Gene info: ID 210

Gene: ALAD

GENE ID: 210

Synonyms: ALADH|PBGS

Description: aminolevulinate dehydratase

Gene type: protein-coding

Location: 9q32

dbXrefs: Ensembl:ENSG00000148218 MIM:125270 Vega:OTTHUMG00000020522 UniprotKB:P13716

RefSeq: NG_008716.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 21

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.247e-1 (AD) 2.256e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NUDT16	0.907
MAP4	0.879
SEPT8	0.856
DENND5A	0.855
PTPN11	0.855
C4orf3	0.853
CRTAP	0.852
ZNF664	0.851
ZBTB47	0.849
SEPT7	0.843

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.679
OR4F5	-0.597
MUC15	-0.173
SDIM1	-0.172
CHRNA2	-0.166
RNF223	-0.161
OR1L3	-0.152
ABRA	-0.151
OR4F16	-0.151
ANGPTL7	-0.15

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00855	Aminolevulinic acid	Small Molecule	106-60-5	Approved	Target
DB02068	Delta-Amino Valeric Acid	Small Molecule		Experimental	Target
DB02239	Laevulinic Acid	Small Molecule	123-76-2	Experimental	Target
DB02260	4-Oxosebacic Acid	Small Molecule		Experimental	Target
DB02272	Porphobilinogen	Small Molecule	487-90-1	Experimental	Target
DB02878	3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid	Small Molecule		Experimental	Target
DB04560	4,7-Dioxosebacic Acid	Small Molecule		Experimental	Target
DB04781	5-hydroxyvaleric acid	Small Molecule	13392-69-3	Experimental	Target

