Gene: ESRRA

2101
ERR1|ERRa|ERRalpha|ESRL1|NR3B1
estrogen related receptor alpha
protein-coding
11q13.1
Ensembl:ENSG00000173153 MIM:601998 Vega:OTTHUMG00000150641 UniprotKB:P11474
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.141e-1 (AD)  1.890e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYC10.895
LONP10.895
SLC25A110.895
YIPF20.895
MRPL40.894
SNX210.892
GPR1370.889
CLPTM10.879
CTBP10.877
MAP2K20.877

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.725
OR4F29-0.656
DNASE1L3-0.354
CNTF-0.346
IL18RAP-0.345
VNN2-0.343
CD48-0.337
CTNNA3-0.333
TFPI2-0.33
EOMES-0.329

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00197TroglitazoneSmall Molecule97322-87-7Investigational|WithdrawnTarget
DB00255DiethylstilbestrolSmall Molecule56-53-1Approved|InvestigationalTarget
DB01645GenisteinSmall Molecule446-72-0InvestigationalTarget
DB04468AfimoxifeneSmall Molecule68392-35-8InvestigationalTarget
DB06732beta-NaphthoflavoneSmall Molecule6051-87-2ExperimentalTarget
DB068331-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINESmall MoleculeExperimentalTarget
DB07776FlavoneSmall Molecule525-82-6Approved|ExperimentalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ESRRA mRNA"26377693
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNA"20211987
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA protein"20211987
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNA]"20211987
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"GPER1 protein promotes the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNA]"20211987
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"Pertussis Toxin inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNA]"20211987
C0354762,2',4,4'-tetrahydroxybenzophenone"2,2',4,4'-tetrahydroxybenzophenone results in decreased expression of ESRRA mRNA"15458797
C0354762,2',4,4'-tetrahydroxybenzophenone"2,2',4,4'-tetrahydroxybenzophenone results in increased expression of ESRRA mRNA"15458797
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNA]"20211987
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA]20211987
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]20211987
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]20211987
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ESRRA mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ESRRA mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ESRRA mRNA"21346803
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile binds to and results in decreased activity of ESRRA protein"21218783
C5047504-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene"4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene results in increased expression of ESRRA protein"24231368
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of ESRRA mRNA]20351196
C0538766-isopropoxy-9-oxoxanthene-2-carboxylic acid6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of ESRRA protein]20351196
D000082AcetaminophenAcetaminophen affects the expression of ESRRA mRNA17562736
C016601afimoxifeneafimoxifene binds to and results in decreased activity of [ESRRG protein binds to ESRRA protein]14751226
C016601afimoxifeneafimoxifene binds to ESRRA protein mutant form11447273
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ESRRA mRNA19770486
C412373AG 1879AG 1879 inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]20211987
C412373AG 1879AG 1879 inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]20211987
C011512alpha-naphthoflavone[alpha-naphthoflavone binds to AHR protein] which binds to ESRRA protein10620335
D019324beta-Naphthoflavone[beta-Naphthoflavone binds to AHR protein] which binds to ESRRA protein10620335
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ESRRA mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ESRRA mRNA19770486
D004958Estradiol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA]20211987
D004958EstradiolDinoprostone promotes the reaction [ESRRA protein promotes the reaction [Testosterone results in increased abundance of Estradiol]]20351196
D004958EstradiolESRRA protein promotes the reaction [Testosterone results in increased abundance of Estradiol]20351196
D004958EstradiolEstradiol affects the expression of ESRRA mRNA22574217
D004958EstradiolEstradiol results in decreased expression of ESRRA mRNA15968320
D004958EstradiolEstradiol results in increased expression of ESRRA mRNA15223131|2021198
D004958EstradiolEstradiol results in increased expression of ESRRA protein20211987
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in decreased expression of ESRRA mRNA]15968320
D004958EstradiolGPER1 protein promotes the reaction [Estradiol results in increased expression of ESRRA mRNA]20211987
D004958EstradiolPertussis Toxin inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA]20211987
D004958EstradiolEstradiol results in decreased expression of ESRRA mRNA15458797
D004958EstradiolEstradiol results in increased expression of ESRRA mRNA12193582|1545879
C004541biochanin Abiochanin A binds to and results in increased activity of ESRRA protein14638870
C004541biochanin Abiochanin A binds to ESRRA protein mutant form14638870
C004541biochanin Abiochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein]14638870
C004541biochanin Abiochanin A binds to and results in increased activity of ESRRA protein16515477
C006780bisphenol Abisphenol A results in decreased activity of ESRRA protein24457025
C006780bisphenol Abisphenol A results in increased expression of ESRRA mRNA21831745
C006780bisphenol Abisphenol A results in increased expression of ESRRA protein24231368
C006780bisphenol Abisphenol A results in decreased expression of ESRRA mRNA12233820
C006780bisphenol Abisphenol A results in increased expression of ESRRA mRNA25111128
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ESRRA mRNA"28433925
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ESRRA promoter23359474
C006780bisphenol Abisphenol A results in increased expression of ESRRA mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of ESRRA mRNA20977926
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ESRRA mRNA23166782
C048491butaprostbutaprost results in increased expression of ESRRA mRNA20351196
C048491butaprostbutaprost results in increased expression of ESRRA protein20351196
C584509C646 compoundC646 compound results in decreased expression of ESRRA mRNA26191083
D002330CarmustineCarmustine results in increased expression of ESRRA mRNA15980968
D002706ChlordanChlordan binds to and results in decreased activity of ESRRA protein11850205|1595569
D002706ChlordanChlordan results in decreased activity of ESRRA protein10493499
D002706ChlordanChlordan binds to and results in decreased activity of ESRRA protein16515477
D002976ClenbuterolClenbuterol results in increased expression of ESRRA mRNA17446185
D005576ColforsinColforsin results in increased expression of ESRRA mRNA20351196
D005576ColforsinColforsin results in increased expression of ESRRA protein20351196
C465366cyazofamidcyazofamid results in increased activity of ESRRA protein20143881
D003520CyclophosphamideCyclophosphamide results in decreased expression of ESRRA mRNA27281708
D003520CyclophosphamideCyclophosphamide results in increased expression of ESRRA mRNA27281708
C004742daidzeindaidzein binds to and results in increased activity of ESRRA protein14638870
C004742daidzeindaidzein binds to and results in increased activity of ESRRA protein mutant form14638870
C004742daidzeindaidzein promotes the reaction [ESRRA protein binds to PNRC1 protein]14638870
C004742daidzeindaidzein binds to and results in increased activity of ESRRA protein16515477
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ESRRA mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of ESRRA gene22964155
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ESRRA promoter23359474
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ESRRA mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of ESRRA mRNA17456854
D004041Dietary FatsESRRA gene mutant form results in decreased susceptibility to Dietary Fats21218783
D004041Dietary Fats[ESRRA gene mutant form results in decreased susceptibility to Dietary Fats] which results in increased expression of ACADM mRNA21218783
D004041Dietary Fatsrosiglitazone inhibits the reaction [Dietary Fats results in decreased expression of ESRRA mRNA]17456854
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ESRRA mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ESRRA mRNA"28433925
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ESRRA promoter23359474
D004054DiethylstilbestrolDiethylstilbestrol binds to and results in decreased activity of ESRRA protein11559547
D004054DiethylstilbestrolDiethylstilbestrol inhibits the reaction [ESRRA protein results in increased expression of TFF1 mRNA]11559547
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ESRRA mRNA22710028
D004054DiethylstilbestrolDiethylstilbestrol binds to and results in decreased activity of ESRRA protein16515477
C024629dimethyl phthalatedimethyl phthalate affects the expression of ESRRA mRNA26924002
D004967EstrogensEstrogens results in increased expression of ESRRA15821111
D004967EstrogensEstrogens results in increased expression of ESRRA mRNA12960079
D004967EstrogensEstrogens results in increased expression of ESRRA15821111
D004967EstrogensEstrogens results in increased expression of ESRRA mRNA12960079
C043562flavoneflavone binds to and results in increased activity of ESRRA protein14638870
C043562flavoneflavone binds to ESRRA protein mutant form14638870
C070081fulvestrant2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]20211987
C070081fulvestrantAG 1879 inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]20211987
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in decreased expression of ESRRA mRNA]15968320
C070081fulvestrantfulvestrant promotes the reaction [SP1 protein binds to ESRRA promoter]20211987
C070081fulvestrantfulvestrant promotes the reaction [SP3 protein binds to ESRRA promoter]20211987
C070081fulvestrantfulvestrant results in increased expression of ESRRA mRNA20211987
C070081fulvestrantfulvestrant results in increased expression of ESRRA protein20211987
C070081fulvestrantGPER1 protein promotes the reaction [fulvestrant results in increased expression of ESRRA mRNA]20211987
C070081fulvestrantPertussis Toxin inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]20211987
