Gene info: ID 2056

Gene: EPO

GENE ID: 2056

Synonyms: DBAL|ECYT5|EP|MVCD2

Description: erythropoietin

Gene type: protein-coding

Location: 7q22.1

dbXrefs: Ensembl:ENSG00000130427 MIM:133170 Vega:OTTHUMG00000152121 UniprotKB:P01588

RefSeq: NG_021471.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 29

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.961e-1 (AD) 3.435e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR14A16	0.739
OR5H14	0.738
TMEM174	0.689
OR52E4	0.68
DPPA4	0.678
OR4L1	0.666
MROH5	0.661
LINC00189	0.656
TRIM64C	0.648
OR4N5	0.645

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TM7SF2	-0.368
C16orf95	-0.358
C16orf46	-0.344
PCDH9	-0.332
HDAC11	-0.319
TMEM53	-0.303
PAQR4	-0.301
MAGIX	-0.3
CYP46A1	-0.297
ASPDH	-0.297

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C068543	1,2-diethyl-3-hydroxypyridin-4-one	"1,2-diethyl-3-hydroxypyridin-4-one results in increased expression of EPO mRNA"	21558026
C401932	15,16-dihydrotanshinone I	"15,16-dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]"	26282490
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased abundance of Nitrites]	23384249
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]	17928571
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased phosphorylation of and results in increased activity of GSK3B protein]	17928571
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased susceptibility to Doxorubicin]	17928571
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in decreased susceptibility to Levodopa]	21683736
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO results in increased phosphorylation of GSK3B protein]	17952604
C506392	2-hydroxyethidium	EPO protein inhibits the reaction [HPH1 gene mutant form results in increased abundance of 2-hydroxyethidium]	25041251
C477898	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GYPA mRNA]	21915944
C477898	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GYPA protein]	21915944
C477898	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]	21915944
C477898	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid	3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
C090937	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11286986
C121707	7,3'-dihydroxy-4'-methoxyisoflavone	"7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of EPO mRNA"	21309574
C017226	7,8-dihydrobiopterin	"EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]"	25490417
C017226	7,8-dihydrobiopterin	"EPO protein inhibits the reaction [HPH1 gene mutant form results in increased abundance of 7,8-dihydrobiopterin]"	25041251
D000082	Acetaminophen	Acetaminophen results in increased expression of EPO mRNA	22610607
D000109	Acetylcholine	EPO protein inhibits the reaction [GCH1 gene mutant form results in decreased susceptibility to Acetylcholine]	25490417
D000109	Acetylcholine	EPO protein results in increased susceptibility to Acetylcholine	25490417
C096064	actein	actein results in decreased expression of EPO mRNA	19527300
D000242	Cyclic AMP	Cyclic AMP results in increased expression of EPO protein	18621143
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of EPO mRNA	21641981\|2210060
C010845	aluminum chloride	EPO protein results in decreased susceptibility to aluminum chloride	22174104
D015081	2-Naphthylamine	2-Naphthylamine results in increased expression of EPO mRNA	18247414
D019798	Neopterin	EPO protein promotes the reaction [GCH1 protein results in increased chemical synthesis of Neopterin]	25490417
D000640	Amitrole	[Amitrole results in increased abundance of Hydrogen Peroxide] which results in decreased expression of EPO protein	7980410
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of EPO mRNA	16483693
D000666	Amphotericin B	Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]	16189267
D000666	Amphotericin B	Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	16189267
D000666	Amphotericin B	Amphotericin B results in decreased expression of EPO protein	2299214\|697352
D000666	Amphotericin B	Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	16189267
C044613	angelicae sinensis extract	angelicae sinensis extract inhibits the reaction [Cyclophosphamide results in decreased expression of EPO mRNA]	19627214
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in decreased expression of EPO protein	2474097
D000967	Antimony Sodium Gluconate	Antimony Sodium Gluconate results in decreased expression of EPO mRNA	9531339
D000967	Antimony Sodium Gluconate	Antimony Sodium Gluconate results in decreased expression of EPO protein	9531339
C526219	apple polyphenol extract	apple polyphenol extract results in increased expression of EPO mRNA	18351577
D034341	Aristolochic Acids	Aristolochic Acids inhibits the reaction [EPO protein affects the localization of and results in increased activity of EPOR protein]	26136230
D034341	Aristolochic Acids	Aristolochic Acids inhibits the reaction [EPO protein results in increased phosphorylation of AKT1 protein]	26136230
D034341	Aristolochic Acids	Aristolochic Acids inhibits the reaction [EPO protein results in increased phosphorylation of EPOR protein]	26136230
D034341	Aristolochic Acids	Aristolochic Acids inhibits the reaction [EPO protein results in increased phosphorylation of JAK1 protein]	26136230
D034341	Aristolochic Acids	Aristolochic Acids inhibits the reaction [EPO protein results in increased phosphorylation of MAPK1 protein]	26136230
D034341	Aristolochic Acids	Aristolochic Acids inhibits the reaction [EPO protein results in increased phosphorylation of MAPK3 protein]	26136230
C543477	Astragali compound	Astragali compound inhibits the reaction [Cyclophosphamide results in decreased expression of EPO mRNA]	19627214
D001554	Benzene	Benzene inhibits the reaction [Formaldehyde results in increased expression of EPO mRNA]	28373009
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of EPO mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of EPO mRNA	18247414
D004958	Estradiol	Estradiol affects the expression of EPO mRNA	23557687
C006780	bisphenol A	bisphenol A affects the expression of EPO mRNA	23557687
C006780	bisphenol A	bisphenol A inhibits the reaction [Cobalt results in increased expression of EPO mRNA]	15147973
C006780	bisphenol A	bisphenol A inhibits the reaction [HIF1A protein results in increased expression of EPO mRNA]	15147973
D000069286	Bortezomib	Bortezomib results in decreased expression of EPO mRNA	18174379
D002104	Cadmium	Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	20447699
D002104	Cadmium	Cadmium inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EPO promoter]]	10866824
D002104	Cadmium	Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	10866824
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]	11090055
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]	11090055
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11090055
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]	11090055
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of EPO protein	21540277
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of EPO promoter	22457795
C526426	calycosin-7-O-beta-D-glucoside	calycosin-7-O-beta-D-glucoside results in increased expression of EPO mRNA	21309574
D002220	Carbamazepine	Carbamazepine affects the expression of EPO mRNA	24752500
D002248	Carbon Monoxide	Carbon Monoxide results in increased expression of EPO mRNA	9263988
D002248	Carbon Monoxide	Carbon Monoxide results in increased expression of EPO protein	9263988
D007464	Clioquinol	Clioquinol results in decreased expression of EPO mRNA	19502547
D007464	Clioquinol	Clioquinol results in increased expression of EPO mRNA	16973622
D003035	Cobalt	bisphenol A inhibits the reaction [Cobalt results in increased expression of EPO mRNA]	15147973
D003035	Cobalt	Cobalt results in increased expression of EPO mRNA	10699462\|1514797
D003035	Cobalt	Cobalt results in increased expression of EPO mRNA	17967803\|2387712
D003035	Cobalt	Cobalt results in increased expression of EPO protein	23877121
D003035	Cobalt	Diethylstilbestrol inhibits the reaction [Cobalt results in increased expression of EPO mRNA]	23877121
D003035	Cobalt	Diethylstilbestrol inhibits the reaction [Cobalt results in increased expression of EPO protein]	23877121
C018021	cobaltous chloride	Cadmium Chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]	11090055
C018021	cobaltous chloride	Cadmium Chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]	11090055
C018021	cobaltous chloride	Cisplatin inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]	11090055
C018021	cobaltous chloride	Cisplatin inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]	11090055
C018021	cobaltous chloride	cobaltous chloride affects the expression of EPO protein	15743794
C018021	cobaltous chloride	cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	23958427
C018021	cobaltous chloride	cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of EPO mRNA]	19128456
C018021	cobaltous chloride	cobaltous chloride results in increased expression of EPO mRNA	11090055\|2186306
C018021	cobaltous chloride	cobaltous chloride results in increased expression of EPO protein	11090055\|1682716
C018021	cobaltous chloride	EPO protein inhibits the reaction [cobaltous chloride results in increased expression of PCNA protein]	23384249
C018021	cobaltous chloride	HIF1A protein promotes the reaction [cobaltous chloride results in increased expression of EPO mRNA]	23065176
C018021	cobaltous chloride	HIPK2 protein inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein results in increased expression of EPO mRNA]]	19128456
C018021	cobaltous chloride	Indican inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]	21863063
C018021	cobaltous chloride	Mercuric Chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]	11090055
C018021	cobaltous chloride	Mercuric Chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]	11090055
C018021	cobaltous chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]	11090055
C018021	cobaltous chloride	cobaltous chloride results in increased expression of EPO mRNA	10756076\|1677233
C018021	cobaltous chloride	cobaltous chloride results in increased expression of EPO protein	16772336
C018021	cobaltous chloride	cobaltous chloride deficiency results in increased expression of EPO protein	18331222
C018021	cobaltous chloride	[cobaltous chloride results in increased expression of and results in increased activity of HIF1A protein] which results in increased expression of EPO protein	21054399
C018021	cobaltous chloride	cobaltous chloride results in increased expression of EPO mRNA	12819242\|1927835
C018021	cobaltous chloride	cobaltous chloride results in increased expression of EPO protein	19278353\|2088103
C018021	cobaltous chloride	EPO protein inhibits the reaction [cobaltous chloride results in increased expression of EPOR protein]	21116766
C018021	cobaltous chloride	EPO protein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]	21116766
C018021	cobaltous chloride	indole inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]	21863063
C018021	cobaltous chloride	indole inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]	21863063
C018021	cobaltous chloride	[Oxygen deficiency co-treated with cobaltous chloride] results in increased expression of EPO mRNA	18331222\|1927835
C018021	cobaltous chloride	[Oxygen deficiency co-treated with cobaltous chloride] results in increased expression of EPO protein	18331222\|1927835
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of EPO mRNA	19549813
C000515	cremophor EL	EPO protein results in decreased susceptibility to cremophor EL	17010629
D003474	Curcumin	Curcumin results in decreased expression of EPO mRNA	16880289
C057862	cyanoginosin LR	cyanoginosin LR results in decreased expression of EPO mRNA	23454832
C057862	cyanoginosin LR	cyanoginosin LR results in decreased expression of EPO protein	23454832
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	10756076
D003520	Cyclophosphamide	angelicae sinensis extract inhibits the reaction [Cyclophosphamide results in decreased expression of EPO mRNA]	19627214
D003520	Cyclophosphamide	Astragali compound inhibits the reaction [Cyclophosphamide results in decreased expression of EPO mRNA]	19627214
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of EPO mRNA	19627214
D003520	Cyclophosphamide	EPO protein results in increased susceptibility to Cyclophosphamide	11245434
D016572	Cyclosporine	Cyclosporine results in decreased expression of EPO mRNA	20106945\|2556210
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	24557580
D003571	Cytochalasin B	[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein	18776917
D003571	Cytochalasin B	[Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein	18776917
D003571	Cytochalasin B	Dexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]	18776917
D003571	Cytochalasin B	resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]	18776917
D003571	Cytochalasin B	resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein]	18776917
D003606	Dacarbazine	EPO protein results in decreased susceptibility to Dacarbazine	15743794
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of EPO mRNA	23914054
C014347	decitabine	decitabine results in increased expression of EPO mRNA	19194470
D003676	Deferoxamine	Deferoxamine results in increased expression of EPO mRNA	10699462
D003676	Deferoxamine	Deferoxamine deficiency results in increased expression of EPO mRNA	10756076
D003676	Deferoxamine	Deferoxamine deficiency results in increased stability of EPO mRNA	10756076
D003676	Deferoxamine	Deferoxamine results in increased expression of EPO mRNA	10756076
D003676	Deferoxamine	Deferoxamine inhibits the reaction [Reactive Oxygen Species results in decreased expression of EPO protein]	9927288
D003676	Deferoxamine	Deferoxamine results in increased expression of EPO mRNA	10559391\|2155802
D003676	Deferoxamine	Deferoxamine results in increased expression of EPO protein	9927288
D003687	Dehydroepiandrosterone	[Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein	15161484
D003907	Dexamethasone	Dexamethasone analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]	18776917
D016190	Carboplatin	Carboplatin results in increased expression of EPO protein	17891399
D002945	Cisplatin	Cisplatin inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]	11090055
D002945	Cisplatin	Cisplatin inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]	11090055
D002945	Cisplatin	Cisplatin inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11090055
D002945	Cisplatin	Cisplatin inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]	11090055
D002945	Cisplatin	EPO protein inhibits the reaction [Cisplatin results in decreased abundance of Glutathione]	22013135
D002945	Cisplatin	EPO protein inhibits the reaction [Cisplatin results in increased activity of CAT protein]	22013135
D002945	Cisplatin	EPO protein results in decreased susceptibility to Cisplatin	23077460
D002945	Cisplatin	EPO protein results in increased susceptibility to Cisplatin	23077460
D002945	Cisplatin	Cisplatin affects the expression of EPO protein	20020992
D002945	Cisplatin	Cisplatin results in increased expression of EPO protein	2206997
D002945	Cisplatin	EPO protein results in decreased susceptibility to Cisplatin	20722073
D002945	Cisplatin	[Cisplatin co-treated with EPO protein] results in increased cleavage of CASP3 protein	21497595
D004008	Diclofenac	Diclofenac affects the expression of EPO mRNA	24752500
D004054	Diethylstilbestrol	Diethylstilbestrol inhibits the reaction [Cobalt results in increased expression of EPO mRNA]	23877121
D004054	Diethylstilbestrol	Diethylstilbestrol inhibits the reaction [Cobalt results in increased expression of EPO protein]	23877121
D004054	Diethylstilbestrol	Diethylstilbestrol inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	23877121
D004054	Diethylstilbestrol	Diethylstilbestrol inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]	23877121
D017323	Dihematoporphyrin Ether	EPO protein results in increased susceptibility to Dihematoporphyrin Ether	12006547
C067883	dihydroethidium	EPO protein inhibits the reaction [HPH1 gene mutant form results in increased oxidation of dihydroethidium]	25041251
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of EPO mRNA"	19502547
C067311	docetaxel	EPO protein results in decreased susceptibility to docetaxel	20722073
D007980	Levodopa	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in decreased susceptibility to Levodopa]	21683736
D007980	Levodopa	EPO protein inhibits the reaction [Levodopa results in decreased expression of GSK3B protein]	21683736
D007980	Levodopa	EPO protein inhibits the reaction [Levodopa results in decreased expression of HSF1 protein]	21683736
D007980	Levodopa	EPO protein inhibits the reaction [Levodopa results in increased cleavage of and results in increased activity of CASP3 protein]	21683736
D007980	Levodopa	EPO protein results in decreased susceptibility to Levodopa	21683736
D004317	Doxorubicin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]	17928571
D004317	Doxorubicin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased susceptibility to Doxorubicin]	17928571
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased expression of DES protein]	16449733
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased expression of EPOR protein]	16449733
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]	16449733
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]	16449733
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]	16449733
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in increased abundance of Reactive Oxygen Species]	17928571
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]	17928571
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in increased expression of PTGS2 protein]	16449733
D004317	Doxorubicin	EPO protein results in increased susceptibility to Doxorubicin	17928571
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione]	16405037
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]	17924179
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased expression of KL mRNA]	20606417
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased expression of KL protein]	20606417
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased expression of TNNT2 protein]	17924179
D004317	Doxorubicin	EPO protein results in increased susceptibility to Doxorubicin	17924179
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of and results in increased secretion of EPO protein"	17963324
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of EPO mRNA"	17963324
C007590	emulphogene BC 720	emulphogene BC 720 results in increased expression of EPO mRNA	25398874
D004656	Enalapril	Enalapril results in decreased expression of EPO protein	2474097\|9434678
D004656	Enalapril	Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]	19958114
D005047	Etoposide	EPO protein results in increased susceptibility to [Organoplatinum Compounds co-treated with Etoposide]	18403296
D005280	Fenoterol	Fenoterol results in increased expression of EPO protein	9209250
D005472	Fluorouracil	EPO protein results in increased susceptibility to Fluorouracil	16103069
D005472	Fluorouracil	Fluorouracil results in increased expression of EPO protein	20020992\|2206997
D005557	Formaldehyde	Benzene inhibits the reaction [Formaldehyde results in increased expression of EPO mRNA]	28373009
D005557	Formaldehyde	Formaldehyde results in increased expression of EPO mRNA	28373009
C007768	formononetin	formononetin results in increased expression of EPO mRNA	21309574
D005839	Gentamicins	EPO protein results in decreased susceptibility to Gentamicins	16467726
D005839	Gentamicins	Gentamicins results in decreased expression of EPO protein	1982298
D005978	Glutathione	EPO protein inhibits the reaction [Cisplatin results in decreased abundance of Glutathione]	22013135
D005978	Glutathione	EPO protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione]	16405037
D006152	Cyclic GMP	EPO protein inhibits the reaction [GCH1 gene mutant form results in increased abundance of Cyclic GMP]	25490417
D006152	Cyclic GMP	EPO protein inhibits the reaction [HPH1 gene mutant form results in decreased abundance of Cyclic GMP]	25041251
D006220	Haloperidol	EPO protein inhibits the reaction [Haloperidol results in decreased expression of BCL2L1 protein]	17805306
D006220	Haloperidol	EPO protein inhibits the reaction [Haloperidol results in decreased expression of BDNF protein]	17805306
D006220	Haloperidol	EPO protein inhibits the reaction [Haloperidol results in increased expression of CASP3 protein]	17805306
C027492	Huang Qi	Huang Qi results in increased expression of EPO mRNA	21309574
D006854	Hydrocortisone	Hydrocortisone results in increased expression of EPO protein	10694834
D006861	Hydrogen Peroxide	[Amitrole results in increased abundance of Hydrogen Peroxide] which results in decreased expression of EPO protein	7980410
D006861	Hydrogen Peroxide	CAT protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of EPO protein]	7980410
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of EPO protein	7980410
D006861	Hydrogen Peroxide	[Vitamin K 3 results in increased abundance of Hydrogen Peroxide] which results in decreased expression of EPO protein	7980410
D006861	Hydrogen Peroxide	EPO protein inhibits the reaction [GCH1 gene mutant form results in increased abundance of Hydrogen Peroxide]	25490417
D006861	Hydrogen Peroxide	Hydrogen Peroxide inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	10756076
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of EPO protein	9927288
D006861	Hydrogen Peroxide	Vitamin A inhibits the reaction [Hydrogen Peroxide results in decreased expression of EPO protein]	9927288
D006918	Hydroxyurea	Hydroxyurea results in increased expression of EPO protein	19724057
D007200	Indican	Indican inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]	21863063
D007200	Indican	Indican inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	21863063
C030374	indole	indole inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]	21863063
C030374	indole	indole inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]	21863063
D007213	Indomethacin	EPO protein inhibits the reaction [Indomethacin results in increased activity of MPO protein]	20723003
D007372	Interferons	[Ribavirin co-treated with Interferons] results in increased expression of EPO protein	20009130
D007501	Iron	Iron affects the susceptibility to EPO protein	24806658
D007608	Kainic Acid	EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]	18711747
D007608	Kainic Acid	EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]	18711747
D007608	Kainic Acid	EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]	18711747
D007608	Kainic Acid	EPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]	18711747
D007608	Kainic Acid	EPO protein inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]	18711747
D007608	Kainic Acid	EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]	18711747
D007608	Kainic Acid	EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]	18711747
D007608	Kainic Acid	EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]]	18711747
D007654	Ketoconazole	Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]	21566342
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	21566342
D008070	Lipopolysaccharides	EPO protein inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]	24561306
D008070	Lipopolysaccharides	EPO protein inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]	24561306
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with EPO protein] results in increased expression of BCL2L1 protein	24561306
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with EPO protein] results in increased expression of EPOR protein	24561306
C032881	lysophosphatidic acid	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
C032881	lysophosphatidic acid	[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA	21915944
C032881	lysophosphatidic acid	[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA	21915944
C032881	lysophosphatidic acid	[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein	21915944
C032881	lysophosphatidic acid	lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA]	21915944
C032881	lysophosphatidic acid	lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GYPA mRNA]	21915944
C032881	lysophosphatidic acid	lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]	21915944
C032881	lysophosphatidic acid	lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
C032881	lysophosphatidic acid	Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA]	21915944
C032881	lysophosphatidic acid	Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]	21915944
C032881	lysophosphatidic acid	Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
C032881	lysophosphatidic acid	WP1066 inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
D008315	Malondialdehyde	EPO protein results in decreased abundance of Malondialdehyde	22013135
D008345	Manganese	Manganese results in increased glycosylation of EPO protein	16937399
D008627	Mercuric Chloride	Mercuric Chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]	11090055
D008627	Mercuric Chloride	Mercuric Chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]	11090055
D008627	Mercuric Chloride	Mercuric Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11090055
D008627	Mercuric Chloride	Mercuric Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]	11090055
D009538	Nicotine	Nicotine results in increased expression of EPO mRNA	18247414
D009569	Nitric Oxide	EPO protein results in decreased susceptibility to Nitric Oxide	15816862
D009573	Nitrites	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased abundance of Nitrites]	23384249
D009573	Nitrites	EPO protein results in increased abundance of Nitrites	23384249
C007350	nitrofen	nitrofen results in decreased expression of EPO mRNA	27880037
C007350	nitrofen	nitrofen results in decreased expression of EPO protein	27880037
D009599	Nitroprusside	Nitroprusside inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11286986
C010615	Nonidet P-40	Nonidet P-40 results in decreased expression of EPO mRNA	26552463
D009638	Norepinephrine	EPO protein results in decreased susceptibility to Norepinephrine	14732207
D009944	Organoplatinum Compounds	EPO protein results in increased susceptibility to [Organoplatinum Compounds co-treated with Etoposide]	18403296
D010100	Oxygen	Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	20447699
D010100	Oxygen	Oxygen deficiency results in increased expression of EPO mRNA	20447699
D010100	Oxygen	"15,16-dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]"	26282490
D010100	Oxygen	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11286986
D010100	Oxygen	Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	16189267
D010100	Oxygen	Cadmium Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11090055
D010100	Oxygen	Cadmium Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]	11090055
D010100	Oxygen	Cadmium inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EPO promoter]]	10866824
D010100	Oxygen	Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	10866824
D010100	Oxygen	Cisplatin inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11090055
D010100	Oxygen	Cisplatin inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]	11090055
D010100	Oxygen	cobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	23958427
D010100	Oxygen	CYP2D6 protein inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	21566342
D010100	Oxygen	CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	21566342
D010100	Oxygen	EPAS1 protein affects the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	23958427
D010100	Oxygen	EPO protein inhibits the reaction [Oxygen deficiency results in increased secretion of EDN1 protein]	24557580
D010100	Oxygen	Indican inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	21863063
D010100	Oxygen	Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]	21566342
D010100	Oxygen	Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	21566342
D010100	Oxygen	Mercuric Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11090055
D010100	Oxygen	Mercuric Chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]	11090055
D010100	Oxygen	Nitroprusside inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11286986
D010100	Oxygen	Oxygen deficiency promotes the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]	16189267
D010100	Oxygen	Oxygen deficiency promotes the reaction [HIF1A protein binds to EPO promoter]	10866824
D010100	Oxygen	Oxygen deficiency results in increased expression of EPO mRNA	10866824\|1109005
D010100	Oxygen	Oxygen deficiency results in increased expression of EPO protein	11090055
D010100	Oxygen	Oxygen deficiency results in increased secretion of EPO protein	23958427
D010100	Oxygen	zinc chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11090055
D010100	Oxygen	Cycloheximide inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	10756076
D010100	Oxygen	Hydrogen Peroxide inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	10756076
D010100	Oxygen	Oxygen deficiency results in increased expression of EPO mRNA	10756076\|2343730
D010100	Oxygen	Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	16189267
D010100	Oxygen	cyclo(Trp-Asp-Pro-Val-Leu) promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	24557580
D010100	Oxygen	Diethylstilbestrol inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	23877121
D010100	Oxygen	Diethylstilbestrol inhibits the reaction [Oxygen deficiency results in increased expression of EPO protein]	23877121
D010100	Oxygen	EPO protein inhibits the reaction [Oxygen results in increased expression of ACHE mRNA alternative form]	19729061
D010100	Oxygen	[Oxygen deficiency co-treated with cobaltous chloride] results in increased expression of EPO mRNA	18331222\|1927835
D010100	Oxygen	[Oxygen deficiency co-treated with cobaltous chloride] results in increased expression of EPO protein	18331222\|1927835
D010100	Oxygen	Oxygen deficiency results in increased expression of EPO	21120517
D010100	Oxygen	Oxygen deficiency results in increased expression of EPO mRNA	18331222\|1927835
D010100	Oxygen	Oxygen deficiency results in increased expression of EPO protein	18331222\|1927835
D010100	Oxygen	HIF1A affects the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	10866824
D010126	Ozone	Ozone results in increased expression of EPO mRNA	27206323
D017239	Paclitaxel	EPO protein results in decreased susceptibility to Paclitaxel	17010629
D010269	Paraquat	EPO protein inhibits the reaction [SOD2 gene mutant form results in increased susceptibility to Paraquat]	16288465
D052638	Particulate Matter	Particulate Matter results in increased expression of EPO mRNA	27832168
C417083	peginterferon alfa-2b	[peginterferon alfa-2b co-treated with Ribavirin] affects the expression of EPO protein	15232364
D010634	Phenobarbital	Phenobarbital results in increased expression of EPO mRNA	23528251
C030299	phenylhydrazine	phenylhydrazine results in increased expression of EPO mRNA	22908232
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of EPO mRNA	21061450
D010862	Pilocarpine	Pilocarpine results in increased expression of EPO mRNA	17166730
C006253	pirinixic acid	NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of EPO mRNA]	17950772
C006253	pirinixic acid	pirinixic acid results in decreased expression of EPO mRNA	17950772
D010936	Plant Extracts	Plant Extracts results in increased expression of EPO mRNA	18351577
D011748	Pyrogallol	Pyrogallol results in decreased expression of EPO protein	9927288
D011794	Quercetin	Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA]	21915944
