Gene: ALAS2

212
ALAS-E|ALASE|ANH1|ASB|SIDBA1|XLDPP|XLEPP|XLSA
5'-aminolevulinate synthase 2
protein-coding
Xp11.21
Ensembl:ENSG00000158578 MIM:301300 Vega:OTTHUMG00000021641 UniprotKB:P22557
NG_008983.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC4A10.858
CA10.809
HBA10.777
AHSP0.765
HBB0.761
HBD0.739
HBA20.735
SPTA10.675
LILRA50.673
IL1R20.661

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.528
MAGIX-0.526
KCNC2-0.526
SVOP-0.522
HAS1-0.521
SLC32A1-0.515
EXTL1-0.512
PRKCZ-0.512
SYT3-0.508
CDK5R2-0.503

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ALAS2 mRNA"15302862
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ALAS2 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ALAS2 mRNA"25614096
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ALAS2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ALAS2 mRNA"20959002
D000082AcetaminophenAcetaminophen affects the expression of ALAS2 mRNA15606129|1756273
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ALAS2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALAS2 mRNA]17585979
D012435S-Adenosylhomocysteinecatechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA]24141029
D012435S-Adenosylhomocysteine[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA24141029
D012436S-Adenosylmethioninecatechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA]24141029
D012436S-Adenosylmethionine[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA24141029
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ALAS2 gene27153756
D000638AmiodaroneAmiodarone results in decreased expression of ALAS2 mRNA24535564
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ALAS2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of ALAS2 mRNA20458559
D016589AstemizoleAstemizole results in increased expression of ALAS2 mRNA20221588
D001280AtrazineAtrazine results in decreased expression of ALAS2 mRNA25929836
D001554BenzeneBenzene results in decreased expression of ALAS2 mRNA15120971|1512265
D001554BenzeneBenzene affects the expression of ALAS2 mRNA15878777
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of ALAS2 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALAS2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ALAS2 mRNA21569818|2719552
C038328BEP protocolBEP protocol results in increased expression of ALAS2 mRNA18987330
D004958EstradiolEstradiol affects the expression of ALAS2 mRNA23557687
D004958EstradiolEstradiol results in increased expression of ALAS2 mRNA16684588
C006780bisphenol Abisphenol A results in increased expression of ALAS2 mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of ALAS2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of ALAS2 mRNA25181051
C584056BMS-764459BMS-764459 results in increased expression of ALAS2 mRNA23831372
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ALAS2 mRNA25993096
D002220CarbamazepineCarbamazepine affects the expression of ALAS2 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ALAS2 mRNA27339419
C010063carbonyl sulfidecarbonyl sulfide results in decreased expression of ALAS2 mRNA19395590
D002330CarmustineCarmustine results in decreased expression of ALAS2 mRNA16005536
C034221catechol[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA24141029
C034221catecholcatechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA]24141029
C034221catecholcatechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA]24141029
C034221catecholcatechol promotes the reaction [Hemin results in increased expression of ALAS2 mRNA]28552822
C034221catecholcatechol results in increased expression of ALAS2 mRNA23022512|2855282
C034221catecholCOMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]24141029
C034221catecholHemin promotes the reaction [catechol results in increased expression of ALAS2 mRNA]28552822
D002737ChloropreneChloroprene results in decreased expression of ALAS2 mRNA23125180
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ALAS2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALAS2 mRNA]17585979
D003300CopperCopper results in increased expression of ALAS2 mRNA17205981
D003300CopperCopper results in decreased expression of ALAS2 mRNA25646894
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of ALAS2 mRNA26033743
D003300CopperCopper deficiency results in increased expression of ALAS2 mRNA26033743
D003471CuprizoneCuprizone results in increased expression of ALAS2 mRNA26577399
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ALAS2 mRNA]27941970
D016190CarboplatinCarboplatin results in decreased expression of ALAS2 mRNA21296123
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ALAS2 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of ALAS2 mRNA28962523
D002945CisplatinCisplatin results in decreased expression of ALAS2 mRNA21296123
D004008DiclofenacDiclofenac affects the expression of ALAS2 mRNA24752500
D004041Dietary FatsDietary Fats results in decreased expression of ALAS2 mRNA22609946
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of ALAS2 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ALAS2 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALAS2 mRNA18164116
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ALAS2 mRNA"19480007
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of ALAS2 mRNA21296123
D004317DoxorubicinDoxorubicin results in decreased expression of ALAS2 mRNA19915844
D000431EthanolEthanol affects the expression of ALAS2 mRNA19167417
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALAS2 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of ALAS2 mRNA28189721
D005839GentamicinsGentamicins results in decreased expression of ALAS2 mRNA22061828
D006418HemeHeme metabolite results in decreased expression of ALAS2 mRNA19191707
D006418HemeALAS2 protein results in increased chemical synthesis of Heme16892088
D006427Hemin[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA24141029
D006427Hemincatechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA]24141029
D006427Hemincatechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA]24141029
D006427Hemincatechol promotes the reaction [Hemin results in increased expression of ALAS2 mRNA]28552822
D006427HeminCOMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]24141029
D006427HeminHemin promotes the reaction [catechol results in increased expression of ALAS2 mRNA]28552822
D006427HeminHemin results in increased expression of ALAS2 mRNA23973255|2855282
D006427HeminPhenol inhibits the reaction [Hemin results in increased expression of ALAS2 mRNA]23973255
D006427Hemin[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA24141029
D006427Hemin[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA24141029
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of ALAS2 mRNA15159207
D017313FenretinideFenretinide results in decreased expression of ALAS2 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of ALAS2 mRNA21396975
C051890irinotecanirinotecan metabolite results in increased expression of ALAS2 mRNA15956246
C051890irinotecanirinotecan results in increased expression of ALAS2 mRNA15956246
D007501IronIron results in increased expression of ALAS2 mRNA16424395
C008261lead acetatelead acetate results in increased expression of ALAS2 mRNA22641619
C018584linaloollinalool results in decreased expression of ALAS2 mRNA20536181
D000069349LinezolidLinezolid results in decreased expression of ALAS2 mRNA21296123
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of ALAS2 mRNA22563483
D008713MethimazoleMethimazole results in increased expression of ALAS2 mRNA20144635
D008727MethotrexateMethotrexate results in decreased expression of ALAS2 mRNA16005536|2413618
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ALAS2 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of ALAS2 mRNA19167457
D010126OzoneOzone results in decreased expression of ALAS2 mRNA12763052
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of ALAS2 mRNA22563483
D010615PhenacetinPhenacetin results in increased expression of ALAS2 mRNA17082564
D019800PhenolPhenol inhibits the reaction [Hemin results in increased expression of ALAS2 mRNA]23973255
C030299phenylhydrazinephenylhydrazine results in increased expression of ALAS2 mRNA17082564
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of ALAS2 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of ALAS2 mRNA15302862|1795077
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of ALAS2 mRNA]20059764
C006253pirinixic acidpirinixic acid results in decreased expression of ALAS2 mRNA19162173
D059808PolyphenolsPolyphenols results in decreased expression of ALAS2 mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ALAS2 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of ALAS2 mRNA20631399
D011374ProgesteroneProgesterone affects the expression of ALAS2 mRNA17251523
D011441PropylthiouracilPropylthiouracil results in decreased expression of ALAS2 mRNA24780913
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of ALAS2 mRNA25626140
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of ALAS2 mRNA16079270
C009277sodium arsenatesodium arsenate results in decreased expression of ALAS2 mRNA23922661
C009277sodium arsenatesodium arsenate results in decreased expression of ALAS2 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of ALAS2 mRNA17682005
C016104sodium bichromatesodium bichromate results in decreased expression of ALAS2 mRNA22155349
D013739TestosteroneTestosterone results in increased expression of ALAS2 mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALAS2 mRNA28922406
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALAS2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALAS2 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALAS2 mRNA16054898|1646670
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALAS2 mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of ALAS2 mRNA23411599
D013866ThioguanineThioguanine results in decreased expression of ALAS2 mRNA16005536
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ALAS2 mRNA20133372
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of ALAS2 gene27618143
C012589trichostatin Atrichostatin A results in decreased expression of ALAS2 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of ALAS2 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased methylation of ALAS2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ALAS2 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of ALAS2 mRNA24535564
C025643vinclozolinvinclozolin affects the expression of ALAS2 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of ALAS2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038705-aminolevulinate synthase activity-IDA14643893  
GO:00038705-aminolevulinate synthase activity-TAS-  
GO:0005515protein binding-IPI10727444  14643893  16234850  25416956  
GO:0016594glycine binding-ISS-  
GO:0030170pyridoxal phosphate binding-IEA-  
GO:0050662coenzyme binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IDA16234850  
GO:0006782protoporphyrinogen IX biosynthetic process-IEA-  
GO:0006783heme biosynthetic process-ISS-  
GO:0006783heme biosynthetic process-NAS14643893  
GO:0006783heme biosynthetic process-TAS-  
GO:0006879cellular iron ion homeostasis-ISS-  
GO:0030218erythrocyte differentiation-ISS-  
GO:0030218erythrocyte differentiation-NAS2050125  
GO:0032364oxygen homeostasis-NAS16234850  
GO:0042541hemoglobin biosynthetic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA10727444  
GO:0005743mitochondrial inner membrane-IDA14643893  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00260Glycine, serine and threonine metabolism
hsa00860Porphyrin and chlorophyll metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-189445Metabolism of porphyrinsTAS
R-HSA-189451Heme biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28158590A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking. (2016 Nov 1)Huan THum Mol Genet