Gene: FBL

2091
FIB|FLRN|Nop1|RNU3IP1
fibrillarin
protein-coding
19q13.2
Ensembl:ENSG00000105202 MIM:134795 Vega:OTTHUMG00000182581 UniprotKB:P22087
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.806e-1 (AD)  2.906e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs616650chr19:39837975 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPL190.925
RPS30.921
RPS80.921
RPL110.92
NACA0.917
PFDN50.917
RPS90.916
RPS50.915
RPL80.914
RPL27A0.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.733
OR4F5-0.687
SP8-0.176
HS6ST3-0.175
HSD3B1-0.167
PCDHAC1-0.161
PRKG2-0.161
IGF1-0.156
NCR3LG1-0.155
NPR3-0.153

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of FBL mRNA"23829299
D000082AcetaminophenAcetaminophen affects the expression of FBL mRNA17562736
D024502alpha-Tocopherolalpha-Tocopherol deficiency results in decreased expression of FBL protein15247049
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FBL mRNA"20382639
D004958EstradiolEstradiol affects the expression of FBL mRNA15598610
C004541biochanin Abiochanin A results in increased expression of FBL mRNA12111696
C006780bisphenol Abisphenol A affects the expression of FBL mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of FBL mRNA29275510
C006780bisphenol Abisphenol A affects the expression of FBL mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of FBL mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of FBL mRNA18804290
D019256Cadmium ChlorideCadmium Chloride affects the localization of FBL protein10942594
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FBL mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FBL mRNA18804290
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FBL mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of FBL mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of FBL mRNA24612858
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FBL mRNA19684285
D016572CyclosporineCyclosporine results in increased expression of FBL mRNA20106945|2798913
D003609DactinomycinDactinomycin analog affects the localization of FBL protein10942594
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FBL mRNA17361019
D002945CisplatinCisplatin analog affects the localization of FBL protein10942594
D002945CisplatinCisplatin results in decreased expression of FBL mRNA21151649
D004004DichlororibofuranosylbenzimidazoleDichlororibofuranosylbenzimidazole analog affects the localization of FBL protein10942594
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FBL protein23301498
D005047EtoposideEtoposide analog affects the localization of FBL protein10942594
D005485FlutamideFlutamide results in increased expression of FBL mRNA24136188
D005839GentamicinsGentamicins results in increased expression of FBL mRNA22061828
D005897GlafenineGlafenine results in increased expression of FBL mRNA24136188
D006052Gold Sodium ThiomalateGold Sodium Thiomalate affects the localization of FBL protein10942594
D006052Gold Sodium ThiomalateCD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]19077085
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased activity of FBL protein19077085
D006052Gold Sodium ThiomalateIFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]19077085
D006052Gold Sodium ThiomalateIL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]19077085
D006052Gold Sodium ThiomalateIL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]19077085
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FBL mRNA25613284
C544151jinfukangjinfukang results in increased expression of FBL mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of FBL24394663
C410337K 7174K 7174 results in decreased expression of FBL mRNA24086573
D007649KetamineKetamine results in decreased expression of FBL mRNA20080153
C008261lead acetatelead acetate affects the localization of FBL protein10942594
D008627Mercuric ChlorideMercuric Chloride affects the localization of FBL protein10942594
D008627Mercuric ChlorideCD28 protein affects the reaction [Mercuric Chloride results in decreased activity of FBL protein]19077085
D008627Mercuric ChlorideIFNG protein affects the reaction [Mercuric Chloride results in decreased activity of FBL protein]19077085
D008627Mercuric ChlorideIL4 protein affects the reaction [Mercuric Chloride results in decreased activity of FBL protein]19077085
D008627Mercuric ChlorideIL6 protein affects the reaction [Mercuric Chloride results in decreased activity of FBL protein]19077085
D008627Mercuric ChlorideMercuric Chloride affects the localization of FBL protein10942594|1238875
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of FBL protein19077085
D008627Mercuric ChlorideMercuric Chloride results in increased cleavage of FBL protein10925315
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FBL mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FBL mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of FBL protein26558463
D016685MitomycinMitomycin analog affects the localization of FBL protein10942594
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of FBL protein20553848
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FBL mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FBL mRNA"25554681
C051752nefazodonenefazodone results in increased expression of FBL mRNA24136188
C022838nickel chloridenickel chloride results in increased expression of FBL mRNA24612858
C012655nimesulidenimesulide results in increased expression of FBL mRNA24136188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FBL protein26879310
C532828potassium hexachloropalladate(IV)potassium hexachloropalladate(IV) analog affects the localization of FBL protein10942594
D012835Silver NitrateCD28 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]19077085
D012835Silver NitrateIFNG protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]19077085
D012835Silver NitrateIL4 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]19077085
D012835Silver NitrateIL6 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]19077085
D012835Silver NitrateSilver Nitrate results in decreased activity of FBL protein19077085
C016104sodium bichromatesodium bichromate results in increased expression of FBL mRNA24612858
C016104sodium bichromatesodium bichromate results in increased expression of FBL mRNA25993096
D012969Sodium FluorideSodium Fluoride results in decreased expression of FBL protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of FBL mRNA18175754
D012999SomanSoman results in increased expression of FBL mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A affects the expression of FBL mRNA18976794
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FBL mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FBL mRNA19684285
C036919tetrachloroplatinatetetrachloroplatinate affects the localization of FBL protein10942594
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FBL mRNA25613284
C406224valdecoxibvaldecoxib results in increased expression of FBL mRNA24136188
D014635Valproic AcidValproic Acid results in increased methylation of FBL gene29154799
D014635Valproic AcidValproic Acid affects the expression of FBL mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FBL gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001094TFIID-class transcription factor binding-IPI17636026  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0005515protein binding-IPI8670859  10837141  11509230  17353931  17498821  17620599  
17636026  19928837  22720776  22916032  29568061  
GO:0008649rRNA methyltransferase activity-IBA21873635  
GO:0051117ATPase binding-IPI17636026  
GO:1990259histone-glutamine methyltransferase activity-IBA21873635  
GO:1990259histone-glutamine methyltransferase activity-IDA24352239  
GO ID GO Term Qualifier Evidence PubMed
GO:0000494box C/D snoRNA 3'-end processing-IBA21873635  
GO:0001649osteoblast differentiation-HDA16210410  
GO:0006364rRNA processing-TAS-  
GO:0031167rRNA methylation-IBA21873635  
GO:0048254snoRNA localization-IMP17636026  
GO:1990258histone glutamine methylation-IBA21873635  
GO:1990258histone glutamine methylation-IDA24352239  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0001651dense fibrillar component-IEA-  
GO:0001652granular component-IEA-  
GO:0005634nucleus-IDA22720776  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-IEA-  
GO:0005730nucleolus-IDA15494374  16687569  17158916  19208757  23203802  24352239  
GO:0015030Cajal body-IBA21873635  
GO:0015030Cajal body-IDA16687569  
GO:0016020membrane-HDA16210410  
GO:0031428box C/D snoRNP complex-IBA21873635  
GO:0031428box C/D snoRNP complex-NAS17636026  
GO:0032040small-subunit processome-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa03008Ribosome biogenesis in eukaryotes
Reactome ID Reactome Term Evidence
R-HSA-6790901rRNA modification in the nucleus and cytosolIEA
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-72312rRNA processingIEA
R-HSA-72312rRNA processingTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolIEA
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNAIEA
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal