Gene: EYA2

2139
EAB1
EYA transcriptional coactivator and phosphatase 2
protein-coding
20q13.12
Ensembl:ENSG00000064655 MIM:601654 Vega:OTTHUMG00000033041 UniprotKB:O00167
NG_011673.2
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.674e-1 (AD)  8.220e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6018185chr20:46928812 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6066110chr20:46911158 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RFX20.884
ACOX20.879
GPR1430.879
BMP70.878
C16orf890.877
CLDN100.874
SOX90.869
PAX60.861
EMX20.859
CDC42EP40.859

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRG1-0.526
TYRP1-0.524
SLC7A14-0.522
BCAT1-0.518
ZNF860-0.513
SPAG6-0.513
OSBPL10-0.509
RHOBTB1-0.509
SH3BP5-0.508
FAR2-0.5

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of EYA2 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EYA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EYA2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of EYA2 mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of EYA2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EYA2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EYA2 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EYA2 mRNA16483693
D001553BenzbromaroneBenzbromarone results in decreased activity of EYA2 protein22545090
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of EYA2 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EYA2 mRNA21839799
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of EYA2 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of EYA2 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of EYA2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of EYA2 mRNA25181051
D002110CaffeineCaffeine results in decreased expression of EYA2 mRNA23774253
D002220CarbamazepineCarbamazepine results in decreased expression of EYA2 mRNA23774253
D002220CarbamazepineCarbamazepine affects the expression of EYA2 mRNA25979313
D003042CocaineCocaine affects the expression of EYA2 mRNA20187946
D003471CuprizoneCuprizone results in increased expression of EYA2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of EYA2 mRNA20106945
D013759DronabinolDronabinol results in decreased expression of EYA2 mRNA16616335
D004026DieldrinDieldrin results in increased expression of EYA2 mRNA28385952
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EYA2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EYA2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EYA2 mRNA17942748
D005419FlavonoidsFlavonoids results in decreased expression of EYA2 mRNA18035473
C004312glycidolglycidol results in decreased expression of EYA2 mRNA24915197
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EYA2 mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EYA2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of EYA2 mRNA"20188158
D009151Mustard GasMustard Gas results in decreased expression of EYA2 mRNA15674843
D009532NickelNickel results in decreased expression of EYA2 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of EYA2 mRNA22714537
D010656PhenylephrineEYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]17327491
D010656PhenylephrineEYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]17327491
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EYA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of EYA2 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of EYA2 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EYA2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EYA2 mRNA22079256|2271453
D011441PropylthiouracilPropylthiouracil results in decreased expression of EYA2 mRNA24780913
C009166retinol acetateretinol acetate results in increased expression of EYA2 mRNA16772331
D012643SeleniumSelenium results in increased expression of EYA2 mRNA19244175
C017947sodium arsenitesodium arsenite affects the methylation of EYA2 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of EYA2 mRNA22714537
D012999SomanSoman results in increased expression of EYA2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EYA2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EYA2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EYA2 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EYA2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of EYA2 mRNA27760801
D014212TretinoinTretinoin results in decreased expression of EYA2 mRNA23774253
D014212TretinoinTretinoin results in increased expression of EYA2 mRNA20530235
D014212TretinoinTretinoin results in increased expression of EYA2 mRNA23830798
D014212TretinoinTretinoin results in increased expression of EYA2 mRNA16604517
C012589trichostatin Atrichostatin A results in increased expression of EYA2 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of EYA2 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of EYA2 mRNA23774253
D014635Valproic AcidValproic Acid affects the expression of EYA2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EYA2 mRNA23179753|2438349
D014810Vitamin EVitamin E results in increased expression of EYA2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA19351884  
GO:0004725protein tyrosine phosphatase activity-IBA21873635  
GO:0004725protein tyrosine phosphatase activity-IDA19351884  
GO:0005515protein binding-IPI19497856  21516116  
GO:0008134transcription factor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0007501mesodermal cell fate specification-TAS9020840  
GO:0014706striated muscle tissue development-IEA-  
GO:0016576histone dephosphorylation-IBA21873635  
GO:0016576histone dephosphorylation-IDA19351884  
GO:0030154cell differentiation-IBA21873635  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0045739positive regulation of DNA repair-IBA21873635  
GO:0048856anatomical structure development-IBA21873635  
GO:0097192extrinsic apoptotic signaling pathway in absence of ligand-IEA-  
GO:0097345mitochondrial outer membrane permeabilization-IEA-  
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal