Gene: EPOR

2057
EPO-R
erythropoietin receptor
protein-coding
19p13.2
Ensembl:ENSG00000187266 MIM:133171 Vega:OTTHUMG00000182027 UniprotKB:P19235
NG_021395.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.030e-1 (AD)  5.177e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RGL30.868
INPPL10.799
FSTL30.794
ITGA70.776
PLXNB20.77
RGL20.767
LAMB20.759
RARG0.757
TCF30.747
MICALL20.743

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.441
CRH-0.417
OR4F29-0.395
SMIM18-0.321
AARD-0.306
ST8SIA2-0.301
PPEF1-0.301
EGFL6-0.288
HAPLN1-0.283
PPP1R17-0.283

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00012Darbepoetin alfaBiotechDrug209810-58-2Approved|InvestigationalTarget
DB00016ErythropoietinBiotechDrug11096-26-7ApprovedTarget
DB07637DibromotyrosineSmall Molecule300-38-9ExperimentalTarget
DB08894PeginesatideBiotechDrug913976-27-9Approved|InvestigationalTarget
DB09107Methoxy polyethylene glycol-epoetin betaBiotechDrug677324-53-7ApprovedTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of EPOR mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPOR mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPOR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPOR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPOR mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of EPOR mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of EPOR mRNA17942131
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of EPOR mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EPOR mRNA]17585979
D000535AluminumAluminum affects the expression of EPOR protein15777837
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EPOR mRNA16483693
D034341Aristolochic AcidsAristolochic Acids binds to EPOR protein26136230
D034341Aristolochic AcidsAristolochic Acids inhibits the reaction [EPO protein affects the localization of and results in increased activity of EPOR protein]26136230
D034341Aristolochic AcidsAristolochic Acids inhibits the reaction [EPO protein results in increased phosphorylation of EPOR protein]26136230
D034341Aristolochic AcidsAristolochic Acids results in increased degradation of and results in decreased expression of EPOR protein26136230
D034341Aristolochic Acidsbafilomycin A1 inhibits the reaction [Aristolochic Acids results in increased degradation of and results in decreased expression of EPOR protein]26136230
C006632arsenic trioxidearsenic trioxide results in decreased expression of EPOR protein16360329
D001280AtrazineAtrazine results in increased expression of EPOR mRNA25929836
C040929bafilomycin A1bafilomycin A1 inhibits the reaction [Aristolochic Acids results in increased degradation of and results in decreased expression of EPOR protein]26136230
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of EPOR mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPOR mRNA27858113
D001554Benzene[Benzene co-treated with Formaldehyde] results in decreased expression of EPOR protein27339418
D001554BenzeneBenzene results in increased expression of EPOR mRNA27339418
D001554Benzene[Formaldehyde co-treated with Benzene] results in increased expression of EPOR mRNA27339418
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPOR mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPOR mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EPOR mRNA17942131|2156981
D004958EstradiolEstradiol affects the expression of EPOR mRNA22574217
D004958EstradiolEstradiol results in increased expression of EPOR mRNA16705744
C006780bisphenol Abisphenol A results in increased expression of EPOR mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of EPOR mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of EPOR mRNA17942131
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of EPOR mRNA19925653
D002211CapsaicinCapsaicin results in increased expression of EPOR mRNA17603282
D002211CapsaicinCapsaicin results in increased expression of EPOR protein17603282
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of EPOR mRNA27858113
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of EPOR mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EPOR mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of EPOR protein21116766
C018021cobaltous chlorideEPO protein inhibits the reaction [cobaltous chloride results in increased expression of EPOR protein]21116766
D019327Copper SulfateCopper Sulfate results in decreased expression of EPOR mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of EPOR mRNA17942131
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) results in increased expression of EPOR protein24557580
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of EPOR mRNA27392435
D002945CisplatinEPOR results in decreased susceptibility to Cisplatin21860424
C000944dicrotophosdicrotophos results in decreased expression of EPOR mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of EPOR mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of EPOR mRNA]17942915
D004317DoxorubicinDoxorubicin results in decreased expression of EPOR protein16449733
D004317DoxorubicinEPO protein inhibits the reaction [Doxorubicin results in decreased expression of EPOR protein]16449733
D004656EnalaprilEnalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]19958114
D004656EnalaprilEnalapril inhibits the reaction [Streptozocin results in increased expression of EPOR protein]19958114
C118739entinostatentinostat results in increased expression of EPOR mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPOR mRNA"27188386
D005472FluorouracilEPOR gene mutant form affects the susceptibility to Fluorouracil16511603
D005557Formaldehyde[Benzene co-treated with Formaldehyde] results in decreased expression of EPOR protein27339418
D005557Formaldehyde[Formaldehyde co-treated with Benzene] results in increased expression of EPOR mRNA27339418
D005557FormaldehydeFormaldehyde results in decreased expression of EPOR protein27339418|2837300
C069837fullerene C60fullerene C60 results in decreased expression of EPOR mRNA19167457
C419708gefitinibgefitinib results in increased expression of EPOR mRNA16685379
D019833GenisteinGenistein results in increased expression of EPOR mRNA16705744
C514771hematidehematide analog binds to and results in increased activity of EPOR protein23911802
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EPOR mRNA20044591
