Gene: ETV5

2119
ERM
ETS variant 5
protein-coding
3q27.2
Ensembl:ENSG00000244405 MIM:601600 Vega:OTTHUMG00000156639 UniprotKB:P41161
NC_000003.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.312e-1 (AD)  5.590e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DUSP60.829
SPATA2L0.808
DUSP40.793
OSBP20.791
KCNIP30.789
SPRY40.789
FMNL10.773
SYT120.772
TRIB20.764
MARCH40.764

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.488
MPZL2-0.479
CLEC2B-0.472
ANG-0.469
CP-0.464
GABRE-0.463
YBX3-0.461
SERPINA3-0.46
CDA-0.455
OSMR-0.452

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ETV5 mRNA28329830
C0326681-nitropyrene1-nitropyrene results in increased expression of ETV5 mRNA19041380
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ETV5 mRNA19933214
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of ETV5 mRNA"20713471
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of ETV5 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ETV5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ETV5 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ETV5 mRNA"19561079
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of ETV5 mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ETV5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ETV5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ETV5 mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of ETV5 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ETV5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ETV5 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ETV5 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ETV5 mRNA24449571
D016589AstemizoleAstemizole results in decreased expression of ETV5 mRNA20221588
C487081belinostatbelinostat results in decreased expression of ETV5 mRNA27188386
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ETV5 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ETV5 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ETV5 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ETV5 mRNA"20018196
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of ETV5 mRNA24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ETV5 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ETV5 mRNA19619570|2118537
C044887beta-methylcholinebeta-methylcholine affects the expression of ETV5 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ETV5 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ETV5 mRNA20170705
C006780bisphenol Abisphenol A affects the expression of ETV5 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ETV5 mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ETV5 mRNA15336504
D002104CadmiumCadmium results in decreased expression of ETV5 mRNA24376830
D002220CarbamazepineCarbamazepine affects the expression of ETV5 mRNA25979313
D002737ChloropreneChloroprene results in decreased expression of ETV5 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of ETV5 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of ETV5 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of ETV5 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ETV5 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased expression of ETV5 mRNA19770486
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ETV5 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ETV5 mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of ETV5 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of ETV5 mRNA28302478
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in decreased expression of ETV5 mRNA21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ETV5 mRNA25975992
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ETV5 mRNA24535843
D004221DisulfiramDisulfiram results in decreased expression of ETV5 mRNA20530235
D004317DoxorubicinDoxorubicin affects the expression of ETV5 mRNA25529476
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ETV5 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ETV5 mRNA20170705
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ETV5 mRNA28329830
D005557FormaldehydeFormaldehyde results in increased expression of ETV5 mRNA27664576
C069837fullerene C60fullerene C60 results in increased expression of ETV5 mRNA19167457
C492448ICG 001ICG 001 results in increased expression of ETV5 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ETV5 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ETV5 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ETV5 mRNA28628672
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ETV5 mRNA25119042
D008731MethoxychlorMethoxychlor affects the expression of ETV5 mRNA20829426
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ETV5 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ETV5 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of ETV5 mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of ETV5 mRNA21664453
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ETV5 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ETV5 mRNA"20188158
C008493methylselenic acidmethylselenic acid results in increased expression of ETV5 mRNA18548127
C100075mibolerone[mibolerone binds to and results in increased activity of AR protein] inhibits the reaction [ETV5 protein results in increased expression of MMP1 mRNA]8798622
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ETV5 mRNA"24389112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of ETV5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ETV5 mRNA"25554681|2562005
C028007nickel monoxidenickel monoxide results in increased expression of ETV5 mRNA19167457
C017557nickel subsulfidenickel subsulfide results in decreased expression of ETV5 mRNA21086188
C025589ochratoxin Aochratoxin A results in decreased expression of ETV5 mRNA23358140
C507134ON 01910ON 01910 results in increased expression of ETV5 mRNA22351695
D010100OxygenOxygen deficiency results in decreased expression of ETV5 mRNA26516004
D052638Particulate MatterParticulate Matter results in increased expression of ETV5 mRNA23085030
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of ETV5 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of ETV5 mRNA25119042
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of ETV5 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of ETV5 mRNA19159669
C047088phenylamilphenylamil results in increased expression of ETV5 mRNA20519739
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ETV5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ETV5 mRNA22079256|2271453
D011374ProgesteroneProgesterone results in decreased expression of ETV5 mRNA20864642
D011441PropylthiouracilPropylthiouracil affects the expression of ETV5 mRNA24780913
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in decreased expression of ETV5 mRNA21852083
C116926rofecoxibrofecoxib results in decreased expression of ETV5 mRNA17070997
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ETV5 mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ETV5 mRNA23623845
D012906SmokeSmoke results in increased expression of ETV5 mRNA21095227
C016104sodium bichromatesodium bichromate results in decreased expression of ETV5 mRNA17685462
C016104sodium bichromatesodium bichromate results in increased expression of ETV5 mRNA22561333
D053260SootSoot results in decreased expression of ETV5 mRNA26551751
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ETV5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ETV5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ETV5 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ETV5 mRNA19933214|2135428
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ETV5 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ETV5 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of ETV5 mRNA22378314
D013893ThiramThiram results in decreased expression of ETV5 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of ETV5 mRNA16054129
C011559tributyltintributyltin results in decreased expression of ETV5 mRNA27614199
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ETV5 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of ETV5 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of ETV5 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of ETV5 mRNA24935251
D014415TunicamycinTunicamycin results in decreased expression of ETV5 mRNA22378314
D014520UrethaneUrethane results in increased expression of ETV5 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ETV5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ETV5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ETV5 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of ETV5 mRNA23527032|2438349
D014635Valproic AcidValproic Acid analog results in decreased expression of ETV5 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of ETV5 mRNA21427059
C111237vorinostatvorinostat results in decreased expression of ETV5 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IMP15857832  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IMP15857832  
GO:0003677DNA binding-TAS8152800  
GO:0003700DNA-binding transcription factor activity-IDA19443906  
GO:0005515protein binding-IPI17126306  
GO:0044212transcription regulatory region DNA binding-IDA19443906  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007274neuromuscular synaptic transmission-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0034599cellular response to oxidative stress-IDA19443906  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP15857832  
GO:0048133male germ-line stem cell asymmetric division-IEA-  
GO:0050807regulation of synapse organization-IEA-  
GO:0060252positive regulation of glial cell proliferation-IEA-  
GO:0060762regulation of branching involved in mammary gland duct morphogenesis-IEA-  
GO:0071340skeletal muscle acetylcholine-gated channel clustering-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA19443906  
GO:0005654nucleoplasm-IDA-  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes
29162857Temporal expression pattern of genes during the period of sex differentiation in human embryonic gonads. (2017 Nov 21)Mamsen LSSci Rep