Gene: SLC36A1

206358
Dct1|LYAAT1|PAT1|TRAMD3
solute carrier family 36 member 1
protein-coding
5q33.1
Ensembl:ENSG00000123643 MIM:606561 Vega:OTTHUMG00000130125 UniprotKB:Q7Z2H8
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.298e-1 (AD)  1.423e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIAA15490.917
CYB561D10.912
MAPK130.909
LMTK20.907
KCNA60.904
PLCL20.9
SHROOM20.899
ARHGAP200.898
PLXNA40.897
KCNH10.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.611
RAB13-0.593
STON2-0.585
ROM1-0.578
MYL3-0.567
YES1-0.566
HEY2-0.556
ASB4-0.552
VAMP5-0.543
CYP11A1-0.541

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00659AcamprosateSmall Molecule77337-76-9Approved|InvestigationalTransporter
DB01080VigabatrinSmall Molecule68506-86-5ApprovedTransporter
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTransporter
DB02530gamma-Aminobutyric acidSmall Molecule56-12-2Approved|InvestigationalTransporter
DB02853D-ProlineSmall Molecule344-25-2ExperimentalTransporter
DB06554GaboxadolSmall Molecule64603-91-4InvestigationalTransporter
DB08835Spaglumic AcidSmall Molecule4910-46-7ApprovedTransporter
DB08847HydroxyprolineSmall Molecule51-35-4Approved|ExperimentalTransporter
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB00160L-AlanineSmall Molecule56-41-7Approved|NutraceuticalTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of SLC36A1 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of SLC36A1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC36A1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC36A1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of SLC36A1 mRNA22378314
D001622BetaineSLC36A1 protein results in increased uptake of Betaine18845132
C006780bisphenol Abisphenol A results in decreased expression of SLC36A1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC36A1 mRNA18804290
D000068579CelecoxibCelecoxib results in decreased expression of SLC36A1 mRNA28201806
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC36A1 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SLC36A1 mRNA28472532
D016572CyclosporineCyclosporine results in increased methylation of SLC36A1 promoter27989131
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of SLC36A1 mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SLC36A1 mRNA17361019|2126653
C000944dicrotophosdicrotophos results in increased expression of SLC36A1 mRNA28302478
D000431EthanolEthanol results in decreased expression of SLC36A1 mRNA20655511
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC36A1 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC36A1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SLC36A1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC36A1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased methylation of SLC36A1 promoter"26251327
D009532NickelNickel results in increased expression of SLC36A1 mRNA25583101
D010100OxygenOxygen deficiency results in decreased expression of SLC36A1 mRNA26516004
C006253pirinixic acidpirinixic acid results in decreased expression of SLC36A1 mRNA20813756
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SLC36A1 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC36A1 mRNA24780913
C016104sodium bichromatesodium bichromate results in decreased expression of SLC36A1 mRNA17685462
C061133tamibarotenetamibarotene results in increased expression of SLC36A1 mRNA15498508
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of SLC36A1 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC36A1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC36A1 mRNA26290441
D019284ThapsigarginThapsigargin results in decreased expression of SLC36A1 mRNA22378314
D014212TretinoinTretinoin results in increased expression of SLC36A1 mRNA15498508
D014415TunicamycinTunicamycin results in decreased expression of SLC36A1 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of SLC36A1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLC36A1 mRNA23179753|2519280
D014640VancomycinVancomycin results in increased expression of SLC36A1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SLC36A1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SLC36A1 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of SLC36A1 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005280amino acid:proton symporter activity-IBA21873635  
GO:0015078proton transmembrane transporter activity-IBA21873635  
GO:0015171amino acid transmembrane transporter activity-IBA21873635  
GO:0015171amino acid transmembrane transporter activity-TAS-  
GO:0015180L-alanine transmembrane transporter activity-IBA21873635  
GO:0015187glycine transmembrane transporter activity-IBA21873635  
GO:0015193L-proline transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0003333amino acid transmembrane transport-IBA21873635  
GO:0006811ion transport-TAS-  
GO:0006865amino acid transport-TAS-  
GO:0015808L-alanine transport-IBA21873635  
GO:0015808L-alanine transport-IEA-  
GO:0015816glycine transport-IBA21873635  
GO:0035524proline transmembrane transport-IBA21873635  
GO:0035524proline transmembrane transport-IEA-  
GO:1902600proton transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-HDA17897319  
GO:0005774vacuolar membrane-IBA21873635  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-352230Amino acid transport across the plasma membraneTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-428559Proton-coupled neutral amino acid transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24419231Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. (2014 May)Tang HCarcinogenesis