Gene: EWSR1

2130
EWS|EWS-FLI1|bK984G1.4
EWS RNA binding protein 1
protein-coding
22q12.2
Ensembl:ENSG00000182944 MIM:133450 Vega:OTTHUMG00000151107 UniprotKB:Q01844
NG_023240.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.423e-1 (AD)  5.164e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11942221chr22:29686496EWSR1Gene body2.493e-4Alcohol use disorders26763658
cg02357416chr22:29668384EWSR1Gene body6.927e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IK0.945
RING10.942
DDX39B0.94
ACTB0.939
HNRNPD0.937
SF3B20.937
CAPZB0.935
CFL10.934
CHMP4B0.934
PUF600.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.862
OR4F29-0.846
MTRNR2L9-0.26
MTRNR2L6-0.26
MTRNR2L10-0.221
OR4F16-0.191
KCNJ15-0.19
C8orf74-0.182
HMHB1-0.178
CXCR2-0.177

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of EWSR1 mRNA"22101062
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EWSR1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of EWSR1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EWSR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EWSR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EWSR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EWSR1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of EWSR1 mRNA17562736
C006632arsenic trioxidearsenic trioxide results in increased expression of EWSR1 protein25419056
D001280AtrazineAtrazine results in increased expression of EWSR1 mRNA22378314
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of EWSR1 mRNA26377693
D004958EstradiolEstradiol results in decreased expression of EWSR1 mRNA20068009
C044887beta-methylcholinebeta-methylcholine affects the expression of EWSR1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of EWSR1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of EWSR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EWSR1 gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of EWSR1 protein28903499
D002065BuspironeBuspirone results in decreased expression of EWSR1 mRNA24136188
D002220CarbamazepineCarbamazepine affects the expression of EWSR1 mRNA25979313
D002392CatechinCatechin results in increased expression of EWSR1 mRNA15465739
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of EWSR1 mRNA23650126
C031180chrysenechrysene results in decreased expression of EWSR1 mRNA26377693
D002995Clofibric AcidClofibric Acid affects the expression of EWSR1 mRNA17602206
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of EWSR1 mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of EWSR1 mRNA21151649
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of EWSR1 mRNA17490981
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EWSR1 protein23301498
D000431EthanolEthanol results in increased expression of EWSR1 mRNA15513904
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EWSR1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EWSR1 mRNA17942748
D005485FlutamideFlutamide results in increased expression of EWSR1 mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EWSR1 mRNA20044591
C561695(+)-JQ1 compoundEWSR1 protein results in increased susceptibility to (+)-JQ1 compound27006472
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to EWSR1 promoter]27006472
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EWSR1 mRNA27006472
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EWSR1 protein26623725|2700647
D007854LeadLead results in decreased expression of EWSR1 mRNA19921347
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to EWSR1 protein]17220478
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EWSR1 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of EWSR1 mRNA25729387
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of EWSR1 protein26879310
C068564phosphatidylbutanolEWSR1 protein affects the reaction [PLD2 protein promotes the reaction [PDGFB protein results in increased abundance of phosphatidylbutanol]]15919668
C006253pirinixic acidpirinixic acid results in increased expression of EWSR1 mRNA18301758|2381119
D010894PiroxicamPiroxicam results in decreased expression of EWSR1 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of EWSR1 mRNA23557933
D010938Plant OilsPlant Oils results in increased expression of EWSR1 mRNA23370395
C005266quinomethionatequinomethionate affects the expression of EWSR1 mRNA15387888
C059514resveratrolresveratrol results in decreased expression of EWSR1 protein25505154
C087123romidepsinromidepsin results in decreased activity of and results in decreased expression of EWSR1 protein mutant form15849726
C087123romidepsinromidepsin results in decreased expression of EWSR1 mRNA mutant form15849726
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of EWSR1 mRNA19244175
D012643SeleniumSelenium results in increased expression of EWSR1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of EWSR1 mRNA25895662
D020123SirolimusSirolimus results in decreased expression of EWSR1 protein mutant form15782132
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EWSR1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EWSR1 mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EWSR1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of EWSR1 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EWSR1 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of EWSR1 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of EWSR1 mRNA26272509
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of EWSR1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of EWSR1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of EWSR1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EWSR1 mRNA27188386|2915479
D014635Valproic AcidValproic Acid affects the expression of EWSR1 mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of EWSR1 mRNA18042343
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of EWSR1 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of EWSR1 mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EWSR1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of EWSR1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003712transcription coregulator activity-IBA21873635  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI16189514  18320585  18347058  18509338  21988832  23455924  
23975937  25416956  25910212  
GO:0005516calmodulin binding-IEA-  
GO:0042802identical protein binding-IPI21988832  23975937  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29434341Hyalinizing clear cell carcinoma of the bronchial glands: presentation of three cases and pathological comparisons with salivary gland counterparts and bronchial mucoepidermoid carcinomas. (2018 Feb 12)Takamatsu MMod Pathol