Gene info: ID 2147

Gene: F2

GENE ID: 2147

Synonyms: PT|RPRGL2|THPH1

Description: coagulation factor II, thrombin

Gene type: protein-coding

Location: 11p11.2

dbXrefs: Ensembl:ENSG00000180210 MIM:176930 Vega:OTTHUMG00000150344 UniprotKB:P00734

RefSeq: NG_008953.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 63

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.683e-1 (AD) 7.236e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg25503804	chr11:46739832	F2		8.700e-14	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
QRICH2	0.583
DNASE1	0.546
HIC2	0.541
POLN	0.537
RAD54L	0.526
ZFHX2	0.525
DHX34	0.522
C1orf226	0.52
GNB3	0.516
ZGLP1	0.515

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CDNF	-0.301
SLC26A7	-0.296
DSG1	-0.286
C9orf153	-0.286
RGS22	-0.275
ENDOU	-0.268
DPH6	-0.262
IL20RA	-0.257
CCT6B	-0.253
COPZ2	-0.251

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00001	Lepirudin	BiotechDrug	138068-37-8	Approved	Target
DB00006	Bivalirudin	Small Molecule	128270-60-0	Approved\|Investigational	Target
DB00055	Drotrecogin alfa	BiotechDrug	98530-76-8	Approved\|Investigational\|Withdrawn	Target
DB00100	Coagulation Factor IX (Recombinant)	BiotechDrug	181054-95-5	Approved\|Investigational	Target
DB00170	Menadione	Small Molecule	58-27-5	Approved\|Nutraceutical	Target
DB00278	Argatroban	Small Molecule	74863-84-6	Approved\|Investigational	Target
DB01123	Proflavine	Small Molecule	92-62-6	Approved	Target
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB01725	2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide	Small Molecule		Experimental	Target
DB01766	Beta-(2-Naphthyl)-Alanine	Small Molecule	-	Experimental	Target
DB01767	Hemi-Babim	Small Molecule		Experimental	Target
DB02287	2-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-Carboxamidine	Small Molecule		Experimental	Target
DB02723	4-Oxo-2-Phenylmethanesulfonyl-Octahydro-Pyrrolo[1,2-a]Pyrazine-6-Carboxylic Acid [1-(N-Hydroxycarbamimidoyl)-Piperidin-4-Ylmethyl]-Amide	Small Molecule		Experimental	Target
DB03136	4-Iodobenzo[B]Thiophene-2-Carboxamidine	Small Molecule		Experimental	Target
DB03159	CRA_8696	Small Molecule		Experimental	Target
DB03847	Gamma-Carboxy-Glutamic Acid	Small Molecule		Experimental	Target
DB03865	6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine	Small Molecule		Experimental	Target
DB04136	Lysophosphotidylserine	Small Molecule		Experimental	Target
DB04591	N-{2,2-DIFLUORO-2-[(2R)-PIPERIDIN-2-YL]ETHYL}-2-[2-(1H-1,2,4-TRIAZOL-1-YL)BENZYL][1,3]OXAZOLO[4,5-C]PYRIDIN-4-AMINE	Small Molecule		Experimental	Target
DB04697	TRANS-4-(GUANIDINOMETHYL)-CYCLOHEXANE-L-YL-D-3-CYCLOHEXYLALANYL-L-AZETIDINE-2-YL-D-TYROSINYL-L-HOMOARGININAMIDE	Small Molecule		Experimental	Target
DB04722	2-(3-CHLORO-6-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-YL)ETHYL]AMINO}-1-OXIDOPYRIDIN-2-YL)-N-[1-(3-CHLOROPHENYL)ETHYL]ACETAMIDE	Small Molecule		Experimental	Target
DB04771	1-GUANIDINO-4-(N-NITRO-BENZOYLAMINO-L-LEUCYL-L-PROLYLAMINO)BUTANE	Small Molecule		Experimental	Target
DB04772	1-GUANIDINO-4-(N-PHENYLMETHANESULFONYL-L-LEUCYL-L-PROLYLAMINO)BUTANE	Small Molecule		Experimental	Target
DB04786	Suramin	Small Molecule	145-63-1	Approved\|Investigational	Target
DB04898	Ximelagatran	Small Molecule	192939-46-1	Approved\|Investigational\|Withdrawn	Target
DB05714	Flovagatran	Small Molecule	871576-03-3	Investigational	Target
DB05777	Thrombomodulin Alfa	BiotechDrug	120313-91-9	Approved\|Investigational	Target
DB06404	Human C1-esterase inhibitor	BiotechDrug		Approved	Target
DB06695	Dabigatran etexilate	Small Molecule	211915-06-9	Approved	Target
DB06838	methyl L-phenylalaninate	Small Molecule		Experimental	Target
DB06841	D-phenylalanyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl)butyl]-L-prolinamide	Small Molecule		Experimental	Target
DB06845	(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide	Small Molecule		Experimental	Target
DB06850	(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide	Small Molecule		Experimental	Target
DB06853	N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide	Small Molecule		Experimental	Target
DB06858	N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide	Small Molecule		Experimental	Target
DB06859	N-ALLYL-5-AMIDINOAMINOOXY-PROPYLOXY-3-CHLORO-N-CYCLOPENTYLBENZAMIDE	Small Molecule		Experimental	Target
DB06861	6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE	Small Molecule		Experimental	Target
DB06865	6-CARBAMIMIDOYL-2-[2-HYDROXY-6-(4-HYDROXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID	Small Molecule		Experimental	Target
DB06866	6-CARBAMIMIDOYL-2-[2-HYDROXY-5-(3-METHOXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID	Small Molecule		Experimental	Target
DB06868	N-(3-chlorobenzyl)-1-(4-methylpentanoyl)-L-prolinamide	Small Molecule		Experimental	Target
DB06869	1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDE	Small Molecule		Experimental	Target
DB06878	1-[(2R)-2-aminobutanoyl]-N-(3-chlorobenzyl)-L-prolinamide	Small Molecule		Experimental	Target
DB06911	D-leucyl-N-(3-chlorobenzyl)-L-prolinamide	Small Molecule		Experimental	Target
DB06919	D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide	Small Molecule		Experimental	Target
DB06929	1-butanoyl-N-(4-carbamimidoylbenzyl)-L-prolinamide	Small Molecule		Experimental	Target
DB06936	N-(4-carbamimidoylbenzyl)-1-(4-methylpentanoyl)-L-prolinamide	Small Molecule		Experimental	Target
DB06942	N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide	Small Molecule	-	Experimental	Target
DB06947	1-[(2R)-2-aminobutanoyl]-N-(4-carbamimidoylbenzyl)-L-prolinamide	Small Molecule		Experimental	Target
DB06996	D-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamide	Small Molecule		Experimental	Target
DB07005	D-phenylalanyl-N-{4-[amino(iminio)methyl]benzyl}-L-prolinamide	Small Molecule		Experimental	Target
DB07016	(3R)-8-(dioxidosulfanyl)-3-methyl-1,2,3,4-tetrahydroquinoline	Small Molecule		Experimental	Target
DB07027	D-phenylalanyl-N-(3-fluorobenzyl)-L-prolinamide	Small Molecule		Experimental	Target
DB07083	beta-phenyl-D-phenylalanyl-N-propyl-L-prolinamide	Small Molecule		Experimental	Target
DB07088	(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide	Small Molecule		Experimental	Target
DB07091	(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide	Small Molecule		Experimental	Target
