Gene: ESD

2098
FGH
esterase D
protein-coding
13q14.2
Ensembl:ENSG00000139684 MIM:133280 Vega:OTTHUMG00000016878 UniprotKB:P10768
NC_000013.11
PubMed
0   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.706e-1 (AD)  3.428e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VAPA0.944
TSN0.944
MFF0.939
VPS290.938
UBA30.938
GDI20.936
PPA10.935
PSMC20.933
PPT10.932
GNPAT0.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.775
OR4F29-0.741
MTRNR2L6-0.223
C8orf74-0.218
MTRNR2L10-0.21
MTRNR2L9-0.205
KLRB1-0.187
TTLL10-0.185
TRPV5-0.179
PPBP-0.178

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of ESD mRNA16014739
D000082AcetaminophenAcetaminophen results in decreased expression of ESD mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ESD mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ESD gene27153756
D000638AmiodaroneAmiodarone affects the expression of ESD mRNA19483382
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ESD mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of ESD mRNA20458559
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in increased expression of ESD mRNA15894712
C015001arsenitearsenite results in increased expression of ESD mRNA15894712|1892958
C015001arseniteTRP53 protein affects the reaction [arsenite results in increased expression of ESD mRNA]18929588
D001280AtrazineAtrazine results in increased expression of ESD mRNA22378314
D001553BenzbromaroneBenzbromarone affects the expression of ESD mRNA19483382
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in increased expression of ESD mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ESD mRNA14625279|1503420
D001564Benzo(a)pyrene[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ESD mRNA]14625279
C006780bisphenol Abisphenol A results in increased expression of ESD mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ESD protein24527689
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ESD mRNA21297351
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ESD mRNA17484886
D002737ChloropreneChloroprene results in increased expression of ESD mRNA23125180
D002994ClofibrateClofibrate affects the expression of ESD mRNA19483382
C018021cobaltous chloridecobaltous chloride results in decreased expression of ESD mRNA24612858
D003300CopperCopper analog results in increased expression of ESD protein23882024
C030973cupric oxidecupric oxide analog results in increased expression of ESD protein23882024
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of ESD protein19822598
D016572CyclosporineCyclosporine results in increased expression of ESD mRNA19770486
D003703DemecolcineDemecolcine results in decreased expression of ESD mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of ESD mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ESD mRNA17361019|2126653
C000944dicrotophosdicrotophos results in decreased expression of ESD mRNA28302478
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ESD mRNA28433925
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ESD mRNA28433925
D004237DiuronDiuron results in decreased expression of ESD mRNA21551480
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ESD protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ESD mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ESD mRNA20227414
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ESD mRNA17942748
D005001EthionineEthionine affects the expression of ESD mRNA19483382
C082360fipronilfipronil results in increased expression of ESD mRNA23962444
D005557FormaldehydeFormaldehyde results in decreased expression of ESD mRNA23649840
C056933fumonisin B1fumonisin B1 results in increased expression of ESD mRNA16221962
C071834glycidamideglycidamide results in increased expression of ESD mRNA17822822
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ESD protein]23178681
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of ESD protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ESD protein23178681
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of ESD mRNA19376150
D007213IndomethacinIndomethacin results in increased expression of ESD mRNA28201806
C544151jinfukangjinfukang results in decreased expression of ESD mRNA27392435
C410337K 7174K 7174 results in decreased expression of ESD mRNA24086573
D007854LeadLead affects the expression of ESD mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ESD mRNA21641980
D008627Mercuric ChlorideMercuric Chloride affects the expression of ESD protein21458406
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ESD mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ESD mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ESD mRNA23649840
C063855microcystin RRmicrocystin RR results in decreased expression of ESD protein19111056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ESD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ESD mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ESD mRNA"25554681
C051752nefazodonenefazodone results in increased expression of ESD mRNA24136188
D009532NickelNickel results in increased expression of ESD mRNA18922574
D009532NickelNickel results in increased expression of ESD mRNA24084258
C029938nickel sulfatenickel sulfate results in increased expression of ESD mRNA16100012
C012655nimesulidenimesulide results in increased expression of ESD mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of ESD mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ESD mRNA25729387
D010100OxygenOxygen deficiency affects the expression of ESD protein19579223
D010100OxygenOxygen deficiency results in decreased expression of ESD mRNA19579223
D010126OzoneOzone results in increased expression of ESD mRNA17095637
D010416PentachlorophenolPentachlorophenol results in increased expression of ESD mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ESD protein22609092
D010705PhosgenePhosgene affects the expression of ESD mRNA16300373
C006253pirinixic acidpirinixic acid results in increased expression of ESD mRNA16221962
C006253pirinixic acidpirinixic acid affects the expression of ESD mRNA19483382
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ESD mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ESD mRNA22079256
C027373potassium chromate(VI)[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ESD mRNA]14625279
D011192Potassium Dichromate[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ESD mRNA]14625279
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ESD mRNA23608068
C045950propiconazolepropiconazole results in increased expression of ESD mRNA19363144
D011441PropylthiouracilPropylthiouracil affects the expression of ESD mRNA19483382
D011748PyrogallolPyrogallol results in increased expression of ESD mRNA20362636
D012834SilverSilver results in increased expression of ESD mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of ESD mRNA23922661
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ESD mRNA21641980
C025462sulindac sulfidesulindac sulfide results in increased expression of ESD mRNA12734198
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ESD mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ESD mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ESD mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ESD mRNA15034205|1879615
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ESD mRNA21215274
D013792ThalidomideThalidomide results in decreased expression of ESD mRNA26217789
D013853ThioacetamideThioacetamide affects the expression of ESD mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of ESD mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ESD mRNA25729387
D014635Valproic AcidValproic Acid affects the expression of ESD mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ESD mRNA19101580|2317975
D014750VincristineVincristine results in decreased expression of ESD mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of ESD mRNA26682919
D019287Zinc SulfateZinc Sulfate results in decreased expression of ESD mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0016788hydrolase activity, acting on ester bonds-IDA19126594  
GO:0018738S-formylglutathione hydrolase activity-IBA21873635  
GO:0018738S-formylglutathione hydrolase activity-TAS-  
GO:0042802identical protein binding-IPI25416956  
GO:0047374methylumbelliferyl-acetate deacetylase activity-IEA-  
GO:0052689carboxylic ester hydrolase activity-NAS3164702  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0046294formaldehyde catabolic process-IEA-  
GO:1901687glutathione derivative biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005829cytosol-IBA21873635  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156590Glutathione conjugationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18844222Serum pepsinogens and risk of esophageal squamous dysplasia. (2009 Jan 15)Kamangar FInt J Cancer
1811491[Aldehyde metabolizing enzymes in the central nervous system and liver--electrophoresis studies of alcoholism]. (1991)Stohlmacher PBeitr Gerichtl Med
21467942Clinical parameters including serum pepsinogen level and management strategy in patients with premalignant gastric dysplasia. (2011 May)Chang YWEur J Gastroenterol Hepatol
27038040ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma. (2016 Jul)Kagemoto KCancer Med
19004324[Molecular-genetic and epidemiologic examination of personnel subjected to occupational irradiation in Russian Federal Nuclear Center (Sarov). Report 1. Genome structural damage rate and radiosensitivity]. (2008 Sep-Oct)Korzeneva IBRadiats Biol Radioecol
3216652Possible linkage between alcoholism and esterase-D. (1988 Sep)Tanna VLJ Stud Alcohol