Gene: ETFDH

2110
ETFQO|MADD
electron transfer flavoprotein dehydrogenase
protein-coding
4q32.1
Ensembl:ENSG00000171503 MIM:231675 Vega:OTTHUMG00000161684 UniprotKB:Q16134
NG_007078.2
PubMed
0   ANCO-SNPs
AD
1   
7.874e-1 (AD)  6.319e-1 (ND)   (Frontal_Cortex)
8.814e-1 (AD)  4.567e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BBS20.872
GPR75-ASB30.832
TMBIM60.825
KIAA03910.823
HADH0.819
SPARCL10.819
ETFA0.818
FYN0.818
HERPUD20.817
ASPH0.817

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.659
OR4F29-0.628
GADL1-0.256
CD40LG-0.254
L1TD1-0.252
FER1L6-0.25
EOMES-0.248
KRT73-0.243
GZMA-0.234
UGT1A10-0.232

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ETFDH mRNA"19162173
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of ETFDH mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of ETFDH mRNA]28655636
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ETFDH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ETFDH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ETFDH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ETFDH mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ETFDH mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of ETFDH mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of ETFDH mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ETFDH mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ETFDH mRNA]17585979
D000082AcetaminophenAcetaminophen results in increased expression of ETFDH protein16538041
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ETFDH protein20106945
D000638AmiodaroneAmiodarone affects the expression of ETFDH mRNA25064622
D000638AmiodaroneAmiodarone results in increased expression of ETFDH mRNA24489787
D001151ArsenicArsenic affects the methylation of ETFDH gene25304211
D001280AtrazineAtrazine results in increased expression of ETFDH mRNA22378314
D004958EstradiolEstradiol results in decreased expression of ETFDH mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of ETFDH mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of ETFDH protein28903499
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ETFDH protein21699967
D002220CarbamazepineCarbamazepine affects the expression of ETFDH mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ETFDH mRNA23650126
D002746ChlorpromazineChlorpromazine affects the expression of ETFDH mRNA25064622
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ETFDH mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ETFDH mRNA]17585979
D002994ClofibrateClofibrate affects the expression of ETFDH mRNA18246545
D002994ClofibrateClofibrate results in decreased expression of ETFDH protein20118634
D002994ClofibrateClofibrate results in increased expression of ETFDH mRNA18246545
D002994ClofibrateClofibrate results in increased expression of ETFDH protein16470657
C018021cobaltous chloridecobaltous chloride results in decreased expression of ETFDH mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of ETFDH mRNA19549813
D016572CyclosporineCyclosporine affects the expression of ETFDH mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of ETFDH mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of ETFDH mRNA19770486|2383089
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ETFDH mRNA24848799
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ETFDH mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of ETFDH mRNA28302478
D004317DoxorubicinDoxorubicin results in decreased expression of ETFDH mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of ETFDH mRNA19915844
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ETFDH mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ETFDH mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ETFDH mRNA17942748
D015025ZearalenoneZearalenone results in increased expression of ETFDH protein25058043
D011345FenofibrateFenofibrate results in increased expression of ETFDH mRNA25572481
D011345FenofibrateFenofibrate results in decreased expression of ETFDH protein20118634
D018120FinasterideFinasteride results in increased expression of ETFDH mRNA24136188
D005485FlutamideFlutamide results in increased expression of ETFDH protein17311803
D005897GlafenineGlafenine results in decreased expression of ETFDH mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ETFDH mRNA25613284
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ETFDH mRNA24848799
D008701MethapyrileneMethapyrilene results in decreased expression of ETFDH mRNA16393664
C500085muraglitazarmuraglitazar results in increased expression of ETFDH mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ETFDH mRNA"25620056
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of ETFDH protein19716841
C025589ochratoxin Aochratoxin A results in decreased expression of ETFDH mRNA23358140
D010269ParaquatParaquat affects the expression of ETFDH mRNA25064622
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of ETFDH mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of ETFDH mRNA28655636
