Gene: ERN1

2081
IRE1|IRE1P|IRE1a|hIRE1p
endoplasmic reticulum to nucleus signaling 1
protein-coding
17q23.3
Ensembl:ENSG00000178607 MIM:604033 Vega:OTTHUMG00000178879 UniprotKB:O75460
NC_000017.11
PubMed
0   ANCO-SNPs
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.707e-1 (AD)  3.001e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STAT30.835
NUP980.812
FNDC3B0.811
NUP1600.811
TMEM39A0.811
PHF80.809
NFKB10.799
TEP10.793
SENP10.793
ZNF5480.787

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.322
PVALB-0.322
OR4F5-0.317
OR4F29-0.301
KIT-0.296
NMU-0.295
LRRC38-0.293
HAPLN1-0.293
CPLX3-0.292
PRLHR-0.285

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB07382N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Palmitates results in increased phosphorylation of ERN1 protein]23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea results in decreased phosphorylation of ERN1 protein23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased phosphorylation of ERN1 protein]23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]23576437
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ERN1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ERN1 mRNA"28903501
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in decreased expression of ERN1 mRNA20682335
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ERN1 mRNA28329830
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of ERN1 protein]25827057
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ERN1 mRNA"22543052
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ERN1 protein"22543052
C5112952,2',4,4'-tetrabromodiphenyl ether"ERN1 protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of BCL2 mRNA]"22543052
C5112952,2',4,4'-tetrabromodiphenyl ether"ERN1 protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAX mRNA]"22543052
C5112952,2',4,4'-tetrabromodiphenyl ether"ERN1 protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DDIT3 mRNA]"22543052
C5112952,2',4,4'-tetrabromodiphenyl ether"ERN1 protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DDIT3 protein]"22543052
C5112952,2',4,4'-tetrabromodiphenyl ether"ERN1 protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MAPK8 mRNA]"22543052
C5112952,2',4,4'-tetrabromodiphenyl ether"ERN1 protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of XBP1 mRNA modified form]"22543052
C5112952,2',4,4'-tetrabromodiphenyl ether"ERN1 protein affects the susceptibility to 2,2',4,4'-tetrabromodiphenyl ether"22543052
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ERN1 protein"25639565
C5112952,2',4,4'-tetrabromodiphenyl ether"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ERN1 protein]]"25639565
C5112952,2',4,4'-tetrabromodiphenyl ether"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ERN1 protein]"25639565
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ERN1 protein"25950987
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased phosphorylation of ERN1 protein"25950987
C0047622,4-dichlorophenol"2,4-dichlorophenol results in increased expression of ERN1 mRNA"25160872
C5240632-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one promotes the reaction [ERN1 protein binds to ERN1 protein]"25164867
C5240632-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one results in increased activity of and results in decreased phosphorylation of ERN1 protein"25164867
C0432473-acetyldeoxynivalenol3-acetyldeoxynivalenol results in increased expression of ERN1 mRNA20682335
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of ERN1 mRNA18544908
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ERN1 mRNA"19561079
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ERN1 mRNA19191707
C0757734-phenylbutyric acid"4-phenylbutyric acid inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]"23885834
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ERN1 protein]23885834
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]23885834
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of ERN1 protein modified form]20399799
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of ERN1 protein]17303341
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of ERN1 mRNA"19936915
D000082AcetaminophenAcetaminophen results in increased expression of ERN1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of ERN1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of ERN1 mRNA18544908
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Benomyl results in increased expression of ERN1 protein]27784618
D000111AcetylcysteineAcetylcysteine inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]24394546
D000111AcetylcysteineAcetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of ERN1 protein]25451595
D000111AcetylcysteineAcetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ERN1 protein]21198628
D000244Adenosine DiphosphateAdenosine Diphosphate inhibits the reaction [ERN1 protein binds to ERN1 protein]25164867
D000244Adenosine DiphosphateAdenosine Diphosphate results in decreased activity of ERN1 protein25164867
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ERN1 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ERN1 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ERN1 mRNA21298039
D000584AmilorideAmiloride inhibits the reaction [Tunicamycin results in increased phosphorylation of and results in increased activity of ERN1 protein]20015086
D006710HomocysteineHomocysteine results in decreased phosphorylation of ERN1 protein22964297
D000638AmiodaroneAmiodarone results in increased phosphorylation of ERN1 protein28962527
D047310ApigeninApigenin inhibits the reaction [Brefeldin A results in increased phosphorylation of ERN1 protein]20493918
D047310ApigeninApigenin inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]20493918
C006632arsenic trioxidearsenic trioxide results in increased expression of ERN1 mRNA17963750|1917612
C006632arsenic trioxidearsenic trioxide results in increased expression of ERN1 protein25449439
D017639Asbestos, Amosite"4-phenylbutyric acid inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]"23885834
D017639Asbestos, Amosite"Asbestos, Amosite results in increased expression of ERN1 mRNA"23885834
D017639Asbestos, Amosite"Asbestos, Amosite results in increased expression of ERN1 protein"23885834
D017639Asbestos, Amosite"BCL2L1 protein inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]"23885834
D017639Asbestos, Amosite"EUK-134 inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]"23885834
D017639Asbestos, Amosite"Asbestos, Amosite results in increased expression of ERN1 protein"23885834
D001280AtrazineAtrazine results in increased expression of ERN1 mRNA22378314
C406592azaspiracidazaspiracid results in decreased expression of ERN1 mRNA28939011
C038044baicalinbaicalin inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]29031535
D001542BenomylAcetylcysteine inhibits the reaction [Benomyl results in increased expression of ERN1 protein]27784618
D001542BenomylBenomyl results in increased expression of ERN1 protein27784618
D001542BenomylMitoTEMPO inhibits the reaction [Benomyl results in increased expression of ERN1 protein]27784618
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ERN1 mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ERN1 protein19139269
D004958EstradiolEstradiol results in increased expression of ERN1 mRNA23373633
C006780bisphenol Abisphenol A results in increased expression of ERN1 mRNA29027980
C006780bisphenol Abisphenol A results in increased methylation of ERN1 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of ERN1 mRNA28938450
C006780bisphenol Abisphenol A results in decreased expression of ERN1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ERN1 mRNA21601586
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of ERN1 mRNA25522274
D000069286BortezomibERN1 results in decreased susceptibility to Bortezomib16357177
D020126Brefeldin AApigenin inhibits the reaction [Brefeldin A results in increased phosphorylation of ERN1 protein]20493918
D020126Brefeldin ABrefeldin A results in increased phosphorylation of ERN1 protein20493918
D020122tert-ButylhydroperoxideAcetylcysteine inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]24394546
D020122tert-ButylhydroperoxideETFA mutant form inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]24394546
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]24394546
C026105butylidenephthalidebutylidenephthalide results in increased expression of ERN1 protein23770345
D002104CadmiumCadmium results in increased expression of ERN1 mRNA21120746
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA"20230807
D002110Caffeine"Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA]"20230807
D000001CalcimycinCalcimycin results in increased expression of ERN1 protein19139269
C077793candesartan cilexetilcandesartan cilexetil results in decreased expression of ERN1 protein22120037
D002193CantharidinCantharidin results in increased expression of ERN1 protein27113412
D002211CapsaicinCapsaicin results in increased expression of ERN1 protein19139269|1969925
D002220CarbamazepineCarbamazepine affects the expression of ERN1 mRNA24752500
D002251Carbon Tetrachloride1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of ERN1 protein]25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased phosphorylation of ERN1 protein25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of ERN1 protein25858767
