1755024
D008627Mercuric ChlorideMercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein24472606
D008627Mercuric Chloride"[Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 11,12-epoxy-5,8,14-eicosatrienoic acid"24472606
D008627Mercuric Chloride"[Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid"24472606
D008748MethylcholanthreneMethylcholanthrene results in decreased activity of EPHX2 protein3621371
D008748MethylcholanthreneMethylcholanthrene results in increased activity of EPHX2 protein19889059
D008748MethylcholanthreneMethylcholanthrene results in increased expression of EPHX2 mRNA19889059
D008748MethylcholanthreneMethylcholanthrene results in increased expression of EPHX2 protein19889059
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EPHX2 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EPHX2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EPHX2 mRNA26011545
D015741MetriboloneMetribolone results in increased expression of EPHX2 protein17152098
C060893MK-886"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]"19896470
C060893MK-886"EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]"19896470
C060893MK-886"EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased abundance of 5-hydroxy-6,8,11,14-eicosatetraenoic acid]]"19896470
C060893MK-886EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]]19896470
C060893MK-886MK-886 promotes the reaction [EPHX2 gene mutant form results in decreased susceptibility to Lipopolysaccharides]19896470
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of EPHX2 mRNA22401849
D009020MorphineMorphine results in increased expression of EPHX2 mRNA21178816
C500085muraglitazarmuraglitazar results in increased expression of EPHX2 mRNA21515302
C031721naphthalenenaphthalene results in increased expression of EPHX2 mRNA20500019
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased activity of EPHX2 protein3621371
D009532NickelNickel results in decreased expression of EPHX2 mRNA24768652
C059405nomilinnomilin inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
D010098OxycodoneOxycodone affects the expression of EPHX2 mRNA20487198
D010126OzoneOzone results in increased expression of EPHX2 mRNA27206323
D017239PaclitaxelPaclitaxel results in increased expression of EPHX2 mRNA18754875
D010168PalmitatesPalmitates results in increased expression of EPHX2 protein23576437
D010168PalmitatesPalmitates results in increased expression of EPHX2 protein23576437
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of EPHX2 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of EPHX2 mRNA20936131
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of EPHX2 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of EPHX2 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of EPHX2 mRNA17681415|1846767
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of EPHX2 mRNA]18467677|2093613
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased activity of EPHX2 protein10528994
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of EPHX2 mRNA16221955|1916217
D015232DinoprostoneEPHX2 gene mutant form affects the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]19896470
D015232DinoprostoneEPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]19896470
D010634PhenobarbitalPhenobarbital results in decreased expression of EPHX2 mRNA17381134|1916217
D010656PhenylephrinePhenylephrine results in decreased expression of EPHX2 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPHX2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of EPHX2 mRNA26272509
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [Cisplatin results in decreased expression of EPHX2 protein]26165641
D010672PhenytoinPhenytoin results in decreased expression of EPHX2 mRNA17381134
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of EPHX2 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of EPHX2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of EPHX2 mRNA15375163|1742611
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of EPHX2 mRNA]18467677|2005976
C006253pirinixic acidpirinixic acid results in increased expression of EPHX2 mRNA19162173|2248451
D017035PravastatinPravastatin results in decreased expression of EPHX2 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of EPHX2 mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of EPHX2 mRNA27413110
D011374ProgesteroneProgesterone results in decreased expression of EPHX2 mRNA23018184
C045950propiconazolepropiconazole results in decreased expression of EPHX2 mRNA22334560
C010423pyrithione zincpyrithione zinc results in increased expression of EPHX2 mRNA21424779
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of EPHX2 mRNA26100227
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in decreased expression of EPHX2 mRNA17639512
D011794QuercetinQuercetin results in decreased activity of EPHX2 protein3621371
D011794QuercetinQuercetin results in decreased expression of EPHX2 mRNA17103110
D011794QuercetinQuercetin results in increased expression of EPHX2 mRNA18095365
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in increased expression of EPHX2 mRNA26667767
C059514resveratrolresveratrol results in increased expression of EPHX2 mRNA25436977
C488333Ro 65-7199Ro 65-7199 affects the expression of EPHX2 mRNA14610520
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EPHX2 mRNA16054899
C089730rosiglitazonerosiglitazone results in increased expression of EPHX2 mRNA15520860
C089730rosiglitazone[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EPHX2 mRNA]16054899
C089730rosiglitazoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EPHX2 mRNA]16054899
C089730rosiglitazonerosiglitazone results in increased expression of EPHX2 mRNA21515302
D012643SeleniumSelenium results in increased expression of EPHX2 mRNA19244175
C009237senecioninesenecionine results in decreased expression of EPHX2 mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of EPHX2 mRNA26100227
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EPHX2 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of EPHX2 mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of EPHX2 protein23570992
C017947sodium arseniteCARM1 mutant form inhibits the reaction [sodium arsenite results in decreased expression of EPHX2 mRNA]23699174
C017947sodium arsenitePRMT1 mutant form inhibits the reaction [sodium arsenite results in decreased expression of EPHX2 mRNA]23699174
C017947sodium arsenitesodium arsenite affects the methylation of EPHX2 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of EPHX2 mRNA23699174
C017947sodium arsenitesodium arsenite results in increased expression of EPHX2 mRNA28229933
C016104sodium bichromatesodium bichromate results in increased expression of EPHX2 mRNA12325037
D0150862,6-Dichloroindophenol"[2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EPHX2 mRNA"21034357
D012969Sodium FluorideSodium Fluoride results in decreased expression of EPHX2 mRNA27862939
D053260SootSoot results in decreased expression of EPHX2 mRNA21914721
C075117squalestatin 1squalestatin 1 affects the expression of EPHX2 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of EPHX2 mRNA27225895
C025906stilbene oxide"16 alpha,17-epoxyprogesterone inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]"2043152
C025906stilbene oxidecholesterol alpha-oxide inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
C025906stilbene oxideDieldrin promotes the reaction [EPHX2 protein results in increased metabolism of stilbene oxide]2043152
C025906stilbene oxideEPHX2 protein results in increased metabolism of stilbene oxide2043152
C025906stilbene oxideEPHX2 protein results in increased metabolism of stilbene oxide analog2043152
C025906stilbene oxideethylphenylepoxygeranyl ether promotes the reaction [EPHX2 protein results in increased metabolism of stilbene oxide]2043152
C025906stilbene oxideHeptachlor Epoxide inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
C025906stilbene oxideHeptachlor Epoxide promotes the reaction [EPHX2 protein results in increased metabolism of stilbene oxide]2043152
C025906stilbene oxideLanosterol analog inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
C025906stilbene oxidelimonin inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
C025906stilbene oxidenomilin inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
C025906stilbene oxidetridiphane promotes the reaction [EPHX2 protein results in increased metabolism of stilbene oxide]2043152
C025906stilbene oxidetridiphane promotes the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
D013311StreptozocinEPHX2 gene mutant form inhibits the reaction [Streptozocin results in increased activity of RELA protein]21832210
D013311StreptozocinEPHX2 gene mutant form inhibits the reaction [Streptozocin results in increased secretion of CCL2 protein]21832210
D013311StreptozocinEPHX2 gene mutant form results in decreased susceptibility to Streptozocin21832210
D013311StreptozocinStreptozocin results in increased expression of EPHX2 protein23611540
C458508T 0070907EPHX2 gene results in decreased susceptibility to T 007090723152114
C458508T 0070907T 0070907 inhibits the reaction [EPHX2 gene mutant form results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine]23152114
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of and results in increased activity of EPHX2 protein"3032197
C501413tesaglitazartesaglitazar results in increased expression of EPHX2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EPHX2 mRNA16039398|2129612
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of EPHX2 mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EPHX2 mRNA]16054899
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of EPHX2 mRNA16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of EPHX2 mRNA]16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EPHX2 mRNA16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPHX2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EPHX2 mRNA21215274
D013752TetracyclineTetracycline results in decreased expression of EPHX2 mRNA24489787
D013893ThiramThiram results in decreased expression of EPHX2 mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of EPHX2 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of EPHX2 mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of EPHX2 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EPHX2 mRNA15289447
D014212TretinoinTretinoin results in decreased expression of EPHX2 mRNA20530235
C011559tributyltintributyltin results in decreased expression of EPHX2 mRNA29191790
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in increased expression of EPHX2 protein]15363585
D014241TrichloroethyleneTrichloroethylene results in increased expression of EPHX2 mRNA15363585
C009540triclocarbantriclocarban results in decreased activity of EPHX2 protein21741984
C051460tridiphanetridiphane promotes the reaction [EPHX2 protein results in increased metabolism of stilbene oxide]2043152
C051460tridiphanetridiphane promotes the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]2043152
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of EPHX2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EPHX2 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of EPHX2 mRNA19631733
C057693troglitazonetroglitazone results in increased expression of EPHX2 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of EPHX2 mRNA21515302
C057693troglitazonetroglitazone results in increased expression of EPHX2 protein21315101
C112106UAB 30UAB 30 analog results in increased expression of EPHX2 mRNA23292798
D014508UreaUrea analog results in decreased activity of EPHX2 protein15798002
D014520UrethaneUrethane results in decreased expression of EPHX2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of EPHX2 mRNA23179753|2915479
D014635Valproic AcidValproic Acid results in decreased methylation of EPHX2 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of EPHX2 mRNA17381134
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EPHX2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of EPHX2 mRNA20566332
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of EPHX2 mRNA"25198161
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of EPHX2 mRNA"23246600
C088658zoledronic acidzoledronic acid results in decreased expression of EPHX2 mRNA24714768
C088658zoledronic acidzoledronic acid results in increased expression of EPHX2 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IBA21873635  
GO:0000287magnesium ion binding-IDA12574510  
GO:0004301epoxide hydrolase activity-IBA21873635  
GO:0004301epoxide hydrolase activity-IDA8342951  10862610  22798687  
GO:0004301epoxide hydrolase activity-TAS-  
GO:0005102signaling receptor binding-IPI20178365  
GO:0015643toxic substance binding-IBA21873635  
GO:0015643toxic substance binding-IDA15096040  
GO:0016791phosphatase activity-IDA12574508  15196990  
GO:003388510-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity-IEA-  
GO:0042577lipid phosphatase activity-IBA21873635  
GO:0042577lipid phosphatase activity-IDA12574510  
GO:0042803protein homodimerization activity-IDA15096040  18513744  
GO:0042803protein homodimerization activity-NAS10862610  
GO ID GO Term Qualifier Evidence PubMed
GO:0006625protein targeting to peroxisome-TAS-  
GO:0006805xenobiotic metabolic process-NAS10862610  
GO:0006874cellular calcium ion homeostasis-NAS10862610  
GO:0006954inflammatory response-NAS10862610  
GO:0008217regulation of blood pressure-NAS10862610  
GO:0009636response to toxic substance-NAS10862610  
GO:0010628positive regulation of gene expression-IDA18974052  
GO:0016311dephosphorylation-IDA12574508  
GO:0017144drug metabolic process-NAS10862610  
GO:0019373epoxygenase P450 pathway-TAS-  
GO:0042632cholesterol homeostasis-IBA21873635  
GO:0042632cholesterol homeostasis-IDA18974052  
GO:0042759long-chain fatty acid biosynthetic process-TAS-  
GO:0046272stilbene catabolic process-IDA8342951  
GO:0046839phospholipid dephosphorylation-IBA21873635  
GO:0046839phospholipid dephosphorylation-IDA12574510  
GO:0072593reactive oxygen species metabolic process-NAS10862610  
GO:0090181regulation of cholesterol metabolic process-IMP18974052  
GO:0097176epoxide metabolic process-IDA22798687  
GO:0097755positive regulation of blood vessel diameter-NAS10862610  
GO ID GO Term Qualifier Evidence PubMed
GO:0005777peroxisome-IBA21873635  
GO:0005777peroxisome-IDA16314446  18513744  
GO:0005782peroxisomal matrix-TAS-  
GO:0005829cytosol-IDA8342951  16314446  18513744  
GO:0005829cytosol-NAS10862610  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2142670Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)TAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9018677Biosynthesis of DHA-derived SPMsTAS
R-HSA-9018678Biosynthesis of specialized proresolving mediators (SPMs)TAS
R-HSA-9018682Biosynthesis of maresinsTAS
R-HSA-9033241Peroxisomal protein importTAS
R-HSA-9033241Peroxisomal protein importIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18216721Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population. (2008 Jan)Zhang LPharmacogenet Genomics
18784359Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population. (2008 Dec)Sun PCarcinogenesis
16545818Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking. (2007 Jan)Wei QAtherosclerosis
17498780The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. (2007 Aug 1)Chen BSci Total Environ
24573875Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene poisoning. (2007 Jul)Sun PFront Med China