Gene info: ID 208

Gene: AKT2

GENE ID: 208

Synonyms: HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA

Description: AKT serine/threonine kinase 2

Gene type: protein-coding

Location: 19q13.2

dbXrefs: Ensembl:ENSG00000105221 MIM:164731 Vega:OTTHUMG00000137375 UniprotKB:P31751

RefSeq: NG_012038.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.105e-1 (AD) 4.273e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NUMA1	0.933
DVL2	0.928
WDR6	0.923
DMPK	0.922
SNRNP70	0.915
NDOR1	0.913
HDAC6	0.911
ZSWIM8	0.91
LENG8	0.909
GGA1	0.905

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.667
OR4F29	-0.626
KLRC2	-0.265
AGTR1	-0.248
OR6C74	-0.248
ODAM	-0.246
UNC45B	-0.239
PAGE4	-0.236
SIM1	-0.229
IAPP	-0.222

ID	Drug Name	Drug Type	Status	Role
DB07812	N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide	Small Molecule	Experimental	Target
DB07859	4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE	Small Molecule	Experimental	Target
DB07947	ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE	Small Molecule	Experimental	Target
DB08073	(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE	Small Molecule	Experimental	Target

ID	Drug Name	Action	PubMed
C532657	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one	"1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one results in decreased activity of AKT2 protein"	20832391\|2209445
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of AKT2 mRNA"	23829299
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT2 protein]	19738051
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in increased expression of AKT2 mRNA"	23829299
C021296	2-ethoxyethanol	2-ethoxyethanol results in increased expression of AKT2 mRNA	19643169
C029955	2-nitrotoluene	2-nitrotoluene results in increased expression of AKT2 mRNA	16460773
C546412	3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide	3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide promotes the reaction [INS1 protein results in increased phosphorylation of AKT2 protein]	19694723
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]"	23452621
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]"	23452621
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AKT2 mRNA"	27188386
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide results in increased expression of AKT2 mRNA	20829426
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AKT2 mRNA"	27188386
C016601	afimoxifene	AKT2 protein results in decreased susceptibility to afimoxifene	18351453
C526957	alisol B 23-acetate	alisol B 23-acetate inhibits the reaction [AGT protein results in increased expression of AKT2 protein]	28578904
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of AKT2 mRNA	24449571
C006632	arsenic trioxide	AKT2 protein results in decreased susceptibility to arsenic trioxide	18048359
D001241	Aspirin	Aspirin results in increased expression of AKT2 mRNA	11906190
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of AKT2 mRNA	21635667
D001599	Berberine	Berberine inhibits the reaction [Dexamethasone results in decreased expression of AKT2 mRNA]	20462044
D004958	Estradiol	Estradiol affects the expression of AKT2 mRNA	22574217
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of AKT2 mRNA	26186136
C006780	bisphenol A	bisphenol A results in increased expression of AKT2 mRNA	29027980
C006780	bisphenol A	bisphenol A results in decreased expression of AKT2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of AKT2 mRNA	27539358
C006780	bisphenol A	bisphenol A results in increased expression of AKT2 protein	24884420
D001786	Blood Glucose	[SMAD5 gene mutant form results in decreased expression of and results in decreased phosphorylation of AKT2 protein] inhibits the reaction [INS1 protein results in increased uptake of Blood Glucose]	20079400
C099813	bromochloroacetic acid	bromochloroacetic acid results in increased expression of AKT2 mRNA	16460773
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of AKT2 mRNA	27509014
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased methylation of AKT2 gene	27509014
C018475	butyraldehyde	butyraldehyde results in decreased expression of AKT2 mRNA	26079696
D002087	Butyrates	Butyrates results in decreased phosphorylation of AKT2 protein	15978324
D020148	Butyric Acid	Butyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein]	27270450
C584509	C646 compound	C646 compound results in decreased expression of AKT2 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of AKT2 mRNA	18974090
D002220	Carbamazepine	Carbamazepine affects the expression of AKT2 mRNA	24752500
D002330	Carmustine	Carmustine results in decreased expression of AKT2 mRNA	15980968
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of AKT2 mRNA	18636392
D004390	Chlorpyrifos	Chlorpyrifos results in decreased phosphorylation of AKT2 protein	23994500
D002976	Clenbuterol	Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein]	16339297
D003024	Clozapine	Clozapine results in increased expression of AKT2 mRNA	15860345
D005576	Colforsin	Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein]	16339297
D003300	Copper	Copper results in decreased expression of AKT2 protein	22692975
D003471	Cuprizone	Cuprizone results in increased expression of AKT2 mRNA	26577399
D003474	Curcumin	Curcumin analog results in decreased expression of AKT2 mRNA	26409325
D003474	Curcumin	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]	23452621
D003474	Curcumin	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]	23452621
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of AKT2 mRNA	23914054
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AKT2 mRNA]	27941970
D003907	Dexamethasone	Berberine inhibits the reaction [Dexamethasone results in decreased expression of AKT2 mRNA]	20462044
D003907	Dexamethasone	Dexamethasone results in decreased expression of AKT2 mRNA	20462044
D003907	Dexamethasone	Dexamethasone inhibits the reaction [SMAD5 protein binds to AKT2 gene]	20079400
D003976	Diazinon	Diazinon affects the expression of AKT2 mRNA	22546817
D002945	Cisplatin	Cisplatin results in increased expression of AKT2 protein	16803524
D004008	Diclofenac	Diclofenac affects the expression of AKT2 mRNA	24752500
D004026	Dieldrin	Dieldrin affects the expression of AKT2 mRNA	22546817
D004041	Dietary Fats	[Dietary Fats co-treated with manganese(III)-tetrakis(4-benzoic acid)porphyrin] results in increased expression of AKT2 protein	26397111
D004041	Dietary Fats	Dietary Fats results in decreased expression of AKT2 mRNA	18042831
D004041	Dietary Fats	Butyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein]	27270450
D004041	Dietary Fats	[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein	27270450
D004041	Dietary Fats	Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein]	27270450
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of AKT2 mRNA	25280772
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of AKT2 mRNA	12807726
D004117	Dimethoate	Dimethoate results in decreased phosphorylation of AKT2 protein	23994500
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of AKT2 mRNA	27638505
D004221	Disulfiram	Disulfiram results in decreased expression of AKT2 mRNA	20530235
D004280	Dobutamine	Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein]	16339297
D004317	Doxorubicin	AKT2 protein affects the susceptibility to Doxorubicin	18071906
D004317	Doxorubicin	Doxorubicin affects the expression of AKT2 mRNA	26969377
D004317	Doxorubicin	[Doxorubicin co-treated with resveratrol] affects the expression of AKT2 mRNA	26969377
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKT2 mRNA	17942748
C024565	ethylene dichloride	ethylene dichloride results in increased expression of AKT2 mRNA	28189721
D018120	Finasteride	Finasteride results in increased expression of AKT2 mRNA	24136188
D005472	Fluorouracil	Fluorouracil results in increased expression of AKT2 protein	16803524
D005485	Flutamide	Flutamide results in increased expression of AKT2 mRNA	24136188
C069837	fullerene C60	fullerene C60 results in increased expression of AKT2 mRNA	19167457
D019833	Genistein	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]	23452621
D019833	Genistein	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]	23452621
D019833	Genistein	Genistein results in decreased expression of AKT2 mRNA	15257099
D019833	Genistein	Genistein results in decreased expression of AKT2 mRNA	24967385
D005947	Glucose	AKT2 protein affects the susceptibility to Glucose	21964073
D006220	Haloperidol	Haloperidol results in increased expression of AKT2 mRNA	15860345
D006581	Hexachlorobenzene	[Hexachlorobenzene co-treated with Methylnitrosourea] results in increased phosphorylation of AKT2 protein	22245120
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of AKT2 mRNA	17183730
C492448	ICG 001	ICG 001 inhibits the reaction [AGT protein results in increased expression of AKT2 protein]	28578904
D007854	Lead	Lead results in decreased expression of AKT2 mRNA	19921347
C008261	lead acetate	lead acetate results in increased expression of AKT2 mRNA	22609695
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of AKT2 mRNA"	24972896
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein]	28578904
C030272	maleic acid	maleic acid results in decreased expression of AKT2 mRNA	28392987
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	[Dietary Fats co-treated with manganese(III)-tetrakis(4-benzoic acid)porphyrin] results in increased expression of AKT2 protein	26397111
D008628	Mercury	Mercury results in decreased expression of AKT2 mRNA	16823088
D008687	Metformin	Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein]	27270450
D008731	Methoxychlor	Methoxychlor results in increased expression of AKT2 mRNA	20829426
C005219	methyl cellosolve	methyl cellosolve results in increased expression of AKT2 mRNA	19643169\|2106145
D008770	Methylnitrosourea	[Hexachlorobenzene co-treated with Methylnitrosourea] results in increased phosphorylation of AKT2 protein	22245120
C008493	methylselenic acid	methylselenic acid results in decreased expression of AKT2 mRNA	11830524
D009151	Mustard Gas	Mustard Gas results in increased expression of AKT2 mRNA	18955075
C104820	N-(3-(aminomethyl)benzyl)acetamidine	AKT2 protein affects the susceptibility to N-(3-(aminomethyl)benzyl)acetamidine	21964073
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of AKT2 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of AKT2 mRNA	25583101
C022838	nickel chloride	nickel chloride affects the expression of AKT2 mRNA	22546817
C028007	nickel monoxide	nickel monoxide results in increased expression of AKT2 mRNA	19167457
C007350	nitrofen	[nitrofen co-treated with Tretinoin] results in increased expression of AKT2 mRNA	20623292
C007350	nitrofen	nitrofen results in decreased expression of AKT2 mRNA	20152353
C025256	nonylphenol	nonylphenol results in decreased expression of AKT2 mRNA	22982499
C042670	N-vinyl-2-pyrrolidinone	[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of AKT2 mRNA	22037397
C464660	obeticholic acid	obeticholic acid results in decreased expression of AKT2 mRNA	27939613
D016627	Oxidopamine	Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein]	16339297
D016627	Oxidopamine	Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein]	16339297
D016627	Oxidopamine	Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein]	16339297
D016627	Oxidopamine	Oxidopamine results in decreased phosphorylation of AKT2 protein	16339297
C507134	ON 01910	ON 01910 results in decreased phosphorylation of AKT2 protein	21924492
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of AKT2 mRNA	25729387
D010100	Oxygen	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]"	23452621
D010100	Oxygen	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]"	23452621
D010100	Oxygen	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]	23452621
D010100	Oxygen	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]	23452621
D010100	Oxygen	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]	23452621
D010100	Oxygen	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]	23452621
D010100	Oxygen	Oxygen deficiency results in increased expression of AKT2 protein	23452621
D010100	Oxygen	Oxygen deficiency results in increased expression of AKT2 protein modified form	23452621
D010100	Oxygen	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]	23452621
D010100	Oxygen	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]	23452621
D010100	Oxygen	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]	23452621
D010100	Oxygen	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]	23452621
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of AKT2 mRNA	18636392
C102487	pachymic acid	pachymic acid analog inhibits the reaction [AGT protein results in increased expression of AKT2 protein]	28578904
D017239	Paclitaxel	AKT2 protein affects the susceptibility to Paclitaxel	18071906
D017239	Paclitaxel	Paclitaxel results in increased phosphorylation of AKT2 protein	18071906
D000073878	Palm Oil	Palm Oil results in decreased expression of AKT2 mRNA	18042831
