Gene: ETV6

2120
TEL|TEL/ABL|THC5
ETS variant 6
protein-coding
12p13.2
Ensembl:ENSG00000139083 MIM:600618 Vega:OTTHUMG00000168538 UniprotKB:P41212
NG_011443.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.428e-1 (AD)  4.407e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs205534chr12:11688183 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07986378chr12:11898284ETV61.000e-9Smoking27651444
cg06516865chr12:11883921ETV62.340e-9Alcohol consumption der day27843151
cg18763536chr12:11812062ETV69.940e-8Alcohol consumption der day27843151
cg07986378chr12:11898284ETV64.440e-8Tobacco smoking28225026
cg07986378chr12:11898284ETV61.080e-15Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PIM10.853
NAMPT0.814
SHC10.8
NFIL30.795
SOD20.79
COL4A20.783
MYC0.78
RBMS10.778
NUP980.776
IL15RA0.768

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.412
DIAPH3-0.351
GPR17-0.35
NEU4-0.342
OR4F5-0.316
SNX22-0.305
OR4F29-0.297
EDN3-0.296
ARSE-0.295
BTBD17-0.29

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ETV6 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ETV6 mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ETV6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ETV6 mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of ETV6 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ETV6 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ETV6 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ETV6 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ETV6 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of ETV6 mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of ETV6 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of ETV6 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of ETV6 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of ETV6 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of ETV6 mRNA24650576
D003471CuprizoneCuprizone results in increased expression of ETV6 mRNA26577399|2752363
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ETV6 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of ETV6 mRNA19561079|2759478
D002945CisplatinCisplatin results in increased expression of ETV6 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of ETV6 mRNA28302478
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ETV6 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ETV6 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of ETV6 mRNA16931933
D004317DoxorubicinETV6 gene mutant form results in increased susceptibility to Doxorubicin15217836
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ETV6 mRNA22079256
D005047EtoposideEtoposide results in increased mutagenesis of ETV6 gene28624474
D005047EtoposideETV6 gene mutant form results in increased susceptibility to Etoposide15217836
C061365flusilazoleflusilazole results in decreased expression of ETV6 mRNA22382673
C061365flusilazoleflusilazole results in increased expression of ETV6 mRNA22382673
D005557FormaldehydeFormaldehyde results in increased expression of ETV6 mRNA23649840
C039281furanfuran results in decreased expression of ETV6 mRNA25539665
D019833GenisteinGenistein results in decreased expression of ETV6 mRNA21048042
D017313FenretinideFenretinide results in increased expression of ETV6 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of ETV6 mRNA26191083
D019469Indinavir[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ETV6 mRNA16931933
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ETV6 mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of ETV6 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of ETV6 mRNA15956246
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ETV6 mRNA24796395
D008294MalathionMalathion results in increased expression of ETV6 mRNA mutant form28624474
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of ETV6 mRNA18804290
C008493methylselenic acidmethylselenic acid results in increased expression of ETV6 mRNA18548127
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ETV6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ETV6 mRNA"25554681
D009532NickelNickel results in increased expression of ETV6 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of ETV6 mRNA22714537
C025256nonylphenolnonylphenol results in decreased expression of ETV6 mRNA22982499
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ETV6 mRNA23948077
D026023PermethrinPermethrin results in increased expression of ETV6 mRNA mutant form28624474
D026023PermethrinPermethrin results in increased mutagenesis of ETV6 gene28624474
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ETV6 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ETV6 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ETV6 mRNA22079256
D019258Saquinavir[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ETV6 mRNA16931933
C017947sodium arsenitesodium arsenite results in increased expression of ETV6 mRNA12016162|1276083
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ETV6 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ETV6 mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ETV6 mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of ETV6 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ETV6 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of ETV6 gene26756918
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ETV6 mRNA"27188386
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ETV6 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of ETV6 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of ETV6 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ETV6 gene25560391
C111237vorinostatvorinostat results in decreased expression of ETV6 mRNA27188386
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ETV6 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ETV6 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of ETV6 mRNA16931933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA9018121  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0003700DNA-binding transcription factor activity-TAS7761424  
GO:0005515protein binding-IPI12590135  25416956  26871637  
GO:0019904protein domain specific binding-IPI12588862  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA10514502  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP10514502  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007296vitellogenesis-IEA-  
GO:0022008neurogenesis-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0071425hematopoietic stem cell proliferation-IMP25581430  
GO:0097152mesenchymal cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa04320Dorso-ventral axis formation
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal