Gene: ERG

2078
erg-3|p55
ERG, ETS transcription factor
protein-coding
21q22.2
Ensembl:ENSG00000157554 MIM:165080 Vega:OTTHUMG00000090767 UniprotKB:P11308
NG_029732.1
PubMed|SNP Mapped
1   ANCO-SNPs
CD|ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.783e-1 (AD)  3.917e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2836364chr21:38395952 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17274064chr21:40033892ERG1.200e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXC10.869
CDH50.866
MECOM0.865
MYCT10.862
TGM20.86
GIMAP70.86
ELOVL70.859
ITGA10.857
MMRN20.855
GIMAP40.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.447
CRH-0.442
ASPDH-0.437
HAS1-0.432
MARCH4-0.417
SMIM18-0.411
FLRT1-0.404
BCL11A-0.403
KCNG1-0.403
CPLX3-0.403

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ERG mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ERG mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ERG mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ERG mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ERG mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ERG gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ERG mRNA24759320
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ERG protein24759320
D013196Dihydrotestosterone(+)-JQ1 compound inhibits the reaction [Dihydrotestosterone results in increased expression of ERG mRNA]24759320
D013196Dihydrotestosterone(+)-JQ1 compound inhibits the reaction [Dihydrotestosterone results in increased expression of ERG protein]24759320
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ERG mRNA16483693
D000728AndrogensAndrogens promotes the reaction [TOP2B protein results in increased mutagenesis of ERG gene]20601956
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ERG mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ERG mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ERG mRNA21839799
C006780bisphenol Abisphenol A affects the expression of ERG mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of ERG promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of ERG mRNA25181051
D002737ChloropreneChloroprene results in increased expression of ERG mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of ERG mRNA19320972
D003520CyclophosphamideCyclophosphamide results in increased expression of ERG mRNA17403535
C014347decitabinedecitabine results in decreased methylation of ERG promoter alternative form19108891
C014347decitabinedecitabine results in increased expression of ERG mRNA19194470
C014347decitabinedecitabine results in increased expression of ERG mRNA alternative form19108891
D005419FlavonoidsFlavonoids results in decreased expression of ERG mRNA18035473
C065180fluvastatin[zoledronic acid co-treated with fluvastatin] results in increased expression of ERG mRNA16996129
D005839GentamicinsGentamicins results in decreased expression of ERG mRNA22061828
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ERG mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Dihydrotestosterone results in increased expression of ERG mRNA]24759320
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Dihydrotestosterone results in increased expression of ERG protein]24759320
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [ERG protein binds to BRD4 protein]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [ERG protein binds to MYC enhancer]24759320
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ERG mRNA24759320
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ERG protein24759320
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to BTK enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to BTK promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to CCL4 enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to CCL4 promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to FCGR2B enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to FCGR2B promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to PECAM1 enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to PECAM1 promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of BTK mRNA]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of CCL4 mRNA]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of FCGR2B mRNA]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of PECAM1 mRNA]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ERG mRNA25982114
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ERG protein25982114
D020366MethylmethacrylateMethylmethacrylate results in increased expression of ERG mRNA16916219
D015741Metribolone[ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AFX protein]] which results in increased expression of ERG mRNA23272087
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ERG mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ERG mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of ERG mRNA19167457
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ERG mRNA26705709
D011374ProgesteroneProgesterone results in decreased expression of ERG mRNA19690047
C010327salinomycinsalinomycin results in decreased expression of ERG mRNA22215106
D020058StyreneStyrene results in decreased expression of ERG mRNA28951217
C016766sulforafansulforafan inhibits the reaction [AR protein binds to ERG enhancer]19805354
C016766sulforafansulforafan results in decreased expression of ERG mRNA19805354
C016766sulforafansulforafan results in decreased expression of ERG protein19805354
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ERG mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of ERG mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ERG mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of ERG mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ERG mRNA18087596
C032910triadimefontriadimefon results in decreased expression of ERG mRNA26705709
C012589trichostatin Atrichostatin A results in decreased expression of ERG mRNA19805354
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ERG mRNA19042947
C022884undecaneundecane results in increased expression of ERG protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ERG mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ERG mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ERG mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of ERG mRNA24383497|2627250
C025643vinclozolinvinclozolin affects the expression of ERG mRNA19015723
C088658zoledronic acid[zoledronic acid co-treated with fluvastatin] results in increased expression of ERG mRNA16996129

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA23093599  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IC-  
GO:0003677DNA binding-TAS8502479  
GO:0003682chromatin binding-IEA-  
GO:0005515protein binding-IPI20478527  21575865  22531786  22722839  27109047  
GO ID GO Term Qualifier Evidence PubMed
GO:0003197endocardial cushion development-IEA-  
GO:0003199endocardial cushion to mesenchymal transition involved in heart valve formation-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006468protein phosphorylation-TAS8502479  
GO:0007165signal transduction-TAS8502479  
GO:0007275multicellular organism development-TAS8502479  
GO:0008283cell proliferation-TAS3476934  
GO:0016477cell migration-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA18195090  23913826  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP18195090  22235125  
GO:2000504positive regulation of blood vessel remodeling-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:1990904ribonucleoprotein complex-IDA17289661  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12415227Prognostic implication of ergonovine echocardiography in patients with near normal coronary angiogram or negative stress test for significant fixed stenosis. (2002 Nov)Song JKJ Am Soc Echocardiogr
2801365[Chronic toxicity of tobacco smoke on the visual system]. (1989 May)Oku HNippon Ganka Gakkai Zasshi
23436207The microstructural and functional changes in the macula of heavy habitual smokers. (2013 Oct)Sobaci GInt Ophthalmol
28368973EFFECT OF SMOKING ON MACULAR FUNCTION AND STRUCTURE IN ACTIVE SMOKERS VERSUS PASSIVE SMOKERS. (2018 May)El-Shazly AAERetina
22128851(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction. (2012 Jan 12)Pan YJ Med Chem