D010269	Paraquat	AKT2 protein affects the reaction [Paraquat results in decreased expression of PPARGC1A protein]	28115273
D010269	Paraquat	AKT2 protein affects the reaction [Paraquat results in increased expression of NFE2L2 protein]	28115273
D010269	Paraquat	AKT2 protein results in increased susceptibility to Paraquat	28115273
D052638	Particulate Matter	Particulate Matter results in increased expression of AKT2 mRNA	28412507
D010634	Phenobarbital	Phenobarbital results in decreased expression of AKT2 mRNA	12807726
D010634	Phenobarbital	Phenobarbital results in increased expression of AKT2 mRNA	22037397
D010795	Phthalic Acids	Phthalic Acids results in increased expression of AKT2 mRNA	21061450
C006253	pirinixic acid	pirinixic acid results in increased expression of AKT2 mRNA	19162173
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]	23452621
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]	23452621
C045950	propiconazole	propiconazole results in decreased expression of AKT2 mRNA	21278054
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of AKT2 mRNA"	21152443
D011794	Quercetin	Quercetin results in decreased activity of AKT2 protein	19814731
C059514	resveratrol	[Doxorubicin co-treated with resveratrol] affects the expression of AKT2 mRNA	26969377
C059514	resveratrol	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]	23452621
C059514	resveratrol	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]	23452621
C059514	resveratrol	resveratrol results in decreased expression of AKT2 mRNA	26969377
C059514	resveratrol	resveratrol inhibits the reaction [INS protein results in increased phosphorylation of AKT2 protein]	19738051
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of AKT2 mRNA	23806026
D020123	Sirolimus	[Sirolimus results in increased activity of AKT2 protein] which results in increased expression of CALD1 protein	17908691
D020123	Sirolimus	[Sirolimus results in increased activity of AKT2 protein] which results in increased expression of MYH11 protein	17908691
D020123	Sirolimus	Sirolimus results in increased phosphorylation of and results in increased activity of AKT2 protein	17908691
C017947	sodium arsenite	sodium arsenite results in decreased expression of AKT2 mRNA	19590694
C017947	sodium arsenite	sodium arsenite results in decreased methylation of AKT2 gene	25199682
C025399	sodium tungstate(VI)	sodium tungstate(VI) affects the expression of AKT2 mRNA	26164860
D013311	Streptozocin	Butyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein]	27270450
D013311	Streptozocin	[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein	27270450
D013311	Streptozocin	Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein]	27270450
D013467	Sulindac	Sulindac results in decreased expression of AKT2 mRNA	11906190
D013467	Sulindac	Sulindac results in increased expression of AKT2 mRNA	24136188
D013739	Testosterone	Testosterone results in increased expression of AKT2 mRNA	21880219
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKT2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of AKT2 mRNA	19465110
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of AKT2 mRNA	15328365
D013893	Thiram	Thiram results in decreased expression of AKT2 mRNA	20530235
C009495	titanium dioxide	titanium dioxide results in increased expression of AKT2 mRNA	29128614
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of AKT2 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of AKT2 mRNA	25729387
C483909	torcetrapib	torcetrapib results in increased expression of AKT2 mRNA	23228038
D014118	Toxins, Biological	"Toxins, Biological affects the expression of AKT2 mRNA"	19682533
D014212	Tretinoin	[nitrofen co-treated with Tretinoin] results in increased expression of AKT2 mRNA	20623292
C023764	triciribine	triciribine results in decreased phosphorylation of AKT2 protein	20857426
C001899	triptolide	triptolide results in decreased expression of AKT2 mRNA	23639586
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of AKT2 mRNA	17183730
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AKT2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of AKT2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of AKT2 mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of AKT2 gene	25560391
C104536	xanthohumol	xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA]	23994090
D015032	Zinc	Zinc deficiency results in increased expression of AKT2 mRNA	19111725

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004674	protein serine/threonine kinase activity	-	IBA	21873635
GO:0004674	protein serine/threonine kinase activity	-	IDA	10983986 16540465
GO:0004674	protein serine/threonine kinase activity	-	TAS	21432781
GO:0005515	protein binding	-	IPI	10490823 10983986 12434148 16417406 16792529 17030088 19713527 20059950 20856200 21737686 22939624 23823123
GO:0005524	ATP binding	-	IDA	16540465
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001934	positive regulation of protein phosphorylation	-	ISS	-
GO:0005978	glycogen biosynthetic process	-	IEA	-
GO:0006006	glucose metabolic process	-	IEA	-
GO:0006417	regulation of translation	-	IEA	-
GO:0006464	cellular protein modification process	-	TAS	1409633
GO:0007165	signal transduction	-	TAS	21432781
GO:0008284	positive regulation of cell proliferation	-	IMP	10983986
GO:0008286	insulin receptor signaling pathway	-	IMP	16814735
GO:0008286	insulin receptor signaling pathway	-	TAS	21432781
GO:0008643	carbohydrate transport	-	IEA	-
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport	-	IMP	16814735
GO:0010907	positive regulation of glucose metabolic process	-	IMP	16814735
GO:0010918	positive regulation of mitochondrial membrane potential	-	IMP	10983986
GO:0018105	peptidyl-serine phosphorylation	-	IBA	21873635
GO:0030334	regulation of cell migration	-	TAS	21432781
GO:0030335	positive regulation of cell migration	-	IDA	25428377
GO:0031340	positive regulation of vesicle fusion	-	ISS	-
GO:0032000	positive regulation of fatty acid beta-oxidation	-	IMP	16814735
GO:0032287	peripheral nervous system myelin maintenance	-	IEA	-
GO:0032869	cellular response to insulin stimulus	-	IMP	16814735
GO:0035556	intracellular signal transduction	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	IMP	10983986
GO:0045444	fat cell differentiation	-	TAS	21432781
GO:0045725	positive regulation of glycogen biosynthetic process	-	IMP	16814735
GO:0046326	positive regulation of glucose import	-	IMP	16814735
GO:0060644	mammary gland epithelial cell differentiation	-	TAS	21432781
GO:0065002	intracellular protein transmembrane transport	-	ISS	-
GO:0071156	regulation of cell cycle arrest	-	TAS	21432781
GO:0071486	cellular response to high light intensity	-	IEA	-
GO:0072659	protein localization to plasma membrane	-	IEA	-
GO:0090314	positive regulation of protein targeting to membrane	-	ISS	-
GO:0090630	activation of GTPase activity	-	IEA	-
GO:0097473	retinal rod cell apoptotic process	-	IEA	-
GO:2000147	positive regulation of cell motility	-	IMP	17332325
GO:2001275	positive regulation of glucose import in response to insulin stimulus	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	20059950
GO:0005634	nucleus	-	TAS	21432781
GO:0005654	nucleoplasm	-	TAS	-
GO:0005769	early endosome	-	IEA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	ISS	-
GO:0005886	plasma membrane	-	TAS	21432781
GO:0005938	cell cortex	-	ISS	-
GO:0032587	ruffle membrane	-	ISS	-
GO:0032991	protein-containing complex	-	IDA	10983986
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04012	ErbB signaling pathway
hsa04062	Chemokine signaling pathway
hsa04150	mTOR signaling pathway
hsa04210	Apoptosis
hsa04370	VEGF signaling pathway
hsa04380	Osteoclast differentiation
hsa04510	Focal adhesion
hsa04530	Tight junction
hsa04620	Toll-like receptor signaling pathway
hsa04630	Jak-STAT signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04722	Neurotrophin signaling pathway
hsa04910	Insulin signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa04920	Adipocytokine signaling pathway
hsa04973	Carbohydrate digestion and absorption
hsa05142	Chagas disease (American trypanosomiasis)
hsa05145	Toxoplasmosis
hsa05160	Hepatitis C
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05218	Melanoma
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05222	Small cell lung cancer
hsa05223	Non-small cell lung cancer

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	IEA
R-HSA-109606	Intrinsic Pathway for Apoptosis	IEA
R-HSA-109703	PKB-mediated events	IEA
R-HSA-109704	PI3K Cascade	TAS
R-HSA-109704	PI3K Cascade	IEA
R-HSA-111447	Activation of BAD and translocation to mitochondria	IEA
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-112399	IRS-mediated signalling	IEA
R-HSA-114452	Activation of BH3-only proteins	IEA
R-HSA-1227986	Signaling by ERBB2	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1257604	PIP3 activates AKT signaling	IEA
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	TAS
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1643685	Disease	TAS
R-HSA-165158	Activation of AKT2	TAS
R-HSA-165159	mTOR signalling	TAS
R-HSA-165160	PDE3B signalling	IEA
R-HSA-165181	Inhibition of TSC complex formation by PKB	TAS
R-HSA-168256	Immune System	TAS
R-HSA-186712	Regulation of beta-cell development	TAS
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-198323	AKT phosphorylates targets in the cytosol	TAS
R-HSA-198323	AKT phosphorylates targets in the cytosol	IEA
R-HSA-198693	AKT phosphorylates targets in the nucleus	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-199991	Membrane Trafficking	IEA
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-210745	Regulation of gene expression in beta cells	TAS
R-HSA-211163	AKT-mediated inactivation of FOXO1A	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	IEA
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428924	IGF1R signaling cascade	IEA
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	IEA
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-388841	Costimulation by the CD28 family	TAS
R-HSA-389356	CD28 co-stimulation	TAS
R-HSA-389357	CD28 dependent PI3K/Akt signaling	TAS
R-HSA-389513	CTLA4 inhibitory signaling	TAS
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	TAS
R-HSA-397795	G-protein beta:gamma signalling	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-5218920	VEGFR2 mediated vascular permeability	TAS
R-HSA-5357801	Programmed Cell Death	IEA
R-HSA-5628897	TP53 Regulates Metabolic Genes	TAS
R-HSA-5633007	Regulation of TP53 Activity	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	TAS
R-HSA-6804757	Regulation of TP53 Degradation	TAS
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	TAS
R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	TAS
R-HSA-6806003	Regulation of TP53 Expression and Degradation	TAS
R-HSA-6807070	PTEN Regulation	TAS
R-HSA-69202	Cyclin E associated events during G1/S transition	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74751	Insulin receptor signalling cascade	IEA
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-74752	Signaling by Insulin receptor	IEA
R-HSA-8863795	Downregulation of ERBB2 signaling	TAS
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8941332	RUNX2 regulates genes involved in cell migration	IEA
R-HSA-8948751	Regulation of PTEN stability and activity	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006925	Intracellular signaling by second messengers	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-9007101	Rab regulation of trafficking	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25122428	Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis. (2014 Sep)	Umemura S	J Thorac Oncol
29246293	miR-124 Inhibits Lung Tumorigenesis Induced by K-ras Mutation and NNK. (2017 Dec 15)	Jin H	Mol Ther Nucleic Acids
21242979	Akt1 deletion prevents lung tumorigenesis by mutant K-ras. (2011 Apr 14)	Hollander MC	Oncogene
25007143	Pulmonary adenocarcinoma with signet ring cell features: a comprehensive study from 3 distinct patient cohorts. (2014 Dec)	Boland JM	Am J Surg Pathol
23435205	Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma. (2013 Apr 1)	Brait M	Cell Cycle
29568927	miR-185 and miR-29a are similarly expressed in the bronchoalveolar lavage cells in IPF and lung cancer but common targets DNMT1 and COL1A1 show disease specific patterns. (2018 May)	Bibaki E	Mol Med Rep
17295719	Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. (2007 Mar)	Wang J	Alcohol Clin Exp Res