D011794	Quercetin	Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]	21915944
D011794	Quercetin	Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
D011794	Quercetin	Quercetin results in decreased expression of EPO mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of EPO mRNA	19729006
D017382	Reactive Oxygen Species	EPO protein results in decreased abundance of Reactive Oxygen Species	12200812
D017382	Reactive Oxygen Species	EPO protein inhibits the reaction [Doxorubicin results in increased abundance of Reactive Oxygen Species]	17928571
D017382	Reactive Oxygen Species	Deferoxamine inhibits the reaction [Reactive Oxygen Species results in decreased expression of EPO protein]	9927288
D017382	Reactive Oxygen Species	tetramethylthiourea inhibits the reaction [Reactive Oxygen Species results in decreased expression of EPO protein]	9927288
C059514	resveratrol	resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with C5 protein] results in increased secretion of EPO protein]	18776917
C059514	resveratrol	resveratrol analog inhibits the reaction [[Cytochalasin B co-treated with IL5 protein] results in increased secretion of EPO protein]	18776917
D012254	Ribavirin	[peginterferon alfa-2b co-treated with Ribavirin] affects the expression of EPO protein	15232364
D012254	Ribavirin	[Ribavirin co-treated with Interferons] results in increased expression of EPO protein	20009130
D012254	Ribavirin	Ribavirin results in increased expression of EPO	12713065
C496827	salubrinal	[salubrinal co-treated with EPO protein] results in decreased expression of ATF4 protein	23690448
C496827	salubrinal	[salubrinal co-treated with EPO protein] results in increased phosphorylation of EIF2S1 protein	23690448
C003402	sapropterin	EPO protein inhibits the reaction [GCH1 mutant form results in decreased abundance of sapropterin]	25041251
C003402	sapropterin	"EPO protein inhibits the reaction [[GCH1 gene mutant form results in increased oxidation of sapropterin] which results in increased chemical synthesis of 7,8-dihydrobiopterin]"	25490417
C003402	sapropterin	EPO protein inhibits the reaction [HPH1 gene mutant form results in increased oxidation of sapropterin]	25041251
C003402	sapropterin	EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]	25490417
C003402	sapropterin	EPO protein results in increased abundance of sapropterin	25490417
D019821	Simvastatin	Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPO protein]	20821229
D019821	Simvastatin	Simvastatin inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]	20821229
D013205	Staphylococcal Protein A	Staphylococcal Protein A results in increased expression of EPO protein	9735323
D013205	Staphylococcal Protein A	Zidovudine promotes the reaction [Staphylococcal Protein A results in increased expression of EPO protein]	9735323
D019311	Staurosporine	EPO protein results in decreased susceptibility to Staurosporine	15816862
D019311	Staurosporine	tin mesoporphyrin inhibits the reaction [EPO protein results in decreased susceptibility to Staurosporine]	15816862
D013311	Streptozocin	Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]	19958114
D013311	Streptozocin	Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPO protein]	20821229
D013311	Streptozocin	Simvastatin inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]	20821229
D013311	Streptozocin	Streptozocin results in decreased expression of EPO protein	20821229
D013311	Streptozocin	Streptozocin results in increased expression of EPO mRNA	19958114\|2082122
D013481	Superoxides	EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]	25490417
D013739	Testosterone	[Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein	15161484
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	EPO affects the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA]	20189893
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	EPO inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of ACTA1 mRNA]	20189893
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	EPO inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased activity of CASP3]	20189893
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of EPO mRNA	20189893
C019107	tetramethylthiourea	tetramethylthiourea inhibits the reaction [Reactive Oxygen Species results in decreased expression of EPO protein]	9927288
C055421	tin mesoporphyrin	tin mesoporphyrin inhibits the reaction [EPO protein results in decreased susceptibility to Staurosporine]	15816862
D014212	Tretinoin	Tretinoin results in increased expression of EPO mRNA	20488242
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EPO mRNA"	26179874
D014520	Urethane	Urethane results in decreased expression of EPO mRNA	28818685
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of EPO mRNA	27832168
D014801	Vitamin A	Vitamin A results in increased expression of EPO protein	16960172
D014801	Vitamin A	Vitamin A inhibits the reaction [Hydrogen Peroxide results in decreased expression of EPO protein]	9927288
D014801	Vitamin A	Vitamin A results in increased expression of EPO protein	9927288
D024483	Vitamin K 3	[Vitamin K 3 results in increased abundance of Hydrogen Peroxide] which results in decreased expression of EPO protein	7980410
C519885	WP1066	WP1066 inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]	21915944
D015215	Zidovudine	Zidovudine results in increased expression of EPO protein	3422548
D015215	Zidovudine	EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]	7646543
D015215	Zidovudine	EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]	7646543
D015215	Zidovudine	IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]	7646543
D015215	Zidovudine	IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]	7646543
D015215	Zidovudine	Zidovudine inhibits the reaction [EPO protein binds to EPOR protein]	7646543
D015215	Zidovudine	Zidovudine promotes the reaction [Staphylococcal Protein A results in increased expression of EPO protein]	9735323
D015215	Zidovudine	Zidovudine results in increased expression of EPO protein	1549625\|1889487
C016837	zinc chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of EPO protein]	11090055
C016837	zinc chloride	zinc chloride inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]	11090055
D015054	Zymosan	EPO protein inhibits the reaction [Zymosan results in increased expression of HAMP mRNA]	18664788

