Gene: ERF

2077
CHYTS|CRS4|PE-2|PE2
ETS2 repressor factor
protein-coding
19q13.2
Ensembl:ENSG00000105722 MIM:611888 Vega:OTTHUMG00000182788 UniprotKB:P50548
NG_042802.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.185e-1 (AD)  1.065e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05016224chr19:42752587ERF3'UTR3.425e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LZTS20.802
FBRS0.785
CRTC20.776
TMEM1890.776
RNH10.773
SCAMP40.773
ZNF6720.773
TMEM2590.766
CNTROB0.765
CCDC1300.761

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.572
OR4F29-0.549
XIRP2-0.21
MTRNR2L9-0.208
MYL1-0.203
MTRNR2L6-0.201
LCE2A-0.2
C17orf112-0.199
ZNF705B-0.198
KRT2-0.184

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ERF mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERF mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ERF mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ERF mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ERF mRNA]17585979
D016604Aflatoxin B1[sulforafan co-treated with Aflatoxin B1] affects the expression of ERF mRNA25450479
D001280AtrazineAtrazine results in increased expression of ERF mRNA25929836
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ERF mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ERF promoter]19654925
C044887beta-methylcholinebeta-methylcholine affects the expression of ERF mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ERF mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of ERF promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of ERF mRNA26063408
C006780bisphenol Abisphenol A affects the expression of ERF mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ERF mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of ERF mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of ERF mRNA26191083
D002104CadmiumCadmium results in increased expression of ERF mRNA24376830
C040048caffeic acidcaffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA]19442820
D004390ChlorpyrifosChlorpyrifos results in increased expression of ERF mRNA21356183
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ERF mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ERF mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of ERF mRNA19376846
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ERF mRNA21266533
D004026DieldrinDieldrin affects the expression of ERF mRNA22546817
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of ERF mRNA]"19442820
C039281furanfuran results in decreased expression of ERF mRNA25539665
D017313FenretinideFenretinide results in increased expression of ERF mRNA28973697
C029424hydrazinehydrazine results in decreased expression of ERF mRNA15282401
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERF protein18951874
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ERF mRNA23430699
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ERF mRNA26924002
C568376MT19c compoundMT19c compound results in decreased expression of ERF mRNA21781307
C045950propiconazolepropiconazole results in decreased expression of ERF mRNA21278054
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ERF mRNA23806026
D053260SootSoot results in increased expression of ERF mRNA22461453
C016766sulforafan[sulforafan co-treated with Aflatoxin B1] affects the expression of ERF mRNA25450479
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ERF mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ERF promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ERF mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ERF mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ERF mRNA21215274
D019284Thapsigargincaffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA]19442820
D019284Thapsigargin"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of ERF mRNA]"19442820
D019284ThapsigarginThapsigargin results in increased expression of ERF mRNA19442820
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERF protein18951874
C009495titanium dioxidetitanium dioxide results in decreased expression of ERF mRNA23557971
D014212TretinoinTretinoin affects the expression of ERF mRNA16054129
D014212TretinoinTretinoin results in increased expression of ERF mRNA16604517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ERF mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERF mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ERF mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ERF mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of ERF gene29154799
D002762CholecalciferolCholecalciferol results in decreased expression of ERF mRNA16508948
D019287Zinc SulfateZinc Sulfate results in increased expression of ERF mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0003714transcription corepressor activity-IDA7588608  
GO:0043565sequence-specific DNA binding-IDA23332764  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA7588608  
GO:0000278mitotic cell cycle-NAS7588608  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0030154cell differentiation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2262752Cellular responses to stressIEA
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559583Cellular SenescenceIEA
R-HSA-2559585Oncogene Induced SenescenceTAS
R-HSA-2559585Oncogene Induced SenescenceIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19555042[Pulmonary hypertension in patients with ankylosing spondilitis: main factors of development]. (2008)Poddubnyi DATer Arkh