Gene: EPS8

2059
DFNB102
epidermal growth factor receptor pathway substrate 8
protein-coding
12p12.3
Ensembl:ENSG00000151491 MIM:600206 Vega:OTTHUMG00000168787 UniprotKB:Q12929
NG_041808.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.224e-1 (AD)  1.139e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKD30.906
MSN0.882
GNG120.88
BNIP20.871
MAML20.869
CMTM60.863
LPP0.862
STOM0.859
PDLIM50.856
CD3020.85

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.628
KCNB2-0.62
SLC7A4-0.599
CALHM1-0.597
HAS1-0.581
PPEF1-0.575
CACNA1F-0.573
MYADML2-0.571
BCL11A-0.57
B3GNT4-0.569

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0319031-UFT protocolEPS8 protein results in increased susceptibility to 1-UFT protocol16734730
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of EPS8 mRNA"27291303
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of EPS8 mRNA"18648102
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of EPS8 mRNA12419474
D000082AcetaminophenAcetaminophen results in increased expression of EPS8 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of EPS8 mRNA17562736
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EPS8 mRNA22129741
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of EPS8 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EPS8 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EPS8 mRNA27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of EPS8 mRNA28522335
D001104ArbutinArbutin results in increased expression of EPS8 mRNA17103032
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of EPS8 mRNA"19446018
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EPS8 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EPS8 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of EPS8 mRNA19484750
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EPS8 mRNA28628672
C006780bisphenol Abisphenol A affects the localization of EPS8 protein24532171
C006780bisphenol Abisphenol A results in decreased expression of EPS8 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of EPS8 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EPS8 mRNA28628672
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of EPS8 mRNA19840844
D000069287CapecitabineEPS8 protein results in increased susceptibility to Capecitabine16734730
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of EPS8 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of EPS8 mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of EPS8 mRNA28472532
C480342clothianidinclothianidin results in increased expression of EPS8 mRNA29044138
D005576ColforsinColforsin results in decreased expression of EPS8 mRNA15313392|1596741
D019327Copper SulfateCopper Sulfate results in increased expression of EPS8 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of EPS8 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of EPS8 mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of EPS8 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EPS8 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EPS8 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of EPS8 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of EPS8 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EPS8 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of EPS8 mRNA18042831
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EPS8 mRNA22129741
C025034doxifluridineEPS8 protein results in increased susceptibility to doxifluridine16734730
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EPS8 mRNA22079256
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of EPS8 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of EPS8 mRNA21233418
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of EPS8 mRNA23649840
D004397FonofosFonofos results in increased methylation of EPS8 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of EPS8 mRNA23649840
C000625835HFPO2 compoundHFPO2 compound results in increased expression of EPS8 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of EPS8 mRNA27553808
D017313FenretinideFenretinide results in increased expression of EPS8 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EPS8 mRNA20044591
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EPS8 mRNA22129741
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EPS8 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EPS8 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EPS8 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EPS8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EPS8 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of EPS8 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of EPS8 mRNA24796395
C045463leflunomideleflunomide results in increased expression of EPS8 mRNA28988120
D008748MethylcholanthreneMethylcholanthrene results in increased expression of EPS8 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EPS8 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of EPS8 mRNA"26251327
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of EPS8 mRNA19840844
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of EPS8 mRNA]12710931
C008493methylselenic acidmethylselenic acid results in increased expression of EPS8 mRNA18548127
C066851mithramycin Amithramycin A results in decreased expression of EPS8 mRNA19799886
C066851mithramycin Amithramycin A results in decreased expression of EPS8 protein19799886
C066851mithramycin Amithramycin A results in decreased expression of EPS8 mRNA19799886
C066851mithramycin Amithramycin A results in decreased expression of EPS8 protein19799886
C523799MRK 003EPS8 results in increased susceptibility to MRK 00319903844
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of EPS8 mRNA19812364
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of EPS8 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of EPS8 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of EPS8 mRNA18042831
D010269ParaquatParaquat results in decreased expression of EPS8 mRNA21371552
D010278ParathionParathion results in increased methylation of EPS8 promoter22847954
D010634PhenobarbitalPhenobarbital affects the expression of EPS8 mRNA19159669
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of EPS8 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of EPS8 mRNA18301758|2081375
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EPS8 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EPS8 mRNA22079256
D011794QuercetinQuercetin results in increased expression of EPS8 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of EPS8 protein25505154
C079198S 1 (combination)EPS8 protein results in increased susceptibility to S 1 (combination)16734730
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EPS8 mRNA25895662
D012834SilverSilver results in increased expression of EPS8 mRNA27131904
D018038Sodium SeleniteSodium Selenite results in decreased expression of EPS8 mRNA18175754
C012568terbufosterbufos results in increased methylation of EPS8 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EPS8 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPS8 mRNA24680724
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EPS8 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of EPS8 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of EPS8 mRNA25729387
D014212TretinoinTretinoin results in increased expression of EPS8 mRNA23830798
C012589trichostatin Atrichostatin A results in increased expression of EPS8 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of EPS8 mRNA15901671
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of EPS8 mRNA]12710931
D014520UrethaneUrethane results in increased expression of EPS8 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of EPS8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of EPS8 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of EPS8 mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of EPS8 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of EPS8 mRNA15901671
D014638VanadatesVanadates results in increased expression of EPS8 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EPS8 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IBA21873635  
GO:0003779actin binding-ISS-  
GO:0005070SH3/SH2 adaptor activity-TAS8084614  
GO:0005515protein binding-IPI15289329  16189514  16688213  19564905  21098279  21988832  
22921828  23314863  24076653  24584464  24658140  25416956  
25814554  
GO:0030676Rac guanyl-nucleotide exchange factor activityCONTRIBUTES_TOIBA21873635  
GO:0048365Rac GTPase binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS8084614  
GO:0007173epidermal growth factor receptor signaling pathway-TAS8084614  
GO:0007266Rho protein signal transduction-IBA21873635  
GO:0008283cell proliferation-TAS8084614  
GO:0008360regulation of cell shape-ISS-  
GO:0009967positive regulation of signal transduction-IEA-  
GO:0010458exit from mitosis-ISS-  
GO:0016601Rac protein signal transduction-ISS-  
GO:0030832regulation of actin filament length-ISS-  
GO:0030833regulation of actin filament polymerization-IBA21873635  
GO:0035023regulation of Rho protein signal transduction-IBA21873635  
GO:0036336dendritic cell migration-ISS-  
GO:0051016barbed-end actin filament capping-ISS-  
GO:0051017actin filament bundle assembly-ISS-  
GO:0051764actin crosslink formation-ISS-  
GO:0070358actin polymerization-dependent cell motility-ISS-  
GO:1900029positive regulation of ruffle assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005938cell cortex-ISS-  
GO:0030054cell junction-IEA-  
GO:0030426growth cone-IEA-  
GO:0031982vesicle-HDA19190083  
GO:0032420stereocilium-ISS-  
GO:0032587ruffle membrane-IBA21873635  
GO:0032587ruffle membrane-ISS-  
GO:0045202synapse-IEA-  
GO:0070062extracellular exosome-HDA11487543  19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29107665Eps8 expression is significantly lower in p16(+) head and neck squamous cell carcinomas (HNSCCs) compared with p16(-) HNSCCs. (2018 Feb)Nasri EHum Pathol