DB07095	(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide	Small Molecule		Experimental	Target
DB07105	2-[2-(4-CHLORO-PHENYLSULFANYL)-ACETYLAMINO]-3-(4-GUANIDINO-PHENYL)-PROPIONAMIDE	Small Molecule		Experimental	Target
DB07120	N4-(N,N-DIPHENYLCARBAMOYL)-AMINOGUANIDINE	Small Molecule		Experimental	Target
DB07128	N7-BUTYL-N2-(5-CHLORO-2-METHYLPHENYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2,7-DIAMINE	Small Molecule		Experimental	Target
DB07131	(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide	Small Molecule		Experimental	Target
DB07133	D-phenylalanyl-N-(3-methylbenzyl)-L-prolinamide	Small Molecule		Experimental	Target
DB07143	D-phenylalanyl-N-benzyl-L-prolinamide	Small Molecule		Experimental	Target
DB07165	N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDE	Small Molecule		Experimental	Target
DB07190	3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamide	Small Molecule		Experimental	Target
DB07211	(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE	Small Molecule		Experimental	Target
DB07277	2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE	Small Molecule		Experimental	Target
DB07278	2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHENESULFONAMIDE	Small Molecule		Experimental	Target
DB07279	N-ETHYL-N-ISOPROPYL-3-METHYL-5-{[(2S)-2-(PYRIDIN-4-YLAMINO)PROPYL]OXY}BENZAMIDE	Small Molecule		Experimental	Target
DB07353	4-(2,5-DIAMINO-5-HYDROXY-PENTYL)-PHENOL	Small Molecule		Experimental	Target
DB07366	2-[N'-(4-AMINO-BUTYL)-HYDRAZINOCARBONYL]-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER	Small Molecule		Experimental	Target
DB07376	5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)	Small Molecule		Experimental	Target
DB07400	1-ETHOXYCARBONYL-D-PHE-PRO-2(4-AMINOBUTYL)HYDRAZINE	Small Molecule		Experimental	Target
DB07440	4-TERT-BUTYLBENZENESULFONIC ACID	Small Molecule		Experimental	Target
DB07461	3-AMINO-3-BENZYL-9-CARBOXAMIDE[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE	Small Molecule		Experimental	Target
DB07508	4-(5-BENZENESULFONYLAMINO-1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-BENZAMIDINE	Small Molecule		Experimental	Target
DB07515	1-(2-{[(6-AMINO-2-METHYLPYRIDIN-3-YL)METHYL]AMINO}ETHYL)-6-CHLORO-3-[(2,2-DIFLUORO-2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL	Small Molecule		Experimental	Target
DB07521	6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL	Small Molecule		Experimental	Target
DB07522	N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]NAPHTHALENE-2-SULFONAMIDE	Small Molecule		Experimental	Target
DB07527	N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONAMIDE	Small Molecule		Experimental	Target
DB07548	2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-6-PYRIDINYL)METHYL]ACETAMIDE	Small Molecule		Experimental	Target
DB07549	2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-3-METHYL-6-PYRIDINYL)METHYL]ACETAMIDE	Small Molecule		Experimental	Target
DB07550	2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDE	Small Molecule		Experimental	Target
DB07639	3-(7-DIAMINOMETHYL-NAPHTHALEN-2-YL)-PROPIONIC ACID ETHYL ESTER	Small Molecule		Experimental	Target
DB07658	AC-(D)PHE-PRO-BOROLYS-OH	Small Molecule		Experimental	Target
DB07659	AC-(D)PHE-PRO-BOROHOMOLYS-OH	Small Molecule		Experimental	Target
DB07660	AC-(D)PHE-PRO-BOROHOMOORNITHINE-OH	Small Molecule		Experimental	Target
DB07665	N-[2-(carbamimidamidooxy)ethyl]-2-{6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-fluorophenyl}acetamide	Small Molecule		Experimental	Target
DB07718	3-(4-HYDROXY-PHENYL)PYRUVIC ACID	Small Molecule		Experimental	Target
DB07741	4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINE	Small Molecule		Experimental	Target
DB07796	(3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINE	Small Molecule		Experimental	Target
DB07809	4-({[4-(3-METHYLBENZOYL)PYRIDIN-2-YL]AMINO}METHYL)BENZENECARBOXIMIDAMIDE	Small Molecule		Experimental	Target
DB07897	1-(HYDROXYMETHYLENEAMINO)-8-HYDROXY-OCTANE	Small Molecule		Experimental	Target
DB07934	[[CYCLOHEXANESULFONYL-GLYCYL]-3[PYRIDIN-4-YL-AMINOMETHYL]ALANYL]PIPERIDINE	Small Molecule		Experimental	Target
DB07944	N-{3-METHYL-5-[2-(PYRIDIN-4-YLAMINO)-ETHOXY]-PHENYL}-BENZENESULFONAMIDE	Small Molecule		Experimental	Target
DB07946	N-[2-({[amino(imino)methyl]amino}oxy)ethyl]-2-{6-chloro-3-[(2,2-difluoro-2-phenylethyl)amino]-2-fluorophenyl}acetamide	Small Molecule		Experimental	Target
DB08061	4-[3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-YL]PIPERIDINE	Small Molecule		Experimental	Target
DB08062	3-(4-CHLOROPHENYL)-5-(METHYLTHIO)-4H-1,2,4-TRIAZOLE	Small Molecule		Experimental	Target
DB08152	{(2S)-1-[N-(tert-butoxycarbonyl)glycyl]pyrrolidin-2-yl}methyl (3-chlorophenyl)acetate	Small Molecule		Experimental	Target
DB08187	METHYL-PHE-PRO-AMINO-CYCLOHEXYLGLYCINE	Small Molecule		Experimental	Target
DB08254	2-NAPHTHALENESULFONIC ACID	Small Molecule		Experimental	Target
DB08422	[PHENYLALANINYL-PROLINYL]-[2-(PYRIDIN-4-YLAMINO)-ETHYL]-AMINE	Small Molecule		Experimental	Target
DB08546	4-[(3AS,4R,7R,8AS,8BR)-2-(1,3-BENZODIOXOL-5-YLMETHYL)-7-HYDROXY-1,3-DIOXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZENECARBOXIMIDAMIDE	Small Molecule		Experimental	Target
DB08624	BENZOTHIAZOLE	Small Molecule		Experimental	Target
DB09109	Turoctocog alfa	BiotechDrug	1192451-26-5	Approved\|Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target
DB09228	Conestat alfa	BiotechDrug	80295-38-1	Approved\|Investigational	Target
DB09332	Kappadione	Small Molecule	131-13-5	Approved	Target
DB11166	Antithrombin Alfa	BiotechDrug	84720-88-7	Approved\|Investigational	Target
DB12598	Nafamostat	Small Molecule	81525-10-2	Approved\|Investigational	Target
DB12831	Gabexate	Small Molecule	39492-01-8	Investigational	Target
DB13151	Anti-inhibitor coagulant complex	BiotechDrug		Approved\|Investigational	Target
DB13152	Coagulation Factor IX Human	BiotechDrug	9001-28-9	Approved	Target
DB00025	Antihemophilic factor, human recombinant	BiotechDrug	139076-62-3	Approved\|Investigational	Enzyme
DB12364	Betrixaban	Small Molecule	330942-05-7	Approved\|Investigational	Enzyme
DB13151	Anti-inhibitor coagulant complex	BiotechDrug		Approved\|Investigational	Enzyme
DB13998	Lonoctocog alfa	BiotechDrug	1388129-63-2	Approved\|Investigational	Enzyme
DB13999	Moroctocog alfa	BiotechDrug	284036-24-4	Approved	Enzyme