D012844Sincalide[Palmitic Acid co-treated with Sincalide] results in increased expression of ERN1 mRNA26873426
D012844Sincalide[Palmitic Acid co-treated with Sincalide] results in increased expression of ERN1 protein26873426
D012844SincalideQuercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of ERN1 protein]26873426
D002569CeruleninCerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA]17283163
D002108CeruletideCeruletide results in increased expression of ERN1 mRNA26873426
D002108CeruletideCeruletide results in increased expression of ERN1 protein26873426
D002108CeruletideDietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 mRNA]26873426
D002108CeruletideDietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 protein]26873426
D002108CeruletideQuercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 mRNA]26873426
D002108CeruletideQuercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 protein]26873426
C006972chloroacetic acidAcetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of ERN1 protein]25451595
C006972chloroacetic acidchloroacetic acid results in increased phosphorylation of ERN1 protein25451595
C100187chloropicrinchloropicrin results in increased expression of ERN1 protein22516760
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ERN1 mRNA27344345
D002793Cholic Acids[Methyltestosterone co-treated with Cholic Acids] affects the expression of ERN1 mRNA27344345
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ERN1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of ERN1 mRNA19320972
D003042Cocaine6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of ERN1 protein]17303341
D003042CocaineCocaine results in increased expression of ERN1 protein17303341
D003042CocaineDizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of ERN1 protein]17303341
D003042CocaineN-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of ERN1 protein]17303341
D003042CocaineSCH 23390 inhibits the reaction [Cocaine results in increased expression of ERN1 protein]17303341
D019327Copper SulfateCopper Sulfate results in increased expression of ERN1 mRNA19549813
D003474CurcuminCurcumin results in decreased expression of ERN1 mRNA17999991
D016572CyclosporineCyclosporine results in increased expression of ERN1 mRNA25562108
D016572CyclosporineCyclosporine affects the localization of ERN1 protein23958496
D016572CyclosporineCyclosporine results in increased expression of ERN1 protein27585667
D016572CyclosporineCyclosporine results in increased phosphorylation of ERN1 protein23958496
D016572Cyclosporineethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of ERN1 protein]27585667
D016572CyclosporineTLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of ERN1 protein]27585667
D016572CyclosporineCyclosporine results in increased expression of ERN1 protein20136702
D016572CyclosporineMelatonin promotes the reaction [Cyclosporine results in increased expression of ERN1 protein]20136702
D003603CytotoxinsERN1 protein affects the reaction [Cytotoxins results in increased phosphorylation of MAPK1 protein]21147958
D003603CytotoxinsERN1 protein affects the reaction [Cytotoxins results in increased phosphorylation of MAPK3 protein]21147958
D003603CytotoxinsERN1 protein affects the reaction [Cytotoxins results in increased phosphorylation of MAPK8 protein]21147958
D003603CytotoxinsERN1 protein affects the reaction [Cytotoxins results in increased phosphorylation of MAPK9 protein]21147958
C107676deguelindeguelin results in decreased expression of ERN1 protein25322282
C050229demethoxycurcumindemethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]26264395
C007262deoxynivalenoldeoxynivalenol results in decreased expression of ERN1 mRNA20682335
C007262deoxynivalenoldeoxynivalenol results in increased expression of ERN1 protein19336499
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ERN1 mRNA]27941970
D002945CisplatinCisplatin results in increased expression of ERN1 mRNA27594783
D004008DiclofenacDiclofenac affects the expression of ERN1 mRNA24752500
D004041Dietary Fats1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased phosphorylation of ERN1 protein]23576437
D004041Dietary FatsDietary Fats results in increased phosphorylation of ERN1 protein23576437
D004041Dietary FatsDietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 mRNA]26873426
D004041Dietary FatsDietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 protein]26873426
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ERN1 mRNA25242112
C012906dihydrocapsaicindihydrocapsaicin results in increased expression of ERN1 protein19139269
C012906dihydrocapsaicinpyrazolanthrone inhibits the reaction [dihydrocapsaicin results in increased expression of ERN1 protein]19139269
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of ERN1 mRNA28939011
D004229DithiothreitolDithiothreitol results in increased phosphorylation of and results in increased activity of ERN1 protein12486162
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of ERN1 protein]17303341
C078846epoxomicin"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ERN1 protein]]"25639565
D000431EthanolEthanol results in increased expression of ERN1 protein modified form24224909
D000431Ethanolresveratrol inhibits the reaction [Ethanol results in increased expression of ERN1 protein modified form]24224909
D000431EthanolEthanol results in decreased phosphorylation of ERN1 protein28119953
D000431EthanolEthanol results in increased expression of ERN1 protein18377926
C507035ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylateethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of ERN1 protein]27585667
C024565ethylene dichlorideethylene dichloride results in decreased expression of ERN1 mRNA28973639
C433928EUK-134"EUK-134 inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]"23885834
C433928EUK-134EUK-134 inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]23885834
D015025ZearalenoneAIFM1 protein promotes the reaction [Zearalenone results in increased expression of ERN1 protein modified form]28011299
D015025ZearalenoneZearalenone results in increased expression of ERN1 protein modified form28011299
D005230Fatty Acids, Nonesterified"Fatty Acids, Nonesterified results in increased phosphorylation of ERN1 protein"23527285
C000499ferric oxideferric oxide analog results in increased expression of and results in increased phosphorylation of ERN1 protein25086211
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ERN1 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ERN1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of ERN1 mRNA17938736|2065599
D005557FormaldehydeFormaldehyde results in increased phosphorylation of ERN1 protein24140967
D005557FormaldehydeDDAH1 protein inhibits the reaction [Formaldehyde results in increased phosphorylation of ERN1 protein]24140967
C056933fumonisin B1fumonisin B1 results in increased phosphorylation of ERN1 protein25925693
C056933fumonisin B1thermozymocidin inhibits the reaction [fumonisin B1 results in increased phosphorylation of ERN1 protein]25925693
C038958gadolinium chlorideAcetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ERN1 protein]21198628
C038958gadolinium chloridegadolinium chloride results in increased expression of ERN1 protein21198628
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ERN1 mRNA22634610
D006046GoldGold analog results in increased phosphorylation of ERN1 protein26551149
D006143GuanabenzGuanabenz inhibits the reaction [Tunicamycin results in increased phosphorylation of ERN1 protein]24892553
D006861Hydrogen Peroxide4-phenylbutyric acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ERN1 protein]23885834
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ERN1 protein23885834
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ERN1 protein23885834
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ERN1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ERN1 mRNA24796395
C008261lead acetatelead acetate results in increased expression of ERN1 mRNA21829687
C008261lead acetatelead acetate results in increased phosphorylation of ERN1 protein25088297
C008261lead acetateProanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of ERN1 protein]25088297
C017461lead nitratelead nitrate results in increased phosphorylation of ERN1 protein20071421
C045463leflunomideleflunomide results in increased expression of ERN1 mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ERN1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ERN1 mRNA26378955
C025340manganese chloridemanganese chloride results in increased phosphorylation of ERN1 protein23934647|2573287
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased phosphorylation of ERN1 protein]23934647
D008550MelatoninMelatonin inhibits the reaction [Methamphetamine results in increased expression of ERN1 protein modified form]28070110
D008550MelatoninMelatonin promotes the reaction [Cyclosporine results in increased expression of ERN1 protein]20136702
D008694MethamphetamineERN1 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]27323860
D008694MethamphetamineERN1 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]27323860
D008694MethamphetamineERN1 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]27323860
D008694MethamphetamineERN1 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]27323860
D008694MethamphetamineERN1 protein affects the reaction [Methamphetamine results in increased phosphorylation of NFKBIA protein]27323860
D008694MethamphetamineMethamphetamine results in increased phosphorylation of ERN1 protein27323860
D008694MethamphetamineNaltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of ERN1 protein]27323860
D008694Methamphetaminenorbinaltorphimine inhibits the reaction [Methamphetamine results in increased phosphorylation of ERN1 protein]27323860
D008694MethamphetamineMethamphetamine results in increased expression of ERN1 protein27323860
D008694MethamphetamineMelatonin inhibits the reaction [Methamphetamine results in increased expression of ERN1 protein modified form]28070110
D008694MethamphetamineMethamphetamine results in increased expression of ERN1 protein modified form28070110
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ERN1 gene20938992
D008727MethotrexateMethotrexate affects the expression of ERN1 mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ERN1 mRNA"26251327
D0156551-Methyl-4-phenylpyridiniumTXN protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ERN1 protein]24140863
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ERN1 protein24140863
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in increased activity of ERN1 protein12486162
D0156551-Methyl-4-phenylpyridiniumTXN protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ERN1 protein]24140863
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"TXN protein inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 protein]"24140863
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 protein"24140863
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA"20230807
D008777Methyltestosterone[Methyltestosterone co-treated with Cholic Acids] affects the expression of ERN1 mRNA27344345
D008911MinocyclineMinocycline results in increased phosphorylation of ERN1 protein22245251
C555916MitoTEMPOMitoTEMPO inhibits the reaction [Benomyl results in increased expression of ERN1 protein]27784618
C000604516MKC9989MKC9989 results in decreased activity of ERN1 protein25164867
C000604516MKC9989MKC9989 binds to and results in decreased activity of ERN1 protein25164867
D009271NaltrexoneNaltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of ERN1 protein]27323860
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased phosphorylation of ERN1 protein"24929217
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ERN1 mRNA27344345
C028007nickel monoxidenickel monoxide results in increased expression of and results in increased phosphorylation of ERN1 protein28945320
C028007nickel monoxidenickel monoxide results in increased expression of ERN1 mRNA28945320
D009538Nicotine"Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA]"20230807
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA"20230807
C051844norbinaltorphiminenorbinaltorphimine inhibits the reaction [Methamphetamine results in increased phosphorylation of ERN1 protein]27323860
C442478N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamideN-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of ERN1 protein]17303341
C570897NSC668394NSC668394 results in decreased expression of ERN1 mRNA27137931
D016627OxidopamineOxidopamine results in increased phosphorylation of and results in increased activity of ERN1 protein12486162
C000604515OICR464OICR464 results in decreased activity of ERN1 protein25164867
C000604515OICR464OICR464 binds to and results in decreased activity of ERN1 protein25164867
C000604517OICR573OICR573 results in decreased activity of ERN1 protein25164867
C000604517OICR573OICR573 binds to and results in decreased activity of ERN1 protein25164867
D019319Okadaic AcidOkadaic Acid results in increased expression of ERN1 mRNA28939011
C055122orlistatorlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA]17283163
D010168Palmitates1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Palmitates results in increased phosphorylation of ERN1 protein]23576437
D010168PalmitatesPalmitates results in increased phosphorylation of ERN1 protein23576437
D019308Palmitic Acidbaicalin inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]29031535
D019308Palmitic AcidPalmitic Acid results in increased phosphorylation of ERN1 protein29031535
D019308Palmitic Acidtauroursodeoxycholic acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]29031535
D019308Palmitic Acid[Palmitic Acid co-treated with Sincalide] results in increased expression of ERN1 mRNA26873426
D019308Palmitic Acid[Palmitic Acid co-treated with Sincalide] results in increased expression of ERN1 protein26873426
D019308Palmitic AcidQuercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of ERN1 protein]26873426