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005125	cytokine activity	-	IBA	21873635
GO:0005125	cytokine activity	-	IDA	28283061
GO:0005128	erythropoietin receptor binding	-	IBA	21873635
GO:0005128	erythropoietin receptor binding	-	IMP	28283061
GO:0005179	hormone activity	-	IEA	-
GO:0005515	protein binding	-	IPI	9774108 26481148
GO:0030295	protein kinase activator activity	-	IBA	21873635
GO:0030295	protein kinase activator activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	16497104
GO:0001666	response to hypoxia	-	IBA	21873635
GO:0006915	apoptotic process	-	IEA	-
GO:0006953	acute-phase response	-	IEA	-
GO:0007165	signal transduction	-	NAS	3838366
GO:0007566	embryo implantation	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0008015	blood circulation	-	NAS	3838366
GO:0008283	cell proliferation	-	IMP	28283061
GO:0008284	positive regulation of cell proliferation	-	IBA	21873635
GO:0008284	positive regulation of cell proliferation	-	IDA	9722506
GO:0009651	response to salt stress	-	IEA	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010523	negative regulation of calcium ion transport into cytosol	-	IDA	14569084
GO:0010976	positive regulation of neuron projection development	-	IEA	-
GO:0018105	peptidyl-serine phosphorylation	-	IEA	-
GO:0030218	erythrocyte differentiation	-	IDA	15084469
GO:0030218	erythrocyte differentiation	-	IMP	28283061
GO:0032147	activation of protein kinase activity	-	IEA	-
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0033189	response to vitamin A	-	IEA	-
GO:0033574	response to testosterone	-	IEA	-
GO:0038162	erythropoietin-mediated signaling pathway	-	IBA	21873635
GO:0038162	erythropoietin-mediated signaling pathway	-	IMP	28283061
GO:0042104	positive regulation of activated T cell proliferation	-	IEA	-
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	-	IDA	9722506
GO:0042541	hemoglobin biosynthetic process	-	IBA	21873635
GO:0042541	hemoglobin biosynthetic process	-	IEA	-
GO:0043249	erythrocyte maturation	-	IEA	-
GO:0043627	response to estrogen	-	IEA	-
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	9722506
GO:0046579	positive regulation of Ras protein signal transduction	-	IBA	21873635
GO:0046579	positive regulation of Ras protein signal transduction	-	IDA	9722506
GO:0048678	response to axon injury	-	IEA	-
GO:0048823	nucleate erythrocyte development	-	IBA	21873635
GO:0051602	response to electrical stimulus	-	IEA	-
GO:0055093	response to hyperoxia	-	IEA	-
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IEA	-
GO:0070555	response to interleukin-1	-	IEA	-
GO:0071474	cellular hyperosmotic response	-	IDA	14569084
GO:0071548	response to dexamethasone	-	IEA	-
GO:1901215	negative regulation of neuron death	-	IEA	-
GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	-	IDA	14569084
GO:1902251	negative regulation of erythrocyte apoptotic process	-	IDA	14569084
GO:2001258	negative regulation of cation channel activity	-	IDA	14569084

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	14569084
GO:0009986	cell surface	-	IDA	14569084
GO:0044297	cell body	-	IEA	-

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction
hsa04630	Jak-STAT signaling pathway
hsa04640	Hematopoietic cell lineage

Reactome ID	Reactome Term	Evidence
R-HSA-1234158	Regulation of gene expression by Hypoxia-inducible Factor	TAS
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	TAS
R-HSA-2262749	Cellular response to hypoxia	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
15498082	Does autonomic neuropathy play a role in erythropoietin regulation in non-proteinuric Type 2 diabetic patients? (2004 Nov)	Spallone V	Diabet Med
19212904	Cardiovascular risk factors in non-diabetic hemodialysis patients: a comparative study. (2009)	Tzanatos HA	Ren Fail
20646855	Prognostic impact of erythropoietin expression and erythropoietin receptor expression on locoregional control and survival of patients irradiated for stage II/III non-small-cell lung cancer. (2011 Jun 1)	Rades D	Int J Radiat Oncol Biol Phys
7618046	Carbon monoxide in chronic uraemia related to erythropoietin treatment and smoking habits. (1995 Mar)	Thunedborg P	Scand J Urol Nephrol
9372326	Effect of smoking on the serum concentration of erythropoietin and granulocyte-colony stimulating factor. (1997 Oct)	Tanabe N	Intern Med
29502563	Active Smoking and Hematocrit and Fasting Circulating Erythropoietin Concentrations in the General Population. (2018 Mar)	Eisenga MF	Mayo Clin Proc
23852087	Disulfiram deregulates HIF-alpha subunits and blunts tumor adaptation to hypoxia in hepatoma cells. (2013 Sep)	Park HJ	Acta Pharmacol Sin
24312736	A case of erythrocytosis in a patient treated with an aromatase inhibitor for breast cancer. (2013)	Iyengar A	Case Rep Hematol
27831681	Primary Familial and Congenital Polycythemia (1993)	Bento C	-
18776724	Increased fetal plasma and amniotic fluid erythropoietin concentrations: markers of intrauterine hypoxia. (2009)	Teramo KA	Neonatology
23931679	Chronic traffic pollution exposure is associated with eosinophilic, but not neutrophilic inflammation in older adult asthmatics. (2013 Nov)	Epstein TG	J Asthma
9883806	Erythropoietin receptor and hematological disease. (1999 Jan)	McMullin MF	Am J Hematol
12846770	The role of hyperparathyroidism, erythropoietin therapy, and CMV infection in the failure of arteriovenous fistula in hemodialysis. (2003 Aug)	Grandaliano G	Kidney Int
12554896	Relationship between inflammatory cells and structural changes in the lungs of asymptomatic and never smokers: a biopsy study. (2003 Feb)	Amin K	Thorax
15151261	The Diamant Alpin Dialysis cohort study: clinico-biological characteristics and cardiovascular genetic risk profile of incident patients. (2004 Jan-Feb)	Pernod G	J Nephrol
8426948	[Polycythemia: primary or secondary? The differential diagnostic value of stem cell cultures]. (1993 Jan 23)	Kung C	Schweiz Med Wochenschr
10595631	Haematological abnormalities in early abstinent alcoholics are closely associated with alterations in thrombopoietin and erythropoietin serum profiles. (1999 Nov)	Schmitt M	Thromb Haemost
19890342	Prohepcidin concentrations and erythroid progenitors in cord blood of appropriate versus small for gestational age neonates. (2010 Jun)	Amarilyo G	J Perinatol
26936435	Renoprotective effect of curcumin against the combined oxidative stress of diabetes and nicotine in rats. (2016 Apr)	Ibrahim ZS	Mol Med Rep
10770417	Erythropoiesis and renal transplant pregnancy. (2000 Apr)	Magee LA	Clin Transplant
27563196	Comparison of serum erythropoietin levels in smokers and nonsmokers with periodontitis: A biochemical study. (2016 May-Jun)	Singh V	J Indian Soc Periodontol
11917058	Serum hepatocyte growth factor is associated with viral hepatitis, cardiovascular disease, erythropoietin treatment, and type of heparin in haemodialysis patients. (2002 Apr)	Borawski J	Nephrol Dial Transplant
18184464	[Expression of erythropoietin receptor in esophageal carcinoma and its correlation to microvessel density]. (2008 Jan)	Li M	Ai Zheng
9740167	Association between human recombinant EPO and peripheral vascular disease in diabetic patients receiving peritoneal dialysis. (1998 Sep)	Wakeen M	Am J Kidney Dis
11687921	Determinants of mean arterial pressure and pulse pressure in chronic haemodialysis patients. (2001 Nov)	Abdelfatah AB	J Hum Hypertens
12195401	[Coronary angiography in uraemic patients awaiting kidney transplantation]. (2002 May-Jun)	Fabbian F	G Ital Nefrol
11716203	Changes in inflammatory markers following treatment of acute exacerbations of obstructive pulmonary disease. (2001 Nov)	Dahlen I	Respir Med
16061597	Erythrocyte zinc protoporphyrin is elevated with prematurity and fetal hypoxemia. (2005 Aug)	Lott DG	Pediatrics
12209679	Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma. (2002 Sep 1)	Acs G	Cancer