Gene info: ID 211

Gene: ALAS1

GENE ID: 211

Synonyms: ALAS|ALAS-H|ALAS3|ALASH|MIG4

Description: 5'-aminolevulinate synthase 1

Gene type: protein-coding

Location: 3p21.2

dbXrefs: Ensembl:ENSG00000023330 MIM:125290 Vega:OTTHUMG00000158108 UniprotKB:P13196

RefSeq: NC_000003.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.731e-1 (AD) 2.164e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg16983541	chr3:52231347	ALAS1		6.300e-11	Smoking	27651444
cg03929796	chr3:52231840	ALAS1		9.900e-9	Smoking	27651444
cg11012543	chr3:52231691	ALAS1		8.500e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
B4GALT5	0.95
TOX4	0.948
VCP	0.947
PGK1	0.947
SND1	0.946
UBQLN1	0.946
PRMT5	0.939
DNAJA3	0.938
RAB35	0.938
PSMC1	0.938

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.604
OR4F29	-0.561
P2RY14	-0.388
MTRNR2L6	-0.37
ASB4	-0.354
CTNNA3	-0.35
MTRNR2L10	-0.342
MTRNR2L9	-0.342
KLRK1	-0.332
KLRB1	-0.324

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00114	Pyridoxal Phosphate	Small Molecule	54-47-7	Approved\|Investigational\|Nutraceutical	Target
DB00114	Pyridoxal Phosphate	Small Molecule	54-47-7	Approved\|Investigational\|Nutraceutical	Target
DB00145	Glycine	Small Molecule	56-40-6	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C009947	1,2,4-trichlorobenzene	"1,2,4-trichlorobenzene results in increased activity of ALAS1 protein"	6636202
C009947	1,2,4-trichlorobenzene	"1,2,4-trichlorobenzene results in increased activity of ALAS1 protein"	11996131\|6895089
C009947	1,2,4-trichlorobenzene	"Buthionine Sulfoximine inhibits the reaction [1,2,4-trichlorobenzene results in increased activity of ALAS1 protein]"	11996131
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ALAS1 mRNA"	25270620\|2890350
C511855	2,2',3,3',4,4',6,6'-octabromodiphenyl ether	"2,2',3,3',4,4',6,6'-octabromodiphenyl ether results in decreased activity of ALAS1 protein"	23086635
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ALAS1 mRNA"	19114083
C083522	2,3,5-trichlorophenyl methyl sulfone	"2,3,5-trichlorophenyl methyl sulfone results in increased activity of ALAS1 protein"	11996131
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ALAS1 mRNA"	20959002
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of ALAS1 mRNA"	16984957
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ALAS1 mRNA]"	19467301
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl affects the expression of ALAS1 mRNA"	21703328
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ALAS1 mRNA"	19692669
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of ALAS1 mRNA"	16984957
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ALAS1 mRNA"	20959002
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of ALAS1 mRNA"	18648102
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]"	24523661
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"[Ascorbic Acid co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]"	24523661
D000082	Acetaminophen	Acetaminophen affects the expression of ALAS1 mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in increased expression of ALAS1 mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of ALAS1 mRNA	15606129\|1756273
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of ALAS1 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALAS1 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen affects the expression of ALAS1 mRNA	17366322
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of ALAS1 protein]	12180188
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of ALAS1 mRNA	21298039
D000622	Aminolevulinic Acid	Aminolevulinic Acid results in decreased expression of ALAS1 mRNA	22859313
D000638	Amiodarone	Amiodarone affects the expression of ALAS1 mRNA	25064622
D000638	Amiodarone	Amiodarone results in increased expression of ALAS1 mRNA	19774075
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ALAS1 mRNA	15725085
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of ALAS1 mRNA	15894607
D001205	Ascorbic Acid	"[Ascorbic Acid co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]"	24523661
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]	24523661
D001241	Aspirin	Aspirin results in increased expression of ALAS1 mRNA	12800193
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of ALAS1 mRNA	26377693
C041512	benzo(b)fluorene	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of ALAS1 mRNA	22120849
D053119	Benzophenanthridines	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of ALAS1 mRNA	22120849
