Gene: EVC

2121
DWF-1|EVC1|EVCL
EvC ciliary complex subunit 1
protein-coding
4p16.2
Ensembl:ENSG00000072840 MIM:604831 Vega:OTTHUMG00000090427 UniprotKB:P57679
NG_008843.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.574e-1 (AD)  2.592e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01442064chr4:5713450EVC1.600e-26Smoking27651444
cg01442064chr4:5713450EVC4.890e-8Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC2A100.885
NOTCH20.873
CDC14A0.86
PPARA0.856
IL17RD0.852
PLEKHA70.849
CHDH0.847
MCC0.847
NHSL10.842
YAP10.842

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GALNT14-0.473
SMIM18-0.453
CRHBP-0.441
TMEFF2-0.434
ENPP6-0.434
CYP26A1-0.433
PCSK1-0.421
NRG1-0.417
CACNA1F-0.413
MYOZ3-0.412

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of EVC mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EVC mRNA23630614
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EVC mRNA24449571
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of EVC mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EVC mRNA15034205
C006780bisphenol Abisphenol A results in decreased expression of EVC mRNA28159858
C006780bisphenol Abisphenol A results in decreased expression of EVC mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of EVC mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of EVC mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of EVC mRNA25270620
C000944dicrotophosdicrotophos results in increased expression of EVC mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of EVC mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of EVC mRNA21592394
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EVC mRNA17942748
C540355fenamidonefenamidone results in increased expression of EVC mRNA27029645
D005557FormaldehydeFormaldehyde results in increased expression of EVC mRNA23649840
C039281furanfuran results in decreased expression of EVC mRNA24183702
C045463leflunomideleflunomide results in decreased expression of EVC mRNA28988120
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EVC mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EVC mRNA"25620056
D009532NickelNickel results in decreased expression of EVC mRNA24768652|2558310
D011192Potassium DichromatePotassium Dichromate results in increased expression of EVC mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of EVC mRNA19690047
C513428pyrachlostrobinpyrachlostrobin results in increased expression of EVC mRNA27029645
D012643SeleniumSelenium results in increased expression of EVC mRNA19244175
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of EVC mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of EVC mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of EVC mRNA25172293
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of EVC mRNA]15034205
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EVC mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EVC mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EVC mRNA19933214
C009495titanium dioxidetitanium dioxide results in decreased expression of EVC mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of EVC mRNA28065790
D014212TretinoinTretinoin results in increased expression of EVC mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of EVC mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of EVC mRNA28001369
D014640VancomycinVancomycin results in increased expression of EVC mRNA18930951
D014750VincristineVincristine results in increased expression of EVC mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of EVC mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS10700184  
GO:0003416endochondral bone growth-ISS-  
GO:0007224smoothened signaling pathway-IEA-  
GO:0007517muscle organ development-TAS10700184  
GO:0045880positive regulation of smoothened signaling pathway-ISS-  
GO:0051216cartilage development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005929cilium-IDA21356043  
GO:0016021integral component of membrane-IEA-  
GO:0036064ciliary basal body-ISS-  
GO:0060170ciliary membrane-TAS-  
GO:0098797plasma membrane protein complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5358351Signaling by HedgehogIEA
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5632684Hedgehog 'on' stateIEA
R-HSA-5635838Activation of SMOIEA
R-HSA-5635838Activation of SMOTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24419231Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. (2014 May)Tang HCarcinogenesis
29526315Identification of genetic risk factors associated with ischaemic stroke in young Mexican patients. (2018 Mar 8)Jimenez-Gonzalez MCNeurologia