Gene: EZH2

2146
ENX-1|ENX1|EZH2b|KMT6|KMT6A|WVS|WVS2
enhancer of zeste 2 polycomb repressive complex 2 subunit
protein-coding
7q36.1
Ensembl:ENSG00000106462 MIM:601573 Vega:OTTHUMG00000158973 UniprotKB:Q15910
NG_032043.1
PubMed
0   ANCO-SNPs
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.582e-1 (AD)  1.804e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05295594chr7:148548336EZH2Promoter1.866e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FNBP40.79
ZNF7000.782
SMC50.782
LTB4R0.778
CCNL10.777
CNTRL0.768
RIPK10.768
HSPBAP10.745
SLC30A70.737
NUP2050.735

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.329
MMD2-0.314
DIO2-0.297
DIAPH3-0.292
CRH-0.289
HPSE2-0.288
WNT7A-0.278
WNT7B-0.267
KCNJ16-0.266
BTBD17-0.261

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0317631,3-butadiene"1,3-butadiene results in increased expression of EZH2 mRNA"25237060
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EZH2 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EZH2 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EZH2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EZH2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EZH2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EZH2 mRNA"25510870
C0484603-deazaneplanocin3-deazaneplanocin inhibits the reaction [EZH2 protein binds to MIR26A1 promoter]23538750
C0484603-deazaneplanocin3-deazaneplanocin inhibits the reaction [EZH2 protein binds to MIR26A2 promoter]23538750
C5550214-acetylantroquinonol B4-acetylantroquinonol B results in decreased expression of EZH2 protein26235807
D000082AcetaminophenAcetaminophen affects the expression of EZH2 mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of EZH2 mRNA21420995|2223033
D000082AcetaminophenAcetaminophen results in decreased expression of EZH2 mRNA17942131
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of EZH2 protein]24582688
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of EZH2 protein]24582688
D020106AcrylamideAcrylamide results in increased expression of EZH2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of EZH2 protein20106945
C430898AGN 194204AGN 194204 results in decreased expression of EZH2 mRNA16339527
D001151ArsenicAcetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of EZH2 protein]24582688
D001151ArsenicArsenic analog results in increased phosphorylation of and affects the localization of EZH2 protein24582688
D001151ArsenicArsenic affects the localization of EZH2 protein22426358
D001151ArsenicArsenic promotes the reaction [EZH2 protein binds to MYOG promoter]22426358
D001151Arsenic[Arsenic promotes the reaction [EZH2 protein binds to MYOG promoter]] which results in decreased expression of MYOG mRNA22426358
D001151Arsenic[[Arsenic results in decreased expression of IGF1 mRNA] co-treated with [Arsenic affects the localization of and results in increased expression of EZH2 protein]] results in decreased expression of MYOG22426358
D001151ArsenicArsenic results in increased expression of EZH2 protein22426358|2284371
D001152ArsenicalsAKT1 mutant form inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein]23255093
D001152ArsenicalsArsenicals results in increased phosphorylation of EZH2 protein23255093
D001152ArsenicalsMAPK8 mutant form inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein]23255093
D001152ArsenicalsMIR21 mRNA affects the reaction [Arsenicals results in increased phosphorylation of EZH2 protein]23255093
D001152Arsenicalspyrazolanthrone inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein]23255093
D001152Arsenicalsstattic inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein]23255093
C006632arsenic trioxidearsenic trioxide results in increased expression of EZH2 protein26592252
C006632arsenic trioxideEZH2 protein results in decreased susceptibility to arsenic trioxide26592252
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of EZH2 mRNA26424790
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of EZH2 protein26424790
D001205Ascorbic AcidEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA]26424790
D001205Ascorbic AcidEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of RUNX2 mRNA]26424790
D001205Ascorbic AcidEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of SATB2 mRNA]26424790
D001205Ascorbic AcidEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of TNFRSF11B mRNA]26424790
D001379AzathioprineAzathioprine results in decreased expression of EZH2 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EZH2 mRNA21632981|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EZH2 mRNA17942131
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EZH2 mRNA"20382639
D004958EstradiolEstradiol promotes the reaction [CREBBP protein binds to EZH2 promoter]25088689
D004958EstradiolEstradiol promotes the reaction [EP300 protein binds to EZH2 promoter]25088689
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to EZH2 promoter]25088689
D004958EstradiolEstradiol promotes the reaction [ESR2 protein binds to EZH2 promoter]25088689
D004958EstradiolEstradiol promotes the reaction [KMT2C protein binds to EZH2 promoter]25088689
D004958EstradiolEstradiol promotes the reaction [KMT2D protein binds to EZH2 promoter]25088689
D004958EstradiolEstradiol results in increased acetylation of EZH2 promoter25088689
D004958EstradiolEstradiol results in increased expression of EZH2 mRNA25088689
D004958EstradiolEstradiol results in increased expression of EZH2 protein25088689
D004958EstradiolEstradiol results in increased methylation of EZH2 promoter25088689
D004958EstradiolKMT2C mutant form inhibits the reaction [Estradiol results in increased expression of EZH2 mRNA]25088689
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol promotes the reaction [CREBBP protein binds to EZH2 promoter]]25088689
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol promotes the reaction [EP300 protein binds to EZH2 promoter]]25088689
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol results in increased acetylation of EZH2 promoter]25088689
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol results in increased expression of EZH2 mRNA]25088689
D004958EstradiolKMT2D mutant form inhibits the reaction [Estradiol results in increased methylation of EZH2 promoter]25088689
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of EZH2 mRNA25088689
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of EZH2 protein25088689
D004958Estradiol[Diethylstilbestrol co-treated with Estradiol] results in increased expression of EZH2 mRNA25088689
D004958Estradiol[Diethylstilbestrol co-treated with Estradiol] results in increased expression of EZH2 protein25088689
D004958EstradiolEstradiol results in increased expression of EZH2 mRNA25088689
D004958EstradiolEstradiol results in increased expression of EZH2 protein25088689
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of EZH2 mRNA26424790
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of EZH2 protein26424790
C031463beta-glycerophosphoric acidEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA]26424790
C031463beta-glycerophosphoric acidEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of RUNX2 mRNA]26424790
C031463beta-glycerophosphoric acidEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of SATB2 mRNA]26424790
C031463beta-glycerophosphoric acidEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of TNFRSF11B mRNA]26424790
C044887beta-methylcholinebeta-methylcholine affects the expression of EZH2 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of EZH2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of EZH2 mRNA29027980
C006780bisphenol Abisphenol A affects the expression of EZH2 mRNA28765096
C006780bisphenol Abisphenol A promotes the reaction [CREBBP protein binds to EZH2 promoter]25088689
C006780bisphenol Abisphenol A promotes the reaction [EP300 protein binds to EZH2 promoter]25088689
C006780bisphenol Abisphenol A promotes the reaction [ESR1 protein binds to EZH2 promoter]25088689
C006780bisphenol Abisphenol A promotes the reaction [ESR2 protein binds to EZH2 promoter]25088689
C006780bisphenol Abisphenol A promotes the reaction [KMT2C protein binds to EZH2 promoter]25088689
C006780bisphenol Abisphenol A promotes the reaction [KMT2D protein binds to EZH2 promoter]25088689
C006780bisphenol Abisphenol A results in decreased expression of EZH2 mRNA29275510
C006780bisphenol Abisphenol A results in increased acetylation of EZH2 promoter25088689
C006780bisphenol Abisphenol A results in increased expression of EZH2 mRNA21761357|2508868
C006780bisphenol Abisphenol A results in increased expression of EZH2 protein21761357|2508868
C006780bisphenol Abisphenol A results in increased methylation of EZH2 promoter25088689
C006780bisphenol AKMT2C mutant form inhibits the reaction [bisphenol A results in increased expression of EZH2 mRNA]25088689
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A promotes the reaction [CREBBP protein binds to EZH2 promoter]]25088689
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A promotes the reaction [EP300 protein binds to EZH2 promoter]]25088689
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A results in increased acetylation of EZH2 promoter]25088689
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A results in increased expression of EZH2 mRNA]25088689
C006780bisphenol AKMT2D mutant form inhibits the reaction [bisphenol A results in increased methylation of EZH2 promoter]25088689
C006780bisphenol Abisphenol A results in increased expression of EZH2 protein21761357
C006780bisphenol Abisphenol A affects the expression of EZH2 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of EZH2 mRNA25088689
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of EZH2 protein25088689
C006780bisphenol Abisphenol A results in increased expression of EZH2 mRNA25088689|2689883
C006780bisphenol Abisphenol A results in increased expression of EZH2 protein25088689
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of EZH2 mRNA17942131
D0151248-Bromo Cyclic Adenosine Monophosphate[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in decreased expression of EZH2 mRNA21903722