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ETFDH mRNA28511854
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ETFDH mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ETFDH mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ETFDH mRNA15728792
C006253pirinixic acidpirinixic acid results in increased expression of ETFDH mRNA17426115|1830175
C006253pirinixic acidpirinixic acid results in increased expression of ETFDH mRNA19162173
D010936Plant ExtractsPlant Extracts results in increased expression of ETFDH mRNA23557933
D015474IsotretinoinIsotretinoin results in decreased expression of ETFDH mRNA20436886
C089730rosiglitazonerosiglitazone affects the expression of ETFDH mRNA22013433
C089730rosiglitazonerosiglitazone results in increased expression of ETFDH mRNA15520860|2484879
C089730rosiglitazonerosiglitazone results in increased expression of ETFDH protein15520860
C089730rosiglitazonerosiglitazone results in increased expression of ETFDH mRNA21515302
D018038Sodium SeleniteSodium Selenite results in increased expression of ETFDH mRNA18175754
D012999SomanSoman results in decreased expression of ETFDH mRNA19281266
D013311StreptozocinStreptozocin affects the expression of ETFDH mRNA18583417
D013467SulindacSulindac results in decreased expression of ETFDH mRNA24136188
C501413tesaglitazartesaglitazar results in increased expression of ETFDH mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ETFDH mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ETFDH mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ETFDH mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ETFDH mRNA17942748
D013752TetracyclineTetracycline affects the expression of ETFDH mRNA25064622
D013752TetracyclineTetracycline results in decreased expression of ETFDH mRNA24489787
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ETFDH mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of ETFDH mRNA25064622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ETFDH protein22609517
D014212TretinoinTretinoin results in increased expression of ETFDH mRNA23724009
C011559tributyltintributyltin results in increased expression of ETFDH mRNA24848799
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of ETFDH gene27618143
D014303TrinitrotolueneTrinitrotoluene affects the expression of ETFDH mRNA21346803
C057693troglitazonetroglitazone results in increased expression of ETFDH protein21315101
D014451UbiquinoneUbiquinone binds to ETFDH protein17050691
D014520UrethaneUrethane results in increased expression of ETFDH mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ETFDH mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ETFDH mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ETFDH mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ETFDH mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of ETFDH mRNA17292431
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of ETFDH mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of ETFDH mRNA28655636
C111237vorinostatvorinostat results in increased expression of ETFDH mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004174electron-transferring-flavoprotein dehydrogenase activity-IBA21873635  
GO:0004174electron-transferring-flavoprotein dehydrogenase activity-IDA8306995  12049629  14640977  
GO:0004174electron-transferring-flavoprotein dehydrogenase activity-TAS-  
GO:0009055electron transfer activity-IBA21873635  
GO:0009055electron transfer activity-IDA8306995  12049629  
GO:0016491oxidoreductase activity-IDA14640977  
GO:0043783oxidoreductase activity, oxidizing metal ions with flavin as acceptor-IBA21873635  
GO:0043783oxidoreductase activity, oxidizing metal ions with flavin as acceptor-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0048038quinone binding-IDA14640977  
GO:0048039ubiquinone binding-IBA21873635  
GO:0048039ubiquinone binding-IDA14640977  
GO:0050660flavin adenine dinucleotide binding-ISS17050691  
GO:00515394 iron, 4 sulfur cluster binding-IBA21873635  
GO:00515394 iron, 4 sulfur cluster binding-IDA18037314  
GO ID GO Term Qualifier Evidence PubMed
GO:0006979response to oxidative stress-ISS-  
GO:0022900electron transport chain-IDA8306995  12049629  
GO:0022904respiratory electron transport chain-IBA21873635  
GO:0022904respiratory electron transport chain-TAS-  
GO:0033539fatty acid beta-oxidation using acyl-CoA dehydrogenase-IMP17412732  
GO ID GO Term Qualifier Evidence PubMed
GO:0005759mitochondrial matrix-TAS-  
GO:0031305integral component of mitochondrial inner membrane-IBA21873635  
GO:0031305integral component of mitochondrial inner membrane-IDA8306995  
GO:0031966mitochondrial membrane-IDA12049629  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-611105Respiratory electron transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28456887Heterogeneous Phenotypes in Lipid Storage Myopathy Due to ETFDH Gene Mutations. (2018)Angelini CJIMD Rep