Gene: EYA4

2070
CMD1J|DFNA10
EYA transcriptional coactivator and phosphatase 4
protein-coding
6q23.2
Ensembl:ENSG00000112319 MIM:603550 Vega:OTTHUMG00000015602 UniprotKB:O95677
NG_011596.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.533e-1 (AD)  8.561e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24535176chr6:133561386EYA42.000e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXPH20.744
HAPLN10.742
ZNF385D0.741
KIT0.736
MYO5B0.726
KIAA10240.716
NXPH10.714
VWC20.708
GRIK10.702
CRHBP0.697

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMPRSS3-0.492
TRAF3IP2-0.48
HEBP2-0.473
MUC1-0.463
FXYD3-0.459
ATOH8-0.459
IFITM2-0.449
TGIF1-0.447
PLP2-0.447
SERPINA3-0.444

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of EYA4 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EYA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EYA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA4 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EYA4 gene27153756
D001151ArsenicArsenic affects the methylation of EYA4 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of EYA4 mRNA26705709
D001507BeclomethasoneBeclomethasone results in increased expression of EYA4 mRNA23656298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EYA4 mRNA"19150397
D004958EstradiolEstradiol affects the expression of EYA4 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of EYA4 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of EYA4 mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of EYA4 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of EYA4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EYA4 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of EYA4 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of EYA4 mRNA25979313
D002857ChromiumChromium results in decreased expression of EYA4 mRNA21437242
D002994ClofibrateClofibrate results in increased expression of EYA4 mRNA17585979
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of EYA4 mRNA]27941970
D004008DiclofenacDiclofenac results in decreased expression of EYA4 mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of EYA4 mRNA25016146
C118739entinostatentinostat results in decreased expression of EYA4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EYA4 mRNA"27188386
D004397FonofosFonofos results in increased methylation of EYA4 promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of EYA4 mRNA19167457
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of EYA4 mRNA24796395
C008261lead acetatelead acetate results in increased expression of EYA4 mRNA22641619
C045463leflunomideleflunomide results in increased expression of EYA4 mRNA19751817
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EYA4 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of EYA4 mRNA26378955
D008345ManganeseManganese results in decreased expression of EYA4 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of EYA4 mRNA17175027
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EYA4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EYA4 mRNA26011545
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of EYA4 promoter18448484
C523799MRK 003EYA4 results in increased susceptibility to MRK 00319903844
D009532NickelNickel results in decreased expression of EYA4 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of EYA4 mRNA19167457
D010278ParathionParathion results in increased methylation of EYA4 promoter22847954
C006253pirinixic acidpirinixic acid results in increased expression of EYA4 mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of EYA4 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EYA4 mRNA22714537
D012834SilverSilver results in decreased expression of EYA4 mRNA27131904
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of EYA4 promoter18448484
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EYA4 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of EYA4 mRNA26378955
C012568terbufosterbufos results in increased methylation of EYA4 promoter22847954
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of EYA4 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EYA4 mRNA19933214
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of EYA4 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of EYA4 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of EYA4 mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA4 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of EYA4 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EYA4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EYA4 mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of EYA4 mRNA22714537
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA4 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of EYA4 mRNA26272509|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-IBA21873635  
GO:0005515protein binding-IPI19606496  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0007601visual perception-TAS9887327  
GO:0007605sensory perception of sound-IEA-  
GO:0009653anatomical structure morphogenesis-TAS9887327  
GO:0016576histone dephosphorylation-IBA21873635  
GO:0030154cell differentiation-IBA21873635  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0045739positive regulation of DNA repair-IBA21873635  
GO:0048856anatomical structure development-IBA21873635  
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19939248Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus. (2009 Nov 25)Li HJ Exp Clin Cancer Res
22083596Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates. (2012 May 15)Kisiel JBCancer
28056267[Association between eye absent homolog 4 gene polymorphisms and occupational noise-induced hearing loss]. (2017 Jan 6)Yang QYZhonghua Yu Fang Yi Xue Za Zhi
26400775Associations of genetic variations in EYA4, GRHL2 and DFNA5 with noise-induced hearing loss in Chinese population: a case- control study. (2015 Sep 24)Zhang XEnviron Health