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ALAS1 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ALAS1 mRNA	19770486\|2156981
D004958	Estradiol	Estradiol results in increased expression of ALAS1 mRNA	20106945
D004958	Estradiol	Estradiol affects the expression of ALAS1 mRNA	15598610
D004958	Estradiol	Estradiol results in increased expression of ALAS1 mRNA	16684588
C023888	beta-hexachlorocyclohexane	beta-hexachlorocyclohexane results in increased expression of ALAS1 mRNA	25270620
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of ALAS1 mRNA	25470364
C006780	bisphenol A	bisphenol A affects the expression of ALAS1 mRNA	21786754
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALAS1 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of ALAS1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of ALAS1 mRNA	17010207
D019328	Buthionine Sulfoximine	"Buthionine Sulfoximine inhibits the reaction [1,2,4-trichlorobenzene results in increased activity of ALAS1 protein]"	11996131
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of ALAS1 protein	21659532
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of ALAS1 mRNA	18804290
D020148	Butyric Acid	Butyric Acid results in increased expression of ALAS1 mRNA	12800193
D019256	Cadmium Chloride	Cadmium Chloride promotes the reaction [ferric nitrilotriacetate promotes the reaction [Glutethimide results in increased expression of ALAS1 protein]]	2759551
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ALAS1 mRNA	18804290
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ALAS1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of ALAS1 mRNA	16239168
D002509	Cephaloridine	Cephaloridine results in increased expression of ALAS1 mRNA	18500788
D002706	Chlordan	Chlordan results in increased activity of ALAS1 protein	7157408
C031294	chlorobenzene	chlorobenzene results in increased activity of ALAS1 protein	6895089
D002737	Chloroprene	Chloroprene results in increased expression of ALAS1 mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine affects the expression of ALAS1 mRNA	25064622
D002793	Cholic Acids	[Methyltestosterone co-treated with Cholic Acids] affects the expression of ALAS1 mRNA	27344345
C036937	chromium protoporphyrin IX	chromium protoporphyrin IX promotes the reaction [Gossypol results in increased activity of ALAS1 protein]	15027808
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of ALAS1 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of ALAS1 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALAS1 mRNA]	17585979
D002994	Clofibrate	Clofibrate results in increased expression of ALAS1 mRNA	11328961\|1285110
C018021	cobaltous chloride	cobaltous chloride results in increased expression of ALAS1 mRNA	24612858
C018021	cobaltous chloride	cobaltous chloride affects the expression of ALAS1 mRNA alternative form	19320972
D003300	Copper	Copper results in decreased expression of ALAS1 mRNA	17205981
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ALAS1 mRNA	19549813
D003474	Curcumin	Curcumin results in increased expression of ALAS1 mRNA	18299980
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]	9879810
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Lindane results in increased activity of ALAS1 protein]	9879810
D016572	Cyclosporine	Cyclosporine affects the expression of ALAS1 mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in increased expression of ALAS1 mRNA	25562108\|2798913
D016572	Cyclosporine	Cyclosporine results in decreased expression of ALAS1 mRNA	19770486
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]	9879810
D003630	Daunorubicin	Daunorubicin results in decreased expression of ALAS1 mRNA	23831762
D003630	Daunorubicin	Dexrazoxane inhibits the reaction [Daunorubicin results in decreased expression of ALAS1 mRNA]	23831762
C010902	decabromobiphenyl ether	decabromobiphenyl ether analog results in increased expression of ALAS1 mRNA	25222814
C010902	decabromobiphenyl ether	decabromobiphenyl ether analog results in increased expression of ALAS1 mRNA	26894911
D003676	Deferoxamine	Deferoxamine results in increased expression of ALAS1 mRNA	9222176
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALAS1 mRNA	28628672
D064730	Dexrazoxane	Dexrazoxane inhibits the reaction [Daunorubicin results in decreased expression of ALAS1 mRNA]	23831762
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of ALAS1 mRNA	17379624\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of ALAS1 mRNA	21266533
D003994	Bucladesine	[NFE2L2 gene mutant form results in increased susceptibility to Bucladesine] which results in increased expression of ALAS1 mRNA	22859313
D004008	Diclofenac	Diclofenac results in decreased expression of ALAS1 mRNA	26934552
C000944	dicrotophos	dicrotophos results in increased expression of ALAS1 mRNA	28302478
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ALAS1 mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in increased expression of ALAS1 mRNA	19467301
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of ALAS1 mRNA	28085963
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of ALAS1 mRNA	19245819
D004147	Dioxins	Dioxins affects the expression of ALAS1 mRNA	20463971
D004317	Doxorubicin	Doxorubicin results in decreased expression of ALAS1 mRNA	19915844
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of ALAS1 mRNA"	23811387
D000431	Ethanol	[Fish Oils co-treated with Ethanol] results in increased expression of ALAS1 mRNA	17347304
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ALAS1 mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ALAS1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ALAS1 mRNA	15901920
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of ALAS1 mRNA	23649840
D005047	Etoposide	Etoposide results in increased expression of ALAS1 mRNA	25270620
C047360	felbamate	felbamate results in increased expression of ALAS1 mRNA	9222176
C020326	ferric nitrilotriacetate	Cadmium Chloride promotes the reaction [ferric nitrilotriacetate promotes the reaction [Glutethimide results in increased expression of ALAS1 protein]]	2759551
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate promotes the reaction [Glutethimide results in increased expression of ALAS1 protein]	2759551
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate promotes the reaction [Mephenytoin results in increased expression of ALAS1 protein]	2759551
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate promotes the reaction [Phenobarbital results in increased expression of ALAS1 protein]	2759551
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate promotes the reaction [propylisopropylacetamide results in increased expression of ALAS1 protein]	2759551
C020326	ferric nitrilotriacetate	Piperonyl Butoxide promotes the reaction [ferric nitrilotriacetate promotes the reaction [Glutethimide results in increased expression of ALAS1 protein]]	2759551
C020326	ferric nitrilotriacetate	Proadifen promotes the reaction [ferric nitrilotriacetate promotes the reaction [Glutethimide results in increased expression of ALAS1 protein]]	2759551
D005395	Fish Oils	[Fish Oils co-treated with Ethanol] results in increased expression of ALAS1 mRNA	17347304
D005419	Flavonoids	Flavonoids results in decreased expression of ALAS1 mRNA	18035473
D005485	Flutamide	Flutamide results in increased expression of ALAS1 mRNA	24136188
C088563	fomesafen	fomesafen results in increased expression of ALAS1 mRNA	12758057
D019833	Genistein	Genistein results in increased expression of ALAS1 mRNA	17010207
D005897	Glafenine	Glafenine results in decreased expression of ALAS1 mRNA	24136188
D005984	Glutethimide	Cadmium Chloride promotes the reaction [ferric nitrilotriacetate promotes the reaction [Glutethimide results in increased expression of ALAS1 protein]]	2759551
D005984	Glutethimide	ferric nitrilotriacetate promotes the reaction [Glutethimide results in increased expression of ALAS1 protein]	2759551
D005984	Glutethimide	Glutethimide results in increased expression of ALAS1 protein	2759551
D005984	Glutethimide	Piperonyl Butoxide promotes the reaction [ferric nitrilotriacetate promotes the reaction [Glutethimide results in increased expression of ALAS1 protein]]	2759551
D005984	Glutethimide	Proadifen promotes the reaction [ferric nitrilotriacetate promotes the reaction [Glutethimide results in increased expression of ALAS1 protein]]	2759551
D006072	Gossypol	chromium protoporphyrin IX promotes the reaction [Gossypol results in increased activity of ALAS1 protein]	15027808
D006072	Gossypol	Gossypol results in increased activity of ALAS1 protein	15027808
D006118	Griseofulvin	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]"	24523661
D006118	Griseofulvin	"[Ascorbic Acid co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]"	24523661
D006118	Griseofulvin	Ascorbic Acid inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]	24523661
D006118	Griseofulvin	Griseofulvin affects the expression of ALAS1 mRNA	12735108
D006118	Griseofulvin	Griseofulvin results in increased activity of ALAS1 protein	24523661
D006118	Griseofulvin	Griseofulvin results in increased expression of ALAS1 mRNA	10215191\|1579328
D006118	Griseofulvin	Melatonin inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]	24523661
D006418	Heme	Heme results in decreased expression of ALAS1 protein	21659532
D006418	Heme	MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]	21659532
D006418	Heme	Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]	21659532
D006418	Heme	succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]	21659532
D006427	Hemin	Hemin inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]	9879810
D006427	Hemin	Hemin inhibits the reaction [Lindane results in increased activity of ALAS1 protein]	9879810
D006533	Heptachlor	Cycloheximide inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]	9879810
D006533	Heptachlor	Dactinomycin inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]	9879810
D006533	Heptachlor	Hemin inhibits the reaction [Heptachlor results in increased activity of ALAS1 protein]	9879810
D006533	Heptachlor	Heptachlor results in increased activity of ALAS1 protein	9879810
C001654	hyperforin	hyperforin results in increased expression of ALAS1 mRNA	24259679
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALAS1 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ALAS1 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ALAS1 mRNA	28628672
D007538	Isoniazid	Isoniazid results in increased expression of ALAS1 protein	27438535
C047781	lamotrigine	lamotrigine results in increased expression of ALAS1 mRNA	9222176
C045463	leflunomide	leflunomide results in increased expression of ALAS1 mRNA	24136188
D001556	Lindane	Cycloheximide inhibits the reaction [Lindane results in increased activity of ALAS1 protein]	9879810
D001556	Lindane	Hemin inhibits the reaction [Lindane results in increased activity of ALAS1 protein]	9879810
D001556	Lindane	Lindane results in increased activity of ALAS1 protein	9879810
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of ALAS1 mRNA	27339419
D008294	Malathion	Malathion results in increased activity of ALAS1 protein	7157408
D008550	Melatonin	Melatonin inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]	24523661
D008617	Mephenytoin	ferric nitrilotriacetate promotes the reaction [Mephenytoin results in increased expression of ALAS1 protein]	2759551
D008617	Mephenytoin	Mephenytoin results in increased expression of ALAS1 protein	2759551
D008727	Methotrexate	Methotrexate affects the expression of ALAS1 mRNA	18502557
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of ALAS1 mRNA	18804290
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ALAS1 mRNA	23458150
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of ALAS1 mRNA	20039754
D020366	Methylmethacrylate	Methylmethacrylate results in increased expression of ALAS1 mRNA	16916219
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of ALAS1 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of ALAS1 mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of ALAS1 mRNA	24810058
D008777	Methyltestosterone	[Methyltestosterone co-treated with Cholic Acids] affects the expression of ALAS1 mRNA	27344345
C423917	MG 262	MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]	21659532
C423917	MG 262	[MG 262 results in decreased activity of LONP1 protein] which results in increased stability of ALAS1 protein	21659532
C423917	MG 262	MG 262 results in increased stability of ALAS1 protein	21659532
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of ALAS1 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ALAS1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ALAS1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ALAS1 mRNA"	25554681\|2562005
D009285	Naphthoquinones	Naphthoquinones results in increased expression of ALAS1 mRNA	23811387
C051752	nefazodone	nefazodone results in increased expression of ALAS1 mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of ALAS1 mRNA	12540486
C012655	nimesulide	nimesulide results in increased expression of ALAS1 mRNA	24136188
C028842	N-methylprotoporphyrin IX	N-methylprotoporphyrin IX results in increased expression of ALAS1 mRNA	22859313
C025256	nonylphenol	nonylphenol results in increased expression of ALAS1 mRNA	17010207
D010269	Paraquat	Paraquat affects the expression of ALAS1 mRNA	25064622
D010269	Paraquat	alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of ALAS1 protein]	12180188
D010269	Paraquat	Paraquat results in increased activity of ALAS1 protein	12180188
D052638	Particulate Matter	Particulate Matter results in decreased expression of ALAS1 mRNA	24769257
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of ALAS1 mRNA	23948077
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of ALAS1 mRNA	23892564
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of ALAS1 mRNA	23567314
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in increased expression of ALAS1 mRNA	23567314
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of ALAS1 mRNA	23567314\|2715376
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ALAS1 mRNA	19162173\|2851185
D010578	Petroleum	Petroleum results in increased expression of ALAS1 mRNA	25208076
D010634	Phenobarbital	ferric nitrilotriacetate promotes the reaction [Phenobarbital results in increased expression of ALAS1 protein]	2759551
D010634	Phenobarbital	Phenobarbital results in increased expression of ALAS1 mRNA	15629111\|9222176
D010634	Phenobarbital	Phenobarbital results in increased expression of ALAS1 protein	2759551
D010634	Phenobarbital	Phenobarbital affects the expression of ALAS1 mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in increased expression of ALAS1 mRNA	19084549
D010634	Phenobarbital	Phenobarbital results in decreased expression of ALAS1 mRNA	19270015
D010634	Phenobarbital	Phenobarbital results in increased expression of ALAS1 mRNA	19270015\|2285931
D010634	Phenobarbital	Phenobarbital results in increased expression of ALAS1 mRNA	19162173
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of ALAS1 mRNA	15728792
D010882	Piperonyl Butoxide	Piperonyl Butoxide promotes the reaction [ferric nitrilotriacetate promotes the reaction [Glutethimide results in increased expression of ALAS1 protein]]	2759551
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ALAS1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid affects the expression of ALAS1 mRNA	18445702\|2381119
C006253	pirinixic acid	pirinixic acid results in increased expression of ALAS1 mRNA	19162173
D011166	Porphyrins	ALAS1 protein results in increased chemical synthesis of Porphyrins	9222176
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of ALAS1 mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of ALAS1 mRNA	19162173
D011335	Proadifen	Proadifen promotes the reaction [ferric nitrilotriacetate promotes the reaction [Glutethimide results in increased expression of ALAS1 protein]]	2759551
D011374	Progesterone	Progesterone results in increased expression of ALAS1 mRNA	20726854
C045950	propiconazole	propiconazole results in increased expression of ALAS1 mRNA	21278054
C009072	propylisopropylacetamide	ferric nitrilotriacetate promotes the reaction [propylisopropylacetamide results in increased expression of ALAS1 protein]	2759551
C009072	propylisopropylacetamide	propylisopropylacetamide results in increased expression of ALAS1 protein	2759551
D011480	Protease Inhibitors	Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]	21659532
D011480	Protease Inhibitors	Protease Inhibitors results in increased expression of ALAS1 protein	21659532
C023666	pyridine	pyridine results in increased activity of ALAS1 protein	10413312
D011794	Quercetin	Quercetin results in increased expression of ALAS1 mRNA	21632981
C447880	retene	[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of ALAS1 mRNA	22120849
D015474	Isotretinoin	Isotretinoin results in decreased expression of ALAS1 mRNA	20436886
D012293	Rifampin	Rifampin results in increased expression of ALAS1 mRNA	24259679\|2455268
C089730	rosiglitazone	rosiglitazone results in increased expression of ALAS1 mRNA	25572481
D012643	Selenium	Selenium results in increased expression of ALAS1 mRNA	19244175
C009250	sevoflurane	sevoflurane affects the expression of ALAS1 mRNA	15967596
C009277	sodium arsenate	sodium arsenate results in increased expression of ALAS1 mRNA	16882884\|2392266
C017947	sodium arsenite	sodium arsenite results in increased expression of ALAS1 mRNA	25493608\|2587980
C017947	sodium arsenite	sodium arsenite results in increased stability of and results in increased expression of ALAS1 mRNA	25493608
D053260	Soot	Soot results in decreased expression of ALAS1 mRNA	26551751
C075117	squalestatin 1	squalestatin 1 results in increased expression of ALAS1 mRNA	15629111
D013311	Streptozocin	Streptozocin results in decreased expression of ALAS1 mRNA	16684804
D013311	Streptozocin	vanadyl sulfate inhibits the reaction [Streptozocin results in decreased expression of ALAS1 mRNA]	16684804
C020804	succinylacetone	succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]	21659532
C020804	succinylacetone	NFE2L2 gene mutant form inhibits the reaction [succinylacetone results in increased expression of ALAS1 mRNA]	22859313
C020804	succinylacetone	succinylacetone results in increased expression of ALAS1 mRNA	22859313
C446685	systhane	systhane results in increased expression of ALAS1 mRNA	19409404
C061133	tamibarotene	tamibarotene results in increased expression of ALAS1 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of ALAS1 mRNA	20937368
D013739	Testosterone	Testosterone results in increased expression of ALAS1 mRNA	20403060
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ALAS1 mRNA	21786751
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ALAS1 mRNA	19692669\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ALAS1 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ALAS1 mRNA	18163543\|2597527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ALAS1 mRNA	16054898\|1646670
D013752	Tetracycline	Tetracycline affects the expression of ALAS1 mRNA	25064622
D013752	Tetracycline	Tetracycline results in decreased expression of ALAS1 mRNA	24489787
C582340	tetradecabromodiphenoxybenzene	tetradecabromodiphenoxybenzene analog results in increased expression of ALAS1 mRNA	25222814
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ALAS1 mRNA	25613284
D013849	Thimerosal	Thimerosal results in decreased expression of ALAS1 mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of ALAS1 mRNA	25064622
C059205	tiagabine	tiagabine results in increased expression of ALAS1 mRNA	9222176
C009495	titanium dioxide	titanium dioxide results in decreased expression of ALAS1 mRNA	23557971
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of ALAS1 mRNA	15894607
D014212	Tretinoin	Tretinoin results in increased expression of ALAS1 mRNA	15498508\|1589460
C032910	triadimefon	triadimefon results in increased expression of ALAS1 mRNA	19409404
D014241	Trichloroethylene	Trichloroethylene results in increased expression of ALAS1 mRNA	28973375
C012589	trichostatin A	trichostatin A affects the expression of ALAS1 mRNA	28542535
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ALAS1 mRNA"	25242413
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ALAS1 mRNA"	25242413
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ALAS1 mRNA"	26179874
D014520	Urethane	Urethane results in increased expression of ALAS1 mRNA	28818685
C406224	valdecoxib	valdecoxib results in increased expression of ALAS1 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of ALAS1 mRNA	25064622
D014635	Valproic Acid	Valproic Acid results in increased expression of ALAS1 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of ALAS1 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of ALAS1 mRNA	17292431
C034028	vanadyl sulfate	vanadyl sulfate inhibits the reaction [Streptozocin results in decreased expression of ALAS1 mRNA]	16684804
C111237	vorinostat	vorinostat results in increased expression of ALAS1 mRNA	22083351
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of ALAS1 mRNA"	25208076
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical promotes the reaction [LEP gene mutant form results in increased expression of ALAS1 mRNA]"	24525044
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of ALAS1 mRNA"	24525044
D015032	Zinc	Zinc deficiency results in decreased expression of ALAS1 mRNA	12672911

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003870	5-aminolevulinate synthase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	21516116 25416956 25910212 27107014
GO:0030170	pyridoxal phosphate binding	-	IEA	-
GO:0042802	identical protein binding	-	IPI	25416956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006782	protoporphyrinogen IX biosynthetic process	-	IEA	-
GO:0006783	heme biosynthetic process	-	TAS	-
GO:0007005	mitochondrion organization	-	TAS	-
GO:0019216	regulation of lipid metabolic process	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	IDA	-
GO:0005739	mitochondrion	-	IDA	-
GO:0005759	mitochondrial matrix	-	TAS	-
GO:0005829	cytosol	-	IDA	-

KEGG ID	KEGG Term
hsa00260	Glycine, serine and threonine metabolism
hsa00860	Porphyrin and chlorophyll metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1592230	Mitochondrial biogenesis	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-189445	Metabolism of porphyrins	TAS
R-HSA-189451	Heme biosynthesis	TAS
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-556833	Metabolism of lipids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29307774	Liaison between heme metabolism and bioenergetics pathways-a multimodal elucidation for early diagnosis of oral cancer. (2018 Mar)	Sarkar R	Photodiagnosis Photodyn Ther