ID	Drug Name	Action	PubMed
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [F2 protein results in increased localization of Calcium]"	19814731
C036423	1-aminomethylphosphonic acid	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of F2 mRNA"	20566314
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl affects the expression of F2 mRNA"	21703328
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [F2 protein results in increased localization of Calcium]	19814731
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl affects the expression of F2 mRNA"	21703328
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of F2 mRNA"	21346803
C017906	3-dinitrobenzene	3-dinitrobenzene affects the expression of F2 mRNA	24140754
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of F2 mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of F2	22507835
D000082	Acetaminophen	Acetaminophen inhibits the reaction [F2 protein affects the localization of PRKCE protein]	21811393
D000082	Acetaminophen	Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]	21811393
D000082	Acetaminophen	Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
C043377	acetochlor	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of F2 mRNA"	20566314
D000242	Cyclic AMP	F2 protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]	22207716
D000242	Cyclic AMP	F2 protein results in decreased chemical synthesis of Cyclic AMP	22207716
D000244	Adenosine Diphosphate	F2 protein results in increased abundance of Adenosine Diphosphate	15342215
D000244	Adenosine Diphosphate	Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]	15342215
D000244	Adenosine Diphosphate	resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]	15342215
D000255	Adenosine Triphosphate	calmidazolium affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]	2030746
D000255	Adenosine Triphosphate	F2 protein results in increased abundance of Adenosine Triphosphate	15342215
D000255	Adenosine Triphosphate	F2 protein results in increased secretion of Adenosine Triphosphate	2030746
D000255	Adenosine Triphosphate	Fendiline affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]	2030746
D000255	Adenosine Triphosphate	Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]	15342215
D000255	Adenosine Triphosphate	resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]	15342215
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of F2 protein	20106945
D000447	Aldehydes	Aldehydes results in decreased expression of F2 mRNA	25014914
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of F2 mRNA	21298039
D000638	Amiodarone	Amiodarone inhibits the reaction [F2 protein results in increased expression of and results in increased activity of F3 protein]	18974383
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of F2 mRNA	16483693
D000661	Amphetamine	Amphetamine promotes the reaction [F2 protein results in increased expression of F3 protein]	20118172
D000991	Antithrombins	Antithrombins results in decreased activity of F2 protein	8322273
D047310	Apigenin	Apigenin inhibits the reaction [F2 protein results in increased localization of Calcium]	19814731
C031942	argatroban	argatroban binds to and results in decreased activity of F2 protein	15080313\|1608435
C031942	argatroban	argatroban inhibits the reaction [Dietary Fats results in increased expression of F2 protein]	22841818
C031942	argatroban	argatroban results in decreased activity of F2 protein	16305522
C015001	arsenite	arsenite inhibits the reaction [F2 protein results in increased abundance of Calcium]	22244921
C015001	arsenite	arsenite inhibits the reaction [F2 protein results in increased abundance of Nitric Oxide]	22244921
C015001	arsenite	arsenite inhibits the reaction [F2 protein results in increased phosphorylation of NOS3 protein]	22244921
D001218	Aspartame	Aspartame analog results in decreased activity of F2 protein	15572260
D001218	Aspartame	Aspartame results in decreased activity of F2 protein	15572260
D001241	Aspirin	Aspirin affects the cleavage of F2 protein	16675000
D001241	Aspirin	ITGB3 polymorphism affects the reaction [Aspirin affects the cleavage of F2 protein]	16675000
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in decreased activity of F2 protein	16907931
D001464	Barium	F2 protein results in increased uptake of Barium	2125206
D001464	Barium	Nickel inhibits the reaction [F2 protein results in increased uptake of Barium]	2125206
C111479	BCH 2763	BCH 2763 results in decreased activity of F2 protein	9684808
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of F2 mRNA	22120849
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of F2 mRNA	22610609
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of F2 mRNA	20440473
D004958	Estradiol	Estradiol results in decreased expression of F2 mRNA	24223173
D004958	Estradiol	Estradiol results in decreased expression of F2 mRNA	23373633
D004958	Estradiol	Estradiol results in increased expression of F2 mRNA	20838740
C095105	bexarotene	bexarotene results in decreased expression of F2 mRNA	16648578
C006780	bisphenol A	bisphenol A results in decreased expression of F2 mRNA	25181051
C074619	bivalirudin	bivalirudin binds to and results in decreased activity of F2 protein	15080313\|1515512
C074619	bivalirudin	bivalirudin inhibits the reaction [F2 protein results in increased expression of SELP protein]	16845256
C074619	bivalirudin	bivalirudin results in decreased activity of F2 protein	1290488\|19644995
C074619	bivalirudin	F2 protein results in increased cleavage of bivalirudin	1290488
C074619	bivalirudin	bivalirudin inhibits the reaction [F2 protein results in increased expression of SERPINE1 mRNA]	9125671\|9579636
C074619	bivalirudin	bivalirudin inhibits the reaction [F2 protein results in increased expression of SERPINE1 protein]	9579636
C074619	bivalirudin	bivalirudin inhibits the reaction [F2 protein results in increased secretion of SERPINE1 protein]	9125671
C074619	bivalirudin	bivalirudin results in decreased activity of F2 protein	15084542
C083739	bothrojaracin	bothrojaracin binds to and results in decreased activity of F2 protein	21714536
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [F2 protein results in increased expression of SERPINE1 protein]	9579636
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of F2 mRNA	18804290
C018475	butyraldehyde	butyraldehyde results in decreased expression of F2 mRNA	26079696
D002104	Cadmium	F2 protein binds to Cadmium	23896426
D002104	Cadmium	Cadmium results in increased expression of F2 mRNA	24084258
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of F2 mRNA	18804290
D002118	Calcium	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [F2 protein results in increased localization of Calcium]"	19814731
D002118	Calcium	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [F2 protein results in increased localization of Calcium]	19814731
D002118	Calcium	Apigenin inhibits the reaction [F2 protein results in increased localization of Calcium]	19814731
D002118	Calcium	arsenite inhibits the reaction [F2 protein results in increased abundance of Calcium]	22244921
D002118	Calcium	F2 protein results in increased abundance of Calcium	22244921
D002118	Calcium	F2 protein results in increased localization of Calcium	19814731
D002118	Calcium	F2 protein results in increased uptake of Calcium	2125206
D002118	Calcium	Genistein inhibits the reaction [F2 protein results in increased localization of Calcium]	19814731
D002118	Calcium	Nickel inhibits the reaction [F2 protein results in increased uptake of Calcium]	2125206
D002118	Calcium	Quercetin inhibits the reaction [F2 protein results in increased localization of Calcium]	19814731
C031938	calmidazolium	calmidazolium affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]	2030746
D002211	Capsaicin	Capsaicin affects the expression of F2 protein	8285224
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased activity of F2 protein	12297134
C086276	cerivastatin	cerivastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein]	12067895
D002713	Chlorine	Chlorine results in decreased expression of F2 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of F2 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of F2 mRNA	18804290
D002726	Chlorogenic Acid	Chlorogenic Acid results in decreased activity of F2 protein	27704645
D002746	Chlorpromazine	Chlorpromazine analog results in decreased expression of F2 mRNA	15924885
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of [F2 protein binds to SERPINC1 protein]"	16961586
C012255	clobazam	[clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein]	16376047
D002994	Clofibrate	Clofibrate results in decreased expression of F2 mRNA	16081524
C055162	clopidogrel	clopidogrel inhibits the reaction [F2 protein results in increased expression of SELP protein]	17043144
D003035	Cobalt	F2 protein results in increased uptake of Cobalt	2125206
D003035	Cobalt	Nickel inhibits the reaction [F2 protein results in increased uptake of Cobalt]	2125206
D003078	Colchicine	Colchicine affects the activity of F2 protein	8574231
D005576	Colforsin	Colforsin inhibits the reaction [F2 protein results in increased uptake of Manganese]	2125206
D005576	Colforsin	Colforsin inhibits the reaction [F2 protein results in increased expression of SERPINE1 protein]	9579636
D005576	Colforsin	F2 protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]	22207716
D003276	Contraceptives, Oral	"Contraceptives, Oral results in increased activity of F2 protein"	4180662
D003276	Contraceptives, Oral	"Contraceptives, Oral results in increased expression of F2 protein"	133615
D003276	Contraceptives, Oral	"Contraceptives, Oral results in increased expression of F2 protein"	5700392
D003277	Contraceptives, Oral, Combined	"Contraceptives, Oral, Combined results in increased expression of F2 protein"	4688259
D003300	Copper	F2 protein binds to Copper	23896426
D003300	Copper	Copper results in decreased expression of F2 mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of F2 mRNA	19549813
C007133	cortisol succinate	cortisol succinate affects the expression of F2 protein	12542493
C029892	cupric chloride	cupric chloride results in increased expression of F2 mRNA	17211630
D003474	Curcumin	Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]	18565277
D003474	Curcumin	Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]	18565277
D003474	Curcumin	Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]	18565277
D003474	Curcumin	Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein]	18565277
C101948	CVS 1123	CVS 1123 results in decreased activity of F2 protein	8840864
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Simvastatin results in decreased activity of F2 protein]	14630613
D016572	Cyclosporine	Cyclosporine results in decreased expression of F2 mRNA	20106945\|2383089
D016572	Cyclosporine	Cyclosporine results in decreased expression of F2 mRNA	23830897
D016572	Cyclosporine	Cyclosporine results in increased expression of F2 mRNA	21865292
D003561	Cytarabine	Cytarabine affects the expression of F2 protein	12542493
D015084	2,4-Dichlorophenoxyacetic Acid	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of F2 mRNA"	20566314
D000069604	Dabigatran	Dabigatran results in decreased activity of F2 protein	17911567
D000069604	Dabigatran	Dabigatran results in decreased activity of F2 protein	25138021
D017985	Dalteparin	Dalteparin deficiency results in increased expression of F2 protein	11869846
D017985	Dalteparin	Dalteparin deficiency results in increased expression of [SERPINC1 protein binds to F2 protein]	11869846
D017985	Dalteparin	Dalteparin results in decreased expression of F2 protein	11869846
C035838	danaparoid	danaparoid results in decreased cleavage of and results in decreased activity of F2 protein	8446935
D003871	Dermatan Sulfate	[Dermatan Sulfate co-treated with SERPIND1 protein] results in decreased activity of F2 protein	11805133
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of F2 mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in increased expression of F2 mRNA	21356098
D003907	Dexamethasone	Dexamethasone promotes the reaction [F2 protein results in increased expression of F3 mRNA]	11733402
D003907	Dexamethasone	Dexamethasone affects the expression of F2 protein	10485340
D003907	Dexamethasone	Dexamethasone promotes the reaction [F2 protein results in increased expression of F3 mRNA]	11733402
D003973	Diatrizoate	Diatrizoate inhibits the reaction [F2 protein binds to SERPINC1 protein]	2020943
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of F2 mRNA	28962523
D004026	Dieldrin	Dieldrin results in increased expression of F2 mRNA	23041725
C023635	dienogest	[Ethinyl Estradiol co-treated with dienogest] results in increased expression of F2 protein	15288212
D004041	Dietary Fats	argatroban inhibits the reaction [Dietary Fats results in increased expression of F2 protein]	22841818
D004041	Dietary Fats	Dietary Fats results in increased expression of F2 protein	22841818
C060340	difethialone	F2 protein affects the susceptibility to difethialone	26860702
D004317	Doxorubicin	Doxorubicin affects the expression of F2 protein	12542493
D004317	Doxorubicin	Doxorubicin results in increased cleavage of F2 protein	21865289
D004317	Doxorubicin	Phosphatidylserines affects the reaction [Doxorubicin results in increased cleavage of F2 protein]	21865289
D004317	Doxorubicin	Doxorubicin results in decreased expression of F2 protein	18440303
C534342	drospirenone and ethinyl estradiol combination	F2 protein affects the susceptibility to drospirenone and ethinyl estradiol combination	19363241
C035276	eicosapentaenoic acid ethyl ester	eicosapentaenoic acid ethyl ester results in decreased activity of F2 protein	14614217
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of F2 protein	20805001
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [F2 protein results in increased activity of F3 protein]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [F2 protein results in increased expression of F3 mRNA]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [F2 protein results in increased expression of F3 protein]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased activity of F3 protein]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 mRNA]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK8 protein]	19944065
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK9 protein]	19944065
C086648	eptifibatide	eptifibatide results in increased expression of F2 protein	16391376
C454300	estradiol valerate-dienogest	[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of F2 protein	15288212
D004967	Estrogens	Estrogens results in increased expression of F2 protein	4688259
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with dienogest] results in increased expression of F2 protein	15288212
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased expression of F2 protein	15288212
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of F2 protein	16522526
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of F2 protein	15504374
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F2 protein	8950781
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of F2 protein	8950781
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of F2 mRNA	17942748
C442659	ethinyl estradiol-desogestrel combination	ethinyl estradiol-desogestrel combination results in increased activity of F2 protein	8908527
C044815	etonogestrel	etonogestrel promotes the reaction [F2 protein results in increased expression of F3 mRNA]	11733402
D005275	Fendiline	Fendiline affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate]	2030746
D011345	Fenofibrate	Fenofibrate promotes the reaction [Warfarin results in decreased expression of F2 protein]	9681093
C025314	ferric citrate	ferric citrate results in decreased activity of F2 protein	6421970
C020748	ferrous sulfate	ferrous sulfate results in decreased activity of F2 protein	6421970
D005472	Fluorouracil	Fluorouracil results in decreased expression of F2 mRNA	16709241
D005485	Flutamide	Flutamide results in decreased expression of F2 mRNA	24136188
C039281	furan	furan results in decreased expression of F2 mRNA	26194646
D019833	Genistein	Genistein affects the expression of F2 mRNA	18214933
D019833	Genistein	Genistein inhibits the reaction [F2 protein results in increased localization of Calcium]	19814731
D019833	Genistein	Genistein results in increased expression of F2 mRNA	20838740
C033273	Gestodene	[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of F2 protein	16522526
C033273	Gestodene	[Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of F2 protein	15504374
C033273	Gestodene	[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of F2 protein	8950781
D006493	Heparin	F2 protein promotes the reaction [Heparin results in increased abundance of Nitric Oxide]	8408661
D006493	Heparin	Heparin deficiency results in increased cleavage of and results in increased activity of F2 protein	7895349
D006493	Heparin	Heparin deficiency results in increased expression of F2 protein	11869846
D006493	Heparin	Heparin deficiency results in increased expression of [SERPINC1 protein binds to F2 protein]	11869846
D006493	Heparin	Heparin inhibits the reaction [F2 protein affects the localization of SELP protein]	9740346
D006493	Heparin	Heparin inhibits the reaction [F2 protein results in increased cleavage of F2R protein]	19468011
D006493	Heparin	Heparin inhibits the reaction [F2 protein results in increased expression of EDN1 mRNA]	8408661
D006493	Heparin	Heparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein]	7509996\|8408661
D006493	Heparin	Heparin results in decreased expression of F2 protein	11869846
D006493	Heparin	Heparin results in increased expression of F2 protein	16391376
D006493	Heparin	Heparin results in increased expression of [F2 protein binds to SERPINC1 protein]	16961586
D006493	Heparin	[Heparin binds to SERPINC1 protein] which results in decreased activity of F2 protein	21138266
D006493	Heparin	Heparin results in decreased activity of F2 protein	21138266
D006493	Heparin	[Heparin results in increased activity of SERPINC1 protein] which results in decreased activity of F2 protein	3698718
D006540	Herbicides	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of F2 mRNA"	20566314
D006629	Hirudins	[Hirudins binds to and results in decreased activity of F2 protein] promotes the reaction [CGB3 protein results in increased chemical synthesis of Progesterone]	22207716
D006629	Hirudins	[Hirudins binds to and results in decreased activity of F2 protein] which results in increased chemical synthesis of Progesterone	22207716
D006629	Hirudins	Hirudins binds to and results in decreased activity of F2 protein	22207716
D006629	Hirudins	Hirudins binds to F2 protein	7923645
C062510	hirugen	hirugen binds to and affects the activity of F2 protein	21714536
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of F2 mRNA	25613284
D007485	Ioxaglic Acid	Ioxaglic Acid inhibits the reaction [F2 protein binds to SERPINC1 protein]	2020943
D007501	Iron	Iron results in decreased activity of F2 protein	6421970
D015056	1-Methyl-3-isobutylxanthine	1-Methyl-3-isobutylxanthine inhibits the reaction [F2 protein results in increased uptake of Manganese]	2125206
C544151	jinfukang	jinfukang results in increased expression of F2 mRNA	27392435
D007854	Lead	F2 protein binds to Lead	23896426
C083544	lepirudin	lepirudin binds to and results in decreased activity of F2 protein	15080313\|1844941
C083544	lepirudin	lepirudin results in decreased activity of F2 protein	16305522
D001556	Lindane	Lindane results in increased expression of F2 mRNA	18804290
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with trovafloxacin] results in increased activity of F2 protein	19367693
D008345	Manganese	1-Methyl-3-isobutylxanthine inhibits the reaction [F2 protein results in increased uptake of Manganese]	2125206
D008345	Manganese	Colforsin inhibits the reaction [F2 protein results in increased uptake of Manganese]	2125206
D008345	Manganese	F2 protein results in increased uptake of Manganese	2125206
D008345	Manganese	Nickel inhibits the reaction [F2 protein results in increased uptake of Manganese]	2125206
D008345	Manganese	Tetradecanoylphorbol Acetate inhibits the reaction [F2 protein results in increased uptake of Manganese]	2125206
C008340	mecoprop	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of F2 mRNA"	20566314
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate promotes the reaction [F2 protein results in increased expression of F3 mRNA]	11733402
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of F2	1828463
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate promotes the reaction [F2 protein results in increased expression of F3 mRNA]	11733402
C109573	melagatran	melagatran binds to and results in decreased activity of F2 protein	16084352
D008727	Methotrexate	Methotrexate results in increased expression of F2 mRNA	17400583
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of F2 mRNA	18804290
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of F2 mRNA	27544571
C070571	ML 7	ML 7 affects the activity of F2 protein	1643115
C070571	ML 7	ML 7 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]	15284075
C070571	ML 7	[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein	16675616
C070571	ML 7	ML 7 affects the activity of F2 protein	14557824
C406082	monomethylarsonous acid	monomethylarsonous acid affects the expression of F2 protein	19167414
D009020	Morphine	Morphine deficiency affects the reaction [Morphine results in increased expression of F2 protein]	23056601
D009020	Morphine	Morphine results in increased expression of F2 protein	23056601
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of F2	17379757
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of and results in increased activity of F2 protein	24633426
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of F2 protein	21070799
D015058	1-Naphthylisothiocyanate	F3 mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of F2 protein]	21070799
D015058	1-Naphthylisothiocyanate	F3 protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of F2 protein]	21070799
D009532	Nickel	F2 protein binds to Nickel	23896426
D009532	Nickel	Nickel inhibits the reaction [F2 protein results in increased uptake of Barium]	2125206
D009532	Nickel	Nickel inhibits the reaction [F2 protein results in increased uptake of Calcium]	2125206
D009532	Nickel	Nickel inhibits the reaction [F2 protein results in increased uptake of Cobalt]	2125206
D009532	Nickel	Nickel inhibits the reaction [F2 protein results in increased uptake of Manganese]	2125206
D009532	Nickel	Nickel results in increased expression of F2 mRNA	24084258
D009538	Nicotine	Nicotine results in increased expression of F2 mRNA	18805435
C012655	nimesulide	nimesulide results in decreased activity of F2	17379757
C012655	nimesulide	nimesulide inhibits the reaction [F2 protein affects the localization of PRKCE protein]	21811393
C012655	nimesulide	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]	21811393
C012655	nimesulide	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
C012655	nimesulide	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]	21811393
D009569	Nitric Oxide	arsenite inhibits the reaction [F2 protein results in increased abundance of Nitric Oxide]	22244921
D009569	Nitric Oxide	F2 protein promotes the reaction [Heparin results in increased abundance of Nitric Oxide]	8408661
D009569	Nitric Oxide	F2 protein results in increased abundance of Nitric Oxide	22244921
C109079	norgestimate, ethinyl estradiol drug combination	"norgestimate, ethinyl estradiol drug combination results in increased expression of F2 protein"	8950781
C025589	ochratoxin A	ochratoxin A results in decreased expression of F2 mRNA	29274910
C025589	ochratoxin A	ochratoxin A results in decreased expression of F2 mRNA	16251485
C076029	olanzapine	olanzapine affects the phosphorylation of F2 protein	25821032
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of F2 mRNA	18636392
D017239	Paclitaxel	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased activity of F3 protein]	19944065
D017239	Paclitaxel	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 mRNA]	19944065
D017239	Paclitaxel	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]	19944065
D017239	Paclitaxel	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK8 protein]	19944065
D017239	Paclitaxel	epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK9 protein]	19944065
D017239	Paclitaxel	[Paclitaxel co-treated with F2 protein] affects the localization of RELA protein	19944065
D017239	Paclitaxel	[Paclitaxel co-treated with F2 protein] results in increased activity of F3 protein	19944065
D017239	Paclitaxel	[Paclitaxel co-treated with F2 protein] results in increased expression of F3 mRNA	19944065
D017239	Paclitaxel	[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein	19944065
D017239	Paclitaxel	[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK8 protein	19944065
D017239	Paclitaxel	[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK9 protein	19944065
D017239	Paclitaxel	pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]	19944065
D010269	Paraquat	Paraquat results in increased expression of F2 mRNA	18198484
C064764	PENTA	PENTA results in decreased cleavage of and results in decreased activity of F2 protein	8446935
C046012	pentanal	pentanal results in decreased expression of F2 mRNA	26079696
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in decreased activity of [F2 protein binds to F9 protein binds to F10 protein]	1279834
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of F2 mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of F2 mRNA	19429403
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of F2 mRNA	20936131
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of F2 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of F2 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of F2 mRNA	18804290
D010578	Petroleum	Petroleum affects the expression of F2 mRNA	25208076
D015232	Dinoprostone	F2 protein results in increased secretion of Dinoprostone	26385185
D015232	Dinoprostone	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]	26385185
D015232	Dinoprostone	zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]]	26385185
D015232	Dinoprostone	Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
D015232	Dinoprostone	[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone	21811393
D015232	Dinoprostone	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
D010634	Phenobarbital	Phenobarbital affects the activity of F2 protein	19952496
C050815	phenylalanyl-prolyl-arginine chloromethyl ketone-thrombin	phenylalanyl-prolyl-arginine chloromethyl ketone-thrombin results in decreased activity of F2 protein	8322273
C020924	phenylalanyl-prolyl-arginine methyl chloride	phenylalanyl-prolyl-arginine methyl chloride inhibits the reaction [F2 protein results in increased expression of FOS mRNA]	18597608
C020924	phenylalanyl-prolyl-arginine methyl chloride	phenylalanyl-prolyl-arginine methyl chloride inhibits the reaction [F2 protein results in increased expression of MYC mRNA]	18597608
D010672	Phenytoin	[clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein]	16376047
C060974	phosphatidylinositol 3,4,5-triphosphate	"F2 protein results in increased abundance of phosphatidylinositol 3,4,5-triphosphate"	16051184
C060974	phosphatidylinositol 3,4,5-triphosphate	"resveratrol inhibits the reaction [F2 protein results in increased abundance of phosphatidylinositol 3,4,5-triphosphate]"	16051184
C060980	phosphatidylinositol 3,4-diphosphate	"F2 protein results in increased abundance of phosphatidylinositol 3,4-diphosphate"	16051184
C060980	phosphatidylinositol 3,4-diphosphate	"resveratrol inhibits the reaction [F2 protein results in increased abundance of phosphatidylinositol 3,4-diphosphate]"	16051184
C037178	phosphatidylinositol 4-phosphate	F2 protein results in increased abundance of phosphatidylinositol 4-phosphate	16051184
C037178	phosphatidylinositol 4-phosphate	resveratrol inhibits the reaction [F2 protein results in increased abundance of phosphatidylinositol 4-phosphate]	16051184
D010716	Phosphatidylinositols	F2 protein results in increased abundance of Phosphatidylinositols	16051184
D010716	Phosphatidylinositols	resveratrol inhibits the reaction [F2 protein results in increased abundance of Phosphatidylinositols]	16051184
D010718	Phosphatidylserines	Phosphatidylserines affects the reaction [Doxorubicin results in increased cleavage of F2 protein]	21865289
D010743	Phospholipids	F2 protein affects the transport of Phospholipids	16293890
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in decreased expression of F2 mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of F2 mRNA	20813756
D028321	Plant Preparations	Plant Preparations results in decreased expression of F2 protein	28284660
D011189	Potassium Chloride	Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]	21811393
D011189	Potassium Chloride	Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
D011189	Potassium Chloride	[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA	21811393
D011189	Potassium Chloride	[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone	21811393
D011189	Potassium Chloride	[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein	21811393
D011189	Potassium Chloride	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]	21811393
D011189	Potassium Chloride	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]	21811393
D011189	Potassium Chloride	nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]	21811393
D011192	Potassium Dichromate	Potassium Dichromate affects the expression of F2 mRNA	23608068
D011374	Progesterone	[Hirudins binds to and results in decreased activity of F2 protein] promotes the reaction [CGB3 protein results in increased chemical synthesis of Progesterone]	22207716
D011374	Progesterone	[Hirudins binds to and results in decreased activity of F2 protein] which results in increased chemical synthesis of Progesterone	22207716
D011374	Progesterone	F2 protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Progesterone]	22207716
D011372	Progestins	Progestins results in increased expression of F2 protein	4688259
C005556	propionaldehyde	propionaldehyde results in decreased expression of F2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of F2 mRNA	24780913
D019269	Phosphatidylinositol 4,5-Diphosphate	"F2 protein results in increased abundance of Phosphatidylinositol 4,5-Diphosphate"	16051184
D019269	Phosphatidylinositol 4,5-Diphosphate	"resveratrol inhibits the reaction [F2 protein results in increased abundance of Phosphatidylinositol 4,5-Diphosphate]"	16051184
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]	19944065
D011794	Quercetin	Quercetin results in increased expression of F2 mRNA	21356098
D011794	Quercetin	Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]	15342215
D011794	Quercetin	Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]	15342215
D011794	Quercetin	Quercetin inhibits the reaction [F2 protein results in increased expression of SELP protein]	14628445
D011794	Quercetin	Quercetin inhibits the reaction [F2 protein results in increased localization of Calcium]	19814731
C503991	quercetin 3,7,3',4'-tetrasulfate	"quercetin 3,7,3',4'-tetrasulfate inhibits the reaction [SERPIND1 protein results in increased degradation of F2 protein]"	11958811
C503992	quercetin 3-acetyl-7,3',4'-trisulfate	"quercetin 3-acetyl-7,3',4'-trisulfate promotes the reaction [SERPIND1 protein results in increased degradation of F2 protein]"	11958811
C041125	quinapril	quinapril results in decreased activity of F2 protein	16907931
D017382	Reactive Oxygen Species	F2 protein results in increased chemical synthesis of Reactive Oxygen Species	14656924
C059514	resveratrol	resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate]	15342215
C059514	resveratrol	resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate]	15342215
C059514	resveratrol	"resveratrol inhibits the reaction [F2 protein results in increased abundance of phosphatidylinositol 3,4,5-triphosphate]"	16051184
C059514	resveratrol	"resveratrol inhibits the reaction [F2 protein results in increased abundance of phosphatidylinositol 3,4-diphosphate]"	16051184
C059514	resveratrol	"resveratrol inhibits the reaction [F2 protein results in increased abundance of Phosphatidylinositol 4,5-Diphosphate]"	16051184
C059514	resveratrol	resveratrol inhibits the reaction [F2 protein results in increased abundance of phosphatidylinositol 4-phosphate]	16051184
C059514	resveratrol	resveratrol inhibits the reaction [F2 protein results in increased abundance of Phosphatidylinositols]	16051184
C059514	resveratrol	resveratrol inhibits the reaction [F2 protein results in increased expression of SELP protein]	16051184
C059514	resveratrol	resveratrol inhibits the reaction [F2 protein results in increased phosphorylation of PLEK protein]	16051184
C059514	resveratrol	resveratrol results in increased expression of F2 mRNA	23419489
C089730	rosiglitazone	rosiglitazone affects the expression of F2 protein	19556978
C021129	S 2238	F2 protein results in increased cleavage of S 2238	6648356
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of F2 mRNA	25895662
D019821	Simvastatin	Cycloheximide inhibits the reaction [Simvastatin results in decreased activity of F2 protein]	14630613
D019821	Simvastatin	Simvastatin affects the reaction [F2 affects the localization of CTTN protein]	14630613
D019821	Simvastatin	Simvastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein]	12067895
D019821	Simvastatin	Simvastatin results in decreased activity of F2 protein	14630613
D020123	Sirolimus	Sirolimus results in decreased expression of F2 mRNA	21865292
C016104	sodium bichromate	sodium bichromate results in decreased expression of F2 mRNA	24612858
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of F2 protein	28918527
C444426	splitomicin	splitomicin promotes the reaction [F2 protein results in increased expression of F3 protein]	20978007
C458525	STO 609	STO 609 results in decreased susceptibility to F2 protein	21145922
D013629	Tamoxifen	Tamoxifen affects the expression of F2 protein	8200368
C004648	testosterone enanthate	testosterone enanthate results in increased expression of F2 protein	8585008
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of F2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of F2 mRNA	16267337
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of F2 mRNA	15644576
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [F2 protein results in increased uptake of Manganese]	2125206
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of F2 mRNA	25613284
D013929	Thromboxane B2	F2 protein results in increased chemical synthesis of Thromboxane B2	16293890
C009495	titanium dioxide	titanium dioxide results in decreased expression of F2 mRNA	23557971
C082097	tocotrienol, delta	"tocotrienol, delta results in increased expression of F2 mRNA"	21356098
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of IL6 mRNA]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of NPPA protein]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of NPPB protein]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 mRNA]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 protein]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased phosphorylation of PDGFRA protein]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased phosphorylation of PTK2B protein]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 protein]]	26385185
C447082	tricarbonyldichlororuthenium (II) dimer	zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]]	26385185
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of F2 mRNA	19448997
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of F2 mRNA	19042947
C080163	trovafloxacin	[Lipopolysaccharides co-treated with trovafloxacin] results in increased activity of F2 protein	19367693
D014635	Valproic Acid	Valproic Acid affects the expression of F2 mRNA	25979313
C524038	variegin protein, Amblyomma variegatum	"F2 protein results in increased cleavage of variegin protein, Amblyomma variegatum"	19644995
C524038	variegin protein, Amblyomma variegatum	"variegin protein, Amblyomma variegatum binds to and results in decreased activity of F2 protein"	19644995
D014750	Vincristine	Vincristine affects the expression of F2 protein	12542493
D012256	Riboflavin	Riboflavin results in increased expression of F2 mRNA	21356098
D014810	Vitamin E	Vitamin E results in decreased expression of and results in decreased activity of F2 protein	10216089
D010837	Vitamin K 1	Vitamin K 1 deficiency results in increased expression of F2 protein modified form	2821104
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of F2 mRNA"	27188386
D014859	Warfarin	F2 gene polymorphism affects the susceptibility to Warfarin	14656880
D014859	Warfarin	Fenofibrate promotes the reaction [Warfarin results in decreased expression of F2 protein]	9681093
D014859	Warfarin	Warfarin results in decreased expression of F2 protein	9681093
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of F2 mRNA"	25208076
C426686	ximelagatran	ximelagatran binds to and results in decreased activity of F2 protein	15155122\|1608435
C426686	ximelagatran	ximelagatran results in decreased cleavage of F2 protein	16194202\|1731411
C426686	ximelagatran	ximelagatran results in decreased activity of F2 protein	16305522
C108830	Y 27632	Y 27632 inhibits the reaction [F2 protein results in increased phosphorylation of MYL9 protein]	15284075
C108830	Y 27632	[Y 27632 results in decreased activity of ROCK1 protein] which results in decreased activity of F2 protein	16675616
D015032	Zinc	F2 protein binds to Zinc	23896426
C017803	zinc protoporphyrin	zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 protein]]	26385185
C017803	zinc protoporphyrin	zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]]	26385185

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001530	lipopolysaccharide binding	-	IDA	20421939
GO:0004252	serine-type endopeptidase activity	-	IDA	1672265 12855810
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0005102	signaling receptor binding	-	IPI	8626514 12855810
GO:0005509	calcium ion binding	-	IEA	-
GO:0005515	protein binding	-	IPI	3279057 6323392 8530382 8626514 14691232 16230339 16230340
GO:0008083	growth factor activity	-	TAS	8626514
GO:0008201	heparin binding	-	IDA	20421939
GO:0070053	thrombospondin receptor activity	-	IDA	2435757

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001934	positive regulation of protein phosphorylation	-	IDA	7559487
GO:0006508	proteolysis	-	IEA	-
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	-
GO:0006953	acute-phase response	-	IEA	-
GO:0007166	cell surface receptor signaling pathway	-	IDA	1672265
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007275	multicellular organism development	-	TAS	9639571
GO:0007596	blood coagulation	-	TAS	-
GO:0007597	blood coagulation, intrinsic pathway	-	TAS	-
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0008360	regulation of cell shape	-	IEA	-
GO:0009611	response to wounding	-	IDA	9639571
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010544	negative regulation of platelet activation	-	TAS	17379830
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	-	IEA	-
GO:0030168	platelet activation	-	IDA	9038223
GO:0030168	platelet activation	-	TAS	-
GO:0030193	regulation of blood coagulation	-	TAS	12855810
GO:0030194	positive regulation of blood coagulation	-	IDA	9038223
GO:0030307	positive regulation of cell growth	-	IEA	-
GO:0030449	regulation of complement activation	-	TAS	-
GO:0032967	positive regulation of collagen biosynthetic process	-	IDA	9639571
GO:0042730	fibrinolysis	-	IDA	12855810
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0045861	negative regulation of proteolysis	-	IDA	1695900
GO:0046427	positive regulation of JAK-STAT cascade	-	NAS	10692450
GO:0048712	negative regulation of astrocyte differentiation	-	IDA	1691280
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	-	IDA	1672265 19052258
GO:0051480	regulation of cytosolic calcium ion concentration	-	IDA	19052258
GO:0051838	cytolysis by host of symbiont cells	-	IDA	20421939
GO:0051918	negative regulation of fibrinolysis	-	TAS	17379830
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	-	IDA	20421939
GO:0070945	neutrophil mediated killing of gram-negative bacterium	-	IDA	20421939
GO:0090218	positive regulation of lipid kinase activity	-	IDA	11309392
GO:1900016	negative regulation of cytokine production involved in inflammatory response	-	IDA	20421939
GO:1900182	positive regulation of protein localization to nucleus	-	IDA	11309392
GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway	-	IDA	20164183
GO:2000379	positive regulation of reactive oxygen species metabolic process	-	IDA	17275676

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	16502470
GO:0005615	extracellular space	-	IDA	9639571 20421939
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005796	Golgi lumen	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0009897	external side of plasma membrane	colocalizes_with	IDA	20421939
GO:0070062	extracellular exosome	-	HDA	23533145
GO:0072562	blood microparticle	-	HDA	22516433

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction
hsa04610	Complement and coagulation cascades
hsa04810	Regulation of actin cytoskeleton

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-140837	Intrinsic Pathway of Fibrin Clot Formation	TAS
R-HSA-140875	Common Pathway of Fibrin Clot Formation	TAS
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	TAS
R-HSA-159740	Gamma-carboxylation of protein precursors	TAS
R-HSA-159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	TAS
R-HSA-159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	TAS
R-HSA-159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-163841	Gamma carboxylation, hypusine formation and arylsulfatase activation	TAS
R-HSA-166658	Complement cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76009	Platelet Aggregation (Plug Formation)	TAS
R-HSA-977606	Regulation of Complement cascade	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28144390	Predictors for advanced fibrosis in morbidly obese non-alcoholic fatty liver patients. (2017 Jan 18)	Zelber-Sagi S	World J Hepatol
15617774	Genetic correlation between the free-choice oral consumption of nicotine and alcohol in C57BL/6JxC3H/HeJ F2 intercross mice. (2005 Feb 10)	Li XC	Behav Brain Res
12657708	The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumption. (2003 Mar 15)	Bachtell RK	J Neurosci
11003198	Mapping of quantitative trait loci for hypnotic sensitivity to ethanol in crosses derived from the C57BL/6 and DBA/2 mouse strains. (2000 Sep)	Radcliffe RA	Alcohol Clin Exp Res
23439618	Postnatal metabolic and reproductive consequences of fetal and neonatal exposure to the smoking cessation drug bupropion. (2013 Oct)	De Long N	Reprod Sci
27599824	Sarcopenia is an independent risk factor for non-alcoholic steatohepatitis and significant fibrosis. (2017 Jan)	Koo BK	J Hepatol
23797033	Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis. (2013 Dec)	D'Amico E	Free Radic Biol Med
16485141	Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5. (2006 Mar)	Siu EC	Psychopharmacology (Berl)
27960139	Oxidative stress, inflammation and treatment response in major depression. (2017 Feb)	Lindqvist D	Psychoneuroendocrinology
11295361	Red wine polyphenols, in the absence of alcohol, reduce lipid peroxidative stress in smoking subjects. (2001 Mar 15)	Abu-Amsha Caccetta R	Free Radic Biol Med
15608595	Quantitative trait loci mapping for ethanol sensitivity and neurotensin receptor density in an F2 intercross derived from inbred high and low alcohol sensitivity selectively bred rat lines. (2004 Dec)	Radcliffe RA	Alcohol Clin Exp Res
12960747	Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat lines. (2003 Sep)	Foroud T	Psychiatr Genet
24611993	Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats. (2014 May)	Yong W	Alcohol Clin Exp Res
28222662	FOXF2 promoter methylation is associated with prognosis in esophageal squamous cell carcinoma. (2017 Feb)	Chen X	Tumour Biol
25106775	Inflammation and oxidative stress markers and esophageal adenocarcinoma incidence in a Barrett's esophagus cohort. (2014 Nov)	Hardikar S	Cancer Epidemiol Biomarkers Prev
25614985	Low serum high density lipoprotein cholesterol concentration is an independent predictor for enhanced inflammation and endothelial activation. (2015)	Wan Ahmad WN	PLoS One
19120064	Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice. (2009 Mar)	Bice P	Alcohol Clin Exp Res
9554084	Generation of carbohydrate-deficient transferrin by enzymatic deglycosylation of human transferrin. (1998 Mar)	Duan C	Appl Biochem Biotechnol
8273801	Effect of cigarette smoking on gallbladder emptying and filling in man. (1994 Jan)	Jonderko K	Am J Gastroenterol
20148880	Genetic susceptibility, smoking, obesity and risk of venous thromboembolism. (2010 Apr)	Severinsen MT	Br J Haematol
27091532	Oxidative Stress and Inflammation Differentially Elevated in Objective Versus Habitual Subjective Reduced Sleep Duration in Obstructive Sleep Apnea. (2016 Jul 1)	DeMartino T	Sleep
22622000	Male germline transmits fetal alcohol adverse effect on hypothalamic proopiomelanocortin gene across generations. (2012 Sep 1)	Govorko D	Biol Psychiatry
21691170	Amniotic fluid eicosanoids in preterm and term births: effects of risk factors for spontaneous preterm labor. (2011 Jul)	Menon R	Obstet Gynecol
28391180	Classifying oxidative stress by F2-isoprostane levels across human diseases: A meta-analysis. (2017 Aug)	van 't Erve TJ	Redox Biol
16036356	Serum selenium predicts levels of F2-isoprostanes and prostaglandin F2alpha in a 27 year follow-up study of Swedish men. (2005 Jul)	Helmersson J	Free Radic Res
23016573	Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study. (2012 Sep 27)	Nerpin E	BMC Res Notes
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