D019833GenisteinGenistein binds to and results in increased activity of ESRRA protein14638870|1595569
D019833GenisteinGenistein binds to and results in increased activity of ESRRA protein mutant form14638870
D019833GenisteinGenistein results in decreased activity of ESRRA protein24457025
D019833GenisteinGenistein results in increased expression of ESRRA mRNA16399490|2301914
D019833GenisteinGenistein binds to and results in increased activity of ESRRA protein16515477
D005947GlucoseGlucose results in decreased expression of ESRRA protein23090186
D005947Glucoseresveratrol inhibits the reaction [Glucose results in decreased expression of ESRRA protein]23090186
D006418HemeHeme metabolite results in decreased expression of ESRRA mRNA19191707
D006861Hydrogen PeroxideESRRA protein inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]24967384
C016517indole-3-carbinolindole-3-carbinol affects the expression of ESRRA mRNA21396975
D007529IsoflavonesIsoflavones binds to and results in increased activity of ESRRA protein14638870
D007529IsoflavonesIsoflavones binds to ESRRA protein mutant form14638870
D007854LeadLead results in increased expression of ESRRA mRNA19921347
D001556LindaneLindane results in increased expression of ESRRA mRNA23777605
C082161lipopolysaccharide Alipopolysaccharide A inhibits the reaction [ESRRA protein binds to ACADM promoter]16061943
C082161lipopolysaccharide Alipopolysaccharide A results in decreased expression of ESRRA mRNA16061943
D008687MetforminMetformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA]23166782
D008687MetforminMetformin results in decreased expression of ESRRA mRNA23166782
D008727MethotrexateESRRA protein inhibits the reaction [Methotrexate results in increased cleavage of CASP7 protein]24967384
D008727MethotrexateESRRA protein inhibits the reaction [Methotrexate results in increased cleavage of PARP1 protein]24967384
D008727MethotrexateESRRA protein inhibits the reaction [Methotrexate results in increased expression of PMAIP1 mRNA]24967384
D008727MethotrexateESRRA protein inhibits the reaction [Methotrexate results in increased expression of TP53 protein]24967384
D008727MethotrexateESRRA protein inhibits the reaction [Methotrexate results in increased expression of XAF1 mRNA]24967384
D008727MethotrexateESRRA protein results in decreased susceptibility to Methotrexate24967384
D008727MethotrexateMethotrexate results in decreased expression of ESRRA mRNA17400583
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ESRRA mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ESRRA mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ESRRA mRNA"25620056
C005290oxybenzoneoxybenzone results in decreased expression of ESRRA mRNA15458797
D010126OzoneOzone results in increased expression of ESRRA mRNA25838073
D010269ParaquatParaquat results in decreased expression of ESRRA mRNA12595580
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ESRRA mRNA19616056
D037342Pertussis Toxin"Pertussis Toxin inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of ESRRA mRNA]"20211987
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA]20211987
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [fulvestrant results in increased expression of ESRRA mRNA]20211987
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]20211987
D015232Dinoprostone6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of ESRRA mRNA]20351196
D015232Dinoprostone6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of ESRRA protein]20351196
D015232DinoprostoneDinoprostone promotes the reaction [ESRRA protein binds to CYP19A1 promoter]20351196
D015232DinoprostoneDinoprostone promotes the reaction [ESRRA protein promotes the reaction [Testosterone results in increased abundance of Estradiol]]20351196
D015232DinoprostoneDinoprostone promotes the reaction [ESRRA protein results in increased expression of CYP19A1 mRNA]20351196
D015232DinoprostoneDinoprostone promotes the reaction [ESRRA protein results in increased expression of CYP19A1 protein]20351196
D015232DinoprostoneDinoprostone results in increased expression of ESRRA mRNA20351196
D015232DinoprostoneDinoprostone results in increased expression of ESRRA protein20351196
D015232DinoprostoneESRRA protein promotes the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]20351196
D015232DinoprostoneESRRA protein promotes the reaction [Dinoprostone results in increased expression of CYP19A1 protein]20351196
C119222phorbol-12-myristatephorbol-12-myristate promotes the reaction [ESRRA protein binds to and results in increased expression of TFF1 mRNA]16024613
D048789PhytoestrogensPhytoestrogens binds to and results in increased activity of ESRRA protein16515477
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ESRRA mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of ESRRA mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of ESRRA mRNA15968320
C059514resveratrolresveratrol results in increased expression of ESRRA protein24365713
C059514resveratrolresveratrol inhibits the reaction [Glucose results in decreased expression of ESRRA protein]23090186
C059514resveratrolresveratrol results in increased expression of ESRRA mRNA19934007
C059514resveratrolresveratrol results in increased expression of ESRRA protein23090186
C059514resveratrolSIRT1 protein promotes the reaction [resveratrol results in increased expression of ESRRA mRNA]19934007
C089730rosiglitazonerosiglitazone affects the expression of ESRRA mRNA22013433
C089730rosiglitazonerosiglitazone inhibits the reaction [Dietary Fats results in decreased expression of ESRRA mRNA]17456854
C089730rosiglitazonerosiglitazone results in increased expression of ESRRA mRNA17361034
D013629Tamoxifen2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]20211987
D013629TamoxifenAG 1879 inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]20211987
D013629TamoxifenGPER1 protein promotes the reaction [Tamoxifen results in increased expression of ESRRA mRNA]20211987
D013629TamoxifenPertussis Toxin inhibits the reaction [Tamoxifen results in increased expression of ESRRA mRNA]20211987
D013629TamoxifenTamoxifen promotes the reaction [SP1 protein binds to ESRRA promoter]20211987
D013629TamoxifenTamoxifen promotes the reaction [SP3 protein binds to ESRRA promoter]20211987
D013629TamoxifenTamoxifen results in increased expression of ESRRA mRNA20211987
D013629TamoxifenTamoxifen results in increased expression of ESRRA protein20211987
D013739TestosteroneDinoprostone promotes the reaction [ESRRA protein promotes the reaction [Testosterone results in increased abundance of Estradiol]]20351196
D013739TestosteroneESRRA protein promotes the reaction [Testosterone results in increased abundance of Estradiol]20351196
D013739TestosteroneTestosterone results in increased expression of ESRRA mRNA19693291
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ESRRA mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ESRRA mRNA24058054
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ESRRA mRNA28973375
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ESRRA mRNA28065790
D014112ToxapheneToxaphene binds to and results in decreased activity of ESRRA protein11356845|1185020
D014112ToxapheneToxaphene binds to and results in increased activity of ESRRA protein mutant form11356845
D014112ToxapheneToxaphene inhibits the reaction [NCOA2 protein results in increased activity of ESRRA protein]10493499
D014112ToxapheneToxaphene results in decreased activity of ESRRA protein10493499
D014112ToxapheneToxaphene binds to and results in decreased activity of ESRRA protein16515477
C012589trichostatin Atrichostatin A results in increased activity of ESRRA protein11705994
C057693troglitazonetroglitazone results in increased expression of ESRRA mRNA20860658
D014425TurpentineTurpentine results in decreased expression of ESRRA mRNA16061943
D014635Valproic AcidValproic Acid affects the expression of ESRRA mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ESRRA gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ESRRA mRNA23034163
C488234XCT790XCT790 results in decreased activity of ESRRA protein24457025
C488234XCT790XCT790 results in decreased expression of ESRRA protein19464277
C488234XCT790XCT790 affects the activity of ESRRA protein21218783
C488234XCT790XCT790 binds to and affects the activity of ESRRA protein19464277
C488234XCT790XCT790 binds to and results in decreased activity of ESRRA protein16515477
D015032ZincZinc deficiency results in increased expression of ESRRA mRNA20932299
D015054ZymosanZymosan results in decreased expression of ESRRA mRNA16061943

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-TAS9286700  
GO:0003700DNA-binding transcription factor activity-IDA21190936  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0004879nuclear receptor activity-TAS9286700  
GO:0005496steroid binding-IEA-  
GO:0005515protein binding-IPI12522104  18063693  18331830  18509053  21190936  21988832  
GO:0008270zinc ion binding-IEA-  
GO:0019904protein domain specific binding-IPI11984006  
GO:0043565sequence-specific DNA binding-IDA23836911  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006355regulation of transcription, DNA-templated-IMP23836911  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007005mitochondrion organization-TAS-  
GO:0030522intracellular receptor signaling pathway-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045667regulation of osteoblast differentiation-IEA-  
GO:0045670regulation of osteoclast differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0051216cartilage development-IEA-  
GO:1900078positive regulation of cellular response to insulin stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA21190936  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA21190936  
GO:0015630microtubule cytoskeleton-IDA-  
GO:0045171intercellular bridge-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1592230Mitochondrial biogenesisIEA
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-1852241Organelle biogenesis and maintenanceIEA
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisIEA
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8939902Regulation of RUNX2 expression and activityIEA
R-HSA-8939902Regulation of RUNX2 expression and activityTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15883633A frequent regulatory variant of the estrogen-related receptor alpha gene associated with BMD in French-Canadian premenopausal women. (2005 Jun)Laflamme NJ Bone Miner Res