D0151248-Bromo Cyclic Adenosine Monophosphate[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in decreased expression of EZH2 protein21903722
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of EZH2 mRNA21903722
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of EZH2 protein21903722
D0151248-Bromo Cyclic Adenosine MonophosphateEZH2 mutant form inhibits the reaction [[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA]21903722
D0151248-Bromo Cyclic Adenosine MonophosphateEZH2 mutant form inhibits the reaction [[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of PRL mRNA]21903722
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of EZH2 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of EZH2 mRNA26472689
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EZH2 mRNA17484886|2733941
D002330CarmustineCarmustine results in decreased expression of EZH2 mRNA15980968
D000068579CelecoxibCelecoxib results in decreased expression of EZH2 mRNA28201806
D003010ClorgylineClorgyline results in decreased expression of EZH2 mRNA19691856
C018021cobaltous chloridecobaltous chloride results in decreased expression of EZH2 mRNA19320972
C018021cobaltous chlorideEZH2 mRNA promotes the reaction [cobaltous chloride deficiency results in decreased expression of DICER1 mRNA]25351418
D019327Copper SulfateCopper Sulfate results in decreased expression of EZH2 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of EZH2 mRNA19789285
D003345CorticosteroneCorticosterone results in decreased expression of EZH2 mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EZH2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of EZH2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of EZH2 mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of EZH2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of EZH2 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of EZH2 mRNA17942131
D000069439DasatinibDasatinib results in decreased expression of EZH2 mRNA20579391
C007262deoxynivalenoldeoxynivalenol results in increased expression of EZH2 mRNA26988607
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of EZH2 mRNA26424790
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of EZH2 protein26424790
D003907DexamethasoneEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA]26424790
D003907DexamethasoneEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of RUNX2 mRNA]26424790
D003907DexamethasoneEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of SATB2 mRNA]26424790
D003907DexamethasoneEZH2 protein inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of TNFRSF11B mRNA]26424790
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of EZH2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of EZH2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of EZH2 mRNA27594783
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of EZH2 mRNA26924002
D004026DieldrinDieldrin results in decreased expression of EZH2 mRNA28385952
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of EZH2 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of EZH2 mRNA]17854601
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [CREBBP protein binds to EZH2 promoter]25088689
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [EP300 protein binds to EZH2 promoter]25088689
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [ESR1 protein binds to EZH2 promoter]25088689
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [ESR2 protein binds to EZH2 promoter]25088689
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [KMT2C protein binds to EZH2 promoter]25088689
D004054DiethylstilbestrolDiethylstilbestrol promotes the reaction [KMT2D protein binds to EZH2 promoter]25088689
D004054DiethylstilbestrolDiethylstilbestrol results in increased acetylation of EZH2 promoter25088689
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EZH2 mRNA21761357|2508868
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EZH2 protein21761357|2508868
D004054DiethylstilbestrolDiethylstilbestrol results in increased methylation of EZH2 promoter25088689
D004054DiethylstilbestrolKMT2C mutant form inhibits the reaction [Diethylstilbestrol results in increased expression of EZH2 mRNA]25088689
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol promotes the reaction [CREBBP protein binds to EZH2 promoter]]25088689
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol promotes the reaction [EP300 protein binds to EZH2 promoter]]25088689
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol results in increased acetylation of EZH2 promoter]25088689
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol results in increased expression of EZH2 mRNA]25088689
D004054DiethylstilbestrolKMT2D mutant form inhibits the reaction [Diethylstilbestrol results in increased methylation of EZH2 promoter]25088689
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EZH2 mRNA21761357
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EZH2 protein21761357
D004054Diethylstilbestrol[Diethylstilbestrol co-treated with Estradiol] results in increased expression of EZH2 mRNA25088689
D004054Diethylstilbestrol[Diethylstilbestrol co-treated with Estradiol] results in increased expression of EZH2 protein25088689
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EZH2 mRNA25088689
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EZH2 protein25088689
D002117CalcitriolCalcitriol results in decreased expression of EZH2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of EZH2 mRNA21592394
C024629dimethyl phthalatedimethyl phthalate affects the expression of EZH2 mRNA26924002
D004147DioxinsDioxins affects the expression of EZH2 mRNA20463971
D004317DoxorubicinEZH2 protein affects the susceptibility to Doxorubicin16217747
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of EZH227478869
D004726EndosulfanEndosulfan results in increased expression of and results in increased activity of EZH2 protein29054638
D004726EndosulfanEndosulfan results in increased expression of EZH2 mRNA29054638
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EZH2 mRNA17942748
D005557FormaldehydeFormaldehyde results in increased expression of EZH2 mRNA23649840
D019833GenisteinGenistein results in increased phosphorylation of EZH2 protein22504913
C577920GSK126GSK126 results in decreased activity of EZH2 protein26424790
C586265GSK343GSK343 results in decreased activity of EZH2 protein23759589|2490043
D006533HeptachlorHeptachlor results in increased expression of EZH2 mRNA23153324
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of EZH2 protein]24582688
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EZH2 mRNA20044591|2117940
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of and affects the localization of EZH2 protein24582688
C031927hydroquinonehydroquinone results in decreased expression of EZH2 protein27979589
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EZH2 mRNA25613284
C561695(+)-JQ1 compoundEZH2 mutant form promotes the reaction [(+)-JQ1 compound results in decreased expression of MYC protein]23538750
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of EZH2 mRNA27169980
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [EZH2 protein binds to MIR26A1 promoter]23538750
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [EZH2 protein binds to MIR26A2 promoter]23538750
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EZH2 protein23538750
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [MYC protein binds to EZH2 promoter]26939702
D007649KetamineKetamine results in decreased expression of EZH2 mRNA20080153
D007854LeadLead affects the expression of EZH2 mRNA28903495
D007854LeadEZH2 protein inhibits the reaction [Lead results in increased expression of HDAC2 mRNA]29301062
D007854LeadEZH2 protein inhibits the reaction [Lead results in increased expression of HDAC2 protein]29301062
D007854LeadLead results in decreased expression of EZH2 protein29301062
D008154LucanthoneLucanthone results in decreased expression of EZH2 mRNA21148553
D017258Medroxyprogesterone Acetate[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in decreased expression of EZH2 mRNA21903722
D017258Medroxyprogesterone Acetate[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in decreased expression of EZH2 protein21903722
D017258Medroxyprogesterone AcetateEZH2 mutant form inhibits the reaction [[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA]21903722
D017258Medroxyprogesterone AcetateEZH2 mutant form inhibits the reaction [[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of PRL mRNA]21903722
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of EZH2 mRNA21903722
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of EZH2 protein21903722
D008727MethotrexateMethotrexate results in decreased expression of EZH2 protein21114963
C030667methylazoxymethanolmethylazoxymethanol results in increased expression of EZH2 mRNA17107856
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EZH2 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of EZH2 mRNA29191790
C517284monomethyl phthalatemonomethyl phthalate affects the expression of EZH2 mRNA26924002
D009020MorphineMorphine promotes the reaction [EZH2 protein binds to BDNF promoter]25643298
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EZH2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EZH2 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of EZH2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of EZH2 mRNA25729387
D010100OxygenOxygen deficiency promotes the reaction [EZH2 protein binds to DICER1 promoter]25351418
C500026palbociclibpalbociclib results in decreased expression of EZH2 mRNA22869556
C500026palbociclibpalbociclib results in decreased expression of EZH2 protein20948315|2473646
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EZH2 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of EZH2 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of EZH2 mRNA25510869
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of EZH2 protein25510869
D010833Phytic AcidPhytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 mRNA]25168426
D010833Phytic AcidPhytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 protein]25168426
D010894PiroxicamPiroxicam results in decreased expression of EZH2 mRNA21858171
D011374ProgesteroneProgesterone results in decreased expression of EZH2 mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of EZH2 mRNA18070364
D011441PropylthiouracilPropylthiouracil results in increased expression of EZH2 mRNA24780913
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein]23255093
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of EZH2 mRNA19167446
C059514resveratrolEZH2 mRNA promotes the reaction [resveratrol results in decreased expression of ACTA2 mRNA]26934322
C059514resveratrolEZH2 mRNA promotes the reaction [resveratrol results in decreased expression of ZEB1 mRNA]26934322
C059514resveratrolEZH2 mRNA results in increased susceptibility to resveratrol26934322
C059514resveratrolresveratrol results in increased expression of EZH2 mRNA26934322
C059514resveratrolresveratrol results in increased expression of EZH2 protein26934322
C059514resveratrolMIR137 mRNA affects the reaction [resveratrol results in decreased expression of EZH2 protein]25505154
C059514resveratrolresveratrol results in decreased expression of EZH2 protein25505154
D012906SmokeEZH2 mutant form inhibits the reaction [HOTAIR mRNA inhibits the reaction [Smoke analog results in increased expression of CDKN1A protein]]26506537
D012906SmokeEZH2 mutant form inhibits the reaction [Smoke analog results in decreased expression of CDKN1A protein]26506537
D012906SmokeEZH2 mutant form inhibits the reaction [Smoke analog results in increased expression of BMI1 protein]25526925
D012906SmokeSmoke analog promotes the reaction [EZH2 protein binds to MIR218-1 promoter]25526925
D012906SmokeSmoke analog results in increased expression of EZH2 protein25526925|2650653
C016104sodium bichromatesodium bichromate affects the expression of EZH2 mRNA22110744
D012999SomanSoman results in increased expression of EZH2 mRNA19281266
C517409statticstattic inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein]23255093
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of EZH2 mRNA"26680231
D013629Tamoxifen[EZH2 protein results in decreased expression of ESR1 protein] which results in decreased susceptibility to Tamoxifen20306127
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of EZH2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of EZH2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EZH2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EZH2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EZH2 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in decreased expression of MIR101A] which results in increased expression of EZH2 protein21602190
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EZH2 mRNA25613284
D019772TopotecanEZH2 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of EZH2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of EZH2 mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of EZH2 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of EZH2 mRNA22906706
D014212TretinoinTretinoin results in increased expression of EZH2 mRNA17198874
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of EZH2 mRNA19042947
C001899triptolidetriptolide results in decreased expression of EZH2 protein19879315
C057693troglitazonetroglitazone results in decreased expression of EZH2 mRNA19140230
D014520UrethaneUrethane results in increased expression of EZH2 mRNA28818685
D014520UrethanePhytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 mRNA]25168426
D014520UrethanePhytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 protein]25168426
D014520UrethaneUrethane results in increased expression of EZH2 mRNA25168426
D014520UrethaneUrethane results in increased expression of EZH2 protein25168426
D014635Valproic AcidValproic Acid affects the expression of EZH2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EZH2 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of EZH2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EZH2 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EZH2 gene25560391
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of EZH2 mRNA27169980
C029297vinylidene chloridevinylidene chloride results in increased expression of EZH2 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of EZH2 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of EZH2 protein21114963
D015032ZincZinc results in decreased expression of EZH2 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-TAS8954776  
GO:0003682chromatin binding-IDA20154697  
GO:0005515protein binding-IPI11571280  16179254  16357870  17560333  19734898  20075857  
20543829  22009739  22094255  22439931  22897849  23079660  
23142980  23238014  23455924  23684459  24074865  24183680  
24474760  25416956  25417162  26496610  27705803  27728805  
27728808  28229514  
GO:0016279protein-lysine N-methyltransferase activity-TAS-  
GO:0018024histone-lysine N-methyltransferase activity-IDA19144645  
GO:0018024histone-lysine N-methyltransferase activity-TAS-  
GO:0031490chromatin DNA binding-IDA19734898  
GO:0042054histone methyltransferase activity-IDA15385962  
GO:0042054histone methyltransferase activity-IMP26694085  
GO:0043021ribonucleoprotein complex binding-IEA-  
GO:0046976histone methyltransferase activity (H3-K27 specific)-IDA22323599  
GO:0046976histone methyltransferase activity (H3-K27 specific)-TAS24474760  
GO:0070878primary miRNA binding-IEA-  
GO:1990841promoter-specific chromatin binding-IDA24623306  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA20154697  
GO:0006306DNA methylation-IEA-  
GO:0006325chromatin organization-TAS8921387  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-TAS8921387  
GO:0010718positive regulation of epithelial to mesenchymal transition-IDA20154697  
GO:0014013regulation of gliogenesis-IEA-  
GO:0014834skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration-IEA-  
GO:0014898cardiac muscle hypertrophy in response to stress-IEA-  
GO:0016571histone methylation-IMP26694085  
GO:0021695cerebellar cortex development-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0034244negative regulation of transcription elongation from RNA polymerase II promoter-IEA-  
GO:0035984cellular response to trichostatin A-IEA-  
GO:0036333hepatocyte homeostasis-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0042752regulation of circadian rhythm-IMP16717091  
GO:0043406positive regulation of MAP kinase activity-IDA20154697  
GO:0043433negative regulation of DNA-binding transcription factor activity-IEA-  
GO:0043547positive regulation of GTPase activity-IDA20154697  
GO:0045605negative regulation of epidermal cell differentiation-IEA-  
GO:0045814negative regulation of gene expression, epigenetic-IDA20154697  
GO:0045814negative regulation of gene expression, epigenetic-IMP24623306  
GO:0045814negative regulation of gene expression, epigenetic-TAS-  
GO:0045892negative regulation of transcription, DNA-templated-IMP16179254  
GO:0048387negative regulation of retinoic acid receptor signaling pathway-IMP16179254  
GO:0048511rhythmic process-IEA-  
GO:0051154negative regulation of striated muscle cell differentiation-IEA-  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:0070314G1 to G0 transition-IEA-  
GO:0070317negative regulation of G0 to G1 transition-TAS-  
GO:0070734histone H3-K27 methylation-IDA24474760  
GO:0071168protein localization to chromatin-IEA-  
GO:0071902positive regulation of protein serine/threonine kinase activity-IDA20154697  
GO:0097421liver regeneration-IEA-  
GO:0098532histone H3-K27 trimethylation-IEA-  
GO:1900006positive regulation of dendrite development-IEA-  
GO:1904772response to tetrachloromethane-IEA-  
GO:2000134negative regulation of G1/S transition of mitotic cell cycle-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA19734898  
GO:0005634nucleus-IDA19144645  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0035098ESC/E(Z) complex-IDA15385962  20075857  23104054  23273982  24474760  
GO:0045120pronucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-212300PRC2 methylates histones and DNATAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-3214841PKMTs methylate histone lysinesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-8953750Transcriptional Regulation by E2F6TAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22855181Quantitative analysis of EZH2 expression and its correlations with lung cancer patients' clinical pathological characteristics. (2013 Feb)Wan LClin Transl Oncol
24097870EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma. (2013 Dec 1)Behrens CClin Cancer Res
29212262A missense variant in EZH2 is associated with colorectal cancer risk in a Chinese population. (2017 Nov 7)Li HOncotarget
22552406The expression and significance of the enhancer of zeste homolog 2 in lung adenocarcinoma. (2012 Jul)Lv YOncol Rep
26415832Posttranscriptional silencing of the lncRNA MALAT1 by miR-217 inhibits the epithelial-mesenchymal transition via enhancer of zeste homolog 2 in the malignant transformation of HBE cells induced by cigarette smoke extract. (2015 Dec 1)Lu LToxicol Appl Pharmacol
28444195DNA methylome analysis reveals distinct epigenetic patterns of ascending aortic dissection and bicuspid aortic valve. (2017 May 1)Pan SCardiovasc Res
29396474Nicotine associated breast cancer in smokers is mediated through high level of EZH2 expression which can be reversed by methyltransferase inhibitor DZNepA. (2018 Feb 2)Kumari KCell Death Dis
28554757Clinicopathological significance and prognostic role of EZH2 expression in non-small cell lung cancer. (2017 Jul)Kim NYPathol Res Pract
29616099Analysis of H3K27me3 expression and DNA methylation at CCGG sites in smoking and non-smoking patients with non-small cell lung cancer and their clinical significance. (2018 May)Zhu KOncol Lett
29435295Identification of candidate responders for anti-PD-L1/PD-1 immunotherapy, Rova-T therapy, or EZH2 inhibitory therapy in small-cell lung cancer. (2018 Feb)Saito MMol Clin Oncol