Gene: ERCC5

2073
COFS3|ERCC5-201|ERCM2|UVDR|XPG|XPGC
ERCC excision repair 5, endonuclease
protein-coding
13q33.1
Ensembl:ENSG00000134899 MIM:133530 Vega:OTTHUMG00000017310 UniprotKB:P28715
NG_007146.1
PubMed
ND
17   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.057e-1 (AD)  6.560e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRSF110.883
ANKRD100.875
CCAR10.874
SRSF50.866
WDR750.866
SF3B10.861
DDX170.859
CCNL20.858
EZH10.855
BLMH0.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.658
OR4F5-0.644
WNT7B-0.248
HES5-0.248
HPSE2-0.246
PLA2G5-0.243
SLC22A6-0.239
REN-0.224
TSPAN12-0.207
NKAIN3-0.207

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5822861-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)ureaERCC5 mutant form results in increased susceptibility to 1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea26208482
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ERCC5 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ERCC5 mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of ERCC5 protein26194647
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ERCC5 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ERCC5 mRNA"27188386
C0138134-anisidine4-anisidine results in increased expression of ERCC5 mRNA12929121
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ERCC5 mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ERCC5 mRNA"27188386
C4996938-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one inhibits the reaction [ERCC5 gene SNP results in decreased susceptibility to Cisplatin]26338418
C4996938-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one inhibits the reaction [[ERCC5 gene SNP results in decreased susceptibility to Cisplatin] which results in increased expression of ERCC5 protein]26338418|2633841
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ERCC5 mRNA19770486
D000393Air PollutantsAir Pollutants results in increased expression of ERCC5 protein28389379
D001151ArsenicArsenic results in increased expression of ERCC5 mRNA11134558
D001205Ascorbic Acid[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC5 mRNA17917374
D001241AspirinAspirin results in increased expression of ERCC5 mRNA11906190
C072019benzo(a)pyrene diolepoxide Ibenzo(a)pyrene diolepoxide I results in increased expression of ERCC5 mRNA27694624
C072019benzo(a)pyrene diolepoxide Ibenzo(a)pyrene diolepoxide I results in increased expression of ERCC5 protein27694624
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ERCC5 mRNA27694624
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ERCC5 protein19748547
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ERCC5 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ERCC5 mRNA14625279|1977048
D001564Benzo(a)pyrene[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ERCC5 mRNA]14625279
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ERCC5 mRNA"26238291
D004958EstradiolEstradiol affects the expression of ERCC5 mRNA15721199
C006780bisphenol Abisphenol A affects the expression of ERCC5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ERCC5 mRNA24901218
C006780bisphenol Abisphenol A affects the expression of ERCC5 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ERCC5 mRNA12419474
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ERCC5 mRNA26525392
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA12634122
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ERCC5 mRNA20883709
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA12634122
C057270cisplatin-DNA adductERCC5 mRNA results in decreased abundance of cisplatin-DNA adduct21452186
D019327Copper SulfateCopper Sulfate results in decreased expression of ERCC5 mRNA19549813
C017160cypermethrincypermethrin results in increased expression of ERCC5 mRNA25569846
C004742daidzeindaidzein affects the expression of ERCC5 mRNA15721199
D003976DiazinonDiazinon results in decreased expression of ERCC5 mRNA16539210
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ERCC5 mRNA21266533
D002945Cisplatin8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one inhibits the reaction [ERCC5 gene SNP results in decreased susceptibility to Cisplatin]26338418
D002945Cisplatin8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one inhibits the reaction [[ERCC5 gene SNP results in decreased susceptibility to Cisplatin] which results in increased expression of ERCC5 protein]26338418|2633841
D002945CisplatinERCC5 gene SNP results in decreased susceptibility to Cisplatin26338418
D002945Cisplatin[ERCC5 gene SNP results in decreased susceptibility to Cisplatin] which results in increased expression of ERCC5 protein26338418|2633841
D002945CisplatinERCC5 mRNA results in decreased susceptibility to Cisplatin21452186
D002945CisplatinERCC5 mutant form inhibits the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]21875941
D002945CisplatinPPP1R15A protein inhibits the reaction [[ERCC5 gene SNP results in decreased susceptibility to Cisplatin] which results in increased expression of ERCC5 protein]26338418|2633841
D002945CisplatinCisplatin results in increased expression of ERCC5 mRNA25270620
D002945CisplatinCisplatin results in increased expression of ERCC5 mRNA26739623
D002945CisplatinLovastatin promotes the reaction [Cisplatin results in increased expression of ERCC5 mRNA]26739623
C121718dicyclanildicyclanil results in increased expression of ERCC5 mRNA15664270
D004041Dietary FatsDietary Fats results in decreased expression of ERCC5 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC5 mRNA17917374
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ERCC5 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ERCC5 mRNA]17854601
D004054DiethylstilbestrolDiethylstilbestrol affects the expression of ERCC5 mRNA15721199
C065180fluvastatin[zoledronic acid co-treated with fluvastatin] results in increased expression of ERCC5 mRNA16996129
C069837fullerene C60fullerene C60 results in decreased expression of ERCC5 mRNA19167457
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ERCC5 mRNA22634610
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERCC5 protein18951874
D006918HydroxyureaHydroxyurea results in increased expression of ERCC5 mRNA12929121
C056493imiquimodimiquimod results in increased expression of ERCC5 mRNA21878529
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC5 mRNA17917374
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA12634122
D008148LovastatinLovastatin promotes the reaction [Cisplatin results in increased expression of ERCC5 mRNA]26739623
D008148LovastatinLovastatin results in increased expression of ERCC5 mRNA26739623
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ERCC5 mRNA23649840
D016685MitomycinMitomycin results in increased expression of ERCC5 mRNA25270620
C028007nickel monoxidenickel monoxide results in decreased expression of ERCC5 mRNA19167457
C025256nonylphenolnonylphenol results in decreased expression of ERCC5 mRNA22982499
D017239PaclitaxelPaclitaxel results in increased expression of ERCC5 mRNA12929121
D000073878Palm OilPalm Oil results in decreased expression of ERCC5 mRNA18042831
D052638Particulate MatterParticulate Matter results in increased expression of ERCC5 mRNA24769257
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of ERCC5 mRNA20442190
D048789PhytoestrogensPhytoestrogens affects the expression of ERCC5 mRNA15721199
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of ERCC5 mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of ERCC5 mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of ERCC5 mRNA]17950772
D010936Plant ExtractsPlant Extracts results in increased expression of ERCC5 mRNA23557933
C027373potassium chromate(VI)[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ERCC5 mRNA]14625279
D011192Potassium Dichromate[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ERCC5 mRNA]14625279
D011374ProgesteroneProgesterone results in increased expression of ERCC5 mRNA23012394
D011794QuercetinQuercetin results in decreased expression of ERCC5 mRNA21632981
C547185riccardin Driccardin D results in increased expression of ERCC5 mRNA24069304
C078903seocalcitolseocalcitol results in decreased expression of ERCC5 mRNA12040012
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA12634122
C017947sodium arsenitesodium arsenite results in decreased expression of ERCC5 mRNA16014739
C017947sodium arsenitesodium arsenite results in increased expression of ERCC5 mRNA20883709
D019311StaurosporineStaurosporine affects the expression of ERCC5 mRNA15721199
C016766sulforafansulforafan results in increased expression of ERCC5 mRNA20442190
D013467SulindacSulindac results in decreased expression of ERCC5 mRNA11906190
D043823TaxoidsERCC5 gene SNP results in decreased susceptibility to Taxoids16981845
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ERCC5 mRNA21570461
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERCC5 protein18951874
C523062thio-dimethylarsinatethio-dimethylarsinate results in increased expression of ERCC5 mRNA27320638
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ERCC5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ERCC5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ERCC5 mRNA26272509
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ERCC5 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ERCC5 mRNA23034163
C108830Y 27632Y 27632 results in increased expression of ERCC5 mRNA20878077
C088658zoledronic acid[zoledronic acid co-treated with fluvastatin] results in increased expression of ERCC5 mRNA16996129

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000405bubble DNA binding-IDA16246722  
GO:0003690double-stranded DNA binding-IDA8090225  12644470  
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0003697single-stranded DNA binding-IDA12644470  
GO:0004520endodeoxyribonuclease activity-IBA21873635  
GO:0004520endodeoxyribonuclease activity-IDA8090225  12644470  
GO:0004520endodeoxyribonuclease activity-TAS-  
GO:0005515protein binding-IPI8652557  9305916  15358233  16246722  17268471  
GO:0042803protein homodimerization activity-IPI10026181  
GO:0046872metal ion binding-IEA-  
GO:0047485protein N-terminus binding-IPI8652557  
GO ID GO Term Qualifier Evidence PubMed
GO:0006283transcription-coupled nucleotide-excision repair-IMP16246722  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006293nucleotide-excision repair, preincision complex stabilization-TAS-  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006295nucleotide-excision repair, DNA incision, 3'-to lesion-IBA21873635  
GO:0006295nucleotide-excision repair, DNA incision, 3'-to lesion-IDA8090225  
GO:0006295nucleotide-excision repair, DNA incision, 3'-to lesion-IMP7657672  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0009411response to UV-IDA8710877  
GO:0009411response to UV-IMP16167068  
GO:0009650UV protection-IGI7510366  
GO:0010225response to UV-C-IMP17208056  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0043066negative regulation of apoptotic process-IMP16167068  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA8710877  
GO:0005654nucleoplasm-TAS-  
GO:0005662DNA replication factor A complexcolocalizes_withIDA7700386  
GO:0005675holo TFIIH complexcolocalizes_withIDA11259578  
GO:0016591DNA-directed RNA polymerase II, holoenzymecolocalizes_withIDA16246722  
KEGG ID KEGG Term
hsa03420Nucleotide excision repair
Reactome ID Reactome Term Evidence
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10910954Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. (2000 Aug)Cheng LCarcinogenesis
16806437Nucleotide excision repair genotype and the incidence of endometrial cancer: effect of other risk factors on the association. (2006 Dec)Weiss JMGynecol Oncol
24582975Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA. (2014 May 25)Lu BGene
16537713Genetic variation in the nucleotide excision repair pathway and bladder cancer risk. (2006 Mar)Garcia-Closas MCancer Epidemiol Biomarkers Prev
16255782CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma. (2005 Oct 29)Mullins DNBMC Cancer
18026184NAT2 and NER genetic variants and sporadic prostate cancer susceptibility in African Americans. (2008)Hooker SProstate Cancer Prostatic Dis
16492920Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. (2006 Feb)Huang WYCancer Epidemiol Biomarkers Prev
26033827Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use. (2015 Oct)Tang XBirth Defects Res A Clin Mol Teratol
24563277Association of single nucleotide polymorphisms of nucleotide excision repair genes with laryngeal cancer risk and interaction with cigarette smoking and alcohol drinking. (2014 May)Li XTumour Biol
19444904Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes. (2009 Sep 15)Abbasi RInt J Cancer
25400036DNA repair gene polymorphisms in B cell non-Hodgkin's lymphoma. (2015 Mar)Bahceci ATumour Biol
18709642Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans. (2008 Nov 1)Chang JSInt J Cancer
22277767Polymorphisms of DNA repair pathway genes and cigarette smoking in relation to susceptibility to large artery atherosclerotic stroke among ethnic Chinese in Taiwan. (2012)Shyu HYJ Atheroscler Thromb
11900225Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck. (2002 Jan 15)Cheng LCancer
26617899Association of NER pathway gene polymorphisms with susceptibility to laryngeal cancer in a Chinese population. (2015)Sun YInt J Clin Exp Pathol
28464886A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells. (2017 May 2)Yeo JBMC Cancer
29581776Association of Smoking and XPG, CYP1A1, OGG1, ERCC5, ERCC1, MMP2, and MMP9 Gene Polymorphisms with the early detection and occurrence of Laryngeal Squamous Carcinoma. (2018)Zhu YJ Cancer