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of EPOR mRNA27392435
C544151jinfukangjinfukang results in increased expression of EPOR mRNA27392435
D007608Kainic AcidEPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]18711747
D007608Kainic AcidEPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]18711747
D007608Kainic AcidEPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]18711747
D007608Kainic AcidEPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]]18711747
D007608Kainic AcidKainic Acid results in decreased expression of EPOR protein18711747
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with EPO protein] results in increased expression of EPOR protein24561306
D008694MethamphetamineMethamphetamine results in decreased expression of EPOR mRNA15644446
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EPOR mRNA23179753
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of EPOR mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of EPOR mRNA24810058
D009151Mustard GasMustard Gas results in increased expression of EPOR mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EPOR mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EPOR mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in increased expression of EPOR mRNA19812364
D009532NickelNickel results in decreased expression of EPOR mRNA25583101
C022838nickel chloridenickel chloride affects the expression of EPOR mRNA26044615
C028007nickel monoxidenickel monoxide results in decreased expression of EPOR mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of EPOR mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of EPOR mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of EPOR mRNA19497871
D010100OxygenOxygen deficiency results in increased expression of EPOR protein19497871
C030299phenylhydrazineEPOR gene mutant form affects the susceptibility to phenylhydrazine16511603
D010862PilocarpinePilocarpine results in increased expression of EPOR mRNA17166730
D010936Plant ExtractsPlant Extracts results in decreased expression of EPOR mRNA23557933
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA]20189893
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of EPOR mRNA14699072
C059514resveratrolresveratrol results in increased expression of EPOR mRNA19228061
D012834SilverSilver results in decreased expression of EPOR mRNA26551752
D019821SimvastatinSimvastatin inhibits the reaction [Streptozocin results in decreased expression of EPOR protein]20821229
D019821SimvastatinSimvastatin inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]20821229
D013311StreptozocinEnalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]19958114
D013311StreptozocinEnalapril inhibits the reaction [Streptozocin results in increased expression of EPOR protein]19958114
D013311StreptozocinSimvastatin inhibits the reaction [Streptozocin results in decreased expression of EPOR protein]20821229
D013311StreptozocinSimvastatin inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]20821229
D013311StreptozocinStreptozocin results in decreased expression of EPOR protein20821229
D013311StreptozocinStreptozocin results in increased expression of EPOR mRNA19958114|2082122
D013311StreptozocinStreptozocin results in increased expression of EPOR protein19958114
D013629TamoxifenEPOR protein affects the susceptibility to Tamoxifen19706814
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugateEPO affects the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA]20189893
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatepyrazolanthrone inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA]20189893
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA20189893
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatewortmannin inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA]20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EPOR mRNA26238291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPOR mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of EPOR mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of EPOR mRNA25729387
D019772TopotecanTopotecan results in decreased expression of EPOR mRNA25729387
D014212TretinoinTretinoin results in increased expression of EPOR mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of EPOR mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of EPOR mRNA19042947
C057693troglitazonetroglitazone results in increased expression of EPOR mRNA28973697
D014501UraniumUranium results in decreased expression of EPOR mRNA18375546
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPOR mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EPOR mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EPOR mRNA19101580|2317975
D014638VanadatesVanadates results in increased expression of EPOR protein16137666
D014750VincristineVincristine results in decreased expression of EPOR mRNA23649840
C009687wortmanninwortmannin inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA]20189893
D015215ZidovudineEPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]7646543
D015215ZidovudineIL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]7646543
D015215ZidovudineZidovudine inhibits the reaction [EPO protein binds to EPOR protein]7646543
D015215ZidovudineZidovudine results in decreased expression of EPOR mRNA1417927|7646543
D015215ZidovudineZidovudine results in decreased expression of EPOR protein1417927

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004900erythropoietin receptor activity-IDA2163696  
GO:0005515protein binding-IPI7228577  7528537  7528577  9774108  11781573  11784712  
14527337  15644415  25092874  26481148  
GO:0042802identical protein binding-IPI16116438  21058338  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-NAS1668606  
GO:0007420brain development-IEA-  
GO:0007507heart development-IEA-  
GO:0038162erythropoietin-mediated signaling pathway-IEA-  
GO:0046697decidualization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005887integral component of plasma membrane-TAS1848667  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24482100Hereditary gene mutations in Korean patients with isolated erythrocytosis. (2014 Jun)Jang JHAnn Hematol
27831681Primary Familial and Congenital Polycythemia (1993)Bento C-
12209679Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma. (2002 Sep 1)Acs GCancer