D010269ParaquatParaquat promotes the reaction [MAP3K5 protein results in increased phosphorylation of ERN1 protein]20929985
D010269ParaquatParaquat results in increased expression of ERN1 protein modified form28986289
D010269ParaquatParaquat results in increased phosphorylation of ERN1 protein20929985|2898628
D010269ParaquatParaquat results in increased phosphorylation of ERN1 protein22245251
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ERN1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ERN1 protein26879310
C005435phenylmethylpyrazolonephenylmethylpyrazolone results in increased expression of ERN1 mRNA19558813
D064209PhytochemicalsPhytochemicals results in decreased expression of ERN1 protein22685690
C006253pirinixic acidpirinixic acid results in decreased expression of ERN1 mRNA16985257
C006253pirinixic acidpirinixic acid results in decreased expression of ERN1 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of ERN1 protein22685690|2395596
D011193Potassium IodidePotassium Iodide promotes the reaction [Sodium Fluoride results in increased expression of ERN1 protein]24231001
D011193Potassium Iodide[Sodium Fluoride co-treated with Potassium Iodide] results in increased expression of ERN1 mRNA24231001
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ERN1 mRNA19162173
D044945ProanthocyanidinsProanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of ERN1 protein]25088297
C045950propiconazolepropiconazole results in increased expression of ERN1 mRNA21278054
D011718PyrazinamidePyrazinamide results in increased expression of ERN1 mRNA28063906
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [dihydrocapsaicin results in increased expression of ERN1 protein]19139269
C031280pyrazolepyrazole results in increased expression of ERN1 mRNA17945193
D011794QuercetinQuercetin results in increased phosphorylation of ERN1 protein24612139
D011794QuercetinQuercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 mRNA]26873426
D011794QuercetinQuercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 protein]26873426
D011794QuercetinQuercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of ERN1 protein]26873426
C059514resveratrolresveratrol inhibits the reaction [Ethanol results in increased expression of ERN1 protein modified form]24224909
C059514resveratrolresveratrol results in increased expression of ERN1 protein24264887
D012402RotenoneMIR384 mRNA promotes the reaction [Rotenone results in increased phosphorylation of ERN1 protein]26864693
D012402RotenoneRotenone results in increased phosphorylation of ERN1 protein26864693
D012402RotenoneRotenone results in increased phosphorylation of and results in increased activity of ERN1 protein12486162
C534628SCH 23390SCH 23390 inhibits the reaction [Cocaine results in increased expression of ERN1 protein]17303341
D020280SertralineSertraline results in increased expression of ERN1 mRNA24865413
D020123SirolimusPPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein]24898257
D020123Sirolimus[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein24898257
C017947sodium arseniteERN1 affects the reaction [sodium arsenite results in increased expression of ACE mRNA]28973481
C017947sodium arseniteERN1 affects the reaction [sodium arsenite results in increased expression of AGT mRNA]28973481
C017947sodium arseniteERN1 affects the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]28973481
C017947sodium arseniteERN1 affects the reaction [sodium arsenite results in increased expression of and results in increased secretion of AGT protein modified form]28973481
C017947sodium arseniteERN1 affects the reaction [sodium arsenite results in increased expression of HIF1A protein]28973481
C017947sodium arseniteERN1 affects the reaction [sodium arsenite results in increased expression of SELE protein]28973481
C017947sodium arseniteERN1 affects the reaction [sodium arsenite results in increased secretion of CCL2 protein]28973481
C017947sodium arseniteERN1 affects the reaction [sodium arsenite results in increased secretion of CXCL8 protein]28973481
C017947sodium arseniteERN1 affects the reaction [sodium arsenite results in increased secretion of ICAM1 protein]28973481
C017947sodium arsenitesodium arsenite results in increased expression of ERN1 mRNA28973481
C017947sodium arsenitesodium arsenite results in increased expression of ERN1 protein21911445
D012969Sodium FluoridePotassium Iodide promotes the reaction [Sodium Fluoride results in increased expression of ERN1 protein]24231001
D012969Sodium Fluoride[Sodium Fluoride co-treated with Potassium Iodide] results in increased expression of ERN1 mRNA24231001
D012969Sodium FluorideSodium Fluoride results in increased expression of ERN1 mRNA24231001
D012969Sodium FluorideSodium Fluoride results in increased expression of ERN1 protein24231001
D012969Sodium FluorideSodium Fluoride results in increased expression of ERN1 mRNA21626649
D012969Sodium FluorideSodium Fluoride results in increased expression of ERN1 mRNA23707774
D012969Sodium FluorideSodium Fluoride results in increased expression of ERN1 protein23707774
C559087SR 1078SR 1078 results in increased phosphorylation of ERN1 protein28698385
D013311Streptozocin4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of ERN1 protein modified form]20399799
D013311StreptozocinStreptozocin results in increased expression of ERN1 protein modified form20399799
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ERN1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ERN1 mRNA26378955
D016559TacrolimusTacrolimus results in increased phosphorylation of ERN1 protein23958496
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]29031535
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of ERN1 mRNA25172293
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased phosphorylation of ERN1 protein28823167
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ERN1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ERN1 mRNA18796159|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ERN1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ERN1 mRNA18796159|2713689
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of ERN1 protein24932542
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ERN1 mRNA25613284
D019284Thapsigargin1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]23576437
D019284Thapsigargin4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]23885834
D019284ThapsigarginBCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]23885834
D019284Thapsigargindemethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]26264395
D019284ThapsigarginEUK-134 inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]23885834
D019284ThapsigarginThapsigargin affects the splicing of ERN1 mRNA27587023
D019284Thapsigargin[Thapsigargin affects the splicing of ERN1 mRNA] which results in increased expression of ERN1 protein alternative form27587023|2758702
D019284ThapsigarginThapsigargin results in increased expression of ERN1 mRNA17963750|2237831
D019284ThapsigarginThapsigargin results in increased expression of ERN1 protein19139269|2388583
D019284ThapsigarginThapsigargin results in increased expression of ERN1 protein modified form24224909
D019284ThapsigarginThapsigargin results in increased phosphorylation of ERN1 protein23576437|2626439
D019284Thapsigargin1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]23576437
D019284ThapsigarginApigenin inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]20493918
D019284Thapsigargin[Thapsigargin co-treated with HRAS protein] results in increased expression of ERN1 protein24898257
D019284ThapsigarginThapsigargin results in increased phosphorylation of ERN1 protein20493918|2357643
D019284ThapsigarginThapsigargin results in increased expression of ERN1 protein23885834
D019284ThapsigarginThapsigargin results in increased phosphorylation of ERN1 protein24638036
C001996thermozymocidinthermozymocidin inhibits the reaction [fumonisin B1 results in increased phosphorylation of ERN1 protein]25925693
C066185tingenin Btingenin B results in increased expression of ERN1 protein27720947
D014212TretinoinTretinoin results in increased expression of ERN1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of ERN1 mRNA22498432
D014212TretinoinTretinoin results in increased expression of ERN1 protein22498432
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ERN1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ERN1 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of ERN1 mRNA28973697
C005865troxerutin"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ERN1 protein]]"25639565
C005865troxerutin"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ERN1 protein]"25639565
D014415TunicamycinERGIC3 protein inhibits the reaction [Tunicamycin results in increased expression of ERN1 protein]27588471
D014415TunicamycinTunicamycin results in increased expression of ERN1 mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of ERN1 protein19139269|2758847
D014415TunicamycinTunicamycin results in increased expression of ERN1 protein modified form24224909
D014415TunicamycinAmiloride inhibits the reaction [Tunicamycin results in increased phosphorylation of and results in increased activity of ERN1 protein]20015086
D014415Tunicamycin[Tunicamycin co-treated with HRAS protein] results in increased expression of ERN1 protein24898257
D014415TunicamycinTunicamycin results in increased expression of ERN1 mRNA17127020|2143221
D014415TunicamycinTunicamycin results in increased phosphorylation of and results in increased activity of ERN1 protein20015086
D014415TunicamycinTunicamycin results in increased phosphorylation of ERN1 protein22001960
D014415TunicamycinGuanabenz inhibits the reaction [Tunicamycin results in increased phosphorylation of ERN1 protein]24892553
D014415TunicamycinTunicamycin results in increased phosphorylation of ERN1 protein24892553
D014520UrethaneUrethane results in increased expression of ERN1 mRNA28818685
C005466ursolic acidursolic acid results in increased activity of ERN1 protein24802810
D014635Valproic AcidValproic Acid results in increased methylation of ERN1 gene29154799
C551177vemurafenib[KRAS protein mutant form affects the susceptibility to vemurafenib] which results in increased expression of ERN1 protein27222248
C025643vinclozolinvinclozolin results in decreased expression of ERN1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA9637683  
GO:0004521endoribonuclease activity-IDA9637683  11779465  19328063  21317875  
GO:0004521endoribonuclease activity-TAS-  
GO:0004674protein serine/threonine kinase activity-IDA9637683  21317875  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005161platelet-derived growth factor receptor binding-IPI26315405  
GO:0005515protein binding-IPI11278723  15234121  16645094  18369366  19135427  19328063  
20103773  23529610  25241761  25742138  27238082  
GO:0005524ATP binding-IDA9637683  
GO:0019899enzyme binding-IPI23103912  
GO:0030544Hsp70 protein binding-IPI20625543  
GO:0042802identical protein binding-IPI12637535  21317875  
GO:0042803protein homodimerization activity-IDA21317875  29198525  
GO:0042803protein homodimerization activity-ISS-  
GO:0043531ADP binding-IDA21317875  
GO:0051879Hsp90 protein binding-IDA12446770  
GO ID GO Term Qualifier Evidence PubMed
GO:0001935endothelial cell proliferation-IDA23529610  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006379mRNA cleavage-ISS-  
GO:0006402mRNA catabolic process-TAS22013210  
GO:0006468protein phosphorylation-IDA9637683  
GO:0007050cell cycle arrest-ISS-  
GO:0007257activation of JUN kinase activity-IDA10650002  
GO:0016241regulation of macroautophagy-TAS22013210  
GO:0033120positive regulation of RNA splicing-IDA11779464  19622636  
GO:0034620cellular response to unfolded protein-IDA19328063  
GO:0034620cellular response to unfolded protein-IMP20625543  
GO:0034976response to endoplasmic reticulum stress-IDA10650002  
GO:0035924cellular response to vascular endothelial growth factor stimulus-IDA23529610  
GO:0036289peptidyl-serine autophosphorylation-IDA20103773  
GO:0036498IRE1-mediated unfolded protein response-IDA19328063  29198525  
GO:0036498IRE1-mediated unfolded protein response-TAS-  
GO:0046777protein autophosphorylation-IDA9637683  19328063  
GO:0070054mRNA splicing, via endonucleolytic cleavage and ligation-IDA11779464  19328063  19622636  21317875  
GO:0070054mRNA splicing, via endonucleolytic cleavage and ligation-IMP20625543  21317875  
GO:0070054mRNA splicing, via endonucleolytic cleavage and ligation-TAS22013210  
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-IEA-  
GO:0071333cellular response to glucose stimulus-IDA20103773  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEA-  
GO:0098787mRNA cleavage involved in mRNA processing-IDA21317875  
GO:1900103positive regulation of endoplasmic reticulum unfolded protein response-IMP16645094  
GO:1901142insulin metabolic process-IDA20103773  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IMP26315405  
GO:1990579peptidyl-serine trans-autophosphorylation-IMP21317875  
GO ID GO Term Qualifier Evidence PubMed
GO:0005637nuclear inner membrane-IEA-  
GO:0005737cytoplasm-IDA19622636  
GO:0005739mitochondrion-IEA-  
GO:0005783endoplasmic reticulum-IDA23529610  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0030176integral component of endoplasmic reticulum membrane-IDA9637683  
GO:1990332Ire1 complex-NAS19328063  
GO:1990597AIP1-IRE1 complex-IEA-  
GO:1990604IRE1-TRAF2-ASK1 complex-IDA23000344  
GO:1990630IRE1-RACK1-PP2A complex-IDA20103773  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
hsa05010Alzheimer's disease
Reactome ID Reactome Term Evidence
R-HSA-381070IRE1alpha activates chaperonesTAS
R-HSA-381070IRE1alpha activates chaperonesIEA
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-381119Unfolded Protein Response (UPR)IEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28847752The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells. (2017 Dec)Lugea AGastroenterology
26043790Cocaine-mediated microglial activation involves the ER stress-autophagy axis. (2015)Guo MLAutophagy