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ALAD mRNA"	28903501
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ALAD mRNA	19933214
C511855	2,2',3,3',4,4',6,6'-octabromodiphenyl ether	"2,2',3,3',4,4',6,6'-octabromodiphenyl ether results in decreased activity of ALAD protein"	23086635
C066841	2,3,7,8-tetrabromodibenzo-4-dioxin	"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ALAD protein"	27604104
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ALAD mRNA"	21346803
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ALAD mRNA"	20959002
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of ALAD mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALAD mRNA"	27188386
C013733	4-vinylcyclohexene	4-vinylcyclohexene results in decreased activity of ALAD protein	24681254
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALAD mRNA"	27188386
C001969	acephate	acephate results in decreased activity of ALAD protein	8687997
D000082	Acetaminophen	Acetaminophen results in decreased expression of ALAD mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of ALAD mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of ALAD mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALAD mRNA]	17585979
D000082	Acetaminophen	Acetaminophen affects the expression of ALAD protein	16687475
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [Zinc Sulfate inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]]	16959597
D012436	S-Adenosylmethionine	S-Adenosylmethionine results in increased activity of ALAD protein	9559101
C016601	afimoxifene	afimoxifene inhibits the reaction [Estrogens results in decreased expression of ALAD mRNA]	21233418
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of ALAD protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ALAD mRNA	22100608
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of ALAD protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of ALAD protein	26597043
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [[Streptozocin results in increased abundance of Blood Glucose] which results in decreased expression of ALAD protein]	7728901
D000535	Aluminum	Aluminum results in decreased activity of ALAD protein	15950499
C010845	aluminum chloride	aluminum chloride results in decreased activity of ALAD protein	8098681
C050609	aluminum nitrate	aluminum nitrate results in decreased activity of ALAD protein	8098681
D000622	Aminolevulinic Acid	ALAD protein results in increased metabolism of Aminolevulinic Acid	8687997
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ALAD mRNA	16483693
D000661	Amphetamine	Amphetamine promotes the reaction [MDK gene mutant form results in increased expression of ALAD protein]	23459167
D001151	Arsenic	[Arsenic co-treated with Cadmium] results in decreased activity of ALAD protein	21034764
D001151	Arsenic	[Arsenic co-treated with Lead co-treated with Cadmium] results in decreased activity of ALAD protein	21034764
D001151	Arsenic	[Arsenic co-treated with Lead] results in decreased activity of ALAD protein	21034764\|2235467
D001151	Arsenic	Arsenic results in decreased activity of ALAD protein	20587388\|2103476
D001151	Arsenic	Arsenic results in decreased expression of ALAD protein	19966145
D001151	Arsenic	[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]	22704994
D001151	Arsenic	Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein]	22704994
D001151	Arsenic	Selenium inhibits the reaction [Arsenic results in decreased activity of ALAD protein]	20587388
C025657	arsenic acid	arsenic acid results in decreased activity of ALAD protein	15202869
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ALAD protein	25542264
C006632	arsenic trioxide	beta Carotene inhibits the reaction [arsenic trioxide results in decreased expression of ALAD protein]	25542264
C015001	arsenite	arsenite results in decreased activity of ALAD protein	15202869
C015001	arsenite	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [arsenite results in decreased activity of ALAD protein]"	15202869
C015001	arsenite	Succimer inhibits the reaction [arsenite results in decreased activity of ALAD protein]	15202869
D018053	Arsenites	Arsenites results in increased expression of and results in increased activity of ALAD protein	11778665
D018053	Arsenites	Arsenites results in increased expression of and results in increased activity of ALAD protein	11778665
D001374	Azacitidine	Azacitidine results in decreased expression of ALAD mRNA	19194470
C547126	AZM551248	AZM551248 results in decreased expression of ALAD mRNA	22323515
D001462	Barbital	Barbital results in increased activity of ALAD protein	16309571
D001462	Barbital	Barbital results in increased expression of ALAD mRNA	16309571
D001554	Benzene	Benzene results in decreased activity of ALAD protein	3344524
D019207	beta Carotene	beta Carotene inhibits the reaction [arsenic trioxide results in decreased expression of ALAD protein]	25542264
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of ALAD mRNA	20660070
D004958	Estradiol	Estradiol results in decreased expression of ALAD mRNA	26865669\|2871154
D004958	Estradiol	Estradiol affects the expression of ALAD mRNA	16684588
D001663	Bilirubin	Bilirubin results in decreased expression of ALAD mRNA	20196124
C006780	bisphenol A	bisphenol A affects the expression of ALAD mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of ALAD mRNA	28711546
C006780	bisphenol A	bisphenol A affects the expression of ALAD mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of ALAD mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ALAD gene	28505145
C581290	bis(phenylimidazoselenazolyl) diselenide	bis(phenylimidazoselenazolyl) diselenide results in decreased activity of ALAD protein	25818048
D001786	Blood Glucose	alpha-Tocopherol inhibits the reaction [[Streptozocin results in increased abundance of Blood Glucose] which results in decreased expression of ALAD protein]	7728901
D001786	Blood Glucose	[Streptozocin results in increased abundance of Blood Glucose] which results in decreased expression of ALAD protein	7728901
C032036	bromobenzene	bromobenzene results in decreased activity of ALAD protein	16140629
C032036	bromobenzene	bromobenzene results in decreased activity of ALAD protein	6740708
C032036	bromobenzene	Carbon Monoxide inhibits the reaction [[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein]	6740708
C032036	bromobenzene	[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein	6740708
C578612	butane-2,3-dione thiosemicarbazone oxime	"butane-2,3-dione thiosemicarbazone oxime inhibits the reaction [Cadmium Chloride results in increased activity of ALAD protein]"	23038000
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased activity of ALAD protein	21620807
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of ALAD mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in decreased expression of ALAD mRNA	26079696
D002104	Cadmium	Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]	21910133
D002104	Cadmium	Cadmium results in decreased activity of ALAD protein	8687997
D002104	Cadmium	Cadmium affects the activity of ALAD protein	15454309
D002104	Cadmium	[Cadmium co-treated with Sucrose] affects the activity of ALAD protein	15454309
D002104	Cadmium	[Arsenic co-treated with Cadmium] results in decreased activity of ALAD protein	21034764
D002104	Cadmium	[Arsenic co-treated with Lead co-treated with Cadmium] results in decreased activity of ALAD protein	21034764
D002104	Cadmium	Cadmium affects the activity of ALAD protein	21034764
D002104	Cadmium	[Lead co-treated with Cadmium] results in decreased activity of ALAD protein	21034764
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ALAD mRNA	26472689
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ALAD mRNA	23741332
D019256	Cadmium Chloride	"butane-2,3-dione thiosemicarbazone oxime inhibits the reaction [Cadmium Chloride results in increased activity of ALAD protein]"	23038000
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]	20472051
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	14615064
D019256	Cadmium Chloride	Cadmium Chloride results in decreased activity of ALAD protein	15331134\|1600023
D019256	Cadmium Chloride	Cadmium Chloride results in increased activity of ALAD protein	23038000
D019256	Cadmium Chloride	[diphenyldiselenide co-treated with Succimer] inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	15331134
D019256	Cadmium Chloride	diphenyldiselenide inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	15331134\|1600023
D019256	Cadmium Chloride	Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]	20472051
D019256	Cadmium Chloride	gamma-oryzanol inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	23395783
D019256	Cadmium Chloride	Plant Extracts inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	26663770
D019256	Cadmium Chloride	Succimer inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	15331134
D019256	Cadmium Chloride	Unithiol inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	16000234
D002248	Carbon Monoxide	Carbon Monoxide inhibits the reaction [[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein]	6740708
D002248	Carbon Monoxide	Carbon Monoxide results in increased activity of ALAD protein	1032310
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ALAD mRNA	17484886
D002330	Carmustine	Carmustine results in decreased expression of ALAD mRNA	15980968
D002330	Carmustine	[Cyclophosphamide co-treated with Carmustine co-treated with Etoposide] results in decreased activity of ALAD protein	19162187
C586464	carvacryl acetate	carvacryl acetate inhibits the reaction [Pentylenetetrazole results in decreased activity of ALAD protein]	25490531
C586464	carvacryl acetate	carvacryl acetate inhibits the reaction [Picrotoxin results in decreased activity of ALAD protein]	25490531
C586464	carvacryl acetate	carvacryl acetate inhibits the reaction [Pilocarpine results in decreased activity of ALAD protein]	25490531
D048271	Chitosan	[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]	22704994
C108217	citronellal	citronellal results in decreased activity of ALAD protein	25218989
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of ALAD mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALAD mRNA]	17585979
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ALAD mRNA	24386269
D003300	Copper	Copper results in decreased activity of ALAD protein	19888908
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ALAD mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein]	23292317
D003474	Curcumin	[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]	22704994
D003474	Curcumin	Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein]	22704994
D003520	Cyclophosphamide	[Cyclophosphamide co-treated with Carmustine co-treated with Etoposide] results in decreased activity of ALAD protein	19162187
D016572	Cyclosporine	Cyclosporine results in decreased expression of ALAD mRNA	20106945\|2383089
D016572	Cyclosporine	Cyclosporine results in decreased expression of ALAD mRNA	23830897
C014347	decitabine	decitabine affects the expression of ALAD mRNA	23300844
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of ALAD mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of ALAD mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of ALAD mRNA	27392435
C539240	dicholesteroyl diselenide	dicholesteroyl diselenide results in decreased activity of ALAD protein	18804525
D004041	Dietary Fats	Dietary Fats results in increased expression of ALAD mRNA	18042831
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of ALAD mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of ALAD mRNA	26865669
D004112	Dimercaprol	Dimercaprol results in decreased expression of ALAD protein	15755317
D004112	Dimercaprol	Dimercaprol results in increased expression of ALAD protein	15755317
C061132	diphenyldiselenide	Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]	20472051
C061132	diphenyldiselenide	[diphenyldiselenide co-treated with Succimer] inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	15331134
C061132	diphenyldiselenide	diphenyldiselenide inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	15331134\|1600023
C061132	diphenyldiselenide	diphenyldiselenide inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	24954677
C061132	diphenyldiselenide	diphenyldiselenide results in decreased activity of ALAD protein	20472051
C061132	diphenyldiselenide	Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]	20472051
C061132	diphenyldiselenide	[Mercuric Chloride co-treated with diphenyldiselenide] results in decreased activity of ALAD protein	21259295
C061132	diphenyldiselenide	diphenyldiselenide results in decreased activity of ALAD protein	18804525\|2162080
C061132	diphenyldiselenide	[Fluphenazine co-treated with diphenyldiselenide] results in decreased activity of ALAD protein	19486337
C061132	diphenyldiselenide	Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]	21620807
D004221	Disulfiram	[Disulfiram co-treated with Lead] results in decreased activity of ALAD protein	2748540
D004229	Dithiothreitol	Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]	21910133
D004229	Dithiothreitol	Dithiothreitol results in increased activity of ALAD protein	2061546
D004229	Dithiothreitol	lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]	2061546
D004229	Dithiothreitol	lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]	2061546
D004229	Dithiothreitol	triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]	2061546
D004229	Dithiothreitol	triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]	2061546
D004229	Dithiothreitol	zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]	2061546
D004229	Dithiothreitol	[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]	21910133
D004229	Dithiothreitol	Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]	20472051
D004229	Dithiothreitol	Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]	23933410
D004050	Ditiocarb	Ditiocarb analog results in decreased activity of ALAD protein	2177232
D004050	Ditiocarb	Ditiocarb inhibits the reaction [Ditiocarb analog results in decreased activity of ALAD protein]	2177232
D004050	Ditiocarb	Ditiocarb inhibits the reaction [lead acetate results in decreased activity of ALAD protein]	2177232
C042986	ebselen	Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]	23933410
C042986	ebselen	ebselen results in decreased activity of ALAD protein	14630126\|2393341
D004737	Enflurane	Enflurane results in increased activity of ALAD protein	16309571
D004737	Enflurane	Enflurane results in increased expression of ALAD mRNA	16309571
D004785	Environmental Pollutants	Environmental Pollutants results in decreased activity of ALAD protein	17335901
D004785	Environmental Pollutants	Environmental Pollutants results in increased activity of ALAD protein	16879869
D004785	Environmental Pollutants	Environmental Pollutants results in decreased activity of ALAD protein	17335901
D004785	Environmental Pollutants	Environmental Pollutants results in decreased activity of ALAD protein	17335901
D004785	Environmental Pollutants	Environmental Pollutants results in increased activity of ALAD protein	16879869
D004785	Environmental Pollutants	Environmental Pollutants results in increased activity of ALAD protein	16879869
D004967	Estrogens	afimoxifene inhibits the reaction [Estrogens results in decreased expression of ALAD mRNA]	21233418
D004967	Estrogens	Estrogens results in decreased expression of ALAD mRNA	21233418
D004970	Estrone	Estrone results in decreased expression of ALAD mRNA	26865669
D000431	Ethanol	Ethanol results in increased activity of ALAD protein	16309571
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ALAD mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ALAD mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALAD mRNA	17942748
D008656	Mestranol	Mestranol results in decreased expression of ALAD mRNA	26865669
D005047	Etoposide	[Cyclophosphamide co-treated with Carmustine co-treated with Etoposide] results in decreased activity of ALAD protein	19162187
D015025	Zearalenone	lycopene inhibits the reaction [Zearalenone results in decreased activity of ALAD protein]	25682699
D015025	Zearalenone	Zearalenone results in decreased activity of ALAD protein	25682699
C004999	ferulic acid	ferulic acid inhibits the reaction [lead acetate results in decreased activity of ALAD protein]	25322819
D005476	Fluphenazine	[Fluphenazine co-treated with diphenyldiselenide] results in decreased activity of ALAD protein	19486337
D005476	Fluphenazine	Fluphenazine results in decreased activity of ALAD protein	19486337
D005632	Fructose	Fructose results in decreased activity of ALAD protein	15950499
C070081	fulvestrant	fulvestrant results in increased expression of ALAD mRNA	26865669
C039281	furan	furan binds to ALAD protein	22240984
D005707	Gallic Acid	Gallic Acid inhibits the reaction [Lead results in decreased activity of ALAD protein]	21402136
C043055	gallium arsenide	gallium arsenide results in decreased activity of ALAD protein	12084615\|2178399
C043055	gallium arsenide	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]"	12084615
C043055	gallium arsenide	Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]	21783994
C013172	gamma-oryzanol	gamma-oryzanol inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	23395783
D019833	Genistein	Genistein results in decreased expression of ALAD mRNA	26865669
D005947	Glucose	Glucose results in decreased activity of ALAD protein	15950499
D005978	Glutathione	ALAD protein results in decreased abundance of Glutathione	25569843
D005978	Glutathione	Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]	21620807
D006418	Heme	[succinylacetone results in decreased activity of ALAD protein] which affects the abundance of Heme	22859313
D006581	Hexachlorobenzene	Hexachlorobenzene affects the expression of ALAD mRNA	15159207
D006589	Hexestrol	Hexestrol results in decreased expression of ALAD mRNA	26865669
D017313	Fenretinide	Fenretinide results in increased expression of ALAD mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ALAD mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of ALAD mRNA	18951874
C020758	indium trichloride	indium trichloride inhibits the reaction [Zinc Sulfate results in increased activity of ALAD protein]	7084431
C020758	indium trichloride	indium trichloride promotes the reaction [lead acetate results in decreased activity of ALAD protein]	7084431
C020758	indium trichloride	indium trichloride results in decreased activity of ALAD protein	7084431
C020758	indium trichloride	lead acetate promotes the reaction [indium trichloride results in decreased activity of ALAD protein]	7084431
C020758	indium trichloride	Zinc Sulfate inhibits the reaction [indium trichloride results in decreased activity of ALAD protein]	7084431
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ALAD mRNA	25613284
D007530	Isoflurane	Isoflurane results in increased activity of ALAD protein	16309571
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of ALAD mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of ALAD mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of ALAD mRNA	24796395
C410337	K 7174	K 7174 results in decreased expression of ALAD mRNA	24086573
D007854	Lead	Lead results in decreased activity of ALAD protein	25569843
D007854	Lead	Lead results in decreased activity of ALAD protein	25569843
D007854	Lead	ALAD gene polymorphism affects the abundance of and affects the susceptibility to Lead	20510440
D007854	Lead	ALAD gene polymorphism affects the susceptibility to and affects the abundance of Lead	17366816
D007854	Lead	ALAD gene polymorphism affects the susceptibility to Lead	16487505\|2012360
D007854	Lead	ALAD gene polymorphism results in increased susceptibility to Lead	22101007
D007854	Lead	ALAD gene SNP affects the abundance of Lead	16341691
D007854	Lead	ALAD gene SNP affects the susceptibility to Lead	17823382\|2179972
D007854	Lead	ALAD gene SNP results in increased susceptibility to Lead	16341691
D007854	Lead	ALAD polymorphism affects the susceptibility to Lead	11049814
D007854	Lead	ALAD protein affects the susceptibility to Lead	22101007
D007854	Lead	ALAD protein results in increased susceptibility to Lead	21439310
D007854	Lead	Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]	21910133
D007854	Lead	Lead results in decreased activity of ALAD protein	16140629\|1736681
D007854	Lead	Lead results in decreased expression of ALAD mRNA	19921347\|2139643
D007854	Lead	Lead results in increased methylation of ALAD promoter	21396434
D007854	Lead	Uric Acid affects the reaction [ALAD polymorphism affects the susceptibility to Lead]	16263504
D007854	Lead	[VDR gene polymorphism co-treated with ALAD gene polymorphism] affects the abundance of Lead	19515364
D007854	Lead	[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]	21910133
D007854	Lead	[Arsenic co-treated with Lead co-treated with Cadmium] results in decreased activity of ALAD protein	21034764
D007854	Lead	[Arsenic co-treated with Lead] results in decreased activity of ALAD protein	21034764\|2235467
D007854	Lead	[Disulfiram co-treated with Lead] results in decreased activity of ALAD protein	2748540
D007854	Lead	Gallic Acid inhibits the reaction [Lead results in decreased activity of ALAD protein]	21402136
D007854	Lead	[Lead co-treated with Cadmium] results in decreased activity of ALAD protein	21034764
D007854	Lead	Lead results in decreased activity of ALAD protein	21034764\|2140213
D007854	Lead	Lead results in decreased expression of ALAD protein	15452883
D007854	Lead	Lead results in decreased activity of ALAD protein	15950499
C008261	lead acetate	Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein]	23292317
C008261	lead acetate	lead acetate results in decreased activity of ALAD protein	23292317
C008261	lead acetate	Ditiocarb inhibits the reaction [lead acetate results in decreased activity of ALAD protein]	2177232
C008261	lead acetate	ferulic acid inhibits the reaction [lead acetate results in decreased activity of ALAD protein]	25322819
C008261	lead acetate	indium trichloride promotes the reaction [lead acetate results in decreased activity of ALAD protein]	7084431
C008261	lead acetate	lead acetate promotes the reaction [indium trichloride results in decreased activity of ALAD protein]	7084431
C008261	lead acetate	lead acetate results in decreased activity of ALAD protein	1032310\|2177232\|
C008261	lead acetate	lead acetate results in decreased expression of ALAD protein	24345272\|2497011
C008261	lead acetate	Vitamin E inhibits the reaction [lead acetate results in decreased activity of ALAD protein]	2604901
C017461	lead nitrate	lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]	2061546
C017461	lead nitrate	lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]	2061546
C017461	lead nitrate	lead nitrate results in decreased activity of ALAD protein	2061546
D016651	Lithium Carbonate	Lithium Carbonate results in decreased activity of ALAD protein	19083387
D016651	Lithium Carbonate	Zinc Sulfate inhibits the reaction [Lithium Carbonate results in decreased activity of ALAD protein]	19083387
C015329	lycopene	lycopene inhibits the reaction [Zearalenone results in decreased activity of ALAD protein]	25682699
C015329	lycopene	lycopene inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	17516994
D008300	Maleic Hydrazide	Maleic Hydrazide results in decreased activity of ALAD protein	8687997
D008558	Melphalan	Melphalan results in decreased activity of ALAD protein	19162187
D008627	Mercuric Chloride	Cadmium Chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	14615064
D008627	Mercuric Chloride	diphenyldiselenide inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	24954677
D008627	Mercuric Chloride	[Mercuric Chloride co-treated with diphenyldiselenide] results in decreased activity of ALAD protein	21259295
D008627	Mercuric Chloride	Mercuric Chloride promotes the reaction [Sodium Selenite results in decreased activity of ALAD protein]	12595158
D008627	Mercuric Chloride	Mercuric Chloride results in decreased activity of ALAD protein	12595158\|1461506
D008627	Mercuric Chloride	Sodium Selenite promotes the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	12595158
D008627	Mercuric Chloride	zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	14615064
D008627	Mercuric Chloride	[zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]] which affects the abundance of Mercury	14615064
D008627	Mercuric Chloride	lycopene inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	17516994
D008627	Mercuric Chloride	Mercuric Chloride results in decreased activity of ALAD protein	14630126\|1751699
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of ALAD protein	24970117
D008627	Mercuric Chloride	Mercuric Chloride results in increased activity of ALAD protein	22413763
D008627	Mercuric Chloride	zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	24619859\|2467935
D008627	Mercuric Chloride	zinc chloride inhibits the reaction [Mercuric Chloride results in increased activity of ALAD protein]	22413763
D008627	Mercuric Chloride	Mercuric Chloride affects the activity of ALAD protein	21183220
D008627	Mercuric Chloride	zinc chloride inhibits the reaction [Mercuric Chloride affects the activity of ALAD protein]	21183220
D008628	Mercury	ALAD gene polymorphism affects the abundance of Mercury	25728017
D008628	Mercury	Mercury results in decreased activity of ALAD protein	12499120
D008628	Mercury	Sodium Selenite inhibits the reaction [Mercury results in decreased activity of ALAD protein]	12499120
D008628	Mercury	[zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]] which affects the abundance of Mercury	14615064
D008628	Mercury	Mercury results in decreased activity of ALAD protein	15950499
C014655	methamidophos	methamidophos results in decreased activity of ALAD protein	8687997
C005219	methyl cellosolve	methyl cellosolve results in decreased activity of ALAD protein	8296314
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ALAD mRNA	23458150
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of ALAD protein	26558463
C008493	methylselenic acid	methylselenic acid results in increased expression of ALAD mRNA	18548127
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [arsenite results in decreased activity of ALAD protein]"	15202869
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]"	12084615
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate results in decreased activity of ALAD protein"	16040228
C091888	monoisoamyl-2,3-dimercaptosuccinate	"[Taurine co-treated with monoisoamyl-2,3-dimercaptosuccinate] inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]"	19794907
D009538	Nicotine	Nicotine results in decreased activity of ALAD protein	8687997
C025589	ochratoxin A	ochratoxin A results in decreased expression of ALAD mRNA	18417182
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of ALAD mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of ALAD mRNA	25729387
D000073878	Palm Oil	Palm Oil results in increased expression of ALAD mRNA	18042831
D010269	Paraquat	Paraquat results in decreased activity of ALAD protein	12180188
D052638	Particulate Matter	Particulate Matter results in increased expression of ALAD mRNA	24769257
D010433	Pentylenetetrazole	carvacryl acetate inhibits the reaction [Pentylenetetrazole results in decreased activity of ALAD protein]	25490531
D010433	Pentylenetetrazole	Pentylenetetrazole results in decreased activity of ALAD protein	25490531
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ALAD mRNA	19162173
D010575	Pesticides	Pesticides results in decreased activity of ALAD protein	15922524
D010634	Phenobarbital	Carbon Monoxide inhibits the reaction [[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein]	6740708
D010634	Phenobarbital	Phenobarbital affects the reaction [Trichloroethylene results in decreased activity of ALAD protein]	6710543
D010634	Phenobarbital	[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein	6740708
D010852	Picrotoxin	carvacryl acetate inhibits the reaction [Picrotoxin results in decreased activity of ALAD protein]	25490531
D010852	Picrotoxin	Picrotoxin results in decreased activity of ALAD protein	25490531
D010862	Pilocarpine	carvacryl acetate inhibits the reaction [Pilocarpine results in decreased activity of ALAD protein]	25490531
D010862	Pilocarpine	Pilocarpine results in decreased activity of ALAD protein	25490531
D010862	Pilocarpine	Pilocarpine results in decreased expression of ALAD protein	19798568\|2002616
D010862	Pilocarpine	Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]	19798568\|2002616
D010862	Pilocarpine	Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]	20584200
C006253	pirinixic acid	pirinixic acid results in increased expression of ALAD mRNA	23811191
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	26663770
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of ALAD mRNA	20660070
D054328	Proton Pump Inhibitors	Proton Pump Inhibitors results in decreased expression of ALAD mRNA	25626140
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of ALAD mRNA	26865669
D017382	Reactive Oxygen Species	ALAD protein results in decreased abundance of Reactive Oxygen Species	25569843
D012643	Selenium	Selenium inhibits the reaction [Arsenic results in decreased activity of ALAD protein]	20587388
D017279	Selenocysteine	Selenocysteine analog results in decreased activity of ALAD protein	14630126
C017947	sodium arsenite	sodium arsenite results in decreased activity of ALAD protein	16828073\|1761301
C017947	sodium arsenite	Acetylcysteine promotes the reaction [Zinc Sulfate inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]]	16959597
C017947	sodium arsenite	sodium arsenite results in decreased activity of ALAD protein	16959597\|1718894
C017947	sodium arsenite	sodium arsenite results in decreased expression of ALAD protein	24970117
C017947	sodium arsenite	Succimer inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]	17188940
C017947	sodium arsenite	"[Taurine co-treated with monoisoamyl-2,3-dimercaptosuccinate] inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]"	19794907
C017947	sodium arsenite	Zinc Sulfate inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]	16959597
D012969	Sodium Fluoride	Sodium Fluoride results in decreased activity of ALAD protein	16828073\|1761301
D018038	Sodium Selenite	Mercuric Chloride promotes the reaction [Sodium Selenite results in decreased activity of ALAD protein]	12595158
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [Mercury results in decreased activity of ALAD protein]	12499120
D018038	Sodium Selenite	Sodium Selenite promotes the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	12595158
D018038	Sodium Selenite	Sodium Selenite results in decreased activity of ALAD protein	12595158
D012989	Soil Pollutants	Soil Pollutants results in decreased activity of ALAD protein	16446990
D012999	Soman	Soman results in decreased expression of ALAD mRNA	19281266
D013311	Streptozocin	alpha-Tocopherol inhibits the reaction [[Streptozocin results in increased abundance of Blood Glucose] which results in decreased expression of ALAD protein]	7728901
D013311	Streptozocin	[Streptozocin results in increased abundance of Blood Glucose] which results in decreased expression of ALAD protein	7728901
D020058	Styrene	Styrene results in decreased activity of ALAD protein	16140629
D004113	Succimer	[diphenyldiselenide co-treated with Succimer] inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	15331134
D004113	Succimer	Succimer inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	15331134
D004113	Succimer	Succimer results in increased activity of ALAD protein	9559101
D004113	Succimer	Succimer inhibits the reaction [arsenite results in decreased activity of ALAD protein]	15202869
D004113	Succimer	Succimer inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]	17188940
C020804	succinylacetone	succinylacetone results in decreased activity of ALAD protein	22859313
C020804	succinylacetone	[succinylacetone results in decreased activity of ALAD protein] which affects the abundance of Heme	22859313
D013395	Sucrose	[Cadmium co-treated with Sucrose] affects the activity of ALAD protein	15454309
D013629	Tamoxifen	Tamoxifen affects the expression of ALAD mRNA	17555576
D013654	Taurine	"[Taurine co-treated with monoisoamyl-2,3-dimercaptosuccinate] inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]"	19794907
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ALAD mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALAD mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ALAD mRNA	18163543\|2821309
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ALAD mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ALAD mRNA	20959002\|2121527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ALAD protein	15822908
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of ALAD protein	2124380
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ALAD mRNA	25613284
D017392	Thiobarbituric Acid Reactive Substances	ALAD protein results in decreased abundance of Thiobarbituric Acid Reactive Substances	25569843
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]	21783994
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]	19798568\|2002616
D019772	Topotecan	ALAD protein affects the susceptibility to Topotecan	16217747
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of ALAD mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of ALAD mRNA	25729387
D014241	Trichloroethylene	Trichloroethylene results in decreased activity of ALAD protein	16140629
D014241	Trichloroethylene	Phenobarbital affects the reaction [Trichloroethylene results in decreased activity of ALAD protein]	6710543
D014241	Trichloroethylene	Trichloroethylene results in decreased activity of ALAD protein	6710543
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALAD mRNA"	27188386
C012589	trichostatin A	trichostatin A affects the expression of ALAD mRNA	28542535
C012589	trichostatin A	trichostatin A results in decreased expression of ALAD mRNA	26272509
C033120	triethyllead acetate	triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]	2061546
C033120	triethyllead acetate	triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]	2061546
C033120	triethyllead acetate	triethyllead acetate results in decreased activity of ALAD protein	2061546
C057693	troglitazone	troglitazone results in increased expression of ALAD mRNA	28973697
C057693	troglitazone	[troglitazone co-treated with TNF protein] results in decreased expression of ALAD mRNA	12732648
D014451	Ubiquinone	Ubiquinone inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein]	20584200
D014494	Unithiol	Unithiol results in decreased expression of ALAD protein	15755317
D014494	Unithiol	Unithiol results in increased expression of ALAD protein	15755317
D014494	Unithiol	Unithiol inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]	16000234
D014527	Uric Acid	Uric Acid affects the reaction [ALAD polymorphism affects the susceptibility to Lead]	16263504
D014635	Valproic Acid	Valproic Acid results in increased expression of ALAD mRNA	22083351\|2317975
D014635	Valproic Acid	Valproic Acid affects the expression of ALAD mRNA	17292431
C025643	vinclozolin	vinclozolin results in decreased expression of ALAD mRNA	23034163
D014810	Vitamin E	Vitamin E inhibits the reaction [lead acetate results in decreased activity of ALAD protein]	2604901
D015032	Zinc	Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]	21910133
D015032	Zinc	[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]	21910133
D015032	Zinc	Zinc affects the activity of ALAD protein	2033469
C016837	zinc chloride	lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]	2061546
C016837	zinc chloride	triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]	2061546
C016837	zinc chloride	zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]	2061546
C016837	zinc chloride	zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	14615064
C016837	zinc chloride	[zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]] which affects the abundance of Mercury	14615064
C016837	zinc chloride	zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]	24619859\|2467935
C016837	zinc chloride	zinc chloride inhibits the reaction [Mercuric Chloride results in increased activity of ALAD protein]	22413763
C016837	zinc chloride	zinc chloride inhibits the reaction [Mercuric Chloride affects the activity of ALAD protein]	21183220
C017803	zinc protoporphyrin	ALAD gene SNP affects the abundance of zinc protoporphyrin	25963508
D019287	Zinc Sulfate	Acetylcysteine promotes the reaction [Zinc Sulfate inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]]	16959597
D019287	Zinc Sulfate	indium trichloride inhibits the reaction [Zinc Sulfate results in increased activity of ALAD protein]	7084431
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [indium trichloride results in decreased activity of ALAD protein]	7084431
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [Lithium Carbonate results in decreased activity of ALAD protein]	19083387
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]	16959597
D019287	Zinc Sulfate	Zinc Sulfate results in increased activity of ALAD protein	7084431

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003824	catalytic activity	-	TAS	2063868
GO:0004655	porphobilinogen synthase activity	-	IBA	21873635
GO:0004655	porphobilinogen synthase activity	-	IDA	8175643 11032836
GO:0004655	porphobilinogen synthase activity	-	TAS	-
GO:0008270	zinc ion binding	-	IBA	21873635
GO:0008270	zinc ion binding	-	IDA	11032836
GO:0042802	identical protein binding	-	IPI	11032836
GO:1904854	proteasome core complex binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IEA	-
GO:0006782	protoporphyrinogen IX biosynthetic process	-	IEA	-
GO:0006783	heme biosynthetic process	-	IBA	21873635
GO:0006783	heme biosynthetic process	-	IDA	11032836
GO:0006783	heme biosynthetic process	-	TAS	-
GO:0006979	response to oxidative stress	-	IEA	-
GO:0009635	response to herbicide	-	IEA	-
GO:0010039	response to iron ion	-	IEA	-
GO:0010043	response to zinc ion	-	IEA	-
GO:0010044	response to aluminum ion	-	IEA	-
GO:0010212	response to ionizing radiation	-	IEA	-
GO:0010266	response to vitamin B1	-	IEA	-
GO:0010269	response to selenium ion	-	IEA	-
GO:0014823	response to activity	-	IEA	-
GO:0032025	response to cobalt ion	-	IEA	-
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0033197	response to vitamin E	-	IEA	-
GO:0043200	response to amino acid	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045471	response to ethanol	-	IEA	-
GO:0046685	response to arsenic-containing substance	-	IEA	-
GO:0046686	response to cadmium ion	-	IEA	-
GO:0046689	response to mercury ion	-	IEA	-
GO:0051260	protein homooligomerization	-	IPI	11032836
GO:0051384	response to glucocorticoid	-	IEA	-
GO:0051597	response to methylmercury	-	IEA	-
GO:0070541	response to platinum ion	-	IEA	-
GO:0070542	response to fatty acid	-	IEA	-
GO:0071284	cellular response to lead ion	-	IEA	-
GO:0071353	cellular response to interleukin-4	-	IEA	-
GO:1901799	negative regulation of proteasomal protein catabolic process	-	IDA	8175643

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005634	nucleus	-	HDA	21630459
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0005839	proteasome core complex	-	IEA	-
GO:0034774	secretory granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	23533145
GO:1904813	ficolin-1-rich granule lumen	-	TAS	-

KEGG ID	KEGG Term
hsa00860	Porphyrin and chlorophyll metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-189445	Metabolism of porphyrins	TAS
R-HSA-189451	Heme biosynthesis	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
4188	A trial of fenfluramine in the treatment of the chronic alcoholic patient. (1976 Apr)	Krasner N	Br J Psychiatry
26351197	Influence of abatement of lead exposure in Croatia on blood lead and ALAD activity. (2016 Jan)	Zorana KG	Environ Sci Pollut Res Int
23797033	Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis. (2013 Dec)	D'Amico E	Free Radic Biol Med
8080400	[Lack of association between alcoholism and alleles in the delta-aminolevulinic acid dehydratase (ALAD) gene]. (1994 Jun)	Muramatsu T	Arukoru Kenkyuto Yakubutsu Ison
19938001	Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers. (2010 May)	Kasuba V	J Appl Toxicol
668658	Placental transfer of lead, mercury, cadmium, and carbon monoxide in women. I. Comparison of the frequency distributions of the biological indices in maternal and umbilical cord blood. (1978 Apr)	Lauwerys R	Environ Res
11683589	Blood pressure in relation to biomarkers of lead, cadmium, copper, zinc, and selenium in men without occupational exposure to metals. (2001 Oct)	Telisman S	Environ Res
15308833	Investigations of vitamin D receptor polymorphism affecting workers' susceptibility to lead. (2004 Jul)	Chuang HY	J Occup Health
22788373	Assessment of essential and nonessential metals and different metal exposure biomarkers in the human placenta in a population from the south of Portugal. (2012)	Serafim A	J Toxicol Environ Health A
17632096	Reproductive toxicity of low-level lead exposure in men. (2007 Oct)	Telisman S	Environ Res
20301372	Acute Intermittent Porphyria (1993)	Whatley SD	-
23277717	Impact of chronic lead exposure on selected biological markers. (2012 Jan)	Jangid AP	Indian J Clin Biochem
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